| Gene Symbol | DEFB1 |
| Entrez Gene ID | 404699 |
| Full Name | defensin beta 1 |
| Synonyms | PBD-2 |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
ORF » Species Summary » Sus scrofa » DEFB1 cDNA ORF clone
| Gene Symbol | DEFB1 |
| Entrez Gene ID | 404699 |
| Full Name | defensin beta 1 |
| Synonyms | PBD-2 |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| mRNA | Protein | Name |
|---|---|---|
| NM_214442.2 | NP_999607.1 | beta-defensin 1 precursor |
Overexpression of Porcine Beta-Defensin 2 Enhances Resistance to Actinobacillus pleuropneumoniae Infection in Pigs.
Yang X, Cheng YT, Tan MF, Zhang HW, Liu WQ, Zou G, Zhang LS, Zhang CY, Deng SM, Yu L, Hu XY, Li L, Zhou R
Infection and immunity83(7)2836-43(2015 Jul)
Zn(2+) and L-isoleucine induce the expressions of porcine ?-defensins in IPEC-J2 cells.
Mao X, Qi S, Yu B, He J, Yu J, Chen D
Molecular biology reports40(2)1547-52(2013 Feb)
Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria.
Veldhuizen EJ, Rijnders M, Claassen EA, van Dijk A, Haagsman HP
Molecular immunology45(2)386-94(2008 Jan)
Bioinformatic and expression analysis of novel porcine beta-defensins.
Sang Y, Patil AA, Zhang G, Ross CR, Blecha F
Mammalian genome : official journal of the International Mammalian Genome Society17(4)332-9(2006 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The results demonstrate that transgenic overexpression of PBD-2 in pigs confers enhanced resistance against Actinobacillus pleuropneumoniae infection.
Title: Overexpression of Porcine Beta-Defensin 2 Enhances Resistance to Actinobacillus pleuropneumoniae Infection in Pigs.
Zinc sulfate and L-isoleucine induce beta defensin expression in a porcine cell line.
Title: Zn(2+) and L-isoleucine induce the expressions of porcine ?-defensins in IPEC-J2 cells.
pBD-2 may be an important defense molecule for intestinal health.
Title: Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria.
The following DEFB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSe29687 | |
| Clone ID Related Accession (Same CDS sequence) | NM_214442.2 | |
| Accession Version | NM_214442.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-05-15 | |
| Organism | Sus scrofa(pig) | |
| Product | beta-defensin 1 precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY506573.1. On Feb 21, 2013 this sequence version replaced NM_214442.1. ##Evidence-Data-START## Transcript exon combination :: AY506573.1, CN155722.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1964466, SAMEA1965831 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGAGGGCCC TCTGCTTGCT GCTGCTGACT GTCTGCCTCC TCTCTTCCCA GCTGGCTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_999607.1 |
| CDS | 52..261 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_214442.2 |
1 | ATGAGGGCCC TCTGCTTGCT GCTGCTGACT GTCTGCCTCC TCTCTTCCCA GCTGGCTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Overexpression of Porcine Beta-Defensin 2 Enhances Resistance to Actinobacillus pleuropneumoniae Infection in Pigs. |
Zn(2+) and L-isoleucine induce the expressions of porcine ?-defensins in IPEC-J2 cells. |
Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria. |
Bioinformatic and expression analysis of novel porcine beta-defensins. |