Bcl10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bcl10
Entrez Gene ID	83477
Full Name	B-cell CLL/lymphoma 10
General protein information	Preferred Names B-cell CLL/lymphoma 10 Names B-cell lymphoma/leukemia 10 B-cell leukemia/lymphoma 10 R-RCD1 RCD bcl-10
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q44

mRNA and Protein(s)

mRNA	Protein	Name
NM_031328.1	NP_112618.1	B-cell lymphoma/leukemia 10

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	BCL10	NP_001188416.2
Canis lupus familiaris (dog)	BCL10	XP_547304.2
Xenopus tropicalis (tropical clawed frog)	bcl10	NP_001015777.2
Homo sapiens (human)	BCL10	NP_003912.1
Bos taurus (cattle)	BCL10	NP_001071496.1
Rattus norvegicus (Norway rat)	Bcl10	NP_112618.1
Pan troglodytes (chimpanzee)	BCL10	XP_513526.2
Mus musculus (house mouse)	Bcl10	NP_033870.1
	BCL10	XP_001104846.2
Danio rerio (zebrafish)	LOC100334750	XP_002660738.1

Gene Ontology
Bibliography

Related articles in PubMed

Germline hypomorphic CARD11 mutations in severe atopic disease.
Ma CA, Stinson JR, Zhang Y, Abbott JK, Weinreich MA, Hauk PJ, Reynolds PR, Lyons JJ, Nelson CG, Ruffo E, Dorjbal B, Glauzy S, Yamakawa N, Arjunaraja S, Voss K, Stoddard J, Niemela J, Zhang Y, Rosenzweig SD, McElwee JJ, DiMaggio T, Matthews HF, Jones N, Stone KD, Palma A, Oleastro M, Prieto E, Bernasconi AR, Dubra G, Danielian S, Zaiat J, Marti MA, Kim B, Cooper MA, Romberg N, Meffre E, Gelfand EW, Snow AL, Milner JD
Nature genetics49(8)1192-1201(2017 Aug)

Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity.
Torres JM, Martinez-Barricarte R, Garc?a-G?mez S, Mazariegos MS, Itan Y, Boisson B, Rholvarez R, Jim?nez-Reinoso A, del Pino L, Rodr?guez-Pena R, Ferreira A, Hern?ndez-Jim?nez E, Toledano V, Cubillos-Zapata C, D?az-Almir?n M, L?pez-Collazo E, Unzueta-Roch JL, S?nchez-Ram?n S, Regueiro JR, L?pez-Granados E, Casanova JL, P?rez de Diego R
The Journal of clinical investigation124(12)5239-48(2014 Dec)

MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.
Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J
Journal of cell science126(Pt 3)825-37(2013 Feb)

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome.
Gringhuis SI, Kaptein TM, Wevers BA, Theelen B, van der Vlist M, Boekhout T, Geijtenbeek TB
Nature immunology13(3)246-54(2012 Jan)

Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
Smith AJ, Karpova Y, D'Agostino R Jr, Willingham M, Kulik G
PloS one4(7)e6224(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Bcl10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bcl10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07833	NM_031328.1 Latest version!	Rattus norvegicus BCL10, immune signaling adaptor (Bcl10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bcl10 ( NM_031328.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112618.1 Rattus norvegicus BCL10, immune signaling adaptor (Bcl10), mRNA.

Price & Availability↑

CloneID	ORa07833
Clone ID Related Accession (Same CDS sequence)	NM_031328.1
Accession Version	NM_031328.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	B-cell lymphoma/leukemia 10
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB016069.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB016069.1, BC061772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGCTC CCGCGCCGTC TCTCACGGAG GAGGACTTAA CTGAAGTGAA GAAGGACGCT 
TTAGAGAATT TGCGAGTTTA CCTGTGTGAG AAAATCATAG CTGAGAGACA TTTTGATCAT 
CTACGAGCAA AAAAAATTCT AAGTAGAGAA GACACAGAAG AAATTTCTTG CCGAACTTCA 
AGTAGAAAAA GGGCTGGGAA GTTGTTAGAC TACTTACAGG AAAACCCCAA GGGACTGGAC 
ACCCTTGTGG AATCCATTCG CAGGGAGAAA ACACAGAACT TCCTGATTCA GAAGATAACG 
GATGAGGTGC TAAAGCTTCG GAATATAAAA CTGGAGCACC TCAAAGGCCT GAAGTGCAGT 
AGCTGTGAGC CCTTCGCAGC TGGAGCCACC AACAACCTTT CTAGGTCCAA TTCTGATGAG 
AGCAACTTCT CCGAGAAACA GAGACCATCC ACGGTCATCT ACCATCCAGA GGGAGAGTCG 
AGCACTGCTC CCTTCTTCTC TACCGAGTCA TCCCTGAATC TGCCGGTCCT GGAAGTTGGC 
AGGCTGGAAA ACAGCAGCTT CTCTTCAGCC TCGCTTCCTC GGCCTGGGGA CCCTGGGGCC 
CCCCCTTTGC CCCCAGACCT GCGGTTAGAA GAGGGGGGGA GTTGTGGAAA CTCAAGTGAG 
ATGTTTCTCC CCTTACGGTC ACGGGCTCTT TCACGGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112618.1
CDS	126..827
Translation	MEAPAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFAAGATNNLSRSNSDESNFSEKQRPSTVIYHPEGESSTAPFFSTESSLNLPVLEVGRLENSSFSSASLPRPGDPGAPPLPPDLRLEEGGSCGNSSEMFLPLRSRALSRQ

Target ORF information:

RefSeq Version	NM_031328.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BCL10, immune signaling adaptor (Bcl10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031328.1

ORF Insert Sequence:

ATGGAGGCTC CCGCGCCGTC TCTCACGGAG GAGGACTTAA CTGAAGTGAA GAAGGACGCT 
TTAGAGAATT TGCGAGTTTA CCTGTGTGAG AAAATCATAG CTGAGAGACA TTTTGATCAT 
CTACGAGCAA AAAAAATTCT AAGTAGAGAA GACACAGAAG AAATTTCTTG CCGAACTTCA 
AGTAGAAAAA GGGCTGGGAA GTTGTTAGAC TACTTACAGG AAAACCCCAA GGGACTGGAC 
ACCCTTGTGG AATCCATTCG CAGGGAGAAA ACACAGAACT TCCTGATTCA GAAGATAACG 
GATGAGGTGC TAAAGCTTCG GAATATAAAA CTGGAGCACC TCAAAGGCCT GAAGTGCAGT 
AGCTGTGAGC CCTTCGCAGC TGGAGCCACC AACAACCTTT CTAGGTCCAA TTCTGATGAG 
AGCAACTTCT CCGAGAAACA GAGACCATCC ACGGTCATCT ACCATCCAGA GGGAGAGTCG 
AGCACTGCTC CCTTCTTCTC TACCGAGTCA TCCCTGAATC TGCCGGTCCT GGAAGTTGGC 
AGGCTGGAAA ACAGCAGCTT CTCTTCAGCC TCGCTTCCTC GGCCTGGGGA CCCTGGGGCC 
CCCCCTTTGC CCCCAGACCT GCGGTTAGAA GAGGGGGGGA GTTGTGGAAA CTCAAGTGAG 
ATGTTTCTCC CCTTACGGTC ACGGGCTCTT TCACGGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Germline hypomorphic CARD11 mutations in severe atopic disease.
Nature genetics49(8)1192-1201(2017 Aug)
Ma CA,Stinson JR,Zhang Y,Abbott JK,Weinreich MA,Hauk PJ,Reynolds PR,Lyons JJ,Nelson CG,Ruffo E,Dorjbal B,Glauzy S,Yamakawa N,Arjunaraja S,Voss K,Stoddard J,Niemela J,Zhang Y,Rosenzweig SD,McElwee JJ,DiMaggio T,Matthews HF,Jones N,Stone KD,Palma A,Oleastro M,Prieto E,Bernasconi AR,Dubra G,Danielian S,Zaiat J,Marti MA,Kim B,Cooper MA,Romberg N,Meffre E,Gelfand EW,Snow AL,Milner JD

Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity.
The Journal of clinical investigation124(12)5239-48(2014 Dec)
Torres JM,Martinez-Barricarte R,Garc?a-G?mez S,Mazariegos MS,Itan Y,Boisson B,Rholvarez R,Jim?nez-Reinoso A,del Pino L,Rodr?guez-Pena R,Ferreira A,Hern?ndez-Jim?nez E,Toledano V,Cubillos-Zapata C,D?az-Almir?n M,L?pez-Collazo E,Unzueta-Roch JL,S?nchez-Ram?n S,Regueiro JR,L?pez-Granados E,Casanova JL,P?rez de Diego R

MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.
Journal of cell science126(Pt 3)825-37(2013 Feb)
Fong KW,Leung JW,Li Y,Wang W,Feng L,Ma W,Liu D,Songyang Z,Chen J

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome.
Nature immunology13(3)246-54(2012 Jan)
Gringhuis SI,Kaptein TM,Wevers BA,Theelen B,van der Vlist M,Boekhout T,Geijtenbeek TB

Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
PloS one4(7)e6224(2009 Jul)
Smith AJ,Karpova Y,D'Agostino R Jr,Willingham M,Kulik G