Aqp3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aqp3
Entrez Gene ID	65133
Full Name	aquaporin 3
General protein information	Preferred Names aquaporin 3 Names aquaporin-3 31.4 kDa water channel protein AQP-3 aquaglyceroporin-3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q22
Summary	acts as a water transport channel in the collecting duct of the renal medulla [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031703.1	NP_113891.1	aquaporin-3

Pathways from BioSystems

Homologies

	AQP3	XP_001099318.1
Bos taurus (cattle)	AQP3	NP_001073262.1
Mus musculus (house mouse)	Aqp3	NP_057898.2
Danio rerio (zebrafish)	aqp3b	NP_001159593.1
Schizosaccharomyces pombe (fission yeast)	SPAC977.17	NP_592788.1
Pan troglodytes (chimpanzee)	AQP3	XP_520531.1
Canis lupus familiaris (dog)	AQP3	XP_854596.1
Rattus norvegicus (Norway rat)	Aqp3	NP_113891.1
Danio rerio (zebrafish)	aqp3a	NP_998633.1
Xenopus tropicalis (tropical clawed frog)	aqp3	NP_001016845.1
Homo sapiens (human)	AQP3	NP_004916.1
Magnaporthe oryzae (rice blast fungus)	MGG_13615	XP_003717502.1
Gallus gallus (chicken)	AQP3	XP_424500.3
Saccharomyces cerevisiae (baker's yeast)	YFL054C	NP_116601.1

Gene Ontology
Bibliography

Related articles in PubMed

Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats' colon via NF-?B pathway.
Chao G, Zhang S
Oncotarget8(29)47175-47183(2017 Jul)

Age-related changes in renal AQP3 and AQP4 expression in Sprague Dawley rats.
Jing XH, Liu J, Hou WY, Gao Y
Genetics and molecular research : GMR15(3)(2016 Aug)

Overexpression of AQP3 Modifies the Cell Cycle and the Proliferation Rate of Mammalian Cells in Culture.
Gal?n-Cobo A, Ram?rez-Lorca R, Serna A, Echevarr?a M
PloS one10(9)e0137692(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The findings indicate that mRNA expression of AQP3 varies with age.
Title: Age-related changes in renal AQP3 and AQP4 expression in Sprague Dawley rats.

one of the functional mechanisms of intense pulsed light might be related to the regulation of AQP3 protein expression
Title: Effect of intense pulsed light on the expression of aquaporin 3 in rat skin.

The results suggest that morphine increases the AQP3 expression level in the colon, which promotes water absorption from the luminal side to the vascular side and causes constipation.
Title: Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion.

Larger expression of AQP3 may confer to the cell a more tumor like phenotype and contributes to explain the presence of this protein in many different tumors.
Title: Overexpression of AQP3 Modifies the Cell Cycle and the Proliferation Rate of Mammalian Cells in Culture.

Reciprocity in the developmental regulation of aquaporins 1, 3 and 5 during pregnancy and lactation
Title: Reciprocity in the developmental regulation of aquaporins 1, 3 and 5 during pregnancy and lactation in the rat.

The following Aqp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aqp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13378	NM_031703.1 Latest version!	Rattus norvegicus aquaporin 3 (Gill blood group) (Aqp3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aqp3 ( NM_031703.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113891.1 Rattus norvegicus aquaporin 3 (Gill blood group) (Aqp3), mRNA.

Price & Availability↑

CloneID	ORa13378
Clone ID Related Accession (Same CDS sequence)	NM_031703.1
Accession Version	NM_031703.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	aquaporin-3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L35108.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L35108.1, BC127490.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMEA2689597 [ECO:0000350] ##Evidence-Data-END##

ATGGGTCGAC AGAAGGAGTT GATGAACCGT TGCGGGGAGA TGCTCCACAT CCGCTACCGG 
CTGCTTCGCC AGGCTCTGGC GGAGTGCCTG GGGACCCTCA TCCTTGTGAT GTTCGGCTGT 
GGTTCCGTGG CTCAAGTGGT GCTCAGCCGA GGGACCCATG GTGGCTTCCT CACCATCAAC 
TTGGCTTTTG GCTTCGCTGT CACCCTTGCC ATCTTGGTGG CTGGCCAAGT GTCTGGAGCC 
CACTTGAACC CTGCTGTGAC CTTTGCAATG TGCTTCCTGG CACGAGAGCC CTGGATCAAG 
CTGCCCATCT ACACACTGGC ACAGACCCTC GGGGCCTTCT TGGGTGCTGG GATTGTTTTT 
GGGCTCTACT ATGATGCAAT CTGGGCCTTT GCTGGCAATG AGCTTGTTGT CTCCGGCCCC 
AATGGCACAG CTGGTATCTT TGCCACCTAT CCCTCTGGAC ACTTGGATAT GGTCAATGGC 
TTCTTTGATC AGTTCATAGG CACAGCAGCC CTTATTGTGT GTGTGCTGGC CATTGTTGAC 
CCTTATAACA ACCCTGTGCC CCGGGGCCTG GAGGCCTTCA CTGTGGGCCT TGTGGTCCTG 
GTCATTGGGA CCTCCATGGG CTTCAATTCT GGCTATGCCG TCAACCCAGC TCGTGACTTT 
GGACCTCGCC TTTTCACTGC CCTGGCTGGC TGGGGTTCAG AAGTCTTTAC GACTGGCCAG 
AACTGGTGGT GGGTACCCAT CGTCTCTCCA CTCCTGGGTT CCATTGGTGG TGTCTTCGTG 
TACCAGCTCA TGATTGGCTG CCACCTGGAG CAGCCCCCGC CTTCCACTGA GGCAGAGAAT 
GTGAAGCTGG CCCACATGAA GCACAAGGAG CAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113891.1
CDS	77..955
Translation	MGRQKELMNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWAFAGNELVVSGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSEVFTTGQNWWWVPIVSPLLGSIGGVFVYQLMIGCHLEQPPPSTEAENVKLAHMKHKEQI

Target ORF information:

RefSeq Version	NM_031703.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aquaporin 3 (Gill blood group) (Aqp3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031703.1

ORF Insert Sequence:

ATGGGTCGAC AGAAGGAGTT GATGAACCGT TGCGGGGAGA TGCTCCACAT CCGCTACCGG 
CTGCTTCGCC AGGCTCTGGC GGAGTGCCTG GGGACCCTCA TCCTTGTGAT GTTCGGCTGT 
GGTTCCGTGG CTCAAGTGGT GCTCAGCCGA GGGACCCATG GTGGCTTCCT CACCATCAAC 
TTGGCTTTTG GCTTCGCTGT CACCCTTGCC ATCTTGGTGG CTGGCCAAGT GTCTGGAGCC 
CACTTGAACC CTGCTGTGAC CTTTGCAATG TGCTTCCTGG CACGAGAGCC CTGGATCAAG 
CTGCCCATCT ACACACTGGC ACAGACCCTC GGGGCCTTCT TGGGTGCTGG GATTGTTTTT 
GGGCTCTACT ATGATGCAAT CTGGGCCTTT GCTGGCAATG AGCTTGTTGT CTCCGGCCCC 
AATGGCACAG CTGGTATCTT TGCCACCTAT CCCTCTGGAC ACTTGGATAT GGTCAATGGC 
TTCTTTGATC AGTTCATAGG CACAGCAGCC CTTATTGTGT GTGTGCTGGC CATTGTTGAC 
CCTTATAACA ACCCTGTGCC CCGGGGCCTG GAGGCCTTCA CTGTGGGCCT TGTGGTCCTG 
GTCATTGGGA CCTCCATGGG CTTCAATTCT GGCTATGCCG TCAACCCAGC TCGTGACTTT 
GGACCTCGCC TTTTCACTGC CCTGGCTGGC TGGGGTTCAG AAGTCTTTAC GACTGGCCAG 
AACTGGTGGT GGGTACCCAT CGTCTCTCCA CTCCTGGGTT CCATTGGTGG TGTCTTCGTG 
TACCAGCTCA TGATTGGCTG CCACCTGGAG CAGCCCCCGC CTTCCACTGA GGCAGAGAAT 
GTGAAGCTGG CCCACATGAA GCACAAGGAG CAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats' colon via NF-?B pathway.
Oncotarget8(29)47175-47183(2017 Jul)
Chao G,Zhang S

Age-related changes in renal AQP3 and AQP4 expression in Sprague Dawley rats.
Genetics and molecular research : GMR15(3)(2016 Aug)
Jing XH,Liu J,Hou WY,Gao Y

Overexpression of AQP3 Modifies the Cell Cycle and the Proliferation Rate of Mammalian Cells in Culture.
PloS one10(9)e0137692(2015)
Gal?n-Cobo A,Ram?rez-Lorca R,Serna A,Echevarr?a M