NOD2 cDNA ORF clone, Sus scrofa(pig)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOD2
Entrez Gene ID	100125838
Full Name	nucleotide binding oligomerization domain containing 2
Gene Type	protein-coding
Organism	Sus scrofa(pig)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001105295.1	NP_001098765.1	nucleotide-binding oligomerization domain-containing protein 2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Influence of polymorphisms in porcine NOD2 on ligand recognition.
Jozaki K, Shinkai H, Tanaka-Matsuda M, Morozumi T, Matsumoto T, Toki D, Okumura N, Eguchi-Ogawa T, Kojima-Shibata C, Kadowaki H, Suzuki E, Wada Y, Uenishi H
Molecular immunology47(2-3)247-52(2009 Dec)

Differences in distribution of single nucleotide polymorphisms among intracellular pattern recognition receptors in pigs.
Kojima-Shibata C, Shinkai H, Morozumi T, Jozaki K, Toki D, Matsumoto T, Kadowaki H, Suzuki E, Uenishi H
Immunogenetics61(2)153-60(2009 Feb)

Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-2 (NOD2).
Tohno M, Ueda W, Azuma Y, Shimazu T, Katoh S, Wang JM, Aso H, Takada H, Kawai Y, Saito T, Kitazawa H
Molecular immunology45(1)194-203(2008 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings suggest that the 2197C allele of NOD2 might confer an immune response advantage in modern pig breeds and may be a useful marker for breeding aimed at disease resistance in pigs.
Title: Influence of polymorphisms in porcine NOD2 on ligand recognition.

NOD2 abounds in nonsynonymous SNPs both throughout the coding sequence and in sequences encoding domains important for ligand recognition. There are 7 SNPs in its leucine-rich repeat section.
Title: Differences in distribution of single nucleotide polymorphisms among intracellular pattern recognition receptors in pigs.

These results implicate NOD2 as an important immunoregulator in the swine intestinal immunity.
Title: Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-2 (NOD2).

The following NOD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSe01144	NM_001105295.1 Latest version!	Sus scrofa nucleotide binding oligomerization domain containing 2 (NOD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$629.30 $899.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOD2 ( NM_001105295.1 ) cDNA ORF clone, Sus scrofa(pig) -> NP_001098765.1 Sus scrofa nucleotide binding oligomerization domain containing 2 (NOD2), mRNA.

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CloneID	OSe01144
Clone ID Related Accession (Same CDS sequence)	NM_001105295.1
Accession Version	NM_001105295.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3042bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-12
Organism	Sus scrofa(pig)
Product	nucleotide-binding oligomerization domain-containing protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB195466.1. ##Evidence-Data-START## CDS exon combination :: AB195466.1 [ECO:0000331] ##Evidence-Data-END##

ATGTGTGCCC AGGGGGCTTT CCAGGCACAG AGAAGCCAGC TGGTGGAGCT CCTGGTCTCG 
GGGTCCCTCG AGGGCTTCGA GAGCATTCTG GACTGGCTGC TGTCCTGGGA CGTCCTCTCC 
TGGGAAGACT ACGAGGGCCT CAGCCTCCTG GGCCAGCCCC TCTCCCACTT GGCCAGGCGC 
CTTCTGGACA CTGTCTGGAG TAAGGGTACG TGGGGCTGTG AGCAGCTCGT GGCGGCTGTG 
CGGGAGGCCC AGGCCGACAG CCAGCCCTCC GAACTTCCTG GCTGCTGGAA CCCCCATTCA 
CCCCACCCAG CCCGTGACCT GCAGAGTCAC CGGCCAGCCG TTGTCAGAAG ACTCTACAGT 
CACGTGGACG GCGTGTTGGA GCGGACGCAG GAGCAGGGTT TCATCAGCCG GTACGAATGT 
GATGAAATCA GGCGACCCAT CTTCACGTCA TGCCAGCGGG CAAGAAGGCT CCTCGATCTT 
GCTGCTGTGA AGGCGAATGG GTTGGCTGCC TTCCTTCTAC AGTGTGTTCA GGAATTACCC 
ATCCCAGTGG CCCTGCCTTT TGAAGATGCT GCCTGTAAGA AGTACATGTC CAAGCTGAGG 
ACCACAGTTT CAGCTCAGTC TCGTTTCCTG AGCACCTACG ATGGGGCAGA GAATCTTTGC 
CTAGAAGAAA TATATACAGA GAATGTTCTG GAGGTCCGGA CAGAGGGGGG CATGACTGGA 
CCTCCGCAGC AGAGCCCTGC CACCCTGAGC CTAGGGGAGC TCTTCAGCCC TCAAGGCCAC 
CTCAACAAGG ATGCGGACAC CGTGCTGGTG GTGGGTGAGG CAGGCAGTGG CAAGAGCACC 
CTCCTGCAGC AGGTGCATCT GCTGTGGGCT TCAGGGCAGG CCTTCCAGGA ATTTCTCTTC 
GTCTTCCCAT TCAGCTGCCG GCAGCTGCAG TGCCTGGCAA AATCTCTGTC CCTGCAGACG 
CTGCTCTTTG AACACTGTTG TTGGCCTGAC CGTGGCCAGC AGGACGTCTT TCAGGTCCTC 
CTTGACCACC CCGAGCGCAT CCTCTTAACT TTCGATGGTT TTGACGAGTT CAGGTTCAGG 
TTCACGGATC ACGAGCGTCA CTGCTGTCCG ACGGCCCCCA CATCTGTTCA GAGTCTCCTC 
TTCAACCTCC TGCAGGGCAA CCTGCTCAAG AATGCCCGCA AGGTGCTGAC CAGCCGACCG 
GACGCGGTGT CTGCGAGCCT CCGGAAGCAC GTGCGCTCAG AACTCAGCCT CAAGGGTTTC 
TCAGAAGAGG GCATTGAACT GTACCTGCGG AAGTGCCATC GCGAGCCTGG CGTGGCCGAC 
CGCCTCATCT GCCTGCTCAG AGCCACCTCG GCCCTGCACG GTCTGTGCCA CCTGCCTGTC 
TTCTCGTGGA TGGTGTCCAA ATGCCACCAG GAACTGTTGC TGCAGGGCAG GGGGTCCCCG 
AAGACCACCA CGGACATGTA CCTGCTGATC CTGCAGCATT TTCTGCTGCG TGCCTCCCCT 
CTAGACTCAG CCGCCCAGCA TCTGGGACCT GACCTGCTTC GGGGGAGCCT CCCCACCCTG 
CTGCATCTCG GTCACCTGGC TCTCTGGGGC CTGGGCACGT GCTGCTACGT GTTCTCAGCC 
GAGCAGCTGC AGGCAGCACA CGTCGACAGT GAGGCTGTTT CTCTTGGCTT CCTGGTTCGT 
GCCAAGAGCG TTGTGCCCGG AGGTACCCCC CCACTGGAAT TCCTGCACGT CACATTCCAG 
TGCTTTTTTG CCGCATTCTA CCTCGCCCTC AGTGCTGACG TGCCACCGTC ATCCCTCAGA 
CACCTCTTCC ATGGTCACCG ACCCGGCAGC TCGCCACTGG CCAAGGTGCT GCCCAAACTG 
TGTGTGCGGG GCTCAGGCTG CAAGAAAAGC AGCGTGGCCC ATTTGCTACA GGAGGCCGAG 
CCGCACAACC TCCAGATCAC GGCGGCCTCC CTGGCAGGGC TGTTGTCCCA GGAGCACCGG 
GGTCTGCTAG CCGAGTGCCA GGTGTCTGAG AAGGCTCTGC TCCAGCGCCA GGCCTGTGCC 
CGGTGGTGTC TGGCCCGCAG CCTCCATAAG CACTTCCGCT CCATCCCACC AGCCGTCCCA 
GGTGAGGTCA AGAGCATGCA TGCCATGCCT GGCTTCATCT GGCTCATCCG CAGCCTGTAC 
GAGATGCAGG AGGAGCGACT GGCCCGGGAC GCTGTGCGTA GGCTGAACGT CGGGCACCTC 
AAGCTGACTT TCTGCAGCGT GGGCCCTGCT GAGTGCGCTG CCCTGGCCTT CGTGCTGCGG 
CACCTCCAGT GGCCCGTGGC CCTGCAGCTG GACCACAACT CTGTGGGCGA CATTGGCGTG 
GAGCAGCTGC TGCCTTGTCT CAACGTCTGC AAGGCTCTTT ACTTGAGAGA TAACAATATC 
TCAGACCGAG GCTTCTGCAA GCTCGTGGAA CATGCTCTTT GCTGTGAGCA GCTGCAGAAG 
TTAGCTCTTT TCAACAACAA ATTGACCGAC GGCTGTGCTC ACTCCATGGC CAGGCTCCTT 
GCATGCAAGA GGAACTTCTT GGCATTGAGG CTGGGAAACA ACCACTTCAC TGCCGTGGGA 
GCCCAGGTGC TGGCCCAGGG ACTCAGAGCC AACACCCCCC TGCAGTTCCT GGGGTTCTGG 
GGCAACCAGG TGGGTGACAA GGGGGCCCAG GCTTTGGCTG AAGCCTTGAG GGACAATCAG 
AGCTTGAAGT GGCTCAGCCT GGTGGGGAAC AACATTGGCA GTGTGGGTGC TCAAGCCTTA 
GCATTGATGT TGGAAAAGAA CATGGCCCTG GAAGAACTCT GCCTGGAGGA GAACCATGTC 
CAAGATGAAG GTGTGTGCTC TCTCGCCAGA GGACTTGAGA GAAATTCAAG CTTGAAAGTC 
CTGAAGCTGT CCAACAACCA CGTCACCTCC CGTGGGGCCG AAGCCCTCCT GCAGGCCCTT 
GAACAGAATG ACACCATCCT GGAAGTCTGG CTCCGAGGAA ACAATTTCTC TCCAGAGGAG 
ACTGAGCAGC TCAGCCAGAG GGACACGAGA CTCCTGCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001098765.1
CDS	739..3780
Translation	MCAQGAFQAQRSQLVELLVSGSLEGFESILDWLLSWDVLSWEDYEGLSLLGQPLSHLARRLLDTVWSKGTWGCEQLVAAVREAQADSQPSELPGCWNPHSPHPARDLQSHRPAVVRRLYSHVDGVLERTQEQGFISRYECDEIRRPIFTSCQRARRLLDLAAVKANGLAAFLLQCVQELPIPVALPFEDAACKKYMSKLRTTVSAQSRFLSTYDGAENLCLEEIYTENVLEVRTEGGMTGPPQQSPATLSLGELFSPQGHLNKDADTVLVVGEAGSGKSTLLQQVHLLWASGQAFQEFLFVFPFSCRQLQCLAKSLSLQTLLFEHCCWPDRGQQDVFQVLLDHPERILLTFDGFDEFRFRFTDHERHCCPTAPTSVQSLLFNLLQGNLLKNARKVLTSRPDAVSASLRKHVRSELSLKGFSEEGIELYLRKCHREPGVADRLICLLRATSALHGLCHLPVFSWMVSKCHQELLLQGRGSPKTTTDMYLLILQHFLLRASPLDSAAQHLGPDLLRGSLPTLLHLGHLALWGLGTCCYVFSAEQLQAAHVDSEAVSLGFLVRAKSVVPGGTPPLEFLHVTFQCFFAAFYLALSADVPPSSLRHLFHGHRPGSSPLAKVLPKLCVRGSGCKKSSVAHLLQEAEPHNLQITAASLAGLLSQEHRGLLAECQVSEKALLQRQACARWCLARSLHKHFRSIPPAVPGEVKSMHAMPGFIWLIRSLYEMQEERLARDAVRRLNVGHLKLTFCSVGPAECAALAFVLRHLQWPVALQLDHNSVGDIGVEQLLPCLNVCKALYLRDNNISDRGFCKLVEHALCCEQLQKLALFNNKLTDGCAHSMARLLACKRNFLALRLGNNHFTAVGAQVLAQGLRANTPLQFLGFWGNQVGDKGAQALAEALRDNQSLKWLSLVGNNIGSVGAQALALMLEKNMALEELCLEENHVQDEGVCSLARGLERNSSLKVLKLSNNHVTSRGAEALLQALEQNDTILEVWLRGNNFSPEETEQLSQRDTRLLL

Target ORF information:

RefSeq Version	NM_001105295.1
Organism	Sus scrofa(pig)
Definition	Sus scrofa nucleotide binding oligomerization domain containing 2 (NOD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105295.1

ORF Insert Sequence:

ATGTGTGCCC AGGGGGCTTT CCAGGCACAG AGAAGCCAGC TGGTGGAGCT CCTGGTCTCG 
GGGTCCCTCG AGGGCTTCGA GAGCATTCTG GACTGGCTGC TGTCCTGGGA CGTCCTCTCC 
TGGGAAGACT ACGAGGGCCT CAGCCTCCTG GGCCAGCCCC TCTCCCACTT GGCCAGGCGC 
CTTCTGGACA CTGTCTGGAG TAAGGGTACG TGGGGCTGTG AGCAGCTCGT GGCGGCTGTG 
CGGGAGGCCC AGGCCGACAG CCAGCCCTCC GAACTTCCTG GCTGCTGGAA CCCCCATTCA 
CCCCACCCAG CCCGTGACCT GCAGAGTCAC CGGCCAGCCG TTGTCAGAAG ACTCTACAGT 
CACGTGGACG GCGTGTTGGA GCGGACGCAG GAGCAGGGTT TCATCAGCCG GTACGAATGT 
GATGAAATCA GGCGACCCAT CTTCACGTCA TGCCAGCGGG CAAGAAGGCT CCTCGATCTT 
GCTGCTGTGA AGGCGAATGG GTTGGCTGCC TTCCTTCTAC AGTGTGTTCA GGAATTACCC 
ATCCCAGTGG CCCTGCCTTT TGAAGATGCT GCCTGTAAGA AGTACATGTC CAAGCTGAGG 
ACCACAGTTT CAGCTCAGTC TCGTTTCCTG AGCACCTACG ATGGGGCAGA GAATCTTTGC 
CTAGAAGAAA TATATACAGA GAATGTTCTG GAGGTCCGGA CAGAGGGGGG CATGACTGGA 
CCTCCGCAGC AGAGCCCTGC CACCCTGAGC CTAGGGGAGC TCTTCAGCCC TCAAGGCCAC 
CTCAACAAGG ATGCGGACAC CGTGCTGGTG GTGGGTGAGG CAGGCAGTGG CAAGAGCACC 
CTCCTGCAGC AGGTGCATCT GCTGTGGGCT TCAGGGCAGG CCTTCCAGGA ATTTCTCTTC 
GTCTTCCCAT TCAGCTGCCG GCAGCTGCAG TGCCTGGCAA AATCTCTGTC CCTGCAGACG 
CTGCTCTTTG AACACTGTTG TTGGCCTGAC CGTGGCCAGC AGGACGTCTT TCAGGTCCTC 
CTTGACCACC CCGAGCGCAT CCTCTTAACT TTCGATGGTT TTGACGAGTT CAGGTTCAGG 
TTCACGGATC ACGAGCGTCA CTGCTGTCCG ACGGCCCCCA CATCTGTTCA GAGTCTCCTC 
TTCAACCTCC TGCAGGGCAA CCTGCTCAAG AATGCCCGCA AGGTGCTGAC CAGCCGACCG 
GACGCGGTGT CTGCGAGCCT CCGGAAGCAC GTGCGCTCAG AACTCAGCCT CAAGGGTTTC 
TCAGAAGAGG GCATTGAACT GTACCTGCGG AAGTGCCATC GCGAGCCTGG CGTGGCCGAC 
CGCCTCATCT GCCTGCTCAG AGCCACCTCG GCCCTGCACG GTCTGTGCCA CCTGCCTGTC 
TTCTCGTGGA TGGTGTCCAA ATGCCACCAG GAACTGTTGC TGCAGGGCAG GGGGTCCCCG 
AAGACCACCA CGGACATGTA CCTGCTGATC CTGCAGCATT TTCTGCTGCG TGCCTCCCCT 
CTAGACTCAG CCGCCCAGCA TCTGGGACCT GACCTGCTTC GGGGGAGCCT CCCCACCCTG 
CTGCATCTCG GTCACCTGGC TCTCTGGGGC CTGGGCACGT GCTGCTACGT GTTCTCAGCC 
GAGCAGCTGC AGGCAGCACA CGTCGACAGT GAGGCTGTTT CTCTTGGCTT CCTGGTTCGT 
GCCAAGAGCG TTGTGCCCGG AGGTACCCCC CCACTGGAAT TCCTGCACGT CACATTCCAG 
TGCTTTTTTG CCGCATTCTA CCTCGCCCTC AGTGCTGACG TGCCACCGTC ATCCCTCAGA 
CACCTCTTCC ATGGTCACCG ACCCGGCAGC TCGCCACTGG CCAAGGTGCT GCCCAAACTG 
TGTGTGCGGG GCTCAGGCTG CAAGAAAAGC AGCGTGGCCC ATTTGCTACA GGAGGCCGAG 
CCGCACAACC TCCAGATCAC GGCGGCCTCC CTGGCAGGGC TGTTGTCCCA GGAGCACCGG 
GGTCTGCTAG CCGAGTGCCA GGTGTCTGAG AAGGCTCTGC TCCAGCGCCA GGCCTGTGCC 
CGGTGGTGTC TGGCCCGCAG CCTCCATAAG CACTTCCGCT CCATCCCACC AGCCGTCCCA 
GGTGAGGTCA AGAGCATGCA TGCCATGCCT GGCTTCATCT GGCTCATCCG CAGCCTGTAC 
GAGATGCAGG AGGAGCGACT GGCCCGGGAC GCTGTGCGTA GGCTGAACGT CGGGCACCTC 
AAGCTGACTT TCTGCAGCGT GGGCCCTGCT GAGTGCGCTG CCCTGGCCTT CGTGCTGCGG 
CACCTCCAGT GGCCCGTGGC CCTGCAGCTG GACCACAACT CTGTGGGCGA CATTGGCGTG 
GAGCAGCTGC TGCCTTGTCT CAACGTCTGC AAGGCTCTTT ACTTGAGAGA TAACAATATC 
TCAGACCGAG GCTTCTGCAA GCTCGTGGAA CATGCTCTTT GCTGTGAGCA GCTGCAGAAG 
TTAGCTCTTT TCAACAACAA ATTGACCGAC GGCTGTGCTC ACTCCATGGC CAGGCTCCTT 
GCATGCAAGA GGAACTTCTT GGCATTGAGG CTGGGAAACA ACCACTTCAC TGCCGTGGGA 
GCCCAGGTGC TGGCCCAGGG ACTCAGAGCC AACACCCCCC TGCAGTTCCT GGGGTTCTGG 
GGCAACCAGG TGGGTGACAA GGGGGCCCAG GCTTTGGCTG AAGCCTTGAG GGACAATCAG 
AGCTTGAAGT GGCTCAGCCT GGTGGGGAAC AACATTGGCA GTGTGGGTGC TCAAGCCTTA 
GCATTGATGT TGGAAAAGAA CATGGCCCTG GAAGAACTCT GCCTGGAGGA GAACCATGTC 
CAAGATGAAG GTGTGTGCTC TCTCGCCAGA GGACTTGAGA GAAATTCAAG CTTGAAAGTC 
CTGAAGCTGT CCAACAACCA CGTCACCTCC CGTGGGGCCG AAGCCCTCCT GCAGGCCCTT 
GAACAGAATG ACACCATCCT GGAAGTCTGG CTCCGAGGAA ACAATTTCTC TCCAGAGGAG 
ACTGAGCAGC TCAGCCAGAG GGACACGAGA CTCCTGCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Influence of polymorphisms in porcine NOD2 on ligand recognition.
Molecular immunology47(2-3)247-52(2009 Dec)
Jozaki K,Shinkai H,Tanaka-Matsuda M,Morozumi T,Matsumoto T,Toki D,Okumura N,Eguchi-Ogawa T,Kojima-Shibata C,Kadowaki H,Suzuki E,Wada Y,Uenishi H

Differences in distribution of single nucleotide polymorphisms among intracellular pattern recognition receptors in pigs.
Immunogenetics61(2)153-60(2009 Feb)
Kojima-Shibata C,Shinkai H,Morozumi T,Jozaki K,Toki D,Matsumoto T,Kadowaki H,Suzuki E,Uenishi H

Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-2 (NOD2).
Molecular immunology45(1)194-203(2008 Jan)
Tohno M,Ueda W,Azuma Y,Shimazu T,Katoh S,Wang JM,Aso H,Takada H,Kawai Y,Saito T,Kitazawa H

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NOD2 cDNA ORF clone, Sus scrofa(pig)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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