cldn6.1.L cDNA ORF clone, Xenopus laevis(African clawed frog)

Gene
Clones
gRNAs

Summary

Gene Symbol	cldn6.1.L
Entrez Gene ID	446591
Full Name	claudin 6, gene 1 L homeolog
Synonyms	cldn4l2,cldn6,cldn6.1
General protein information	Preferred Names claudin 6, gene 1 L homeolog Names claudin 6, gene 1 L homeolog
Gene Type	protein-coding
Organism	Xenopus laevis(African clawed frog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001093287.1	NP_001086756.1	claudin 6, gene 1 L homeolog

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Xenopus Claudin-6 is required for embryonic pronephros morphogenesis and terminal differentiation.
Sun J, Wang X, Li C, Mao B
Biochemical and biophysical research communications462(3)178-83(2015 Jul)

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW, Richardson P
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)

Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning.
Gawantka V, Pollet N, Delius H, Vingron M, Pfister R, Nitsch R, Blumenstock C, Niehrs C
Mechanisms of development77(2)95-141(1998 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

claudin-6 is expressed in the developing pronephric tubule and duct but not glomus. Knockdown of claudin-6 by specific morpholino led to severe defects in pronephros tubular morphogenesis and blocked the terminal differentiation of the tubule cells.
Title: Xenopus Claudin-6 is required for embryonic pronephros morphogenesis and terminal differentiation.

The following cldn6.1.L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the cldn6.1.L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OAf02116	NM_001093287.1 Latest version!	Xenopus laevis claudin 6, gene 1 L homeolog (cldn6.1.L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

cldn6.1.L ( NM_001093287.1 ) cDNA ORF clone, Xenopus laevis(African clawed frog) -> NP_001086756.1 Xenopus laevis claudin 6, gene 1 L homeolog (cldn6.1.L), mRNA.

Price & Availability↑

CloneID	OAf02116
Clone ID Related Accession (Same CDS sequence)	NM_001093287.1
Accession Version	NM_001093287.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-10-28
Organism	Xenopus laevis(African clawed frog)
Product	claudin 6, gene 1 L homeolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC077402.1. ##Evidence-Data-START## Transcript exon combination :: BC077402.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00012418, SAMD00012420 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCTA CTGGTCTCCA GATCCTTGGC ATGGCCCTTG CCCTCATTGG CTGGGTGGGA 
TGTATAATCA CCTGTGCCAT GCCCATGTGG AGGGTGACTG CCTTCATTGG GAACAACATA 
GTGGTGGCTC AAACCATCTG GGAAGGACTG TGGATGAATT GCATTGTGCA GATTACTGGA 
CAGATGCAGT GCAAGGTCTA TGACTCCATG TTGGCTCTCT CCCAGGATTT GCAGGCTGCC 
CGTGCCCTTA CTGTCATCTG TATACTGGTA GCCCTGCTGG CCTTGCTCAT TGGTGTTGTG 
GGAGCCAAGT GCACCAACTG CATAGAAGAT GAGAACACCA AGGCCAAAGT CAGCATGGTA 
TCCGGCGTGG TCTACCTGGT GGCCGGTATC CTCATGCTCA TCCCTGTCTG CTGGTCTGCA 
AACAGCATCA TCCGTGACTT CTACAATCCC CTGGTGGTGG AGGCTCAGAA GAGAGAACTG 
GGAGCTGCCA TATACATAGG GTGGGCTTCC TCTACACTGA TGCTCCTGGG TGGAGGCCTC 
CTGTGCTGCT CTTGCCCCAA GAAGGAAGAT AACCACTACT CTGCCAGATA CACTGCTGCT 
GCTTCCCAGC CACGAAGTGA CTATCCCAGC AAGGATTATG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001086756.1
CDS	45..689
Translation	MASTGLQILGMALALIGWVGCIITCAMPMWRVTAFIGNNIVVAQTIWEGLWMNCIVQITGQMQCKVYDSMLALSQDLQAARALTVICILVALLALLIGVVGAKCTNCIEDENTKAKVSMVSGVVYLVAGILMLIPVCWSANSIIRDFYNPLVVEAQKRELGAAIYIGWASSTLMLLGGGLLCCSCPKKEDNHYSARYTAAASQPRSDYPSKDYV

Target ORF information:

RefSeq Version	NM_001093287.1
Organism	Xenopus laevis(African clawed frog)
Definition	Xenopus laevis claudin 6, gene 1 L homeolog (cldn6.1.L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001093287.1

ORF Insert Sequence:

ATGGCTTCTA CTGGTCTCCA GATCCTTGGC ATGGCCCTTG CCCTCATTGG CTGGGTGGGA 
TGTATAATCA CCTGTGCCAT GCCCATGTGG AGGGTGACTG CCTTCATTGG GAACAACATA 
GTGGTGGCTC AAACCATCTG GGAAGGACTG TGGATGAATT GCATTGTGCA GATTACTGGA 
CAGATGCAGT GCAAGGTCTA TGACTCCATG TTGGCTCTCT CCCAGGATTT GCAGGCTGCC 
CGTGCCCTTA CTGTCATCTG TATACTGGTA GCCCTGCTGG CCTTGCTCAT TGGTGTTGTG 
GGAGCCAAGT GCACCAACTG CATAGAAGAT GAGAACACCA AGGCCAAAGT CAGCATGGTA 
TCCGGCGTGG TCTACCTGGT GGCCGGTATC CTCATGCTCA TCCCTGTCTG CTGGTCTGCA 
AACAGCATCA TCCGTGACTT CTACAATCCC CTGGTGGTGG AGGCTCAGAA GAGAGAACTG 
GGAGCTGCCA TATACATAGG GTGGGCTTCC TCTACACTGA TGCTCCTGGG TGGAGGCCTC 
CTGTGCTGCT CTTGCCCCAA GAAGGAAGAT AACCACTACT CTGCCAGATA CACTGCTGCT 
GCTTCCCAGC CACGAAGTGA CTATCCCAGC AAGGATTATG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Xenopus Claudin-6 is required for embryonic pronephros morphogenesis and terminal differentiation.
Biochemical and biophysical research communications462(3)178-83(2015 Jul)
Sun J,Wang X,Li C,Mao B

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)
Klein SL,Strausberg RL,Wagner L,Pontius J,Clifton SW,Richardson P

Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning.
Mechanisms of development77(2)95-141(1998 Oct)
Gawantka V,Pollet N,Delius H,Vingron M,Pfister R,Nitsch R,Blumenstock C,Niehrs C