| Gene Symbol | IL1RN |
| Entrez Gene ID | 100034236 |
| Full Name | interleukin 1 receptor antagonist |
| Synonyms | IL-1RA |
| Gene Type | protein-coding |
| Organism | Equus caballus(horse) |
ORF » Species Summary » Equus caballus » IL1RN cDNA ORF clone
| Gene Symbol | IL1RN |
| Entrez Gene ID | 100034236 |
| Full Name | interleukin 1 receptor antagonist |
| Synonyms | IL-1RA |
| Gene Type | protein-coding |
| Organism | Equus caballus(horse) |
| mRNA | Protein | Name |
|---|---|---|
| XM_005599766.2 | XP_005599823.1 | interleukin-1 receptor antagonist protein isoform X2 |
| XM_014730883.2 | XP_014586369.1 | interleukin-1 receptor antagonist protein isoform X1 |
| NM_001082525.2 | NP_001075994.1 | interleukin-1 receptor antagonist protein precursor |
| XM_014730883.1 | XP_014586369.1 | interleukin-1 receptor antagonist protein isoform X1 |
| XM_005599766.3 | XP_005599823.1 | interleukin-1 receptor antagonist protein isoform X2 |
scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy.
Goodrich LR, Grieger JC, Phillips JN, Khan N, Gray SJ, McIlwraith CW, Samulski RJ
Gene therapy22(7)536-45(2015 Jul)
Annotation of the Protein Coding Regions of the Equine Genome.
Hestand MS, Kalbfleisch TS, Coleman SJ, Zeng Z, Liu J, Orlando L, MacLeod JN
PloS one10(6)e0124375(2015)
Interleukin-1 receptor antagonist expression in the equine endometrium during the peri-implantation period.
Haneda S, Nagaoka K, Nambo Y, Kikuchi M, Nakano Y, Matsui M, Miyake Y, Macleod JN, Imakawa K
Domestic animal endocrinology36(4)209-18(2009 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This is the first study in an equine model to establish a dosing/redosing protocol, as well as examine the Nab response to capsid and supports further clinical investigation to determine the clinical efficacy of scAAVIL-1ra to treat osteoarthritis.
Title: scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy.
Expression of IL-1RN in the endometrium is likely regulated by estradiol and progesterone and suggest that IL-1RN regulates the degree of IL-1 signal transduction and thereby plays an important role in the establishment of equine pregnancy.
Title: Interleukin-1 receptor antagonist expression in the equine endometrium during the peri-implantation period.
The following IL1RN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL1RN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHb00043 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001082525.2 | |
| Accession Version | NM_001082525.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-24 | |
| Organism | Equus caballus(horse) | |
| Product | interleukin-1 receptor antagonist protein precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD465095.1, AF088186.1, U92482.1, D83714.1 and CD470329.1. On May 29, 2015 this sequence version replaced NM_001082525.1. ##Evidence-Data-START## Transcript exon combination :: CD466354.1, U92482.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2452530, SAMEA2452531 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGAAATCC GCAGGCGTTC TGTCAGACAC CTAATCTCTC TCCTCCTTTT CTTGCTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001075994.1 |
| CDS | 60..593 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001082525.2 |
1 | ATGGAAATCC GCAGGCGTTC TGTCAGACAC CTAATCTCTC TCCTCCTTTT CTTGCTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHb05821 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005599766.2 , XM_005599766.3 | |
| Accession Version | XM_005599766.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-11-19 | |
| Organism | Equus caballus(horse) | |
| Product | interleukin-1 receptor antagonist protein isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_001867379.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 20, 2015 this sequence version replaced XM_005599766.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Equus caballus Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCAAGCCT TCAGAATCTG GGATGTTAAC CAGAAGACCT TCTACATGAG GAATAACCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005599823.1 |
| CDS | 125..556 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005599766.2 |
1 | ATGCAAGCCT TCAGAATCTG GGATGTTAAC CAGAAGACCT TCTACATGAG GAATAACCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHb05821 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005599766.2 , XM_005599766.3 | |
| Accession Version | XM_005599766.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-01-22 | |
| Organism | Equus caballus(horse) | |
| Product | interleukin-1 receptor antagonist protein isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_009158.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 23, 2018 this sequence version replaced XM_005599766.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Equus caballus Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCAAGCCT TCAGAATCTG GGATGTTAAC CAGAAGACCT TCTACATGAG GAATAACCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005599823.1 |
| CDS | 120..551 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005599766.3 |
1 | ATGCAAGCCT TCAGAATCTG GGATGTTAAC CAGAAGACCT TCTACATGAG GAATAACCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHb35243 | |
| Clone ID Related Accession (Same CDS sequence) | XM_014730883.2 , XM_014730883.1 | |
| Accession Version | XM_014730883.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-01-22 | |
| Organism | Equus caballus(horse) | |
| Product | interleukin-1 receptor antagonist protein isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_009158.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 23, 2018 this sequence version replaced XM_014730883.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Equus caballus Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGCTTTAG AGACAGCCTG CCACCCTTTG GGGAAGAGAC CCTGCAAGAT GCAAGCCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_014586369.1 |
| CDS | 155..634 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_014730883.2 |
1 | ATGGCTTTAG AGACAGCCTG CCACCCTTTG GGGAAGAGAC CCTGCAAGAT GCAAGCCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHb35243 | |
| Clone ID Related Accession (Same CDS sequence) | XM_014730883.2 , XM_014730883.1 | |
| Accession Version | XM_014730883.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-11-19 | |
| Organism | Equus caballus(horse) | |
| Product | interleukin-1 receptor antagonist protein isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_001867379.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Equus caballus Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGCTTTAG AGACAGCCTG CCACCCTTTG GGGAAGAGAC CCTGCAAGAT GCAAGCCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_014586369.1 |
| CDS | 154..633 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_014730883.1 |
1 | ATGGCTTTAG AGACAGCCTG CCACCCTTTG GGGAAGAGAC CCTGCAAGAT GCAAGCCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy. |
Annotation of the Protein Coding Regions of the Equine Genome. |
Interleukin-1 receptor antagonist expression in the equine endometrium during the peri-implantation period. |