dner cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	dner
Entrez Gene ID	100332110
Full Name	delta/notch-like EGF repeat containing
General protein information	Preferred Names delta/notch-like EGF repeat containing Names delta and Notch-like epidermal growth factor-related receptor delta/notch-like EGF-related receptor zmp:0000000696
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001282486.1	NP_001269415.1	delta and Notch-like epidermal growth factor-related receptor precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DNER	XP_516135.2
	DNER	XP_002799116.1
Canis lupus familiaris (dog)	DNER	XP_852345.2
Bos taurus (cattle)	DNER	XP_003585822.1
Danio rerio (zebrafish)	dner	XP_002665457.3
Homo sapiens (human)	DNER	NP_620711.3
Mus musculus (house mouse)	Dner	NP_690879.1
Rattus norvegicus (Norway rat)	Dner	XP_001077059.2
Gallus gallus (chicken)	DNER	XP_422604.2
Xenopus tropicalis (tropical clawed frog)	dner	NP_001116263.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants.
Ma Z, Zhu P, Pang M, Guo L, Chang N, Zheng J, Zhu X, Gao C, Huang H, Cui Z, Xiong JW, Peng J, Chen J
Scientific reports7(1)10381(2017 Sep)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish.
Hsieh FY, Ma TL, Shih HY, Lin SJ, Huang CW, Wang HY, Cheng YC
Developmental biology375(1)1-12(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study found that dner was sufficient to inhibit the proliferation of neural progenitors and Dner antagonized DeltaD to induce neuronal and glial differentiation
Title: Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish.

The following dner gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the dner cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa38939	NM_001282486.1 Latest version!	Danio rerio delta/notch-like EGF repeat containing (dner), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

dner ( NM_001282486.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001269415.1 Danio rerio delta/notch-like EGF repeat containing (dner), mRNA.

Price & Availability↑

CloneID	ODa38939
Clone ID Related Accession (Same CDS sequence)	NM_001282486.1
Accession Version	NM_001282486.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2235bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	delta and Notch-like epidermal growth factor-related receptor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JX277053.1. ##Evidence-Data-START## Transcript exon combination :: JX277053.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA4476763, SAMEA4476774 [ECO:0000350] ##Evidence-Data-END##

ATGCAGCTCT TCATCCTTCC TCTCCTCCTC CTTCTCCTCG GGGAGATGGA CGGACTCTTT 
GGGACCCCTC TGACGTCCAG CCCGGGCCCC GGCGAGGACC CAAGCACTGC GCCGGACCCC 
TGCGAGGGCC GACCGTGCCT GAACGGAGGC GTCTGCAGCC GGCTGGGAGA GATGGAGGAC 
AGTCAGAGCA CGCAGATGCA GACTCTGGAG CCGTGGGCTT ATATTTGTGT CTGCAGCCGG 
GGCTTCACAG GGCAGAACTG TGAGTTTTTT GCAGATCCGT GTGCCAGCAG TCCCTGTCTC 
CATGGCAACT GTAGTCAGGA TGGCGAAGGG GAAGGGTTTA CATGCGAGTG CAGTGAGGGC 
TACAGCGGTG CCCGGTGTGA CCTGCCAACC TTGACGTTTG ACCTGTCCGA GTCCACCTGG 
GACCTCGCTG AGAGCCTCGT ACCCGAGCAC GCCACGCCTG CCACTCCGGC CACACCCGCC 
ACCACCACTC AGGTGCTTCA GCCAACCACA GTCCTCACCA CCACTCAAGC CCCACCCACC 
CTGGAGCCCT GGCAGCCCAG AGCCGGTCAG AGAGTGCTGG AGATACTGTG GGACGATCAG 
CAGATTACTA ATGAAGCTGA ATGTGTGAGC ACCGCAGGAG GAGAGTCTGC CGGAATGATG 
AGCATCTCCT TGGAGCTCGC AGAGGAAACA GCTGTGAAGC TGGTTGGAAA TGTGAGTGGT 
TCTGCGGTGC TGTGGCGTGT TGGTGCGTCT GGTTATGAGC AGTGCTCGGT TGCTGACGGC 
ACGATCATGT GGTTCCAGCA GAGCTCTGAG GGTCTGGTGC TGCCCGATCA GTCCCTGCCG 
CTGGGGCACA ACTACTTCAT CACCCTGCTG GTTGGCTCTC CCTCTGGTCC AGAGGTCACT 
TTGAGGCTTC ATCTCCTGGT CAAAACCAAT AACTGCATGG AGCCCGGCAG TGCATTCAGT 
GACCCACAAT GCTCCGGGAA AGGCAAATGC GTCACCCAGT CCTCCGTGGA CACCTTTTAC 
TGTCGGTGTG ATGATGGTTA TTCTGGGATC TTCTGCGAGG AGTTTGATGC CTGCCATCTG 
AAGCCCTGTG AAAACAACGG CTCTTGTGCT GACCTCAGAC AGAGAGATGA AGGACAAAAC 
TACACCTGTA CCTGCCAGAC AGGTTTTGAA GGAGAGCGCT GTCAGTCATT GGTGGATCAC 
TGTGTTTCTG GACCCTGCAG GAACGGAGCC ACTTGCTCCA GCAGCCTTGA AGGACCTCAC 
TGCTATTGTG CTGAAGGTTA TCAGGGCATC ATGTGTGAGC AGAAGATTGA TCCCTGTGCT 
TCAGGGCCCT GCCATAATAA TGCCAGCTGC TCCCCACAGG GTGCTGGTTT GGGCTTCAGC 
TGCACTTGTC CTGCAGGTTT CACTGGACCC ACCTGTGCCC AGCTGGTGGA CTTCTGTGCC 
CTCAACCCAT GCGCTCACGG CATCTGCCGC AGCATCGGCA CTAGTTACCG CTGTCTGTGT 
GTTCCAGGTT ATCATGGTCT GTACTGTGAG GAGGAGTATA ATGAATGCCT GTCTGCTCCG 
TGTCAGAATT ACGCCACATG CAGAGATCTG ATCAACGCTT ACGAGTGCAT CTGCGCCTCT 
CAGTTCACAG GTAAGCACTG TGAGATCTAT AAGGACCCCT GTCTGAAGCT CAGGTGCCAG 
AATGGAGGAC ACTGTGAAAG TGGAGGGAGA AACGCGTCCT GTGTGTGTCC TCCAGGATAT 
ATGGGTGAGA ACTGTGAGGT TGACGTCAAC GAGTGTGAGA GTAACCCCTG CCACCATGGC 
GGGACCTGCA TCGACCAATC AAACGGCTAC ACCTGTCATT GTCCTCCCGG CTGGGTCGGT 
GGAAGCTGTG AGATCCATCT GCAGTGGAAG ATGGCTCAGC CGGTGGACTC TCTGACCAAC 
ATGCCACGTC ACTCTCTGTA TATCATCATC GGGGCTCTGT GTGTGGCCTT CGTCTTGATG 
CTCATCATCC TCATCGTCGG GATCTGTCGC ATCAGCCGTA TTGAATACCA GGGCTCATCT 
CGTCACGCCT ACCAAGAGTT TTACAACTGC CGCAGTATCG ACAGTGATTT CAGCAATGCG 
ATCGCCTCTA TCCGCCACGC ACGGTTTGGC AAGAAATCCA GACCAGCGAT GTATGATGCG 
ACTCCCATCA GTTATGAAGA TTACAGCCCT GATGACAAGC CTCTGGTCGC ACTCATTAAA 
ACTAAAGATT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269415.1
CDS	1..2235
Translation	MQLFILPLLLLLLGEMDGLFGTPLTSSPGPGEDPSTAPDPCEGRPCLNGGVCSRLGEMEDSQSTQMQTLEPWAYICVCSRGFTGQNCEFFADPCASSPCLHGNCSQDGEGEGFTCECSEGYSGARCDLPTLTFDLSESTWDLAESLVPEHATPATPATPATTTQVLQPTTVLTTTQAPPTLEPWQPRAGQRVLEILWDDQQITNEAECVSTAGGESAGMMSISLELAEETAVKLVGNVSGSAVLWRVGASGYEQCSVADGTIMWFQQSSEGLVLPDQSLPLGHNYFITLLVGSPSGPEVTLRLHLLVKTNNCMEPGSAFSDPQCSGKGKCVTQSSVDTFYCRCDDGYSGIFCEEFDACHLKPCENNGSCADLRQRDEGQNYTCTCQTGFEGERCQSLVDHCVSGPCRNGATCSSSLEGPHCYCAEGYQGIMCEQKIDPCASGPCHNNASCSPQGAGLGFSCTCPAGFTGPTCAQLVDFCALNPCAHGICRSIGTSYRCLCVPGYHGLYCEEEYNECLSAPCQNYATCRDLINAYECICASQFTGKHCEIYKDPCLKLRCQNGGHCESGGRNASCVCPPGYMGENCEVDVNECESNPCHHGGTCIDQSNGYTCHCPPGWVGGSCEIHLQWKMAQPVDSLTNMPRHSLYIIIGALCVAFVLMLIILIVGICRISRIEYQGSSRHAYQEFYNCRSIDSDFSNAIASIRHARFGKKSRPAMYDATPISYEDYSPDDKPLVALIKTKDL

Target ORF information:

RefSeq Version	NM_001282486.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio delta/notch-like EGF repeat containing (dner), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282486.1

ORF Insert Sequence:

ATGCAGCTCT TCATCCTTCC TCTCCTCCTC CTTCTCCTCG GGGAGATGGA CGGACTCTTT 
GGGACCCCTC TGACGTCCAG CCCGGGCCCC GGCGAGGACC CAAGCACTGC GCCGGACCCC 
TGCGAGGGCC GACCGTGCCT GAACGGAGGC GTCTGCAGCC GGCTGGGAGA GATGGAGGAC 
AGTCAGAGCA CGCAGATGCA GACTCTGGAG CCGTGGGCTT ATATTTGTGT CTGCAGCCGG 
GGCTTCACAG GGCAGAACTG TGAGTTTTTT GCAGATCCGT GTGCCAGCAG TCCCTGTCTC 
CATGGCAACT GTAGTCAGGA TGGCGAAGGG GAAGGGTTTA CATGCGAGTG CAGTGAGGGC 
TACAGCGGTG CCCGGTGTGA CCTGCCAACC TTGACGTTTG ACCTGTCCGA GTCCACCTGG 
GACCTCGCTG AGAGCCTCGT ACCCGAGCAC GCCACGCCTG CCACTCCGGC CACACCCGCC 
ACCACCACTC AGGTGCTTCA GCCAACCACA GTCCTCACCA CCACTCAAGC CCCACCCACC 
CTGGAGCCCT GGCAGCCCAG AGCCGGTCAG AGAGTGCTGG AGATACTGTG GGACGATCAG 
CAGATTACTA ATGAAGCTGA ATGTGTGAGC ACCGCAGGAG GAGAGTCTGC CGGAATGATG 
AGCATCTCCT TGGAGCTCGC AGAGGAAACA GCTGTGAAGC TGGTTGGAAA TGTGAGTGGT 
TCTGCGGTGC TGTGGCGTGT TGGTGCGTCT GGTTATGAGC AGTGCTCGGT TGCTGACGGC 
ACGATCATGT GGTTCCAGCA GAGCTCTGAG GGTCTGGTGC TGCCCGATCA GTCCCTGCCG 
CTGGGGCACA ACTACTTCAT CACCCTGCTG GTTGGCTCTC CCTCTGGTCC AGAGGTCACT 
TTGAGGCTTC ATCTCCTGGT CAAAACCAAT AACTGCATGG AGCCCGGCAG TGCATTCAGT 
GACCCACAAT GCTCCGGGAA AGGCAAATGC GTCACCCAGT CCTCCGTGGA CACCTTTTAC 
TGTCGGTGTG ATGATGGTTA TTCTGGGATC TTCTGCGAGG AGTTTGATGC CTGCCATCTG 
AAGCCCTGTG AAAACAACGG CTCTTGTGCT GACCTCAGAC AGAGAGATGA AGGACAAAAC 
TACACCTGTA CCTGCCAGAC AGGTTTTGAA GGAGAGCGCT GTCAGTCATT GGTGGATCAC 
TGTGTTTCTG GACCCTGCAG GAACGGAGCC ACTTGCTCCA GCAGCCTTGA AGGACCTCAC 
TGCTATTGTG CTGAAGGTTA TCAGGGCATC ATGTGTGAGC AGAAGATTGA TCCCTGTGCT 
TCAGGGCCCT GCCATAATAA TGCCAGCTGC TCCCCACAGG GTGCTGGTTT GGGCTTCAGC 
TGCACTTGTC CTGCAGGTTT CACTGGACCC ACCTGTGCCC AGCTGGTGGA CTTCTGTGCC 
CTCAACCCAT GCGCTCACGG CATCTGCCGC AGCATCGGCA CTAGTTACCG CTGTCTGTGT 
GTTCCAGGTT ATCATGGTCT GTACTGTGAG GAGGAGTATA ATGAATGCCT GTCTGCTCCG 
TGTCAGAATT ACGCCACATG CAGAGATCTG ATCAACGCTT ACGAGTGCAT CTGCGCCTCT 
CAGTTCACAG GTAAGCACTG TGAGATCTAT AAGGACCCCT GTCTGAAGCT CAGGTGCCAG 
AATGGAGGAC ACTGTGAAAG TGGAGGGAGA AACGCGTCCT GTGTGTGTCC TCCAGGATAT 
ATGGGTGAGA ACTGTGAGGT TGACGTCAAC GAGTGTGAGA GTAACCCCTG CCACCATGGC 
GGGACCTGCA TCGACCAATC AAACGGCTAC ACCTGTCATT GTCCTCCCGG CTGGGTCGGT 
GGAAGCTGTG AGATCCATCT GCAGTGGAAG ATGGCTCAGC CGGTGGACTC TCTGACCAAC 
ATGCCACGTC ACTCTCTGTA TATCATCATC GGGGCTCTGT GTGTGGCCTT CGTCTTGATG 
CTCATCATCC TCATCGTCGG GATCTGTCGC ATCAGCCGTA TTGAATACCA GGGCTCATCT 
CGTCACGCCT ACCAAGAGTT TTACAACTGC CGCAGTATCG ACAGTGATTT CAGCAATGCG 
ATCGCCTCTA TCCGCCACGC ACGGTTTGGC AAGAAATCCA GACCAGCGAT GTATGATGCG 
ACTCCCATCA GTTATGAAGA TTACAGCCCT GATGACAAGC CTCTGGTCGC ACTCATTAAA 
ACTAAAGATT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants.
Scientific reports7(1)10381(2017 Sep)
Ma Z,Zhu P,Pang M,Guo L,Chang N,Zheng J,Zhu X,Gao C,Huang H,Cui Z,Xiong JW,Peng J,Chen J

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish.
Developmental biology375(1)1-12(2013 Mar)
Hsieh FY,Ma TL,Shih HY,Lin SJ,Huang CW,Wang HY,Cheng YC