| Gene Symbol | IL1B2 |
| Entrez Gene ID | 396565 |
| Full Name | interleukin 1, beta 2 |
| Synonyms | IL-1beta,IL1B |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
ORF » Species Summary » Sus scrofa » IL1B2 cDNA ORF clone
| Gene Symbol | IL1B2 |
| Entrez Gene ID | 396565 |
| Full Name | interleukin 1, beta 2 |
| Synonyms | IL-1beta,IL1B |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| mRNA | Protein | Name |
|---|---|---|
| NM_001005149.1 | NP_001005149.1 | interleukin 1, beta |
| NM_001302388.1 | NP_001289317.1 | interleukin 1, beta |
| NM_001302388.2 | NP_001289317.2 | interleukin 1, beta |
Inactivation of porcine interleukin-1? results in failure of rapid conceptus elongation.
Whyte JJ, Meyer AE, Spate LD, Benne JA, Cecil R, Samuel MS, Murphy CN, Prather RS, Geisert RD
Proceedings of the National Academy of Sciences of the United States of America115(2)307-312(2018 Jan)
Activation of the transcription factor nuclear factor-kappa B in uterine luminal epithelial cells by interleukin 1 Beta 2: a novel interleukin 1 expressed by the elongating pig conceptus.
Mathew DJ, Newsom EM, Guyton JM, Tuggle CK, Geisert RD, Lucy MC
Biology of reproduction92(4)107(2015 Apr)
The interleukin-1? system in the corpora lutea of pigs during early pregnancy and the estrous cycle.
Zmijewska A, Franczak A, Kotwica G
Journal of reproductive immunology98(1-2)61-8(2013 Jun)
Mechanisms underlying Actinobacillus pleuropneumoniae exotoxin ApxI induced expression of IL-1?, IL-8 and TNF-? in porcine alveolar macrophages.
Chen ZW, Chien MS, Chang NY, Chen TH, Wu CM, Huang C, Lee WC, Hsuan SL
Veterinary research4225(2011 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Both IL1B1 and IL1B2 activated nuclear factor-kappa B in the uterine luminal epithelium within 4 hours
Title: Activation of the transcription factor nuclear factor-kappa B in uterine luminal epithelial cells by interleukin 1 Beta 2: a novel interleukin 1 expressed by the elongating pig conceptus.
involved in intraluteal, luteotrophic regulation of corpora lutea
Title: The interleukin-1? system in the corpora lutea of pigs during early pregnancy and the estrous cycle.
Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta, IL-8 and TNF-alpha in porcine alveolar macrophages.
Title: Mechanisms underlying Actinobacillus pleuropneumoniae exotoxin ApxI induced expression of IL-1?, IL-8 and TNF-? in porcine alveolar macrophages.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha, IL-6, IL-12p40, IL-1beta, and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1.
Title: L-cysteine supplementation attenuates local inflammation and restores gut homeostasis in a porcine model of colitis.
findings show that Brachyspira hyodysenteriae inoculation induced production of systemic levels of IL-1beta during the dysentery period and increased levels of IL-10 coincided with recovery from dysentery
Title: Blood concentrations of the cytokines IL-1beta, IL-6, IL-10, TNF-alpha and IFN-gamma during experimentally induced swine dysentery.
The following IL1B2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL1B2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSe00692 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001005149.1 | |
| Accession Version | NM_001005149.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-05-15 | |
| Organism | Sus scrofa(pig) | |
| Product | interleukin 1, beta | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X74568.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. | |
1 | ATGGCCACGG TACCTGAACC TGCCAAGGAA GTGATGGCTA ACAATGGTGA CAACAATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001005149.1 |
| CDS | 85..888 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001005149.1 |
1 | ATGGCCACGG TACCTGAACC TGCCAAGGAA GTGATGGCTA ACAATGGTGA CAACAATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe251961 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001302388.2 | |
| Accession Version | NM_001302388.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-20 | |
| Organism | Sus scrofa(pig) | |
| Product | interleukin 1, beta | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AEMK02000612.1. On Jan 19, 2018 this sequence version replaced NM_001302388.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCCACGG TACCTGAACC TGCCAAGGAA GTGATGGCTA ACAATGGTGA CAACAATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001289317.2 |
| CDS | 231..1034 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001302388.2 |
1 | ATGGCCACGG TACCTGAACC TGCCAAGGAA GTGATGGCTA ACAATGGTGA CAACAATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe30566 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001302388.1 | |
| Accession Version | NM_001302388.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-05-15 | |
| Organism | Sus scrofa(pig) | |
| Product | interleukin 1, beta | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW619421.1, AW619779.1, AY291592.1, CK466359.1 and BQ600202.1. On Oct 16, 2014 this sequence version replaced XM_005655197.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. | |
1 | ATGGCCACGG TACCTGAACC TGCCAAGGAA GTGATGGCTA ACAATGGTGA CAACAATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001289317.1 |
| CDS | 231..1034 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001302388.1 |
1 | ATGGCCACGG TACCTGAACC TGCCAAGGAA GTGATGGCTA ACAATGGTGA CAACAATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Inactivation of porcine interleukin-1? results in failure of rapid conceptus elongation. |
Activation of the transcription factor nuclear factor-kappa B in uterine luminal epithelial cells by interleukin 1 Beta 2: a novel interleukin 1 expressed by the elongating pig conceptus. |
The interleukin-1? system in the corpora lutea of pigs during early pregnancy and the estrous cycle. |
Mechanisms underlying Actinobacillus pleuropneumoniae exotoxin ApxI induced expression of IL-1?, IL-8 and TNF-? in porcine alveolar macrophages. |