SHOX cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	SHOX
Entrez Gene ID	418669
Full Name	short stature homeobox
General protein information	Preferred Names short stature homeobox Names short stature homeobox protein
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001079724.1	NP_001073192.1	short stature homeobox protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	SHOX	NP_000442.1
Xenopus tropicalis (tropical clawed frog)	shox	XP_004911874.1
Bos taurus (cattle)	SHOX	NP_001178475.1
Gallus gallus (chicken)	SHOX	NP_001073192.1
Danio rerio (zebrafish)	shox	NP_001119883.1
Canis lupus familiaris (dog)	SHOX	NP_001020793.1

Gene Ontology
Bibliography

Related articles in PubMed

Enhancer elements upstream of the SHOX gene are active in the developing limb.
Durand C, Bangs F, Signolet J, Decker E, Tickle C, Rappold G
European journal of human genetics : EJHG18(5)527-32(2010 May)

Long-range conserved non-coding SHOX sequences regulate expression in developing chicken limb and are associated with short stature phenotypes in human patients.
Sabherwal N, Bangs F, R?th R, Weiss B, Jantz K, Tiecke E, Hinkel GK, Spaich C, Hauffa BP, van der Kamp H, Kapeller J, Tickle C, Rappold G
Human molecular genetics16(2)210-22(2007 Jan)

Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements.
Tiecke E, Bangs F, Blaschke R, Farrell ER, Rappold G, Tickle C
Developmental biology298(2)585-96(2006 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SHOX upstream deletions occur at a lower frequency because of the structural organization of this genomic region.
Title: Enhancer elements upstream of the SHOX gene are active in the developing limb.

Long-range conserved non-coding SHOX sequences regulate expression in developing chicken limb and are associated with short stature phenotypes in human patients.
Title: Long-range conserved non-coding SHOX sequences regulate expression in developing chicken limb and are associated with short stature phenotypes in human patients.

These results fit well with the proposed role of Shox in cartilage and bone differentiation and suggest chick embryos as a useful model to study further the role of Shox in limb development.
Title: Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements.

The following SHOX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SHOX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa24372	NM_001079724.1 Latest version!	Gallus gallus short stature homeobox (SHOX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SHOX ( NM_001079724.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001073192.1 Gallus gallus short stature homeobox (SHOX), mRNA.

Price & Availability↑

CloneID	OGa24372
Clone ID Related Accession (Same CDS sequence)	NM_001079724.1
Accession Version	NM_001079724.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	short stature homeobox protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ675517.1. On Dec 12, 2006 this sequence version replaced XM_416865.2. ##Evidence-Data-START## Transcript exon combination :: DQ675517.1 [ECO:0000332] ##Evidence-Data-END##

ATGGAAGAAC TCACGGCTTT TGTATCCAAA TCTTTCGACC AGAAAAGCAA AGAGAGCGGC 
GGCGGCGGCG GCGGCGGCAA CAAGAAGGAG ACCATCACGT ACCGGGAAGT TTTGGAGAGT 
GGGTTGGCTC GCTCCAGGGA GCTTGGGAAC TCCGATTCGG CGCTGCCGGA CATGACCGAG 
GGCAGCAATC ATTGCCCCGT GCACCTTTTC AAGGACCACG TAGAAAGCGA CAAGGACAAG 
CTGAAGGAGT TCGCGGCGGG CAGGACGGCG GAAGGGATCT ACGAGTGCAA GGAGAAGCGG 
GAGGACGTGA AGTCGGAGGA CGAGGACGGC CAGACCAAGC TGAAACAAAG GAGAAGCAGA 
ACCAATTTCA CACTAGAGCA GCTGAACGAG CTGGAAAGAC TTTTTGATGA GACTCACTAC 
CCGGATGCCT TCATGCGGGA GGAACTAAGC CAGAGGCTGG GACTGTCTGA AGCTAGGGTG 
CAGGTCTGGT TCCAGAACAG GAGAGCCAAG TGCCGAAAGC AGGAGAACCA GATGCACAAA 
GGTGTGATCT TGGGCACCGC CAGCCACTTA GACGCCTGCA GAGTGGCCCC GTACGTCAAT 
ATGGGAGCCC TGAGGATGCC TTTCCAACAG GTCCAGGCTC AGCTGCAGCT GGAGGGAGTG 
GCCCACGCAC ACCCGCACCT GCACCCGCAC CTGGCGGCCC ACGCGCCCTA CCTGATGTTC 
CCACCTCCGC CCTTCGGGCT GCCCATCGCC TCCCTGGCGG AGTCCGCCTC CGCCGCCGCC 
GTGGTGGCCG CAGCCGCCAA GAGCAACAGC AAGAACTCCA GCATCGCCGA CCTGCGGCTG 
AAGGCCCGCA AGCACGCCGA GGCCCTGGGG CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001073192.1
CDS	30..905
Translation	MEELTAFVSKSFDQKSKESGGGGGGGNKKETITYREVLESGLARSRELGNSDSALPDMTEGSNHCPVHLFKDHVESDKDKLKEFAAGRTAEGIYECKEKREDVKSEDEDGQTKLKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMHKGVILGTASHLDACRVAPYVNMGALRMPFQQVQAQLQLEGVAHAHPHLHPHLAAHAPYLMFPPPPFGLPIASLAESASAAAVVAAAAKSNSKNSSIADLRLKARKHAEALGL

Target ORF information:

RefSeq Version	NM_001079724.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus short stature homeobox (SHOX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001079724.1

ORF Insert Sequence:

ATGGAAGAAC TCACGGCTTT TGTATCCAAA TCTTTCGACC AGAAAAGCAA AGAGAGCGGC 
GGCGGCGGCG GCGGCGGCAA CAAGAAGGAG ACCATCACGT ACCGGGAAGT TTTGGAGAGT 
GGGTTGGCTC GCTCCAGGGA GCTTGGGAAC TCCGATTCGG CGCTGCCGGA CATGACCGAG 
GGCAGCAATC ATTGCCCCGT GCACCTTTTC AAGGACCACG TAGAAAGCGA CAAGGACAAG 
CTGAAGGAGT TCGCGGCGGG CAGGACGGCG GAAGGGATCT ACGAGTGCAA GGAGAAGCGG 
GAGGACGTGA AGTCGGAGGA CGAGGACGGC CAGACCAAGC TGAAACAAAG GAGAAGCAGA 
ACCAATTTCA CACTAGAGCA GCTGAACGAG CTGGAAAGAC TTTTTGATGA GACTCACTAC 
CCGGATGCCT TCATGCGGGA GGAACTAAGC CAGAGGCTGG GACTGTCTGA AGCTAGGGTG 
CAGGTCTGGT TCCAGAACAG GAGAGCCAAG TGCCGAAAGC AGGAGAACCA GATGCACAAA 
GGTGTGATCT TGGGCACCGC CAGCCACTTA GACGCCTGCA GAGTGGCCCC GTACGTCAAT 
ATGGGAGCCC TGAGGATGCC TTTCCAACAG GTCCAGGCTC AGCTGCAGCT GGAGGGAGTG 
GCCCACGCAC ACCCGCACCT GCACCCGCAC CTGGCGGCCC ACGCGCCCTA CCTGATGTTC 
CCACCTCCGC CCTTCGGGCT GCCCATCGCC TCCCTGGCGG AGTCCGCCTC CGCCGCCGCC 
GTGGTGGCCG CAGCCGCCAA GAGCAACAGC AAGAACTCCA GCATCGCCGA CCTGCGGCTG 
AAGGCCCGCA AGCACGCCGA GGCCCTGGGG CTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Enhancer elements upstream of the SHOX gene are active in the developing limb.
European journal of human genetics : EJHG18(5)527-32(2010 May)
Durand C,Bangs F,Signolet J,Decker E,Tickle C,Rappold G

Long-range conserved non-coding SHOX sequences regulate expression in developing chicken limb and are associated with short stature phenotypes in human patients.
Human molecular genetics16(2)210-22(2007 Jan)
Sabherwal N,Bangs F,R?th R,Weiss B,Jantz K,Tiecke E,Hinkel GK,Spaich C,Hauffa BP,van der Kamp H,Kapeller J,Tickle C,Rappold G

Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements.
Developmental biology298(2)585-96(2006 Oct)
Tiecke E,Bangs F,Blaschke R,Farrell ER,Rappold G,Tickle C