NFKB1 cDNA ORF clone, Sus scrofa(pig)

Gene
Clones
gRNAs

Summary

Gene Symbol	NFKB1
Entrez Gene ID	751869
Full Name	nuclear factor kappa B subunit 1
Gene Type	protein-coding
Organism	Sus scrofa(pig)
Genome	Chromosome: 8 Map Location: 8\|8q23-q27

mRNA and Protein(s)

mRNA	Protein	Name
NM_001048232.1	NP_001041697.1	nuclear factor NF-kappa-B p105 subunit

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Activation of porcine alveolar macrophages by
Li B, Fang J, Zuo Z, Yin S, He T, Yang M, Deng J, Shen L, Ma X, Yu S, Wang Y, Ren Z
Infection and immunity(2017 Dec)

Inhibition of NF-?B activity by the porcine epidemic diarrhea virus nonstructural protein 1 for innate immune evasion.
Zhang Q, Ma J, Yoo D
Virology510111-126(2017 10)

Porcine parvovirus infection activates inflammatory cytokine production through Toll-like receptor 9 and NF-?B signaling pathways in porcine kidney cells.
Zhou Y, Jin XH, Jing YX, Song Y, He XX, Zheng LL, Wang YB, Wei ZY, Zhang GP
Veterinary microbiology20756-62(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study showed that porcine epidemic diarrhea virus inhibited NF-kappaB activity and nsp1 was a potent NF-kappaB antagonist for suppression of both interferon and early production of pro-inflammatory cytokines.
Title: Inhibition of NF-?B activity by the porcine epidemic diarrhea virus nonstructural protein 1 for innate immune evasion.

inhibition of NF-kappaB increases autophagy via JNK signaling, and promotes steroidogenesis in porcine granulosa cells
Title: Inhibition of NF-?B promotes autophagy via JNK signaling pathway in porcine granulosa cells.

SIRT1, p53 and NF-kappaB are involved in the control of both the proliferation and the apoptosis of ovarian cells.
Title: Interrelationships between sirtuin 1 and transcription factors p53 and NF-?B (p50/p65) in the control of ovarian cell apoptosis and proliferation.

porcine CD74 significantly enhanced the inflammatory response by regulating the NF-kappaB signalling pathway during PCV2 infection, which suggests that porcine CD74 may be implicated in the pathogenesis of PCV2 infection.
Title: Porcine CD74 is involved in the inflammatory response activated by nuclear factor kappa B during porcine circovirus type 2 (PCV-2) infection.

These results suggest that trans-10, cis-12-conjugated linoleic acid can modulate TNF-alpha production and NF-kappa B expression by a PPARgamma-dependent pathway in porcine peripheral blood mononuclear cells.
Title: Trans-10, cis-12-conjugated linoleic acid modulates NF-?B activation and TNF-? production in porcine peripheral blood mononuclear cells via a PPAR?-dependent pathway.

The following NFKB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NFKB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSe30398	NM_001048232.1 Latest version!	Sus scrofa nuclear factor kappa B subunit 1 (NFKB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	Quote Price

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NFKB1 ( NM_001048232.1 ) cDNA ORF clone, Sus scrofa(pig) -> NP_001041697.1 Sus scrofa nuclear factor kappa B subunit 1 (NFKB1), mRNA.

Price & Availability↑

CloneID	OSe30398
Clone ID Related Accession (Same CDS sequence)	NM_001048232.1
Accession Version	NM_001048232.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2880bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Sus scrofa(pig)
Product	nuclear factor NF-kappa-B p105 subunit
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ834921.1. ##Evidence-Data-START## Transcript exon combination :: DQ834921.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1487420, SAMEA1876824 [ECO:0000348] ##Evidence-Data-END##

ATGTTTCATT TGGATCCTTT GAATCATACA ATATTTAATC CAGAATTATT TCAACCGGAG 
ATGCCACTGC CAACAGCAGA TGGCCCATAC CTTCAAATAT TAGAGCAACC TAAACAGAGA 
GGATTTCGTT TCCGTTATGT GTGTGAAGGC CCCTCCCATG GTGGACTCCC TGGCGCATCT 
AGTGAAAAGA ACAAGAAGTC CTACCCTCAG GTCAAAATCT GCAACTATGT TGGACCTGCA 
AAGGTTATTG TTCAGTTGGT CACAAATGGA AAAAACATCC ACCTGCATGC ACACAGCCTG 
GTGGGAAAAC ACGGAGAGGA TGGGATCTGC ACTGTCACTG CTGGACCCAA GGACATGGTG 
GTCGGCTTTG CAAACCTGGG TATACTTCAT GTGACAAAGA AAAAAGTATT TGAAACACTG 
GAAGCACGAA TGACAGAGGC ATGTATAAGG GGCTATAATC CCGGACTTTT GGTGCACCCT 
GATCTTGCTT ATTTGCAAGC GGAAGGTGGA GGGGACCGGC AGCTCACAGA TCGGGAAAAG 
GAGATCATCC GTCAGGCAGC TCTTCAGCAG ACGAAGGAGA TGGACCTCAG CGTGGTACGG 
CTCATGTTTA CAGCTTTCCT TCCGGACAGC ACGGGCAGCT TCACTAGGCG CCTGGAACCC 
GTGGTATCTG ATGCCATCTA TGACAGCAAA GCCCCCAATG CGTCCAACTT GAAAATAGTA 
AGAATGGACA GGACAGCCGG ATGTGTAACT GGAGGGGAAG AGATTTATCT TCTCTGTGAC 
AAGGTTCAGA AAGATGACAT CCAGATTCGA TTTTATGAAG AGGAAGAAAA TGGTGGAATC 
TGGGAAGGAT TTGGAGATTT TTCCCCCACA GACGTTCATA GACAATTTGC CATCGTCTTC 
AAAACTCCAA AGTATAAAGA TGTCAACATT ACAAAACCAG CCTCTGTGTT TGTCCAACTT 
CGGAGGAAGT CTGATTTGGA AACTAGTGAA CCGAAACCTT TTCTCTACTA TCCTGAAATC 
AAAGATAAAG AGGAAGTACA AAGGAAACGG CAGAAGCTCA TGCCCAATTT CTCAGATAGT 
TTCGGTGGCG GGAGTGGGGC TGGAGCTGGA GGCGGAGGCA TGTTTGGCAG CGGCGGTGGA 
GGAGGGGGTG CTGGAAGTAC TGGACCAGGG TATGGCTTCC CCCACTATGG ATTTCCTACA 
TATGGTGGAA TTACCTTCCA TGCTGGAACC ACTAAATCTA ATGCTGGAAT GAAGCACGGA 
ACTGTAGACA CCCCATCTAA AAATGACCCT GAGGATTGTG ACAAGAGTGA TGACAGAGAG 
GCCGTAAATC TCTCTGGGAA AGTCACAGAA ACCACAGAAC AAGATAAGGA GTCCAGCAAT 
GGAGAGGATG AGGTGCATCT GACGTATTCA GTAGGAGTAA AGGAGGAGAA TTACAGGTTC 
CAGGATAACC TCTTTCTAGA GAAGGCCATG CAACTTGCCA AGCAGCACGC CAATGCCCTT 
TTTGACTATG CAGTGACAGG AGATGTGAAG ATGCTGCTGG CTGTCCAGCG CCATCTCACT 
GCAGTGCAGG ATGAGAATGG GGACAGTGTC TTACACTTGG CAATCATCCA CCTTCATGCT 
CAGCTTGTGA GAGACCTGCT AGAAGTCACA TCTGGTTTGA TTTCTGATGA AATTATCAAC 
ATGAGAAATG ATCTCTACCA GACACCCTTG CACTTGGCAG TGATCACCAA GCAGGAGGCT 
GTGGTGGAGG ACTTGCTGAG GGCAGGGGCC GACCTGAGTC TTCTGGACCG CTTGGGTAAC 
TCTGTTTTGC ACCTCGCTGC CAAAGAAGGA CATGATAAAA TTCTCAGTAT TTTACTCAAG 
CACAAAAAGG CAGCACTACT TATCAACCAC CCCAACGGTG AAGGTCTGAA CGCTATTCAC 
GTGGCCATGA TGAGCAACAG CTTGCCGTGT CTGCTGCTGC TGATGGCCGC GGGGGCCGAC 
GTCAACGCCC AGGAGCGGAA GTCAGGACGC ACAGCGCTGC ACCTGGCCGT GGAGCTCGAC 
AACATCTCCT TGGCGGGCTG CCTGCTCTTG GAGGGTGATG CCCATGTAGA CAGCACCACC 
TATGATGGAA CTACACCCCT GCACATAGCG GCCGGGAGAG GGTCCACCAG GCTGGCAGCT 
CTCCTCAAAG CAGCAGGAGC AGATCCCCTG GTGGAGAACT TTGAGCCTCT GTATGACCTG 
GATGACTCGT GGGACGAGGA TGGAGAGGAT GAAGGCGTCG TGCCTGGAAC TACACCTCTA 
GACATGGCCA CCAACTGGCA GGTATTTGAC ATATTAAATG GGAAACCCTA TGAGCCAGAG 
TTTACATCGG ATGATTTACT CGCACAAGGA GACATGAAAC AGCTGACTGA AGATACAAAG 
TTACAGCTCT ACAAGTTGCT AGAAATTCCT GATCCTGACA AAAACTGGGC TACCCTGGCA 
CAGAAATTAG GTCTGGGGAT ACTGAATAAT GCCTTCCGGC TGAGTGCTGC TCCTTCCAAA 
ACTCTCATGG ACAACTACGA GGTCTCCGGG GGGACAATAA AGGAGCTGGT GGAGGCCCTG 
AGACAGATGG GCTACACTGA AGCCATTGAC GTGATCCAGG CGGCCTTCTG CACCTCAGGA 
ACCGCAGCCA CCAGCCCTGT GAAGACCACC TCTCAGGCCC ACTCGCTGCC CTTCTCGCCT 
GCCTCCACAA GGCAGCAAAT AGACGAGCTC CGGGATGACA GCATCTGTGA CAGCGGCGTG 
GAGACGTCCT TTCGCAAACT CAGCTTCACA GAGTCTCTGA CCAGCAGCAG CTCATTGCTA 
ACTCTCAACA AAGTGCCCCA CGATTTCGGG CAGGAAGGAC CTCTAGAAGG CAAAATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001041697.1
CDS	1..2880
Translation	MFHLDPLNHTIFNPELFQPEMPLPTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHGEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLTDREKEIIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGIWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGAGSTGPGYGFPHYGFPTYGGITFHAGTTKSNAGMKHGTVDTPSKNDPEDCDKSDDREAVNLSGKVTETTEQDKESSNGEDEVHLTYSVGVKEENYRFQDNLFLEKAMQLAKQHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDEIINMRNDLYQTPLHLAVITKQEAVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKILSILLKHKKAALLINHPNGEGLNAIHVAMMSNSLPCLLLLMAAGADVNAQERKSGRTALHLAVELDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWDEDGEDEGVVPGTTPLDMATNWQVFDILNGKPYEPEFTSDDLLAQGDMKQLTEDTKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSAAPSKTLMDNYEVSGGTIKELVEALRQMGYTEAIDVIQAAFCTSGTAATSPVKTTSQAHSLPFSPASTRQQIDELRDDSICDSGVETSFRKLSFTESLTSSSSLLTLNKVPHDFGQEGPLEGKI

Target ORF information:

RefSeq Version	NM_001048232.1
Organism	Sus scrofa(pig)
Definition	Sus scrofa nuclear factor kappa B subunit 1 (NFKB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001048232.1

ORF Insert Sequence:

ATGTTTCATT TGGATCCTTT GAATCATACA ATATTTAATC CAGAATTATT TCAACCGGAG 
ATGCCACTGC CAACAGCAGA TGGCCCATAC CTTCAAATAT TAGAGCAACC TAAACAGAGA 
GGATTTCGTT TCCGTTATGT GTGTGAAGGC CCCTCCCATG GTGGACTCCC TGGCGCATCT 
AGTGAAAAGA ACAAGAAGTC CTACCCTCAG GTCAAAATCT GCAACTATGT TGGACCTGCA 
AAGGTTATTG TTCAGTTGGT CACAAATGGA AAAAACATCC ACCTGCATGC ACACAGCCTG 
GTGGGAAAAC ACGGAGAGGA TGGGATCTGC ACTGTCACTG CTGGACCCAA GGACATGGTG 
GTCGGCTTTG CAAACCTGGG TATACTTCAT GTGACAAAGA AAAAAGTATT TGAAACACTG 
GAAGCACGAA TGACAGAGGC ATGTATAAGG GGCTATAATC CCGGACTTTT GGTGCACCCT 
GATCTTGCTT ATTTGCAAGC GGAAGGTGGA GGGGACCGGC AGCTCACAGA TCGGGAAAAG 
GAGATCATCC GTCAGGCAGC TCTTCAGCAG ACGAAGGAGA TGGACCTCAG CGTGGTACGG 
CTCATGTTTA CAGCTTTCCT TCCGGACAGC ACGGGCAGCT TCACTAGGCG CCTGGAACCC 
GTGGTATCTG ATGCCATCTA TGACAGCAAA GCCCCCAATG CGTCCAACTT GAAAATAGTA 
AGAATGGACA GGACAGCCGG ATGTGTAACT GGAGGGGAAG AGATTTATCT TCTCTGTGAC 
AAGGTTCAGA AAGATGACAT CCAGATTCGA TTTTATGAAG AGGAAGAAAA TGGTGGAATC 
TGGGAAGGAT TTGGAGATTT TTCCCCCACA GACGTTCATA GACAATTTGC CATCGTCTTC 
AAAACTCCAA AGTATAAAGA TGTCAACATT ACAAAACCAG CCTCTGTGTT TGTCCAACTT 
CGGAGGAAGT CTGATTTGGA AACTAGTGAA CCGAAACCTT TTCTCTACTA TCCTGAAATC 
AAAGATAAAG AGGAAGTACA AAGGAAACGG CAGAAGCTCA TGCCCAATTT CTCAGATAGT 
TTCGGTGGCG GGAGTGGGGC TGGAGCTGGA GGCGGAGGCA TGTTTGGCAG CGGCGGTGGA 
GGAGGGGGTG CTGGAAGTAC TGGACCAGGG TATGGCTTCC CCCACTATGG ATTTCCTACA 
TATGGTGGAA TTACCTTCCA TGCTGGAACC ACTAAATCTA ATGCTGGAAT GAAGCACGGA 
ACTGTAGACA CCCCATCTAA AAATGACCCT GAGGATTGTG ACAAGAGTGA TGACAGAGAG 
GCCGTAAATC TCTCTGGGAA AGTCACAGAA ACCACAGAAC AAGATAAGGA GTCCAGCAAT 
GGAGAGGATG AGGTGCATCT GACGTATTCA GTAGGAGTAA AGGAGGAGAA TTACAGGTTC 
CAGGATAACC TCTTTCTAGA GAAGGCCATG CAACTTGCCA AGCAGCACGC CAATGCCCTT 
TTTGACTATG CAGTGACAGG AGATGTGAAG ATGCTGCTGG CTGTCCAGCG CCATCTCACT 
GCAGTGCAGG ATGAGAATGG GGACAGTGTC TTACACTTGG CAATCATCCA CCTTCATGCT 
CAGCTTGTGA GAGACCTGCT AGAAGTCACA TCTGGTTTGA TTTCTGATGA AATTATCAAC 
ATGAGAAATG ATCTCTACCA GACACCCTTG CACTTGGCAG TGATCACCAA GCAGGAGGCT 
GTGGTGGAGG ACTTGCTGAG GGCAGGGGCC GACCTGAGTC TTCTGGACCG CTTGGGTAAC 
TCTGTTTTGC ACCTCGCTGC CAAAGAAGGA CATGATAAAA TTCTCAGTAT TTTACTCAAG 
CACAAAAAGG CAGCACTACT TATCAACCAC CCCAACGGTG AAGGTCTGAA CGCTATTCAC 
GTGGCCATGA TGAGCAACAG CTTGCCGTGT CTGCTGCTGC TGATGGCCGC GGGGGCCGAC 
GTCAACGCCC AGGAGCGGAA GTCAGGACGC ACAGCGCTGC ACCTGGCCGT GGAGCTCGAC 
AACATCTCCT TGGCGGGCTG CCTGCTCTTG GAGGGTGATG CCCATGTAGA CAGCACCACC 
TATGATGGAA CTACACCCCT GCACATAGCG GCCGGGAGAG GGTCCACCAG GCTGGCAGCT 
CTCCTCAAAG CAGCAGGAGC AGATCCCCTG GTGGAGAACT TTGAGCCTCT GTATGACCTG 
GATGACTCGT GGGACGAGGA TGGAGAGGAT GAAGGCGTCG TGCCTGGAAC TACACCTCTA 
GACATGGCCA CCAACTGGCA GGTATTTGAC ATATTAAATG GGAAACCCTA TGAGCCAGAG 
TTTACATCGG ATGATTTACT CGCACAAGGA GACATGAAAC AGCTGACTGA AGATACAAAG 
TTACAGCTCT ACAAGTTGCT AGAAATTCCT GATCCTGACA AAAACTGGGC TACCCTGGCA 
CAGAAATTAG GTCTGGGGAT ACTGAATAAT GCCTTCCGGC TGAGTGCTGC TCCTTCCAAA 
ACTCTCATGG ACAACTACGA GGTCTCCGGG GGGACAATAA AGGAGCTGGT GGAGGCCCTG 
AGACAGATGG GCTACACTGA AGCCATTGAC GTGATCCAGG CGGCCTTCTG CACCTCAGGA 
ACCGCAGCCA CCAGCCCTGT GAAGACCACC TCTCAGGCCC ACTCGCTGCC CTTCTCGCCT 
GCCTCCACAA GGCAGCAAAT AGACGAGCTC CGGGATGACA GCATCTGTGA CAGCGGCGTG 
GAGACGTCCT TTCGCAAACT CAGCTTCACA GAGTCTCTGA CCAGCAGCAG CTCATTGCTA 
ACTCTCAACA AAGTGCCCCA CGATTTCGGG CAGGAAGGAC CTCTAGAAGG CAAAATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activation of porcine alveolar macrophages by
Infection and immunity(2017 Dec)
Li B,Fang J,Zuo Z,Yin S,He T,Yang M,Deng J,Shen L,Ma X,Yu S,Wang Y,Ren Z

Inhibition of NF-?B activity by the porcine epidemic diarrhea virus nonstructural protein 1 for innate immune evasion.
Virology510111-126(2017 10)
Zhang Q,Ma J,Yoo D

Porcine parvovirus infection activates inflammatory cytokine production through Toll-like receptor 9 and NF-?B signaling pathways in porcine kidney cells.
Veterinary microbiology20756-62(2017 Aug)
Zhou Y,Jin XH,Jing YX,Song Y,He XX,Zheng LL,Wang YB,Wei ZY,Zhang GP