Adamts1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adamts1
Entrez Gene ID	79252
Full Name	ADAM metallopeptidase with thrombospondin type 1 motif, 1
General protein information	Preferred Names ADAM metallopeptidase with thrombospondin type 1 motif, 1 Names A disintegrin and metalloproteinase with thrombospondin motifs 1 ADAM-TS 1 ADAM-TS1 ADAMTS-1 a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1) a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q11
Summary	disintegrin and metalloprotease that may be necessary for normal kidney morphology and function [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024400.2	NP_077376.2	A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ADAMTS1	NP_001094550.1
Mus musculus (house mouse)	Adamts1	NP_033751.3
Pan troglodytes (chimpanzee)	ADAMTS1	XP_531406.2
	ADAMTS1	XP_001103864.1
Canis lupus familiaris (dog)	ADAMTS1	XP_003434043.3
Gallus gallus (chicken)	ADAMTS1	XP_416687.4
Danio rerio (zebrafish)	adamts1	XP_693535.6
Homo sapiens (human)	ADAMTS1	NP_008919.3
Xenopus tropicalis (tropical clawed frog)	adamts1	NP_001120905.1
Rattus norvegicus (Norway rat)	Adamts1	NP_077376.2

Gene Ontology
Bibliography

Related articles in PubMed

MiR-362-3p inhibits the proliferation and migration of vascular smooth muscle cells in atherosclerosis by targeting ADAMTS1.
Li M, Liu Q, Lei J, Wang X, Chen X, Ding Y
Biochemical and biophysical research communications493(1)270-276(2017 11)

A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons.
Roet KC, Franssen EH, de Bree FM, Essing AH, Zijlstra SJ, Fagoe ND, Eggink HM, Eggers R, Smit AB, van Kesteren RE, Verhaagen J
The Journal of neuroscience : the official journal of the Society for Neuroscience33(27)11116-35(2013 Jul)

Proteomic evaluation of inflammatory proteins in rat spleen interstitial fluid and lymph during LPS-induced systemic inflammation reveals increased levels of ADAMST1.
Oveland E, Karlsen TV, Haslene-Hox H, Semaeva E, Janaczyk B, Tenstad O, Wiig H
Journal of proteome research11(11)5338-49(2012 Nov)

ADAMTS-1 expression in rat myocardium after ischemic preconditioning: age-associated differences.
Wang Y, Huang CX, Zhou YF, Cheng JS, Wang H, Wu WJ, Liao WQ, Wen JY, Ke YN, Zheng JG
Chinese medical journal124(1)95-9(2011 Jan)

[Effect of ischemia preconditioning on pro- and anti- angiogenic molecule expression and functional arteries formation].
WANG Y, HUANG CX, CHENG JS, WANG H, WU WJ, LIAO WQ, WEN JY, KE YN, ZHENG JG
Zhonghua xin xue guan bing za zhi38(9)819-22(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) was detected by proteomics (the pro- region) in lymph only after LPS
Title: Proteomic evaluation of inflammatory proteins in rat spleen interstitial fluid and lymph during LPS-induced systemic inflammation reveals increased levels of ADAMST1.

Results demonstrate the shear stress-dependent expression of ADAMTS1 in vitro and in vivo and suggest it as a mechanism connecting blood flow with the regulation of angiogenesis.
Title: Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries.

Cardioprotection with IPC is attenuated in the older heart. ADAMTS-1 expression induced by IPC is greater in old rats. Over-expression of anti-angiogenic factors might be a potential mechanism behind reduced protection after IPC associated with aging.
Title: ADAMTS-1 expression in rat myocardium after ischemic preconditioning: age-associated differences.

Ischemic preconditioning promoted the formation of mature new arteries, which may be modulated by upregulating VEGF, PDGF-B, and ADAMTS-1 expressions.
Title: [Effect of ischemia preconditioning on pro- and anti- angiogenic molecule expression and functional arteries formation].

Enhanced expression of Adamts1 may predispose the development of chronic kidney reperfusion injury.
Title: Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor.

The following Adamts1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adamts1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07048	NM_024400.2 Latest version!	Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 1 (Adamts1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$566.30 $809.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adamts1 ( NM_024400.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077376.2 Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 1 (Adamts1), mRNA.

Price & Availability↑

CloneID	ORa07048
Clone ID Related Accession (Same CDS sequence)	NM_024400.2
Accession Version	NM_024400.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2904bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC080237.1. On Jun 10, 2007 this sequence version replaced NM_024400.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC080237.1, AF149118.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCCAG AAGTCCCTTT GGGGTCAGGC AAGCTGAAGC CCTGCTCAGA CATGGGGGAC 
ATCCAGCGGG CAGCGAAGTT TCGGAGCTCT CAGTCTGCAC ACATGCTGTT GCTACTCCTC 
GCTTCCATAA CAATGCTGCT ATGTGTGCGG GGCGCACACG GGCGCCCCAC GGAGGAAGAC 
GAGGAGCTGG TGCTGCCCTC GCTGGAGCGC GCCCGGGGCC ACGGTTCCAC CACACTCCTC 
CGTCTGGACG CCTTTGGTCA GCAGCTGCAT CTGAAGTTGC AGCCAGACAG CGGTTTCTTA 
GCGCCTGGCT TCACCCTCCA GACGGTGGGG CGCAGTCCTG GGTCCGAGGC ACAGCATCTG 
GACCCCACTG GGGACCTGGC CCACTGCTTC TACTCTGGCA CGGTGAACGG TGACCCCAGC 
TCCGCCGCCG CCCTCAGCCT CTGTGAAGGT GTGCGCGGTG CCTTCTACCT ACAAGGCGAG 
GAGTTCTTCA TTCAGCCAGC GCCTGCGGTG GCCACCGAGC GCCTGGTCCC CGCCGAACCG 
AAGGAGGAGT CAATCGCACC TCCGCGGTTC CACATCCTGA GGCGAAGGCG GCGGGGCAGC 
GGCGGCGCAA AGTGCGGTGT CATGGACGAA GAGACCCTGC CAACCAGCAA CTCGGGTCGC 
GAAAGCCAGA ACACCCCGGA CCAGTGGCCT CTGCGGAACC CCACTCCTCA GGGCGCGGGA 
AAGCCAACAG GACCAGGAAG CATAAGGAAG AAGCGATTTG TGTCCAGCCC CCGTTATGTG 
GAAACCATGC TCGTGGCTGA CCAGTCCATG GCTGACTTCC ACGGCAGCGG TCTAAAGCAT 
TACCTTCTAA CCCTGTTCTC GGTGGCAGCC AGATTTTACA AGCACCCCAG CATTAGGAAT 
TCAATTAGTC TGGTGGTGGT GAAGATCTTG GTCATATATG AGGAGCAGAA GGGACCGGAA 
GTTACTTCCA ATGCCGCTCT CACCCTTAGG AATTTCTGTA GCTGGCAGAA ACAGCACAAC 
AGCCCCAGTG ACCGGGATCC AGAGCACTAT GACACAGCGA TTCTGTTCAC CAGACAGGAT 
TTATGTGGCT CCCACACCTG TGACACTCTC GGGATGGCTG ATGTTGGAAC TGTATGTGAC 
CCCAGCAGGA GCTGTTCGGT CATCGAAGAT GATGGTTTAC AGGCTGCCTT CACCACAGCC 
CATGAATTGG GCCATGTGTT TAACATGCCA CACGATGACG CCAAGCACTG CGCCAGCTTT 
AATGGCGTGA GTGGGGATTC CCATCTGATG GCCTCGATGC TCTCCAGCTT GGACCACAGC 
CAGCCCTGGT CTCCTTGCAG TGCCTACATG GTCACATCAT TCCTGGACAA CGGCCATGGG 
GAATGTTTGA TGGACAAGCC GCAGAACCCA ATCAAGCTCC CATCTGATCT TCCCGGTACC 
TTGTACGATG CCAACCGCCA GTGTCAGTTT ACCTTCGGGG AGGAATCCAC GCACTGCCCT 
GATGCAGCCA GCACATGCAG TACCCTGTGG TGCACTGGCA CCTCCGGTGG CTTACTGGTG 
TGCCAAACAA AACACTTCCC TTGGGCAGAT GGCACCAGCT GCGGAGAAGG GAAATGGTGT 
GTCAGCGGCA AGTGTGTGAA CAAGACCGAC ATGAAGCACT TTGCTACTCC TGTTCATGGG 
AGCTGGGGAC CGTGGGGACC ATGGGGAGAC TGCTCAAGAA CCTGTGGTGG AGGAGTTCAA 
TATACAATGA GAGAATGTGA CAACCCGGTC CCAAAGAACG GGGGGAAGTA CTGCGAAGGC 
AAACGAGTCC GCTACAGGTC CTGTAACATT GAGGACTGTC CAGACAATAA CGGAAAAACA 
TTCAGAGAGG AGCAATGCGA GGCGCACAAT GAGTTTTCCA AAGCTTCCTT TGGGAATGAA 
CCCACGGTGG AATGGACACC CAAGTATGCT GGCGTCTCGC CAAAGGACAG GTGCAAGCTT 
ACCTGCGAAG CCAAAGGCAT TGGCTACTTC TTTGTTTTAC AGCCCAAGGT GGTAGATGGC 
ACTCCCTGTA GTCCAGACTC TACTTCTGTC TGTGTGCAAG GACAGTGTGT GAAAGCTGGC 
TGTGATCGCA TCATAGACTC CAAAAAGAAG TTCGATAAGT GTGGCGTTTG TGGAGGAAAT 
GGCTCCACGT GCAAGAAAAT ATCAGGAACG GTCACTAGTA CAAGACCTGG GTATCATGAC 
ATTGTCACAA TTCCTGCTGG AGCCACCAAC ATTGAAGTGA AACATCGTAA TCCAAGGGGG 
TCCAGAAACA ATGGCAGCTT TCTGGCTATT AGAGCTGCAG ATGGTACCTA TATTCTGAAT 
GGAAACTTCA CTCTGTCCAC TCTAGAGCAA GACCTCACCT ACAAAGGTAC TGTCTTAAGA 
TACAGTGGTT CCTCAGCAGC ATTGGAAAGA ATCCGCAGCT TTAGTCCACT CAAAGAACCC 
CTGACCATCC AGGTTCTTAT GGTGGGCCAT GCTCTCCGAC CCAAAATCAA GTACACCTAT 
TTTATGAAGA AGAAGACGGA GCCCTTCAAC GCTATTCCCA CATTTTCGGA GTGGGTGATT 
GAAGAGTGGG GGGAGTGCTC CAAGACATGT GGTTCCGGTT GGCAGAGGAG AGTGGTAGAG 
TGCAGAGACA TTAATGGACA CCCTGCTTCT GAATGTGCCA AAGAAGTGAA GCCAGCCAGT 
ACCAGACCTT GTGCAGACCT TCCTTGCCCA CGTTGGCAGG TGGGGGATTG GTCACCATGT 
TCTAAAACTT GTGGGAAGGG TTATAAGAAG AGAACCTTGA AATGTCTGTC CCATGATGGC 
GGTGTGTTAT CAAATGAGAG CTGTGATCCT TTGAAGAAAC CAAAGCATTA CATTGACTTT 
TGCATACTGA CACAGTGCAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077376.2
CDS	382..3285
Translation	MQPEVPLGSGKLKPCSDMGDIQRAAKFRSSQSAHMLLLLLASITMLLCVRGAHGRPTEEDEELVLPSLERARGHGSTTLLRLDAFGQQLHLKLQPDSGFLAPGFTLQTVGRSPGSEAQHLDPTGDLAHCFYSGTVNGDPSSAAALSLCEGVRGAFYLQGEEFFIQPAPAVATERLVPAEPKEESIAPPRFHILRRRRRGSGGAKCGVMDEETLPTSNSGRESQNTPDQWPLRNPTPQGAGKPTGPGSIRKKRFVSSPRYVETMLVADQSMADFHGSGLKHYLLTLFSVAARFYKHPSIRNSISLVVVKILVIYEEQKGPEVTSNAALTLRNFCSWQKQHNSPSDRDPEHYDTAILFTRQDLCGSHTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKHCASFNGVSGDSHLMASMLSSLDHSQPWSPCSAYMVTSFLDNGHGECLMDKPQNPIKLPSDLPGTLYDANRQCQFTFGEESTHCPDAASTCSTLWCTGTSGGLLVCQTKHFPWADGTSCGEGKWCVSGKCVNKTDMKHFATPVHGSWGPWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNIEDCPDNNGKTFREEQCEAHNEFSKASFGNEPTVEWTPKYAGVSPKDRCKLTCEAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGTVTSTRPGYHDIVTIPAGATNIEVKHRNPRGSRNNGSFLAIRAADGTYILNGNFTLSTLEQDLTYKGTVLRYSGSSAALERIRSFSPLKEPLTIQVLMVGHALRPKIKYTYFMKKKTEPFNAIPTFSEWVIEEWGECSKTCGSGWQRRVVECRDINGHPASECAKEVKPASTRPCADLPCPRWQVGDWSPCSKTCGKGYKKRTLKCLSHDGGVLSNESCDPLKKPKHYIDFCILTQCS

Target ORF information:

RefSeq Version	NM_024400.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 1 (Adamts1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024400.2

ORF Insert Sequence:

ATGCAGCCAG AAGTCCCTTT GGGGTCAGGC AAGCTGAAGC CCTGCTCAGA CATGGGGGAC 
ATCCAGCGGG CAGCGAAGTT TCGGAGCTCT CAGTCTGCAC ACATGCTGTT GCTACTCCTC 
GCTTCCATAA CAATGCTGCT ATGTGTGCGG GGCGCACACG GGCGCCCCAC GGAGGAAGAC 
GAGGAGCTGG TGCTGCCCTC GCTGGAGCGC GCCCGGGGCC ACGGTTCCAC CACACTCCTC 
CGTCTGGACG CCTTTGGTCA GCAGCTGCAT CTGAAGTTGC AGCCAGACAG CGGTTTCTTA 
GCGCCTGGCT TCACCCTCCA GACGGTGGGG CGCAGTCCTG GGTCCGAGGC ACAGCATCTG 
GACCCCACTG GGGACCTGGC CCACTGCTTC TACTCTGGCA CGGTGAACGG TGACCCCAGC 
TCCGCCGCCG CCCTCAGCCT CTGTGAAGGT GTGCGCGGTG CCTTCTACCT ACAAGGCGAG 
GAGTTCTTCA TTCAGCCAGC GCCTGCGGTG GCCACCGAGC GCCTGGTCCC CGCCGAACCG 
AAGGAGGAGT CAATCGCACC TCCGCGGTTC CACATCCTGA GGCGAAGGCG GCGGGGCAGC 
GGCGGCGCAA AGTGCGGTGT CATGGACGAA GAGACCCTGC CAACCAGCAA CTCGGGTCGC 
GAAAGCCAGA ACACCCCGGA CCAGTGGCCT CTGCGGAACC CCACTCCTCA GGGCGCGGGA 
AAGCCAACAG GACCAGGAAG CATAAGGAAG AAGCGATTTG TGTCCAGCCC CCGTTATGTG 
GAAACCATGC TCGTGGCTGA CCAGTCCATG GCTGACTTCC ACGGCAGCGG TCTAAAGCAT 
TACCTTCTAA CCCTGTTCTC GGTGGCAGCC AGATTTTACA AGCACCCCAG CATTAGGAAT 
TCAATTAGTC TGGTGGTGGT GAAGATCTTG GTCATATATG AGGAGCAGAA GGGACCGGAA 
GTTACTTCCA ATGCCGCTCT CACCCTTAGG AATTTCTGTA GCTGGCAGAA ACAGCACAAC 
AGCCCCAGTG ACCGGGATCC AGAGCACTAT GACACAGCGA TTCTGTTCAC CAGACAGGAT 
TTATGTGGCT CCCACACCTG TGACACTCTC GGGATGGCTG ATGTTGGAAC TGTATGTGAC 
CCCAGCAGGA GCTGTTCGGT CATCGAAGAT GATGGTTTAC AGGCTGCCTT CACCACAGCC 
CATGAATTGG GCCATGTGTT TAACATGCCA CACGATGACG CCAAGCACTG CGCCAGCTTT 
AATGGCGTGA GTGGGGATTC CCATCTGATG GCCTCGATGC TCTCCAGCTT GGACCACAGC 
CAGCCCTGGT CTCCTTGCAG TGCCTACATG GTCACATCAT TCCTGGACAA CGGCCATGGG 
GAATGTTTGA TGGACAAGCC GCAGAACCCA ATCAAGCTCC CATCTGATCT TCCCGGTACC 
TTGTACGATG CCAACCGCCA GTGTCAGTTT ACCTTCGGGG AGGAATCCAC GCACTGCCCT 
GATGCAGCCA GCACATGCAG TACCCTGTGG TGCACTGGCA CCTCCGGTGG CTTACTGGTG 
TGCCAAACAA AACACTTCCC TTGGGCAGAT GGCACCAGCT GCGGAGAAGG GAAATGGTGT 
GTCAGCGGCA AGTGTGTGAA CAAGACCGAC ATGAAGCACT TTGCTACTCC TGTTCATGGG 
AGCTGGGGAC CGTGGGGACC ATGGGGAGAC TGCTCAAGAA CCTGTGGTGG AGGAGTTCAA 
TATACAATGA GAGAATGTGA CAACCCGGTC CCAAAGAACG GGGGGAAGTA CTGCGAAGGC 
AAACGAGTCC GCTACAGGTC CTGTAACATT GAGGACTGTC CAGACAATAA CGGAAAAACA 
TTCAGAGAGG AGCAATGCGA GGCGCACAAT GAGTTTTCCA AAGCTTCCTT TGGGAATGAA 
CCCACGGTGG AATGGACACC CAAGTATGCT GGCGTCTCGC CAAAGGACAG GTGCAAGCTT 
ACCTGCGAAG CCAAAGGCAT TGGCTACTTC TTTGTTTTAC AGCCCAAGGT GGTAGATGGC 
ACTCCCTGTA GTCCAGACTC TACTTCTGTC TGTGTGCAAG GACAGTGTGT GAAAGCTGGC 
TGTGATCGCA TCATAGACTC CAAAAAGAAG TTCGATAAGT GTGGCGTTTG TGGAGGAAAT 
GGCTCCACGT GCAAGAAAAT ATCAGGAACG GTCACTAGTA CAAGACCTGG GTATCATGAC 
ATTGTCACAA TTCCTGCTGG AGCCACCAAC ATTGAAGTGA AACATCGTAA TCCAAGGGGG 
TCCAGAAACA ATGGCAGCTT TCTGGCTATT AGAGCTGCAG ATGGTACCTA TATTCTGAAT 
GGAAACTTCA CTCTGTCCAC TCTAGAGCAA GACCTCACCT ACAAAGGTAC TGTCTTAAGA 
TACAGTGGTT CCTCAGCAGC ATTGGAAAGA ATCCGCAGCT TTAGTCCACT CAAAGAACCC 
CTGACCATCC AGGTTCTTAT GGTGGGCCAT GCTCTCCGAC CCAAAATCAA GTACACCTAT 
TTTATGAAGA AGAAGACGGA GCCCTTCAAC GCTATTCCCA CATTTTCGGA GTGGGTGATT 
GAAGAGTGGG GGGAGTGCTC CAAGACATGT GGTTCCGGTT GGCAGAGGAG AGTGGTAGAG 
TGCAGAGACA TTAATGGACA CCCTGCTTCT GAATGTGCCA AAGAAGTGAA GCCAGCCAGT 
ACCAGACCTT GTGCAGACCT TCCTTGCCCA CGTTGGCAGG TGGGGGATTG GTCACCATGT 
TCTAAAACTT GTGGGAAGGG TTATAAGAAG AGAACCTTGA AATGTCTGTC CCATGATGGC 
GGTGTGTTAT CAAATGAGAG CTGTGATCCT TTGAAGAAAC CAAAGCATTA CATTGACTTT 
TGCATACTGA CACAGTGCAG TTAA