Ntrk1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ntrk1
Entrez Gene ID	59109
Full Name	neurotrophic receptor tyrosine kinase 1
Synonyms	Trk
General protein information	Preferred Names neurotrophic receptor tyrosine kinase 1 Names high affinity nerve growth factor receptor TrkA neurotrophin receptor neurotrophic tyrosine kinase, receptor, type 1 p140-TrkA slow nerve growth factor receptor trk trk-A trkA proto-oncogene receptor tropomyosin-related kinase A
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	a protooncogene; receptor that binds to nerve growth factor (NGF) [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021589.1	NP_067600.1	high affinity nerve growth factor receptor precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	ntrk1	XP_002939035.1
Pan troglodytes (chimpanzee)	NTRK1	XP_003308563.1
	NTRK1	XP_001114243.2
Mus musculus (house mouse)	Ntrk1	NP_001028296.1
Canis lupus familiaris (dog)	NTRK1	XP_851619.3
Rattus norvegicus (Norway rat)	Ntrk1	NP_067600.1
Homo sapiens (human)	NTRK1	NP_002520.2
Bos taurus (cattle)	NTRK1	XP_002686012.2
Gallus gallus (chicken)	NTRK1	NP_990709.1
Danio rerio (zebrafish)	ntrk1	XP_697246.5

Gene Ontology
Bibliography

Related articles in PubMed

Nogo-A interacts with TrkA to alter nerve growth factor signaling in Nogo-A-overexpressing PC12 cells.
Farrer RG, Kartje GL
Cellular signalling4420-27(2018 Jan)

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.
Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger JR, Moran MF, Rubin LL, Miller FD, Kaplan DR
The Journal of cell biology216(11)3655-3675(2017 Nov)

Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway.
Zhang CC, Cao CY, Kubo M, Harada K, Yan XT, Fukuyama Y, Gao JM
International journal of molecular sciences18(8)(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Foretinib protected neurons by suppressing both known degenerative pathways and a new pathway involving unliganded TrkA and transcriptional regulation of the proapoptotic BH3 family members.
Title: A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.

As a result, overexpression of PTP-MEG2 down-regulates NGF/TrkA signaling and blocks neurite outgrowth and differentiation
Title: The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.

USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.
Title: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).

It has been shown that ischemia influenced the expression of neurotrophins (Bdnf, Ngf, Nt-3) and their receptors (TrkB, TrkA, TrkC, p75) in brain structures outside the lesion focus, including the contralateral hemisphere.
Title: [Effects of ischemia on the expression of neurotrophins and their receptors in rat brain structures outside the lesion site, including on the opposite hemisphere].

Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.
Title: Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.

The following Ntrk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ntrk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13402	NM_021589.1 Latest version!	Rattus norvegicus neurotrophic receptor tyrosine kinase 1 (Ntrk1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ntrk1 ( NM_021589.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067600.1 Rattus norvegicus neurotrophic receptor tyrosine kinase 1 (Ntrk1), mRNA.

Price & Availability↑

CloneID	ORa13402
Clone ID Related Accession (Same CDS sequence)	NM_021589.1
Accession Version	NM_021589.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2400bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	high affinity nerve growth factor receptor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M85214.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M85214.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCTGCGAG GCCAGCGGCA CGGGCAGCTG GGTTGGCATC GCCCGGCCGC GGGGCTAGGC 
GGTCTGGTGA CTTCGTTGAT GCTGGCTTGT GCTTGCGCCG CATCCTGTCG TGAGACCTGC 
TGTCCCGTGG GCCCCTCGGG GTTGCGCTGC ACCAGGGCAG GGACCCTGAA TACCCTCCGC 
GGCCTGCGGG GCGCCGGGAA CCTGACGGAG CTCTATGTGG AAAACCAGCG GGATCTGCAA 
CGCCTGGAGT TTGAGGACCT GCAGGGCCTG GGGGAGTTGA GAAGCCTAAC CATCGTGAAG 
AGTGGCCTCC GCTTTGTGGC CCCTGATGCC TTCCATTTCA CCCCTCGGCT CAGTCACCTG 
AATCTCTCCT CCAATGCTTT GGAGTCCCTC TCCTGGAAAA CTGTGCAGGG CCTCTCCCTA 
CAGGACTTGA CCCTGTCAGG GAACCCACTG CACTGTTCCT GTGCCCTATT GTGGCTCCAG 
CGCTGGGAGC AGGAGGATTT GTGTGGTGTG TATACACAAA AGCTTCAGGG CTCTGGGTCT 
GGAGACCAGT TCCTCCCACT GGGACACAAC AACAGTTGTG GTGTACCCTC AGTGAAGATC 
CAGATGCCCA ATGACTCTGT GGAAGTGGGG GATGACGTTT TTCTGCAGTG CCAGGTGGAG 
GGGCAGGCCC TACAGCAGGC TGACTGGATC CTCACAGAGC TGGAAGGGAC AGCCACCATG 
AAGAAATCTG GAGATCTGCC ATCCCTGGGG CTAACTCTGG TCAATGTCAC CAGTGATCTC 
AACAAGAAGA ATGTGACGTG CTGGGCAGAG AATGATGTGG GCCGGGCTGA GGTCTCTGTC 
CAAGTCAGCG TCTCCTTCCC AGCCAGTGTG CATCTGGGCA AAGCCGTGGA ACAGCATCAC 
TGGTGCATTC CCTTCTCTGT GGACGGGCAG CCAGCACCGT CCCTGCGCTG GTTCTTCAAC 
GGCTCTGTGC TCAATGAGAC CAGCTTCATC TTCACTCAGT TCTTGGAGTC AGCGCTGACC 
AATGAGACCA TGCGGCATGG CTGCCTTCGC CTCAACCAGC CCACGCATGT CAACAACGGG 
AACTACACCC TGCTGGCTGC CAACCCCTAT GGCCAGGCTG CTGCCTCCAT CATGGCTGCC 
TTTATGGACA ACCCTTTTGA GTTCAACCCT GAGGACCCCA TCCCTGTCTC CTTCTCGCCA 
GTGGACACTA ACAGCACATC AAGAGACCCA GTGGAGAAGA AGGACGAAAC ACCTTTTGGG 
GTCTCTGTGG CTGTGGGCCT GGCCGTCTCC GCCGCCCTCT TCCTTTCTGC CCTCCTCCTA 
GTGCTCAACA AATGTGGACA GAGGAGCAAA TTTGGGATCA ACCGCCCTGC TGTGCTGGCG 
CCAGAGGATG GGCTGGCCAT GTCCCTACAC TTCATGACAC TGGGTGGCAG TTCTCTTTCC 
CCTACTGAGG GCAAAGGCTC CGGACTCCAG GGCCACATCA TGGAGAACCC ACAGTACTTC 
AGTGATACCT GTGTCCACCA TATCAAGCGC CAGGACATCA TTCTCAAGTG GGAGCTAGGG 
GAGGGAGCCT TTGGAAAGGT CTTTCTTGCT GAGTGCTACA ACCTTCTGAA TGATCAGGAC 
AAGATGCTGG TGGCTGTCAA GGCACTGAAG GAGACATCTG AGAATGCTCG TCAGGACTTC 
CATCGTGAGG CAGAGCTGCT CACCATGCTA CAGCACCAAC ACATCGTACG CTTCTTTGGA 
GTCTGCACGG AGGGTGGCCC ATTGCTCATG GTCTTCGAGT ACATGCGCCA TGGGGACCTC 
AACCGTTTCC TCCGGTCCCA CGGACCTGAT GCAAAACTGC TGGCTGGCGG CGAGGATGTG 
GCTCCTGGTC CTTTGGGCCT TGGGCAGCTT CTGGCTGTGG CTAGCCAGGT GGCTGCTGGT 
ATGGTGTACC TAGCCAGCCT GCACTTTGTG CACCGGGACC TGGCCACACG CAACTGTCTG 
GTGGGTCAGG GACTAGTGGT CAAGATTGGA GACTTCGGCA TGAGCAGGGA CATCTACAGC 
ACAGACTACT ACCGTGTGGG AGGTCGGACC ATGCTGCCCA TCCGCTGGAT GCCTCCAGAG 
AGCATCCTCT ACCGCAAGTT CAGCACCGAG AGTGATGTGT GGAGCTTCGG GGTGGTGCTC 
TGGGAGATCT TCACCTATGG AAAGCAACCC TGGTACCAGC TCTCCAACAC TGAGGCGATC 
GAGTGCATCA CGCAGGGCCG GGAGCTGGAG CGGCCGCGCG CCTGCCCTCC TGATGTCTAC 
GCCATCATGC GCGGCTGCTG GCAGCGTGAG CCGCAACAGC GCCTCAGCAT GAAGGATGTG 
CACGCGCGGC TGCAGGCCTT GGCACAGGCG CCACCGAGTT ACCTGGACGT TCTGGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067600.1
CDS	62..2461
Translation	MLRGQRHGQLGWHRPAAGLGGLVTSLMLACACAASCRETCCPVGPSGLRCTRAGTLNTLRGLRGAGNLTELYVENQRDLQRLEFEDLQGLGELRSLTIVKSGLRFVAPDAFHFTPRLSHLNLSSNALESLSWKTVQGLSLQDLTLSGNPLHCSCALLWLQRWEQEDLCGVYTQKLQGSGSGDQFLPLGHNNSCGVPSVKIQMPNDSVEVGDDVFLQCQVEGQALQQADWILTELEGTATMKKSGDLPSLGLTLVNVTSDLNKKNVTCWAENDVGRAEVSVQVSVSFPASVHLGKAVEQHHWCIPFSVDGQPAPSLRWFFNGSVLNETSFIFTQFLESALTNETMRHGCLRLNQPTHVNNGNYTLLAANPYGQAAASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSRDPVEKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQRSKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIMENPQYFSDTCVHHIKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQALAQAPPSYLDVLG

Target ORF information:

RefSeq Version	NM_021589.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neurotrophic receptor tyrosine kinase 1 (Ntrk1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021589.1

ORF Insert Sequence:

ATGCTGCGAG GCCAGCGGCA CGGGCAGCTG GGTTGGCATC GCCCGGCCGC GGGGCTAGGC 
GGTCTGGTGA CTTCGTTGAT GCTGGCTTGT GCTTGCGCCG CATCCTGTCG TGAGACCTGC 
TGTCCCGTGG GCCCCTCGGG GTTGCGCTGC ACCAGGGCAG GGACCCTGAA TACCCTCCGC 
GGCCTGCGGG GCGCCGGGAA CCTGACGGAG CTCTATGTGG AAAACCAGCG GGATCTGCAA 
CGCCTGGAGT TTGAGGACCT GCAGGGCCTG GGGGAGTTGA GAAGCCTAAC CATCGTGAAG 
AGTGGCCTCC GCTTTGTGGC CCCTGATGCC TTCCATTTCA CCCCTCGGCT CAGTCACCTG 
AATCTCTCCT CCAATGCTTT GGAGTCCCTC TCCTGGAAAA CTGTGCAGGG CCTCTCCCTA 
CAGGACTTGA CCCTGTCAGG GAACCCACTG CACTGTTCCT GTGCCCTATT GTGGCTCCAG 
CGCTGGGAGC AGGAGGATTT GTGTGGTGTG TATACACAAA AGCTTCAGGG CTCTGGGTCT 
GGAGACCAGT TCCTCCCACT GGGACACAAC AACAGTTGTG GTGTACCCTC AGTGAAGATC 
CAGATGCCCA ATGACTCTGT GGAAGTGGGG GATGACGTTT TTCTGCAGTG CCAGGTGGAG 
GGGCAGGCCC TACAGCAGGC TGACTGGATC CTCACAGAGC TGGAAGGGAC AGCCACCATG 
AAGAAATCTG GAGATCTGCC ATCCCTGGGG CTAACTCTGG TCAATGTCAC CAGTGATCTC 
AACAAGAAGA ATGTGACGTG CTGGGCAGAG AATGATGTGG GCCGGGCTGA GGTCTCTGTC 
CAAGTCAGCG TCTCCTTCCC AGCCAGTGTG CATCTGGGCA AAGCCGTGGA ACAGCATCAC 
TGGTGCATTC CCTTCTCTGT GGACGGGCAG CCAGCACCGT CCCTGCGCTG GTTCTTCAAC 
GGCTCTGTGC TCAATGAGAC CAGCTTCATC TTCACTCAGT TCTTGGAGTC AGCGCTGACC 
AATGAGACCA TGCGGCATGG CTGCCTTCGC CTCAACCAGC CCACGCATGT CAACAACGGG 
AACTACACCC TGCTGGCTGC CAACCCCTAT GGCCAGGCTG CTGCCTCCAT CATGGCTGCC 
TTTATGGACA ACCCTTTTGA GTTCAACCCT GAGGACCCCA TCCCTGTCTC CTTCTCGCCA 
GTGGACACTA ACAGCACATC AAGAGACCCA GTGGAGAAGA AGGACGAAAC ACCTTTTGGG 
GTCTCTGTGG CTGTGGGCCT GGCCGTCTCC GCCGCCCTCT TCCTTTCTGC CCTCCTCCTA 
GTGCTCAACA AATGTGGACA GAGGAGCAAA TTTGGGATCA ACCGCCCTGC TGTGCTGGCG 
CCAGAGGATG GGCTGGCCAT GTCCCTACAC TTCATGACAC TGGGTGGCAG TTCTCTTTCC 
CCTACTGAGG GCAAAGGCTC CGGACTCCAG GGCCACATCA TGGAGAACCC ACAGTACTTC 
AGTGATACCT GTGTCCACCA TATCAAGCGC CAGGACATCA TTCTCAAGTG GGAGCTAGGG 
GAGGGAGCCT TTGGAAAGGT CTTTCTTGCT GAGTGCTACA ACCTTCTGAA TGATCAGGAC 
AAGATGCTGG TGGCTGTCAA GGCACTGAAG GAGACATCTG AGAATGCTCG TCAGGACTTC 
CATCGTGAGG CAGAGCTGCT CACCATGCTA CAGCACCAAC ACATCGTACG CTTCTTTGGA 
GTCTGCACGG AGGGTGGCCC ATTGCTCATG GTCTTCGAGT ACATGCGCCA TGGGGACCTC 
AACCGTTTCC TCCGGTCCCA CGGACCTGAT GCAAAACTGC TGGCTGGCGG CGAGGATGTG 
GCTCCTGGTC CTTTGGGCCT TGGGCAGCTT CTGGCTGTGG CTAGCCAGGT GGCTGCTGGT 
ATGGTGTACC TAGCCAGCCT GCACTTTGTG CACCGGGACC TGGCCACACG CAACTGTCTG 
GTGGGTCAGG GACTAGTGGT CAAGATTGGA GACTTCGGCA TGAGCAGGGA CATCTACAGC 
ACAGACTACT ACCGTGTGGG AGGTCGGACC ATGCTGCCCA TCCGCTGGAT GCCTCCAGAG 
AGCATCCTCT ACCGCAAGTT CAGCACCGAG AGTGATGTGT GGAGCTTCGG GGTGGTGCTC 
TGGGAGATCT TCACCTATGG AAAGCAACCC TGGTACCAGC TCTCCAACAC TGAGGCGATC 
GAGTGCATCA CGCAGGGCCG GGAGCTGGAG CGGCCGCGCG CCTGCCCTCC TGATGTCTAC 
GCCATCATGC GCGGCTGCTG GCAGCGTGAG CCGCAACAGC GCCTCAGCAT GAAGGATGTG 
CACGCGCGGC TGCAGGCCTT GGCACAGGCG CCACCGAGTT ACCTGGACGT TCTGGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nogo-A interacts with TrkA to alter nerve growth factor signaling in Nogo-A-overexpressing PC12 cells.
Cellular signalling4420-27(2018 Jan)
Farrer RG,Kartje GL

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.
The Journal of cell biology216(11)3655-3675(2017 Nov)
Feinberg K,Kolaj A,Wu C,Grinshtein N,Krieger JR,Moran MF,Rubin LL,Miller FD,Kaplan DR

Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway.
International journal of molecular sciences18(8)(2017 Jul)
Zhang CC,Cao CY,Kubo M,Harada K,Yan XT,Fukuyama Y,Gao JM