Bcl2l2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bcl2l2
Entrez Gene ID	60434
Full Name	Bcl2-like 2
Synonyms	BCL-W,BCL-WEL,BCL-WS,Bclw
General protein information	Preferred Names Bcl2-like 2 Names bcl-2-like protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p13
Summary	may be involved in inhibition of apoptosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006252016.3	XP_006252078.1	bcl-2-like protein 2 isoform X2
NM_021850.2	NP_068622.1	bcl-2-like protein 2
XM_017599794.1	XP_017455283.1	bcl-2-like protein 2 isoform X2
XM_017599793.1	XP_017455282.1	bcl-2-like protein 2 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	BCL2L2	XP_003314309.1
Rattus norvegicus (Norway rat)	Bcl2l2	NP_068622.1
Mus musculus (house mouse)	Bcl2l2	NP_031563.1
Bos taurus (cattle)	BCL2L2	NP_001070001.1
Xenopus tropicalis (tropical clawed frog)	bcl2l2	NP_001011065.1
Homo sapiens (human)	BCL2L2	NP_004041.1
Canis lupus familiaris (dog)	BCL2L2	NP_001026805.1

Gene Ontology
Bibliography

Related articles in PubMed

BCL-W has a fundamental role in B cell survival and lymphomagenesis.
Adams CM, Kim AS, Mitra R, Choi JK, Gong JZ, Eischen CM
The Journal of clinical investigation127(2)635-650(2017 Feb)

Regulation of Apoptosis by miR-122 in Pterygium via Targeting Bcl-w.
Cui YH, Li HY, Gao ZX, Liang N, Ma SS, Meng FJ, Li ZJ, Pan HW
Investigative ophthalmology & visual science57(8)3723-30(2016 07)

Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains.
Huynh JL, Garg P, Thin TH, Yoo S, Dutta R, Trapp BD, Haroutunian V, Zhu J, Donovan MJ, Sharp AJ, Casaccia P
Nature neuroscience17(1)121-30(2014 Jan)

Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration.
Cosker KE, Pazyra-Murphy MF, Fenstermacher SJ, Segal RA
The Journal of neuroscience : the official journal of the Society for Neuroscience33(12)5195-207(2013 Mar)

Upregulated miR-29b promotes neuronal cell death by inhibiting Bcl2L2 after ischemic brain injury.
Shi G, Liu Y, Liu T, Yan W, Liu X, Wang Y, Shi J, Jia L
Experimental brain research216(2)225-30(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Target-derived neurotrophins coordinate transcription of the antiapoptotic gene bclw with transport of bclw mRNA to the axon, and thereby prevent axonal degeneration in rat and mouse sensory neurons.
Title: Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration.

we verified that miR-29b directly targeted and inhibited Bcl2L2 gene expression
Title: Upregulated miR-29b promotes neuronal cell death by inhibiting Bcl2L2 after ischemic brain injury.

the first evidence of Bcl-w localization in the growth cones of differentiating neuronal cells was provided, suggestive of a potential synaptic neuroprotective role.
Title: Cloning and characterization of the 5'UTR of the rat anti-apoptotic Bcl-w gene.

E2 attenuates Abeta-induced neuronal death by Bcl-w upregulation & Bim downregulation, & by inhibition of Abeta-induced JNK activation & JNK-dependent downregulation of Bcl-w & upregulation of Bim, & mitochondrial release of cytochrome c & Smac.
Title: Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.

The mechanism of Abeta-induced neuronal apoptosis sequentially involves JNK activation, Bcl-w downregulation, and release of mitochondrial Smac, followed by cell death.
Title: Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w.

The following Bcl2l2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bcl2l2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa05278	NM_021850.2 Latest version!	Rattus norvegicus Bcl2-like 2 (Bcl2l2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa05278	XM_006252016.3 Latest version!	Rattus norvegicus Bcl2-like 2 (Bcl2l2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa05278	XM_017599794.1 Latest version!	Rattus norvegicus Bcl2-like 2 (Bcl2l2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa36702	XM_017599793.1 Latest version!	Rattus norvegicus Bcl2-like 2 (Bcl2l2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bcl2l2 ( NM_021850.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_068622.1 Rattus norvegicus Bcl2-like 2 (Bcl2l2), mRNA.

Price & Availability↑

CloneID	ORa05278
Clone ID Related Accession (Same CDS sequence)	XM_006252016.3 , NM_021850.2 , XM_017599794.1
Accession Version	NM_021850.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-01
Organism	Rattus norvegicus(Norway rat)
Product	bcl-2-like protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC074021.1. On Oct 17, 2004 this sequence version replaced NM_021850.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC074021.1, AY185098.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGACCC CAGCCTCAAC CCCAGACACA CGGGCTCTAG TGGCTGACTT TGTAGGCTAT 
AAGCTGAGGC AGAAGGGTTA TGTCTGTGGA GCTGGCCCTG GGGAAGGCCC AGCAGCCGAC 
CCGCTGCACC AAGCCATGCG GGCAGCTGGA GACGAGTTTG AGACCCGCTT CCGGCGCACC 
TTCTCTGACC TGGCCGCTCA GCTACACGTG ACCCCAGGCT CAGCCCAGCA ACGCTTCACC 
CAGGTTTCCG ACGAACTTTT CCAAGGGGGC CCCAACTGGG GCCGTCTTGT GGCATTCTTT 
GTCTTTGGGG CTGCCCTGTG TGCTGAGAGT GTCAACAAAG AAATGGAGCC ATTGGTGGGA 
CAAGTGCAGG ATTGGATGGT GACCTACCTG GAGACACGCT TGGCTGACTG GATCCACAGC 
AGTGGGGGCT GGGCGGAGTT CACAGCTCTA TACGGGGACG GGGCCCTGGA GGAGGCACGG 
CGTCTGCGGG AGGGGAACTG GGCATCAGTG AGGACAGTGC TGACGGGGGC TGTGGCACTG 
GGGGCCCTGG TAACTGTAGG GGCCTTTTTT GCTAGCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068622.1
CDS	199..780
Translation	MATPASTPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQDWMVTYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK

Target ORF information:

RefSeq Version	NM_021850.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Bcl2-like 2 (Bcl2l2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021850.2

ORF Insert Sequence:

ATGGCGACCC CAGCCTCAAC CCCAGACACA CGGGCTCTAG TGGCTGACTT TGTAGGCTAT 
AAGCTGAGGC AGAAGGGTTA TGTCTGTGGA GCTGGCCCTG GGGAAGGCCC AGCAGCCGAC 
CCGCTGCACC AAGCCATGCG GGCAGCTGGA GACGAGTTTG AGACCCGCTT CCGGCGCACC 
TTCTCTGACC TGGCCGCTCA GCTACACGTG ACCCCAGGCT CAGCCCAGCA ACGCTTCACC 
CAGGTTTCCG ACGAACTTTT CCAAGGGGGC CCCAACTGGG GCCGTCTTGT GGCATTCTTT 
GTCTTTGGGG CTGCCCTGTG TGCTGAGAGT GTCAACAAAG AAATGGAGCC ATTGGTGGGA 
CAAGTGCAGG ATTGGATGGT GACCTACCTG GAGACACGCT TGGCTGACTG GATCCACAGC 
AGTGGGGGCT GGGCGGAGTT CACAGCTCTA TACGGGGACG GGGCCCTGGA GGAGGCACGG 
CGTCTGCGGG AGGGGAACTG GGCATCAGTG AGGACAGTGC TGACGGGGGC TGTGGCACTG 
GGGGCCCTGG TAACTGTAGG GGCCTTTTTT GCTAGCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bcl2l2 ( XM_006252016.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252078.1 Rattus norvegicus Bcl2-like 2 (Bcl2l2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa05278
Clone ID Related Accession (Same CDS sequence)	XM_006252016.3 , NM_021850.2 , XM_017599794.1
Accession Version	XM_006252016.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	bcl-2-like protein 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252016.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGACCC CAGCCTCAAC CCCAGACACA CGGGCTCTAG TGGCTGACTT TGTAGGCTAT 
AAGCTGAGGC AGAAGGGTTA TGTCTGTGGA GCTGGCCCTG GGGAAGGCCC AGCAGCCGAC 
CCGCTGCACC AAGCCATGCG GGCAGCTGGA GACGAGTTTG AGACCCGCTT CCGGCGCACC 
TTCTCTGACC TGGCCGCTCA GCTACACGTG ACCCCAGGCT CAGCCCAGCA ACGCTTCACC 
CAGGTTTCCG ACGAACTTTT CCAAGGGGGC CCCAACTGGG GCCGTCTTGT GGCATTCTTT 
GTCTTTGGGG CTGCCCTGTG TGCTGAGAGT GTCAACAAAG AAATGGAGCC ATTGGTGGGA 
CAAGTGCAGG ATTGGATGGT GACCTACCTG GAGACACGCT TGGCTGACTG GATCCACAGC 
AGTGGGGGCT GGGCGGAGTT CACAGCTCTA TACGGGGACG GGGCCCTGGA GGAGGCACGG 
CGTCTGCGGG AGGGGAACTG GGCATCAGTG AGGACAGTGC TGACGGGGGC TGTGGCACTG 
GGGGCCCTGG TAACTGTAGG GGCCTTTTTT GCTAGCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252078.1
CDS	432..1013
Translation	MATPASTPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQDWMVTYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK

Target ORF information:

RefSeq Version	XM_006252016.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Bcl2-like 2 (Bcl2l2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252016.3

ORF Insert Sequence:

ATGGCGACCC CAGCCTCAAC CCCAGACACA CGGGCTCTAG TGGCTGACTT TGTAGGCTAT 
AAGCTGAGGC AGAAGGGTTA TGTCTGTGGA GCTGGCCCTG GGGAAGGCCC AGCAGCCGAC 
CCGCTGCACC AAGCCATGCG GGCAGCTGGA GACGAGTTTG AGACCCGCTT CCGGCGCACC 
TTCTCTGACC TGGCCGCTCA GCTACACGTG ACCCCAGGCT CAGCCCAGCA ACGCTTCACC 
CAGGTTTCCG ACGAACTTTT CCAAGGGGGC CCCAACTGGG GCCGTCTTGT GGCATTCTTT 
GTCTTTGGGG CTGCCCTGTG TGCTGAGAGT GTCAACAAAG AAATGGAGCC ATTGGTGGGA 
CAAGTGCAGG ATTGGATGGT GACCTACCTG GAGACACGCT TGGCTGACTG GATCCACAGC 
AGTGGGGGCT GGGCGGAGTT CACAGCTCTA TACGGGGACG GGGCCCTGGA GGAGGCACGG 
CGTCTGCGGG AGGGGAACTG GGCATCAGTG AGGACAGTGC TGACGGGGGC TGTGGCACTG 
GGGGCCCTGG TAACTGTAGG GGCCTTTTTT GCTAGCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bcl2l2 ( XM_017599794.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455283.1 Rattus norvegicus Bcl2-like 2 (Bcl2l2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa05278
Clone ID Related Accession (Same CDS sequence)	XM_006252016.3 , NM_021850.2 , XM_017599794.1
Accession Version	XM_017599794.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	bcl-2-like protein 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGACCC CAGCCTCAAC CCCAGACACA CGGGCTCTAG TGGCTGACTT TGTAGGCTAT 
AAGCTGAGGC AGAAGGGTTA TGTCTGTGGA GCTGGCCCTG GGGAAGGCCC AGCAGCCGAC 
CCGCTGCACC AAGCCATGCG GGCAGCTGGA GACGAGTTTG AGACCCGCTT CCGGCGCACC 
TTCTCTGACC TGGCCGCTCA GCTACACGTG ACCCCAGGCT CAGCCCAGCA ACGCTTCACC 
CAGGTTTCCG ACGAACTTTT CCAAGGGGGC CCCAACTGGG GCCGTCTTGT GGCATTCTTT 
GTCTTTGGGG CTGCCCTGTG TGCTGAGAGT GTCAACAAAG AAATGGAGCC ATTGGTGGGA 
CAAGTGCAGG ATTGGATGGT GACCTACCTG GAGACACGCT TGGCTGACTG GATCCACAGC 
AGTGGGGGCT GGGCGGAGTT CACAGCTCTA TACGGGGACG GGGCCCTGGA GGAGGCACGG 
CGTCTGCGGG AGGGGAACTG GGCATCAGTG AGGACAGTGC TGACGGGGGC TGTGGCACTG 
GGGGCCCTGG TAACTGTAGG GGCCTTTTTT GCTAGCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455283.1
CDS	341..922
Translation	MATPASTPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQDWMVTYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK

Target ORF information:

RefSeq Version	XM_017599794.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Bcl2-like 2 (Bcl2l2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599794.1

ORF Insert Sequence:

ATGGCGACCC CAGCCTCAAC CCCAGACACA CGGGCTCTAG TGGCTGACTT TGTAGGCTAT 
AAGCTGAGGC AGAAGGGTTA TGTCTGTGGA GCTGGCCCTG GGGAAGGCCC AGCAGCCGAC 
CCGCTGCACC AAGCCATGCG GGCAGCTGGA GACGAGTTTG AGACCCGCTT CCGGCGCACC 
TTCTCTGACC TGGCCGCTCA GCTACACGTG ACCCCAGGCT CAGCCCAGCA ACGCTTCACC 
CAGGTTTCCG ACGAACTTTT CCAAGGGGGC CCCAACTGGG GCCGTCTTGT GGCATTCTTT 
GTCTTTGGGG CTGCCCTGTG TGCTGAGAGT GTCAACAAAG AAATGGAGCC ATTGGTGGGA 
CAAGTGCAGG ATTGGATGGT GACCTACCTG GAGACACGCT TGGCTGACTG GATCCACAGC 
AGTGGGGGCT GGGCGGAGTT CACAGCTCTA TACGGGGACG GGGCCCTGGA GGAGGCACGG 
CGTCTGCGGG AGGGGAACTG GGCATCAGTG AGGACAGTGC TGACGGGGGC TGTGGCACTG 
GGGGCCCTGG TAACTGTAGG GGCCTTTTTT GCTAGCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bcl2l2 ( XM_017599793.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455282.1 Rattus norvegicus Bcl2-like 2 (Bcl2l2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa36702
Clone ID Related Accession (Same CDS sequence)	XM_017599793.1
Accession Version	XM_017599793.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	bcl-2-like protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCTTT TTGGTCTCTG TCAATATTTT TCATATATTT ATGTCAGTCT GTCATCCTTG 
CCCCTTTCAG CCGCCCGGAT GGCGACCCCA GCCTCAACCC CAGACACACG GGCTCTAGTG 
GCTGACTTTG TAGGCTATAA GCTGAGGCAG AAGGGTTATG TCTGTGGAGC TGGCCCTGGG 
GAAGGCCCAG CAGCCGACCC GCTGCACCAA GCCATGCGGG CAGCTGGAGA CGAGTTTGAG 
ACCCGCTTCC GGCGCACCTT CTCTGACCTG GCCGCTCAGC TACACGTGAC CCCAGGCTCA 
GCCCAGCAAC GCTTCACCCA GGTTTCCGAC GAACTTTTCC AAGGGGGCCC CAACTGGGGC 
CGTCTTGTGG CATTCTTTGT CTTTGGGGCT GCCCTGTGTG CTGAGAGTGT CAACAAAGAA 
ATGGAGCCAT TGGTGGGACA AGTGCAGGAT TGGATGGTGA CCTACCTGGA GACACGCTTG 
GCTGACTGGA TCCACAGCAG TGGGGGCTGG GCGGAGTTCA CAGCTCTATA CGGGGACGGG 
GCCCTGGAGG AGGCACGGCG TCTGCGGGAG GGGAACTGGG CATCAGTGAG GACAGTGCTG 
ACGGGGGCTG TGGCACTGGG GGCCCTGGTA ACTGTAGGGG CCTTTTTTGC TAGCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455282.1
CDS	388..1047
Translation	MSLFGLCQYFSYIYVSLSSLPLSAARMATPASTPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQDWMVTYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK

Target ORF information:

RefSeq Version	XM_017599793.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Bcl2-like 2 (Bcl2l2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599793.1

ORF Insert Sequence:

ATGTCCCTTT TTGGTCTCTG TCAATATTTT TCATATATTT ATGTCAGTCT GTCATCCTTG 
CCCCTTTCAG CCGCCCGGAT GGCGACCCCA GCCTCAACCC CAGACACACG GGCTCTAGTG 
GCTGACTTTG TAGGCTATAA GCTGAGGCAG AAGGGTTATG TCTGTGGAGC TGGCCCTGGG 
GAAGGCCCAG CAGCCGACCC GCTGCACCAA GCCATGCGGG CAGCTGGAGA CGAGTTTGAG 
ACCCGCTTCC GGCGCACCTT CTCTGACCTG GCCGCTCAGC TACACGTGAC CCCAGGCTCA 
GCCCAGCAAC GCTTCACCCA GGTTTCCGAC GAACTTTTCC AAGGGGGCCC CAACTGGGGC 
CGTCTTGTGG CATTCTTTGT CTTTGGGGCT GCCCTGTGTG CTGAGAGTGT CAACAAAGAA 
ATGGAGCCAT TGGTGGGACA AGTGCAGGAT TGGATGGTGA CCTACCTGGA GACACGCTTG 
GCTGACTGGA TCCACAGCAG TGGGGGCTGG GCGGAGTTCA CAGCTCTATA CGGGGACGGG 
GCCCTGGAGG AGGCACGGCG TCTGCGGGAG GGGAACTGGG CATCAGTGAG GACAGTGCTG 
ACGGGGGCTG TGGCACTGGG GGCCCTGGTA ACTGTAGGGG CCTTTTTTGC TAGCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

BCL-W has a fundamental role in B cell survival and lymphomagenesis.
The Journal of clinical investigation127(2)635-650(2017 Feb)
Adams CM,Kim AS,Mitra R,Choi JK,Gong JZ,Eischen CM

Regulation of Apoptosis by miR-122 in Pterygium via Targeting Bcl-w.
Investigative ophthalmology & visual science57(8)3723-30(2016 07)
Cui YH,Li HY,Gao ZX,Liang N,Ma SS,Meng FJ,Li ZJ,Pan HW

Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains.
Nature neuroscience17(1)121-30(2014 Jan)
Huynh JL,Garg P,Thin TH,Yoo S,Dutta R,Trapp BD,Haroutunian V,Zhu J,Donovan MJ,Sharp AJ,Casaccia P

Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience33(12)5195-207(2013 Mar)
Cosker KE,Pazyra-Murphy MF,Fenstermacher SJ,Segal RA

Upregulated miR-29b promotes neuronal cell death by inhibiting Bcl2L2 after ischemic brain injury.
Experimental brain research216(2)225-30(2012 Jan)
Shi G,Liu Y,Liu T,Yan W,Liu X,Wang Y,Shi J,Jia L

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Bcl2l2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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