Ccnh cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccnh
Entrez Gene ID	84389
Full Name	cyclin H
General protein information	Preferred Names cyclin H Names cyclin-H
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q11
Summary	cyclin; involved in cell cycle control and may also have a role in neurons during ischemia [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_052981.2	NP_443213.2	cyclin-H

Pathways from BioSystems

Homologies

	CCNH	XP_001084672.1
Drosophila melanogaster (fruit fly)	CycH	NP_524207.1
Pan troglodytes (chimpanzee)	CCNH	NP_001075882.1
Bos taurus (cattle)	CCNH	NP_001073256.1
Danio rerio (zebrafish)	ccnh	NP_001013471.1
Caenorhabditis elegans (roundworm)	cyh-1	NP_494564.2
Oryza sativa (rice)	Os03g0737600	NP_001051203.1
Xenopus tropicalis (tropical clawed frog)	ccnh	NP_001016256.1
Canis lupus familiaris (dog)	CCNH	XP_005618199.1
Arabidopsis thaliana (thale cress)	CYCH;1	NP_198114.2
Homo sapiens (human)	CCNH	NP_001230.1
Rattus norvegicus (Norway rat)	Ccnh	NP_443213.2
Mus musculus (house mouse)	Ccnh	NP_075732.1
Gallus gallus (chicken)	CCNH	XP_424908.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008417	XP_317030.3

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-23b regulates cyclin-dependent kinase-activating kinase complex through cyclin H repression to modulate endothelial transcription and growth under flow.
Wang KC, Nguyen P, Weiss A, Yeh YT, Chien HS, Lee A, Teng D, Subramaniam S, Li YS, Chien S
Arteriosclerosis, thrombosis, and vascular biology34(7)1437-45(2014 Jul)

Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration.
Wang Y, Liu F, Mao F, Hang Q, Huang X, He S, Wang Y, Cheng C, Wang H, Xu G, Zhang T, Shen A
The Journal of biological chemistry288(13)9028-34(2013 Mar)

CDK7 and CCNH are components of CDK-activating kinase and are required for meiotic progression of pig oocytes.
Fujii W, Nishimura T, Kano K, Sugiura K, Naito K
Biology of reproduction85(6)1124-32(2011 Dec)

Temporal and spatial expression of cyclin H in rat spinal cord injury.
Wu G, Cao J, Peng C, Yang H, Cui Z, Zhao J, Wu Q, Han J, Li H, Gu X, Zhang F
Neuromolecular medicine13(3)187-96(2011 Sep)

A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.
Egly JM, Coin F
DNA repair10(7)714-21(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hemodynamic forces modulate EC proliferative phenotype through the miR-23b/CAK/cyclin H pathway.
Title: MicroRNA-23b regulates cyclin-dependent kinase-activating kinase complex through cyclin H repression to modulate endothelial transcription and growth under flow.

Data suggest that cyclin H may play a proliferative role in spinal cord injury (SCI).
Title: Temporal and spatial expression of cyclin H in rat spinal cord injury.

The following Ccnh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccnh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42325	NM_052981.2 Latest version!	Rattus norvegicus cyclin H (Ccnh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccnh ( NM_052981.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_443213.2 Rattus norvegicus cyclin H (Ccnh), mRNA.

Price & Availability↑

CloneID	ORa42325
Clone ID Related Accession (Same CDS sequence)	NM_052981.2
Accession Version	NM_052981.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-H
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ276495.1. On Jun 9, 2003 this sequence version replaced NM_052981.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ276495.1 [ECO:0000332] ##Evidence-Data-END##

ATGTACCACA ACAGCAGCCA GAAGCGGCAC TGGACCTTCG CTAGCGAGGA GCAACTGGCG 
CGTCTGCGGG CCGACGCCAA CCGCAAATTC AAGTGCAAAG CTGTGGCTAA CGGGAAGGTT 
CTTCCAAATG ATCCGTTGTT TCTTGAGCCT CATGAAGAAA TGACACTTTG CAAATACTAT 
GAAAAAAGAT TGTTGGAATT TTGTTCAGTG TTTAAACCAG CTATGCCACG GTCTGTTGTG 
GGTACAGCTT GTATGTATTT CAAGCGTTTT TATCTTAATA ACTCAGTAAT GGAATATCAC 
CCTCGGATAA TAATGCTTAC TTGTGCATTT TTGGCCTGCA AAGTAGATGA ATTCAATGTG 
TCTAGTCCTC AGAAAGAAGG GAACCTTCGA GAGAGTCCTC TTGGACAGGA GAAGGCACTG 
GAACAGATTT TGGAATATGA ACTACTACTT ATACAACAAC TTAATTTTCA CCTCATTGTC 
CACAATCCAT ATAGACCATT TGAAGGCTTC CTCATTGATA TAAAGACTCG ATACCCCATG 
TTGGAGAATC CAGAGATTTT GAGGAAAACG GCTGATGATT TTCTTAGTAG AATTGCATTG 
ACAGATGCTT ATCTTTTGTA CACACCTTCA CAAATTGCCC TGACTGCCAT TTTATCAAGA 
GCCTCTAGGG CTGGAATTAC TATGGAAAGC TATTTATCAG AGAGTCTAAT GCTGAAAGAG 
AACAGAACTT GCCTGTCACA GCTACTGGAT ATAATGAAAA GCATGAGAAA TCTAGTAAAA 
AAGTATGAGC CACCCAGATC TGAAGAAGTT GCTATTCTGA AACAGAAGTT GGAGCGATGT 
CATTCTTCTG ACCTTGCACT TAATATGGTT ACAAAGAAGA GGAAAGGCTA CGAAGACGAT 
GACTATGTAT CAAAGAAACC CAAACAGGAA GAGGAGGAGT GGACGGACGA TGACCTGGTA 
GATGCTCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443213.2
CDS	305..1276
Translation	MYHNSSQKRHWTFASEEQLARLRADANRKFKCKAVANGKVLPNDPLFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQKEGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDIKTRYPMLENPEILRKTADDFLSRIALTDAYLLYTPSQIALTAILSRASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAILKQKLERCHSSDLALNMVTKKRKGYEDDDYVSKKPKQEEEEWTDDDLVDAL

Target ORF information:

RefSeq Version	NM_052981.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin H (Ccnh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052981.2

ORF Insert Sequence:

ATGTACCACA ACAGCAGCCA GAAGCGGCAC TGGACCTTCG CTAGCGAGGA GCAACTGGCG 
CGTCTGCGGG CCGACGCCAA CCGCAAATTC AAGTGCAAAG CTGTGGCTAA CGGGAAGGTT 
CTTCCAAATG ATCCGTTGTT TCTTGAGCCT CATGAAGAAA TGACACTTTG CAAATACTAT 
GAAAAAAGAT TGTTGGAATT TTGTTCAGTG TTTAAACCAG CTATGCCACG GTCTGTTGTG 
GGTACAGCTT GTATGTATTT CAAGCGTTTT TATCTTAATA ACTCAGTAAT GGAATATCAC 
CCTCGGATAA TAATGCTTAC TTGTGCATTT TTGGCCTGCA AAGTAGATGA ATTCAATGTG 
TCTAGTCCTC AGAAAGAAGG GAACCTTCGA GAGAGTCCTC TTGGACAGGA GAAGGCACTG 
GAACAGATTT TGGAATATGA ACTACTACTT ATACAACAAC TTAATTTTCA CCTCATTGTC 
CACAATCCAT ATAGACCATT TGAAGGCTTC CTCATTGATA TAAAGACTCG ATACCCCATG 
TTGGAGAATC CAGAGATTTT GAGGAAAACG GCTGATGATT TTCTTAGTAG AATTGCATTG 
ACAGATGCTT ATCTTTTGTA CACACCTTCA CAAATTGCCC TGACTGCCAT TTTATCAAGA 
GCCTCTAGGG CTGGAATTAC TATGGAAAGC TATTTATCAG AGAGTCTAAT GCTGAAAGAG 
AACAGAACTT GCCTGTCACA GCTACTGGAT ATAATGAAAA GCATGAGAAA TCTAGTAAAA 
AAGTATGAGC CACCCAGATC TGAAGAAGTT GCTATTCTGA AACAGAAGTT GGAGCGATGT 
CATTCTTCTG ACCTTGCACT TAATATGGTT ACAAAGAAGA GGAAAGGCTA CGAAGACGAT 
GACTATGTAT CAAAGAAACC CAAACAGGAA GAGGAGGAGT GGACGGACGA TGACCTGGTA 
GATGCTCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-23b regulates cyclin-dependent kinase-activating kinase complex through cyclin H repression to modulate endothelial transcription and growth under flow.
Arteriosclerosis, thrombosis, and vascular biology34(7)1437-45(2014 Jul)
Wang KC,Nguyen P,Weiss A,Yeh YT,Chien HS,Lee A,Teng D,Subramaniam S,Li YS,Chien S

Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration.
The Journal of biological chemistry288(13)9028-34(2013 Mar)
Wang Y,Liu F,Mao F,Hang Q,Huang X,He S,Wang Y,Cheng C,Wang H,Xu G,Zhang T,Shen A

CDK7 and CCNH are components of CDK-activating kinase and are required for meiotic progression of pig oocytes.
Biology of reproduction85(6)1124-32(2011 Dec)
Fujii W,Nishimura T,Kano K,Sugiura K,Naito K

Temporal and spatial expression of cyclin H in rat spinal cord injury.
Neuromolecular medicine13(3)187-96(2011 Sep)
Wu G,Cao J,Peng C,Yang H,Cui Z,Zhao J,Wu Q,Han J,Li H,Gu X,Zhang F

A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.
DNA repair10(7)714-21(2011 Jul)
Egly JM,Coin F