Tuba1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tuba1a
Entrez Gene ID	64158
Full Name	tubulin, alpha 1A
Synonyms	Tuba1
General protein information	Preferred Names tubulin, alpha 1A Names tubulin alpha-1A chain alpha-tubulin 1 tubulin alpha-1 chain tubulin, alpha 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q36
Summary	forms heterodimers with beta-tubulin; acts as a structural component of the microtubule cytoskeleton; plays a role in microtubule-based processes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022298.1	NP_071634.1	tubulin alpha-1A chain

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TUBA1A	NP_001092014.1
	TUBA1A	XP_001108924.2
Gallus gallus (chicken)	TUBA3E	XP_419249.3
Bos taurus (cattle)	TUBA1A	NP_001159977.1
Mus musculus (house mouse)	Tuba1a	NP_035783.1
Caenorhabditis elegans (roundworm)	tba-5	NP_492268.1
Homo sapiens (human)	TUBA1A	NP_006000.2
Canis lupus familiaris (dog)	TUBA1A	XP_862471.2
Danio rerio (zebrafish)	tuba1l2	NP_001177911.1
Rattus norvegicus (Norway rat)	Tuba1a	NP_071634.1
Xenopus tropicalis (tropical clawed frog)	tuba1b	XP_002935154.1

Gene Ontology
Bibliography

Related articles in PubMed

Adrenalectomy facilitates ATAT1 expression and ?-tubulin acetylation in ACTH-producing corticotrophs.
Nakakura T, Nemoto T, Suzuki T, Asano-Hoshino A, Tanaka H, Arisawa K, Nishijima Y, Kiuchi Y, Hagiwara H
Cell and tissue research366(2)363-370(2016 Nov)

Epigenetic factors MeCP2 and HDAC6 control ?-tubulin acetylation in cardiac fibroblast proliferation and fibrosis.
Tao H, Yang JJ, Shi KH, Li J
Inflammation research : official journal of the European Histamine Research Society ... [et al.]65(5)415-26(2016 May)

Novel ?-tubulin mutation disrupts neural development and tubulin proteostasis.
Gartz Hanson M, Aiken J, Sietsema DV, Sept D, Bates EA, Niswander L, Moore JK
Developmental biology409(2)406-19(2016 Jan)

Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel (VDAC).
Sheldon KL, Gurnev PA, Bezrukov SM, Sackett DL
The Journal of biological chemistry290(44)26784-9(2015 Oct)

Rab11 endosomes contribute to mitotic spindle organization and orientation.
Hehnly H, Doxsey S
Developmental cell28(5)497-507(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results agree with the hypothesis that the acetylation of alpha-tubulin by ATAT1 regulates the intracellular transport of secretory granules in corticotrophs.
Title: Adrenalectomy facilitates ATAT1 expression and ?-tubulin acetylation in ACTH-producing corticotrophs.

We demonstrated that MeCP2 may negatively control the acetylation of alpha-tubulin through HDAC6 in cardiac fibroblast proliferation and fibrosis
Title: Epigenetic factors MeCP2 and HDAC6 control ?-tubulin acetylation in cardiac fibroblast proliferation and fibrosis.

Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel, VDAC.
Title: Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel (VDAC).

TTL has specifically evolved to recognize and modify tubulin.
Title: Structural basis of tubulin tyrosination by tubulin tyrosine ligase.

This finding reveals the importance of MEC-17 and alpha-tubulin acetylation in cortical development.
Title: MEC-17 deficiency leads to reduced ?-tubulin acetylation and impaired migration of cortical neurons.

The following Tuba1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tuba1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05665	NM_022298.1 Latest version!	Rattus norvegicus tubulin, alpha 1A (Tuba1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tuba1a ( NM_022298.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071634.1 Rattus norvegicus tubulin, alpha 1A (Tuba1a), mRNA.

Price & Availability↑

CloneID	ORa05665
Clone ID Related Accession (Same CDS sequence)	NM_022298.1
Accession Version	NM_022298.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1356bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	tubulin alpha-1A chain
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from V01227.1. On Jan 12, 2005 this sequence version replaced XM_217040.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: V01227.1, BC078830.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCGTGAGT GTATCTCCAT CCACGTCGGC CAGGCTGGTG TCCAGATCGG CAATGCCTGC 
TGGGAGCTCT ACTGCCTGGA ACATGGCATC CAGCCTGATG GCCAGATGCC AAGCGACAAG 
ACCATTGGGG GAGGAGATGA CTCCTTCAAC ACCTTCTTCA GTGAGACAGG AGCTGGCAAG 
CACGTGCCCC GGGCGGTGTT CGTAGACCTG GAACCCACAG TTATTGATGA AGTTCGCACT 
GGCACCTACC GCCAGCTCTT CCACCCAGAG CAGCTCATCA CAGGCAAGGA AGATGCTGCC 
AATAACTATG CCCGTGGCCA CTACACCATT GGCAAGGAGA TCATTGACCT TGTCTTGGAC 
AGAATTCGCA AGCTGGCTGA CCAGTGCACG GGTCTCCAGG GCTTCTTGGT TTTCCACAGC 
TTTGGTGGGG GAACTGGCTC TGGGTTCACC TCCCTGCTGA TGGAGAGGCT CTCTGTCGAC 
TACGGAAAGA AGTCCAAGCT GGAGTTCTCC ATTTACCCAG CCCCCCAGGT TTCCACTGCT 
GTGGTTGAGC CCTACAATTC CATCCTCACC ACCCACACCA CCCTGGAGCA CTCTGATTGT 
GCCTTCATGG TAGACAATGA GGCCATCTAT GACATCTGTC GTAGAAACCT CGACATTGAG 
CGCCCAACCT ACACTAACTT AAACAGGTTG ATAGGTCAAA TTGTGTCTTC CATCACTGCT 
TCCCTCAGAT TTGATGGGGC CCTGAATGTT GATCTGACAG AATTCCAGAC CAACCTGGTG 
CCCTACCCTC GCATCCACTT CCCTCTGGCC ACTTATGCCC CTGTCATCTC TGCTGAGAAA 
GCCTACCATG AACAGCTTTC TGTAGCAGAG ATCACCAATG CCTGCTTTGA GCCAGCCAAC 
CAGATGGTGA AATGTGACCC TCGCCATGGT AAATACATGG CTTGCTGCCT GCTGTACCGT 
GGTGATGTGG TCCCCAAAGA TGTCAATGCT GCCATTGCCA CCATCAAGAC CAAGCGTACC 
ATCCAGTTTG TGGACTGGTG CCCCACTGGC TTCAAGGTTG GCATTAATTA CCAGCCTCCC 
ACTGTGGTCC CTGGTGGCGA CCTGGCCAAG GTCCAGAGAG CTGTGTGTAT GCTGAGCAAC 
ACCACAGCCA TTGCTGAGGC CTGGGCTCGC CTGGATCACA AGTTTGATCT GATGTATGCC 
AAGCGTGCCT TTGTGCACTG GTACGTGGGT GAGGGCATGG AGGAGGGAGA GTTCTCTGAG 
GCCCGTGAGG ACATGGCTGC CCTAGAGAAG GATTATGAGG AGGTTGGTGT GGATTCTGTG 
GAGGGTGAGG GTGAGGAAGA AGGAGAGGAA TACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071634.1
CDS	67..1422
Translation	MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Target ORF information:

RefSeq Version	NM_022298.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tubulin, alpha 1A (Tuba1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022298.1

ORF Insert Sequence:

ATGCGTGAGT GTATCTCCAT CCACGTCGGC CAGGCTGGTG TCCAGATCGG CAATGCCTGC 
TGGGAGCTCT ACTGCCTGGA ACATGGCATC CAGCCTGATG GCCAGATGCC AAGCGACAAG 
ACCATTGGGG GAGGAGATGA CTCCTTCAAC ACCTTCTTCA GTGAGACAGG AGCTGGCAAG 
CACGTGCCCC GGGCGGTGTT CGTAGACCTG GAACCCACAG TTATTGATGA AGTTCGCACT 
GGCACCTACC GCCAGCTCTT CCACCCAGAG CAGCTCATCA CAGGCAAGGA AGATGCTGCC 
AATAACTATG CCCGTGGCCA CTACACCATT GGCAAGGAGA TCATTGACCT TGTCTTGGAC 
AGAATTCGCA AGCTGGCTGA CCAGTGCACG GGTCTCCAGG GCTTCTTGGT TTTCCACAGC 
TTTGGTGGGG GAACTGGCTC TGGGTTCACC TCCCTGCTGA TGGAGAGGCT CTCTGTCGAC 
TACGGAAAGA AGTCCAAGCT GGAGTTCTCC ATTTACCCAG CCCCCCAGGT TTCCACTGCT 
GTGGTTGAGC CCTACAATTC CATCCTCACC ACCCACACCA CCCTGGAGCA CTCTGATTGT 
GCCTTCATGG TAGACAATGA GGCCATCTAT GACATCTGTC GTAGAAACCT CGACATTGAG 
CGCCCAACCT ACACTAACTT AAACAGGTTG ATAGGTCAAA TTGTGTCTTC CATCACTGCT 
TCCCTCAGAT TTGATGGGGC CCTGAATGTT GATCTGACAG AATTCCAGAC CAACCTGGTG 
CCCTACCCTC GCATCCACTT CCCTCTGGCC ACTTATGCCC CTGTCATCTC TGCTGAGAAA 
GCCTACCATG AACAGCTTTC TGTAGCAGAG ATCACCAATG CCTGCTTTGA GCCAGCCAAC 
CAGATGGTGA AATGTGACCC TCGCCATGGT AAATACATGG CTTGCTGCCT GCTGTACCGT 
GGTGATGTGG TCCCCAAAGA TGTCAATGCT GCCATTGCCA CCATCAAGAC CAAGCGTACC 
ATCCAGTTTG TGGACTGGTG CCCCACTGGC TTCAAGGTTG GCATTAATTA CCAGCCTCCC 
ACTGTGGTCC CTGGTGGCGA CCTGGCCAAG GTCCAGAGAG CTGTGTGTAT GCTGAGCAAC 
ACCACAGCCA TTGCTGAGGC CTGGGCTCGC CTGGATCACA AGTTTGATCT GATGTATGCC 
AAGCGTGCCT TTGTGCACTG GTACGTGGGT GAGGGCATGG AGGAGGGAGA GTTCTCTGAG 
GCCCGTGAGG ACATGGCTGC CCTAGAGAAG GATTATGAGG AGGTTGGTGT GGATTCTGTG 
GAGGGTGAGG GTGAGGAAGA AGGAGAGGAA TACTAA