Pik3c3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pik3c3
Entrez Gene ID	65052
Full Name	phosphatidylinositol 3-kinase, catalytic subunit type 3
General protein information	Preferred Names phosphatidylinositol 3-kinase, catalytic subunit type 3 Names phosphatidylinositol 3-kinase catalytic subunit type 3 PI-3K Vps34p PI3-kinase type 3 PI3K type 3 catalytic phosphatidylinositol 3-kinase 3 phosphoinositide-3-kinase, class 3 ptdIns-3-kinase type 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p12
Summary	activation and intracellular signaling mediates leukotriene B4-induced chemotaxis, generation of reactive oxygen species, and degranulation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006254488.3	XP_006254550.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1
NM_022958.2	NP_075247.1	phosphatidylinositol 3-kinase catalytic subunit type 3

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	PIK3C3	XP_003642950.2
Caenorhabditis elegans (roundworm)	vps-34	NP_001020954.1
Saccharomyces cerevisiae (baker's yeast)	VPS34	NP_013341.1
Kluyveromyces lactis	KLLA0D18645g	XP_453887.1
Eremothecium gossypii	AGOS_AGL113C	NP_986554.1
Arabidopsis thaliana (thale cress)	VPS34	NP_176251.1
Pan troglodytes (chimpanzee)	PIK3C3	XP_001142812.1
Mus musculus (house mouse)	Pik3c3	NP_852079.2
Drosophila melanogaster (fruit fly)	Pi3K59F	NP_477133.1
Schizosaccharomyces pombe (fission yeast)	pik3	NP_594699.1
Xenopus tropicalis (tropical clawed frog)	pik3c3	XP_002935097.2
Canis lupus familiaris (dog)	PIK3C3	XP_547599.3
Homo sapiens (human)	PIK3C3	NP_002638.2
Magnaporthe oryzae (rice blast fungus)	MGG_03069	XP_003720606.1
Oryza sativa (rice)	Os05g0180600	NP_001054810.1
	PIK3C3	XP_001082892.1
Bos taurus (cattle)	PIK3C3	NP_001092537.1
Rattus norvegicus (Norway rat)	Pik3c3	NP_075247.1
Danio rerio (zebrafish)	pik3c3	NP_001017550.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010273	XP_319464.4
Neurospora crassa	NCU00656	XP_965796.1

Gene Ontology
Bibliography

Related articles in PubMed

Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: Roles of Nrf2/HO-1 and PI3K/Akt pathway.
Li H, Song F, Duan LR, Sheng JJ, Xie YH, Yang Q, Chen Y, Dong QQ, Zhang BL, Wang SW
Scientific reports623693(2016 Mar)

PI(5)P regulates autophagosome biogenesis.
Vicinanza M, Korolchuk VI, Ashkenazi A, Puri C, Menzies FM, Clarke JH, Rubinsztein DC
Molecular cell57(2)219-34(2015 Jan)

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO
Nature cell biology16(11)1069-79(2014 Nov)

GA binding protein augments autophagy via transcriptional activation of BECN1-PIK3C3 complex genes.
Zhu W, Swaminathan G, Plowey ED
Autophagy10(9)1622-36(2014 Sep)

Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.
Devereaux K, Dall'Armi C, Alcazar-Roman A, Ogasawara Y, Zhou X, Wang F, Yamamoto A, De Camilli P, Di Paolo G
PloS one8(10)e76405(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that the cardioprotective effect of paeonol and danshensu combination is, at least partly, via activation of Nrf2/HO-1 signaling and involvement of the PI3K/Akt cell survival signaling pathway.
Title: Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: Roles of Nrf2/HO-1 and PI3K/Akt pathway.

reveal a novel function of GABP in the regulation of autophagy via transcriptional activation of the BECN1-PIK3C3 complex
Title: GA binding protein augments autophagy via transcriptional activation of BECN1-PIK3C3 complex genes.

Somatostatin stimulates the migration of hepatic oval cells within injured liver through SSTR4, and this action appears to be mediated by the PI3K pathway.
Title: Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver.

following high-resistance contractions, Vps34 activity is stimulated by an influx of essential amino acids such as leucine and this may prolong mTORC1 signalling and contribute to muscle hypertrophy
Title: mVps34 is activated following high-resistance contractions.

Inhibition of PI 3-K/Akt signaling pathway induces apoptosis in rat hepatic stellate cells (HSC).
Title: Phosphatidylinositol 3-kinase/Akt pathway regulates hepatic stellate cell apoptosis.

The following Pik3c3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pik3c3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06542	NM_022958.2 Latest version!	Rattus norvegicus phosphatidylinositol 3-kinase, catalytic subunit type 3 (Pik3c3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$475.30 $679.00
ORa38233	XM_006254488.3 Latest version!	Rattus norvegicus phosphatidylinositol 3-kinase, catalytic subunit type 3 (Pik3c3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pik3c3 ( NM_022958.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_075247.1 Rattus norvegicus phosphatidylinositol 3-kinase, catalytic subunit type 3 (Pik3c3), mRNA.

Price & Availability↑

CloneID	ORa06542
Clone ID Related Accession (Same CDS sequence)	NM_022958.2
Accession Version	NM_022958.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2664bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	phosphatidylinositol 3-kinase catalytic subunit type 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061981.1. On Jan 1, 2004 this sequence version replaced NM_022958.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061981.1, AJ006710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGAGG CGGAGAAGTT CCACTACATC TACAGCTGTG ACCTGGACAT CAACGTGCAG 
CTGAAGATAG GGAGCTTGGA AGGGAAGAGA GAACAAAAGA GCTACAAAGC TGTCCTAGAA 
GATCCCATGC TAAAGTTTTC CGGACTATAC CAAGAGACAT GCTCTGATCT GTATGTGACT 
TGTCAAGTTT TTGCTGAAGG GAAGCCCCTG GCCTTGCCAG TCAGAACATC CTACAAACCA 
TTTAGTACAC GATGGAATTG GAACGAGTGG CTGAAACTCC CGGTGAAATA CCCTGACCTG 
CCCAGGAACG CCCAAGTGGC CTTGACTATA TGGGATGTGT ATGGACCCGG AAGGGCTGTG 
CCGGTGGGAG GAACAACCGT GTCACTCTTT GGAAAATATG GCATGTTTCG CCAAGGAATG 
CACGACTTGA AAGTCTGGCC TAACGTGGAG GCAGATGGCT CCGAACCCAC ACGAACCCCG 
GGCAGAACAA GCAGCACACT CTCAGAAGAC CAGATGAGCC GCCTTGCCAA GCTTACCAAG 
GCTCATCGGC AGGGACACAT GGTGAAGGTG GATTGGTTGG ACAGACTAAC GTTTAGAGAG 
ATAGAAATGA TAAATGAGAG TGAGAAACGA AGCTCTAATT TCATGTACTT GATGGTTGAG 
TTTCGCTGTG TCAAATGCGA TGACAAGGAA TATGGTATTG TCTACTATGA AAAGGATGGT 
GACGAATCAT CTCCAATTTT AACAAGCTTT GAGTTAGTGA AAGTTCCTGA TCCTCAAATG 
TCTATGGAGA ACTTAGTGGA GAGCAAACAC CACAAGCTTG CTCGGAGTTT AAGAAGTGGA 
CCATCTGACC ACGATCTCAA ACCCAACGCT ACCACAAGAG ATCAGCTAAA TATTATTGTG 
AGCTACCCAC CAACCAAGCA GCTCACATAT GAAGAACAAG ATCTTGTTTG GAAATTTAGA 
TATTATCTTA CTAATCAAGA AAAGGCTCTG ACAAAGTTCT TGAAGTGTGT TAACTGGGAC 
CTACCCCAGG AGGCCAAGCA GGCGCTGGAA CTTCTGGGAA AGTGGAAGCC AATGGATGTG 
GAGGATTCCC TAGAGCTGCT CTCCTCTCAT TACACCAACC CCACCGTGCG GCGGTACGCT 
GTGGCCCGCT TGAGGCAGGC CGATGACGAG GATTTGCTGA TGTACTTGCT GCAGCTGGTC 
CAGGCTCTGA AATATGAAAA CTTTGATGAC ATAAAGAACG GTTTGGAGCC TACCAAGAAG 
GATAGTCAAG CTTCCGTGTC AGAGAGCCTG TCAAGTTCTG GAGTCAGTTC TGCAGATATA 
GATAGCTCTC AAATTATAAC CAACCCTCTT CCTCCGGTGG CCTCCCCTCC TCCTGCATCT 
AAATCAAAGG AAGTTTCTGA TGGGGAAAAC CTAGAGCAGG ATCTTTGTAC CTTCTTGATA 
TCAAGAGCCT GTAAGAACTC AACACTGGCT AACTATTTAT ACTGGTATGT GATAGTGGAG 
TGCGAAGATC AGGACACACA GCAGAGGGAC CCAAAGACTC ACGAGATGTA CCTGAACGTC 
ATGAGGCGCT TCAGCCAAGC CCTGCTCAAG GGTGACAAGT CCGTGCGGGT CATGCGCTCC 
CTGCTGGCGG CACAGCAGAC CTTTGTAGAT CGCCTGGTGC ATCTGATGAA GGCAGTGCAG 
AGAGAAAGTG GGAACCGCAA GAAGAAGAAT GAGAGACTTC AAGCCTTGCT TGGAGATAAT 
GAAAAAATGA ACTTATCAGA TGTGGAGCTG ATCCCATTGC CGTTAGAGCC ACAGGTGAAA 
ATACGGGGAA TCATCCCGGA AACAGCCACA CTGTTCAAGA GTGCTCTTAT GCCTGCCCAG 
CTGTTCTTCA AGACAGAAGA CGGTGGCAAA TACCCTGTGA TCTTCAAGCA TGGGGACGAC 
TTGCGTCAAG ATCAGCTTAT CCTTCAGATC ATCTCCCTCA TGGACAAGCT GTTGCGGAAA 
GAAAATCTGG ATTTGAAATT GACCCCTTAC AAGGTGTTAG CCACGAGTAC AAAACATGGC 
TTCATGCAGT TCATCCAGTC AGTTCCCGTC GCCGAAGTTC TTGACACGGA GGGAAGCATT 
CAGAACTTTT TCAGGAAATA TGCCCCAAGC GAGACTGGAC CCAATGGCAT CAGTGCAGAG 
GTCATGGACA CTTACGTTAA GAGCTGTGCT GGCTACTGTG TGATCACCTA CATCCTTGGG 
GTTGGAGACC GGCACCTGGA TAACCTTCTG TTAACAAAGA CAGGCAAACT CTTCCATATA 
GATTTCGGGT ATATTCTGGG CCGAGATCCC AAGCCTCTTC CTCCTCCAAT GAAGCTGAAT 
AAGGAGATGG TCGAAGGGAT GGGTGGTACC CAGAGTGAGC AGTACCAAGA GTTCAGAAAG 
CAGTGTTACA CGGCCTTCCT CCACCTGCGA AGGTATTCAA ATCTGATTCT GAACTTGTTC 
TCCTTGATGG TTGATGCAAA CATTCCAGAT ATTGCTCTTG AACCAGATAA AACTGTAAAA 
AAGGTTCAGG ATAAGTTCCG TCTGGACCTG TCAGATGAGG AGGCCGTGCA TTACATGCAG 
AGTCTGATCG ACGAAAGTGT TCACGCCCTG TTCGCTGCGG TGGTGGAGCA GATCCATAAG 
TTTGCCCAGT ACTGGAGAAA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075247.1
CDS	25..2688
Translation	MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKPFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGRAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQASVSESLSSSGVSSADIDSSQIITNPLPPVASPPPASKSKEVSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK

Target ORF information:

RefSeq Version	NM_022958.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus phosphatidylinositol 3-kinase, catalytic subunit type 3 (Pik3c3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022958.2

ORF Insert Sequence:

ATGGGGGAGG CGGAGAAGTT CCACTACATC TACAGCTGTG ACCTGGACAT CAACGTGCAG 
CTGAAGATAG GGAGCTTGGA AGGGAAGAGA GAACAAAAGA GCTACAAAGC TGTCCTAGAA 
GATCCCATGC TAAAGTTTTC CGGACTATAC CAAGAGACAT GCTCTGATCT GTATGTGACT 
TGTCAAGTTT TTGCTGAAGG GAAGCCCCTG GCCTTGCCAG TCAGAACATC CTACAAACCA 
TTTAGTACAC GATGGAATTG GAACGAGTGG CTGAAACTCC CGGTGAAATA CCCTGACCTG 
CCCAGGAACG CCCAAGTGGC CTTGACTATA TGGGATGTGT ATGGACCCGG AAGGGCTGTG 
CCGGTGGGAG GAACAACCGT GTCACTCTTT GGAAAATATG GCATGTTTCG CCAAGGAATG 
CACGACTTGA AAGTCTGGCC TAACGTGGAG GCAGATGGCT CCGAACCCAC ACGAACCCCG 
GGCAGAACAA GCAGCACACT CTCAGAAGAC CAGATGAGCC GCCTTGCCAA GCTTACCAAG 
GCTCATCGGC AGGGACACAT GGTGAAGGTG GATTGGTTGG ACAGACTAAC GTTTAGAGAG 
ATAGAAATGA TAAATGAGAG TGAGAAACGA AGCTCTAATT TCATGTACTT GATGGTTGAG 
TTTCGCTGTG TCAAATGCGA TGACAAGGAA TATGGTATTG TCTACTATGA AAAGGATGGT 
GACGAATCAT CTCCAATTTT AACAAGCTTT GAGTTAGTGA AAGTTCCTGA TCCTCAAATG 
TCTATGGAGA ACTTAGTGGA GAGCAAACAC CACAAGCTTG CTCGGAGTTT AAGAAGTGGA 
CCATCTGACC ACGATCTCAA ACCCAACGCT ACCACAAGAG ATCAGCTAAA TATTATTGTG 
AGCTACCCAC CAACCAAGCA GCTCACATAT GAAGAACAAG ATCTTGTTTG GAAATTTAGA 
TATTATCTTA CTAATCAAGA AAAGGCTCTG ACAAAGTTCT TGAAGTGTGT TAACTGGGAC 
CTACCCCAGG AGGCCAAGCA GGCGCTGGAA CTTCTGGGAA AGTGGAAGCC AATGGATGTG 
GAGGATTCCC TAGAGCTGCT CTCCTCTCAT TACACCAACC CCACCGTGCG GCGGTACGCT 
GTGGCCCGCT TGAGGCAGGC CGATGACGAG GATTTGCTGA TGTACTTGCT GCAGCTGGTC 
CAGGCTCTGA AATATGAAAA CTTTGATGAC ATAAAGAACG GTTTGGAGCC TACCAAGAAG 
GATAGTCAAG CTTCCGTGTC AGAGAGCCTG TCAAGTTCTG GAGTCAGTTC TGCAGATATA 
GATAGCTCTC AAATTATAAC CAACCCTCTT CCTCCGGTGG CCTCCCCTCC TCCTGCATCT 
AAATCAAAGG AAGTTTCTGA TGGGGAAAAC CTAGAGCAGG ATCTTTGTAC CTTCTTGATA 
TCAAGAGCCT GTAAGAACTC AACACTGGCT AACTATTTAT ACTGGTATGT GATAGTGGAG 
TGCGAAGATC AGGACACACA GCAGAGGGAC CCAAAGACTC ACGAGATGTA CCTGAACGTC 
ATGAGGCGCT TCAGCCAAGC CCTGCTCAAG GGTGACAAGT CCGTGCGGGT CATGCGCTCC 
CTGCTGGCGG CACAGCAGAC CTTTGTAGAT CGCCTGGTGC ATCTGATGAA GGCAGTGCAG 
AGAGAAAGTG GGAACCGCAA GAAGAAGAAT GAGAGACTTC AAGCCTTGCT TGGAGATAAT 
GAAAAAATGA ACTTATCAGA TGTGGAGCTG ATCCCATTGC CGTTAGAGCC ACAGGTGAAA 
ATACGGGGAA TCATCCCGGA AACAGCCACA CTGTTCAAGA GTGCTCTTAT GCCTGCCCAG 
CTGTTCTTCA AGACAGAAGA CGGTGGCAAA TACCCTGTGA TCTTCAAGCA TGGGGACGAC 
TTGCGTCAAG ATCAGCTTAT CCTTCAGATC ATCTCCCTCA TGGACAAGCT GTTGCGGAAA 
GAAAATCTGG ATTTGAAATT GACCCCTTAC AAGGTGTTAG CCACGAGTAC AAAACATGGC 
TTCATGCAGT TCATCCAGTC AGTTCCCGTC GCCGAAGTTC TTGACACGGA GGGAAGCATT 
CAGAACTTTT TCAGGAAATA TGCCCCAAGC GAGACTGGAC CCAATGGCAT CAGTGCAGAG 
GTCATGGACA CTTACGTTAA GAGCTGTGCT GGCTACTGTG TGATCACCTA CATCCTTGGG 
GTTGGAGACC GGCACCTGGA TAACCTTCTG TTAACAAAGA CAGGCAAACT CTTCCATATA 
GATTTCGGGT ATATTCTGGG CCGAGATCCC AAGCCTCTTC CTCCTCCAAT GAAGCTGAAT 
AAGGAGATGG TCGAAGGGAT GGGTGGTACC CAGAGTGAGC AGTACCAAGA GTTCAGAAAG 
CAGTGTTACA CGGCCTTCCT CCACCTGCGA AGGTATTCAA ATCTGATTCT GAACTTGTTC 
TCCTTGATGG TTGATGCAAA CATTCCAGAT ATTGCTCTTG AACCAGATAA AACTGTAAAA 
AAGGTTCAGG ATAAGTTCCG TCTGGACCTG TCAGATGAGG AGGCCGTGCA TTACATGCAG 
AGTCTGATCG ACGAAAGTGT TCACGCCCTG TTCGCTGCGG TGGTGGAGCA GATCCATAAG 
TTTGCCCAGT ACTGGAGAAA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pik3c3 ( XM_006254488.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254550.1 Rattus norvegicus phosphatidylinositol 3-kinase, catalytic subunit type 3 (Pik3c3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa38233
Clone ID Related Accession (Same CDS sequence)	XM_006254488.3
Accession Version	XM_006254488.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2661bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254488.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGAGG CGGAGAAGTT CCACTACATC TACAGCTGTG ACCTGGACAT CAACGTGCAG 
CTGAAGATAG GGAGCTTGGA AGGGAAGAGA GAACAAAAGA GCTACAAAGC TGTCCTAGAA 
GATCCCATGC TAAAGTTTTC CGGACTATAC CAAGAGACAT GCTCTGATCT GTATGTGACT 
TGTCAAGTTT TTGCTGAAGG GAAGCCCCTG GCCTTGCCAG TCAGAACATC CTACAAACCA 
TTTAGTACAC GATGGAATTG GAACGAGTGG CTGAAACTCC CGGTGAAATA CCCTGACCTG 
CCCAGGAACG CCCAAGTGGC CTTGACTATA TGGGATGTGT ATGGACCCGG AAGGGCTGTG 
CCGGTGGGAG GAACAACCGT GTCACTCTTT GGAAAATATG GCATGTTTCG CCAAGGAATG 
CACGACTTGA AAGTCTGGCC TAACGTGGAG GCAGATGGCT CCGAACCCAC ACGAACCCCG 
GGCAGAACAA GCAGCACACT CTCAGAAGAC CAGATGAGCC GCCTTGCCAA GCTTACCAAG 
GCTCATCGGC AGGGACACAT GGTGAAGGTG GATTGGTTGG ACAGACTAAC GTTTAGAGAG 
ATAGAAATGA TAAATGAGAG TGAGAAACGA AGCTCTAATT TCATGTACTT GATGGTTGAG 
TTTCGCTGTG TCAAATGCGA TGACAAGGAA TATGGTATTG TCTACTATGA AAAGGATGGT 
GACGAATCAT CTCCAATTTT AACAAGCTTT GAGTTAGTGA AAGTTCCTGA TCCTCAAATG 
TCTATGGAGA ACTTAGTGGA GAGCAAACAC CACAAGCTTG CTCGGAGTTT AAGAAGTGGA 
CCATCTGACC ACGATCTCAA ACCCAACGCT ACCACAAGAG ATCAGCTAAA TATTATTGTG 
AGCTACCCAC CAACCAAGCA GCTCACATAT GAAGAACAAG ATCTTGTTTG GAAATTTAGA 
TATTATCTTA CTAATCAAGA AAAGGCTCTG ACAAAGTTCT TGAAGTGTGT TAACTGGGAC 
CTACCCCAGG AGGCCAAGCA GGCGCTGGAA CTTCTGGGAA AGTGGAAGCC AATGGATGTG 
GAGGATTCCC TAGAGCTGCT CTCCTCTCAT TACACCAACC CCACCGTGCG GCGGTACGCT 
GTGGCCCGCT TGAGGCAGGC CGATGACGAG GATTTGCTGA TGTACTTGCT GCAGCTGGTC 
CAGGCTCTGA AATATGAAAA CTTTGATGAC ATAAAGAACG GTTTGGAGCC TACCAAGAAG 
GATAGTCAAG CTTCCGTGTC AGAGAGCCTG TCAAGTTCTG GAGTCAGTTC TGCAGATATA 
GATAGCTCTC AAATTATAAC CAACCCTCTT CCTCCGGTGG CCTCCCCTCC TCCTGCATCT 
AAATCAAAGG AAGTTTCTGA TGGGGAAAAC CTAGAGGATC TTTGTACCTT CTTGATATCA 
AGAGCCTGTA AGAACTCAAC ACTGGCTAAC TATTTATACT GGTATGTGAT AGTGGAGTGC 
GAAGATCAGG ACACACAGCA GAGGGACCCA AAGACTCACG AGATGTACCT GAACGTCATG 
AGGCGCTTCA GCCAAGCCCT GCTCAAGGGT GACAAGTCCG TGCGGGTCAT GCGCTCCCTG 
CTGGCGGCAC AGCAGACCTT TGTAGATCGC CTGGTGCATC TGATGAAGGC AGTGCAGAGA 
GAAAGTGGGA ACCGCAAGAA GAAGAATGAG AGACTTCAAG CCTTGCTTGG AGATAATGAA 
AAAATGAACT TATCAGATGT GGAGCTGATC CCATTGCCGT TAGAGCCACA GGTGAAAATA 
CGGGGAATCA TCCCGGAAAC AGCCACACTG TTCAAGAGTG CTCTTATGCC TGCCCAGCTG 
TTCTTCAAGA CAGAAGACGG TGGCAAATAC CCTGTGATCT TCAAGCATGG GGACGACTTG 
CGTCAAGATC AGCTTATCCT TCAGATCATC TCCCTCATGG ACAAGCTGTT GCGGAAAGAA 
AATCTGGATT TGAAATTGAC CCCTTACAAG GTGTTAGCCA CGAGTACAAA ACATGGCTTC 
ATGCAGTTCA TCCAGTCAGT TCCCGTCGCC GAAGTTCTTG ACACGGAGGG AAGCATTCAG 
AACTTTTTCA GGAAATATGC CCCAAGCGAG ACTGGACCCA ATGGCATCAG TGCAGAGGTC 
ATGGACACTT ACGTTAAGAG CTGTGCTGGC TACTGTGTGA TCACCTACAT CCTTGGGGTT 
GGAGACCGGC ACCTGGATAA CCTTCTGTTA ACAAAGACAG GCAAACTCTT CCATATAGAT 
TTCGGGTATA TTCTGGGCCG AGATCCCAAG CCTCTTCCTC CTCCAATGAA GCTGAATAAG 
GAGATGGTCG AAGGGATGGG TGGTACCCAG AGTGAGCAGT ACCAAGAGTT CAGAAAGCAG 
TGTTACACGG CCTTCCTCCA CCTGCGAAGG TATTCAAATC TGATTCTGAA CTTGTTCTCC 
TTGATGGTTG ATGCAAACAT TCCAGATATT GCTCTTGAAC CAGATAAAAC TGTAAAAAAG 
GTTCAGGATA AGTTCCGTCT GGACCTGTCA GATGAGGAGG CCGTGCATTA CATGCAGAGT 
CTGATCGACG AAAGTGTTCA CGCCCTGTTC GCTGCGGTGG TGGAGCAGAT CCATAAGTTT 
GCCCAGTACT GGAGAAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254550.1
CDS	114..2774
Translation	MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKPFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGRAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQASVSESLSSSGVSSADIDSSQIITNPLPPVASPPPASKSKEVSDGENLEDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK

Target ORF information:

RefSeq Version	XM_006254488.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus phosphatidylinositol 3-kinase, catalytic subunit type 3 (Pik3c3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254488.3

ORF Insert Sequence:

ATGGGGGAGG CGGAGAAGTT CCACTACATC TACAGCTGTG ACCTGGACAT CAACGTGCAG 
CTGAAGATAG GGAGCTTGGA AGGGAAGAGA GAACAAAAGA GCTACAAAGC TGTCCTAGAA 
GATCCCATGC TAAAGTTTTC CGGACTATAC CAAGAGACAT GCTCTGATCT GTATGTGACT 
TGTCAAGTTT TTGCTGAAGG GAAGCCCCTG GCCTTGCCAG TCAGAACATC CTACAAACCA 
TTTAGTACAC GATGGAATTG GAACGAGTGG CTGAAACTCC CGGTGAAATA CCCTGACCTG 
CCCAGGAACG CCCAAGTGGC CTTGACTATA TGGGATGTGT ATGGACCCGG AAGGGCTGTG 
CCGGTGGGAG GAACAACCGT GTCACTCTTT GGAAAATATG GCATGTTTCG CCAAGGAATG 
CACGACTTGA AAGTCTGGCC TAACGTGGAG GCAGATGGCT CCGAACCCAC ACGAACCCCG 
GGCAGAACAA GCAGCACACT CTCAGAAGAC CAGATGAGCC GCCTTGCCAA GCTTACCAAG 
GCTCATCGGC AGGGACACAT GGTGAAGGTG GATTGGTTGG ACAGACTAAC GTTTAGAGAG 
ATAGAAATGA TAAATGAGAG TGAGAAACGA AGCTCTAATT TCATGTACTT GATGGTTGAG 
TTTCGCTGTG TCAAATGCGA TGACAAGGAA TATGGTATTG TCTACTATGA AAAGGATGGT 
GACGAATCAT CTCCAATTTT AACAAGCTTT GAGTTAGTGA AAGTTCCTGA TCCTCAAATG 
TCTATGGAGA ACTTAGTGGA GAGCAAACAC CACAAGCTTG CTCGGAGTTT AAGAAGTGGA 
CCATCTGACC ACGATCTCAA ACCCAACGCT ACCACAAGAG ATCAGCTAAA TATTATTGTG 
AGCTACCCAC CAACCAAGCA GCTCACATAT GAAGAACAAG ATCTTGTTTG GAAATTTAGA 
TATTATCTTA CTAATCAAGA AAAGGCTCTG ACAAAGTTCT TGAAGTGTGT TAACTGGGAC 
CTACCCCAGG AGGCCAAGCA GGCGCTGGAA CTTCTGGGAA AGTGGAAGCC AATGGATGTG 
GAGGATTCCC TAGAGCTGCT CTCCTCTCAT TACACCAACC CCACCGTGCG GCGGTACGCT 
GTGGCCCGCT TGAGGCAGGC CGATGACGAG GATTTGCTGA TGTACTTGCT GCAGCTGGTC 
CAGGCTCTGA AATATGAAAA CTTTGATGAC ATAAAGAACG GTTTGGAGCC TACCAAGAAG 
GATAGTCAAG CTTCCGTGTC AGAGAGCCTG TCAAGTTCTG GAGTCAGTTC TGCAGATATA 
GATAGCTCTC AAATTATAAC CAACCCTCTT CCTCCGGTGG CCTCCCCTCC TCCTGCATCT 
AAATCAAAGG AAGTTTCTGA TGGGGAAAAC CTAGAGGATC TTTGTACCTT CTTGATATCA 
AGAGCCTGTA AGAACTCAAC ACTGGCTAAC TATTTATACT GGTATGTGAT AGTGGAGTGC 
GAAGATCAGG ACACACAGCA GAGGGACCCA AAGACTCACG AGATGTACCT GAACGTCATG 
AGGCGCTTCA GCCAAGCCCT GCTCAAGGGT GACAAGTCCG TGCGGGTCAT GCGCTCCCTG 
CTGGCGGCAC AGCAGACCTT TGTAGATCGC CTGGTGCATC TGATGAAGGC AGTGCAGAGA 
GAAAGTGGGA ACCGCAAGAA GAAGAATGAG AGACTTCAAG CCTTGCTTGG AGATAATGAA 
AAAATGAACT TATCAGATGT GGAGCTGATC CCATTGCCGT TAGAGCCACA GGTGAAAATA 
CGGGGAATCA TCCCGGAAAC AGCCACACTG TTCAAGAGTG CTCTTATGCC TGCCCAGCTG 
TTCTTCAAGA CAGAAGACGG TGGCAAATAC CCTGTGATCT TCAAGCATGG GGACGACTTG 
CGTCAAGATC AGCTTATCCT TCAGATCATC TCCCTCATGG ACAAGCTGTT GCGGAAAGAA 
AATCTGGATT TGAAATTGAC CCCTTACAAG GTGTTAGCCA CGAGTACAAA ACATGGCTTC 
ATGCAGTTCA TCCAGTCAGT TCCCGTCGCC GAAGTTCTTG ACACGGAGGG AAGCATTCAG 
AACTTTTTCA GGAAATATGC CCCAAGCGAG ACTGGACCCA ATGGCATCAG TGCAGAGGTC 
ATGGACACTT ACGTTAAGAG CTGTGCTGGC TACTGTGTGA TCACCTACAT CCTTGGGGTT 
GGAGACCGGC ACCTGGATAA CCTTCTGTTA ACAAAGACAG GCAAACTCTT CCATATAGAT 
TTCGGGTATA TTCTGGGCCG AGATCCCAAG CCTCTTCCTC CTCCAATGAA GCTGAATAAG 
GAGATGGTCG AAGGGATGGG TGGTACCCAG AGTGAGCAGT ACCAAGAGTT CAGAAAGCAG 
TGTTACACGG CCTTCCTCCA CCTGCGAAGG TATTCAAATC TGATTCTGAA CTTGTTCTCC 
TTGATGGTTG ATGCAAACAT TCCAGATATT GCTCTTGAAC CAGATAAAAC TGTAAAAAAG 
GTTCAGGATA AGTTCCGTCT GGACCTGTCA GATGAGGAGG CCGTGCATTA CATGCAGAGT 
CTGATCGACG AAAGTGTTCA CGCCCTGTTC GCTGCGGTGG TGGAGCAGAT CCATAAGTTT 
GCCCAGTACT GGAGAAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: Roles of Nrf2/HO-1 and PI3K/Akt pathway.
Scientific reports623693(2016 Mar)
Li H,Song F,Duan LR,Sheng JJ,Xie YH,Yang Q,Chen Y,Dong QQ,Zhang BL,Wang SW

PI(5)P regulates autophagosome biogenesis.
Molecular cell57(2)219-34(2015 Jan)
Vicinanza M,Korolchuk VI,Ashkenazi A,Puri C,Menzies FM,Clarke JH,Rubinsztein DC

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Nature cell biology16(11)1069-79(2014 Nov)
Dowdle WE,Nyfeler B,Nagel J,Elling RA,Liu S,Triantafellow E,Menon S,Wang Z,Honda A,Pardee G,Cantwell J,Luu C,Cornella-Taracido I,Harrington E,Fekkes P,Lei H,Fang Q,Digan ME,Burdick D,Powers AF,Helliwell SB,D'Aquin S,Bastien J,Wang H,Wiederschain D,Kuerth J,Bergman P,Schwalb D,Thomas J,Ugwonali S,Harbinski F,Tallarico J,Wilson CJ,Myer VE,Porter JA,Bussiere DE,Finan PM,Labow MA,Mao X,Hamann LG,Manning BD,Valdez RA,Nicholson T,Schirle M,Knapp MS,Keaney EP,Murphy LO

GA binding protein augments autophagy via transcriptional activation of BECN1-PIK3C3 complex genes.
Autophagy10(9)1622-36(2014 Sep)
Zhu W,Swaminathan G,Plowey ED

Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.
PloS one8(10)e76405(2013)
Devereaux K,Dall'Armi C,Alcazar-Roman A,Ogasawara Y,Zhou X,Wang F,Yamamoto A,De Camilli P,Di Paolo G

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Pik3c3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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