Tnfaip6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tnfaip6
Entrez Gene ID	84397
Full Name	TNF alpha induced protein 6
Synonyms	Tnfip6
General protein information	Preferred Names TNF alpha induced protein 6 Names tumor necrosis factor-inducible gene 6 protein tumor necrosis factor alpha induced protein 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q12
Summary	mouse homolog is a catalyst in the formation of the cumulus extracellular matrix and indispensable for female fertility [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053382.1	NP_445834.1	tumor necrosis factor-inducible gene 6 protein precursor

Pathways from BioSystems

Homologies

	TNFAIP6	XP_001083111.1
Homo sapiens (human)	TNFAIP6	NP_009046.2
Bos taurus (cattle)	TNFAIP6	NP_001007814.1
Mus musculus (house mouse)	Tnfaip6	NP_033424.1
Rattus norvegicus (Norway rat)	Tnfaip6	NP_445834.1
Canis lupus familiaris (dog)	TNFAIP6	XP_533354.3
Gallus gallus (chicken)	TNFAIP6	NP_001032926.2
Xenopus tropicalis (tropical clawed frog)	tnfaip6	XP_002936705.1
Pan troglodytes (chimpanzee)	TNFAIP6	XP_516218.2
Danio rerio (zebrafish)	tnfaip6	NP_001035333.2

Gene Ontology
Bibliography

Related articles in PubMed

Tumor necrosis factor alpha-stimulated gene-6 (TSG-6) inhibits the inflammatory response by inhibiting the activation of P38 and JNK signaling pathway and decreases the restenosis of vein grafts in rats.
Zhang C, Zhang B, Wang H, Tao Q, Ge S, Zhai Z
Heart and vessels32(12)1536-1545(2017 Dec)

Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Is Constitutively Expressed in Adult Central Nervous System (CNS) and Associated with Astrocyte-mediated Glial Scar Formation following Spinal Cord Injury.
Coulson-Thomas VJ, Lauer ME, Soleman S, Zhao C, Hascall VC, Day AJ, Fawcett JW
The Journal of biological chemistry291(38)19939-52(2016 09)

Tumor necrosis factor-inducible gene 6 protein: A novel neuroprotective factor against inflammation-induced developmental brain injury.
Bertling F, Bendix I, Drommelschmidt K, Wisniewski HG, Felderhoff-Mueser U, Keller M, Prager S
Experimental neurology279283-289(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study shows that TSG-6 is expressed in the CNS, suggesting a role for TSG-6 in astrocyte activation and tissue repair.
Title: Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Is Constitutively Expressed in Adult Central Nervous System (CNS) and Associated with Astrocyte-mediated Glial Scar Formation following Spinal Cord Injury.

Reduction of cleaved caspase-3 by TSG-6 treatment demonstrates the putative neuroprotective potential of exogenous TSG-6 administration in inflammation-induced developmental brain injury
Title: Tumor necrosis factor-inducible gene 6 protein: A novel neuroprotective factor against inflammation-induced developmental brain injury.

TSG-6 silenced group (3.36 +/- 0.96 N/mm(2)) showed no benefit over the control group.
Title: TSG-6 mediates the effect of tendon derived stem cells for rotator cuff healing.

Data indicate that TNFalpha-stimulating gene (TSG)-6 (TSG-6) of mesenchymal stem cells (MSCs) was involved in the reduction of peritoneal injury.
Title: Mesenchymal stem cells attenuate peritoneal injury through secretion of TSG-6.

The following Tnfaip6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tnfaip6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09413	NM_053382.1 Latest version!	Rattus norvegicus TNF alpha induced protein 6 (Tnfaip6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tnfaip6 ( NM_053382.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445834.1 Rattus norvegicus TNF alpha induced protein 6 (Tnfaip6), mRNA.

Price & Availability↑

CloneID	ORa09413
Clone ID Related Accession (Same CDS sequence)	NM_053382.1
Accession Version	NM_053382.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Rattus norvegicus(Norway rat)
Product	tumor necrosis factor-inducible gene 6 protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC158666.1. On Aug 28, 2008 this sequence version replaced XM_001065494.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC158666.1, FQ228783.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTCTTCC TCCTTTGCTT ATGCGTCTTG CTGTGGGAAG AGGCTCACGG ATGGGGATTC 
AAGAATGGAA TCTTTCATAA TTCCATATGG CTTGAACAAG CAGCAGGCGT ATACCATAGA 
GAAGCCCGGG CTGGCAGATA CAAGCTAACC TATGCAGAAG CCAAGGCGGT ATGTGAATAT 
GAAGGTGGCC GTCTTGCAAC CTACAAGCAG CTAGAAGCAG CCAGAAAGAT TGGATTCCAT 
GTCTGTGCTG CTGGGTGGAT GGCCAAGGGT AGAGTTGGGT ACCCCATTGT GAAACCTGGG 
CCCAACTGTG GATTTGGCAA AACCGGCATC ATTGATTATG GAATCCGGCT CAACAGGAGC 
GAGCGGTGGG ACGCCTATTG CTACAACCCG AACGCAAAGG AGTGTGGTGG TGTCTTTACA 
GACCCGAAGC GAATCTTTAA ATCCCCAGGC TTCCCAAATG AGTATGACGA CAACCAGGTT 
TGCTACTGGC ACATCCGGCT CAAGTACGGT CAGCGAATTC ACCTGAGCTT TTTGGACTTT 
GACCTTGAAC ATGATCCAGG CTGTTTGGCT GACTATGTAG AAATATATGA CAGTTATGAC 
GATGTCCACG GCTTTGTAGG AAGATACTGC GGTGATGAAC TTCCAGAAGA CATCATCAGC 
ACAGGAAATG TCATGACCTT GAAGTTTCTG AGTGATGCGT CCGTCACAGC CGGAGGCTTC 
CAGATTAAAT ACGTCACAGT GGATCCTGCA CCTAAATCCA ATCAAGGCAA AAATACAACT 
ATGACTGGAA ATAAAAAGTT CTTAGCTGGA CGGTTTAGCC ATCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445834.1
CDS	16..843
Translation	MVFLLCLCVLLWEEAHGWGFKNGIFHNSIWLEQAAGVYHREARAGRYKLTYAEAKAVCEYEGGRLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCGFGKTGIIDYGIRLNRSERWDAYCYNPNAKECGGVFTDPKRIFKSPGFPNEYDDNQVCYWHIRLKYGQRIHLSFLDFDLEHDPGCLADYVEIYDSYDDVHGFVGRYCGDELPEDIISTGNVMTLKFLSDASVTAGGFQIKYVTVDPAPKSNQGKNTTMTGNKKFLAGRFSHL

Target ORF information:

RefSeq Version	NM_053382.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TNF alpha induced protein 6 (Tnfaip6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053382.1

ORF Insert Sequence:

ATGGTCTTCC TCCTTTGCTT ATGCGTCTTG CTGTGGGAAG AGGCTCACGG ATGGGGATTC 
AAGAATGGAA TCTTTCATAA TTCCATATGG CTTGAACAAG CAGCAGGCGT ATACCATAGA 
GAAGCCCGGG CTGGCAGATA CAAGCTAACC TATGCAGAAG CCAAGGCGGT ATGTGAATAT 
GAAGGTGGCC GTCTTGCAAC CTACAAGCAG CTAGAAGCAG CCAGAAAGAT TGGATTCCAT 
GTCTGTGCTG CTGGGTGGAT GGCCAAGGGT AGAGTTGGGT ACCCCATTGT GAAACCTGGG 
CCCAACTGTG GATTTGGCAA AACCGGCATC ATTGATTATG GAATCCGGCT CAACAGGAGC 
GAGCGGTGGG ACGCCTATTG CTACAACCCG AACGCAAAGG AGTGTGGTGG TGTCTTTACA 
GACCCGAAGC GAATCTTTAA ATCCCCAGGC TTCCCAAATG AGTATGACGA CAACCAGGTT 
TGCTACTGGC ACATCCGGCT CAAGTACGGT CAGCGAATTC ACCTGAGCTT TTTGGACTTT 
GACCTTGAAC ATGATCCAGG CTGTTTGGCT GACTATGTAG AAATATATGA CAGTTATGAC 
GATGTCCACG GCTTTGTAGG AAGATACTGC GGTGATGAAC TTCCAGAAGA CATCATCAGC 
ACAGGAAATG TCATGACCTT GAAGTTTCTG AGTGATGCGT CCGTCACAGC CGGAGGCTTC 
CAGATTAAAT ACGTCACAGT GGATCCTGCA CCTAAATCCA ATCAAGGCAA AAATACAACT 
ATGACTGGAA ATAAAAAGTT CTTAGCTGGA CGGTTTAGCC ATCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tumor necrosis factor alpha-stimulated gene-6 (TSG-6) inhibits the inflammatory response by inhibiting the activation of P38 and JNK signaling pathway and decreases the restenosis of vein grafts in rats.
Heart and vessels32(12)1536-1545(2017 Dec)
Zhang C,Zhang B,Wang H,Tao Q,Ge S,Zhai Z

Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Is Constitutively Expressed in Adult Central Nervous System (CNS) and Associated with Astrocyte-mediated Glial Scar Formation following Spinal Cord Injury.
The Journal of biological chemistry291(38)19939-52(2016 09)
Coulson-Thomas VJ,Lauer ME,Soleman S,Zhao C,Hascall VC,Day AJ,Fawcett JW

Tumor necrosis factor-inducible gene 6 protein: A novel neuroprotective factor against inflammation-induced developmental brain injury.
Experimental neurology279283-289(2016 May)
Bertling F,Bendix I,Drommelschmidt K,Wisniewski HG,Felderhoff-Mueser U,Keller M,Prager S