Uts2r cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Uts2r
Entrez Gene ID	57305
Full Name	urotensin 2 receptor
Synonyms	Gpr14,Senr,UR-2-R
General protein information	Preferred Names urotensin 2 receptor Names urotensin-2 receptor G-protein coupled receptor 14 G-protein coupled sensory epithelial neuropeptide-like receptor UR-II-R putative G protein-coupled receptor (SENR) urotensin II receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.3
Summary	G protein-coupled receptor isolated from retinal and taste cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_020537.1	NP_065412.1	urotensin-2 receptor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	UTS2R	NP_001035574.1
Xenopus tropicalis (tropical clawed frog)	LOC100485936	XP_004918483.1
Pan troglodytes (chimpanzee)	UTS2R	XP_001167994.1
	UTS2R	NP_001028066.1
Gallus gallus (chicken)	UTS2R	XP_004946151.1
Danio rerio (zebrafish)	LOC559133	XP_005156379.1
Homo sapiens (human)	UTS2R	NP_061822.1
Mus musculus (house mouse)	Uts2r	NP_663415.1
Canis lupus familiaris (dog)	UTS2R	XP_548799.3
Rattus norvegicus (Norway rat)	Uts2r	NP_065412.1

Gene Ontology
Bibliography

Related articles in PubMed

Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats.
Cadirci E, Halici Z, Yayla M, Toktay E, Bayir Y, Karakus E, Topcu A, Buyuk B, Albayrak A
Peptides8235-43(2016 Aug)

The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-?B pathways in LPS-stimulated Kupffer cells.
Liu LM, Liang DY, Ye CG, Tu WJ, Zhu T
PloS one10(3)e0121383(2015)

Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor.
Sainsily X, Cabana J, Holleran BJ, Escher E, Lavigne P, Leduc R
Biochemical pharmacology92(2)280-8(2014 Nov)

Expression of Urotensin II During Focal Cerebral Ischemic in Diabetic Rats.
Tian L, Li Y, Hua W, Jia Y, Zhou M, Gu Y, Qi J
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques41(4)498-503(2014 Jul)

Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity.
Desrues L, Lefebvre T, Lecointre C, Schouft MT, Leprince J, Comp?re V, Morin F, Proust F, Gandolfo P, Tonon MC, Castel H
PloS one7(5)e36319(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation
Title: Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats.

The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-kappaB pathways in LPS-stimulated Kupffer cells.
Title: The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-?B pathways in LPS-stimulated Kupffer cells.

Key transmembrane domain 1 and 2 residues were identified in urotensin-II receptor (UT) that participate in the formation of the UT receptor binding pocket.
Title: Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor.

Expression of GPR14 was increased at mRNA and protein levels in brain from cerebral ischemia rats.
Title: Expression of Urotensin II During Focal Cerebral Ischemic in Diabetic Rats.

Data show that vasoactive peptide urotensin II receptor and GABA(A)R are co-expressed in cerebellar glial cells from rat brain slices, in human native astrocytes and in glioma cell line.
Title: Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity.

The following Uts2r gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Uts2r cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42722	NM_020537.1 Latest version!	Rattus norvegicus urotensin 2 receptor (Uts2r), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Uts2r ( NM_020537.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_065412.1 Rattus norvegicus urotensin 2 receptor (Uts2r), mRNA.

Price & Availability↑

CloneID	ORa42722
Clone ID Related Accession (Same CDS sequence)	NM_020537.1
Accession Version	NM_020537.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1161bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	urotensin-2 receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB012210.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB012210.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCTCTGA GCCTGGAGTC TACAACAAGC TTTCATATGC TCACCGTGTC CGGAAGCACT 
GTGACTGAGC TGCCTGGTGA CTCCAACGTG TCCCTCAACA GTTCCTGGTC CGGCCCAACA 
GATCCCAGCT CCCTGAAAGA CCTTGTGGCC ACGGGTGTCA TCGGGGCAGT GCTCTCAGCC 
ATGGGTGTGG TGGGCATGGT GGGAAATGTA TACACTTTGG TGGTCATGTG CCGGTTTCTG 
CGTGCCTCGG CCTCCATGTA CGTCTATGTG GTCAACCTAG CGCTGGCTGA TCTGCTGTAC 
CTGCTGAGCA TTCCCTTCAT CATAGCCACC TACGTCACTA AGGACTGGCA CTTTGGAGAT 
GTGGGCTGCA GAGTCCTCTT TAGCCTGGAC TTCCTGACAA TGCACGCCAG CATCTTCACC 
CTGACCATAA TGAGCAGCGA ACGCTATGCA GCCGTACTGA GGCCTCTGGA CACAGTCCAG 
CGCTCCAAGG GTTACCGTAA GCTGCTGGTG CTGGGCACCT GGTTGCTGGC ACTGCTGCTG 
ACCCTACCCA TGATGCTTGC CATCCAGCTG GTCCGCAGGG GCTCTAAGAG CCTCTGCCTG 
CCAGCCTGGG GCCCTCGTGC CCACCGTACT TACCTAACGT TGCTCTTTGG GACCAGCATT 
GTGGGGCCTG GCTTGGTCAT TGGGCTGCTC TATGTCCGTC TGGCCAGGGC CTACTGGCTA 
TCTCAGCAAG CTTCTTTCAA GCAGACACGG CGGCTGCCCA ACCCCAGGGT GCTCTACCTC 
ATCCTTGGTA TCGTCCTTCT CTTCTGGGCC TGCTTTCTAC CCTTCTGGCT GTGGCAGCTG 
CTGGCCCAGT ACCACGAGGC CATGCCACTG ACTCCCGAGA CTGCACGCAT TGTCAACTAC 
CTGACCACCT GCCTCACTTA TGGCAACAGT TGCATCAATC CCTTCCTCTA CACTCTGCTC 
ACCAAGAACT ATCGAGAGTA CCTACGTGGC CGCCAGCGGT CACTGGGTAG TAGTTGCCAC 
AGCCCAGGGA GTCCTGGCAG CTTCCTGCCC AGCCGAGTCC ACCTCCAGCA GGACTCGGGC 
CGCTCGCTGT CCTCCAGCAG CCAACAGGCC ACAGAGACCC TCATGCTGTC TCCAGTCCCC 
CGTAACGGGG CCCTTCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065412.1
CDS	1..1161
Translation	MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL

Target ORF information:

RefSeq Version	NM_020537.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus urotensin 2 receptor (Uts2r), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020537.1

ORF Insert Sequence:

ATGGCTCTGA GCCTGGAGTC TACAACAAGC TTTCATATGC TCACCGTGTC CGGAAGCACT 
GTGACTGAGC TGCCTGGTGA CTCCAACGTG TCCCTCAACA GTTCCTGGTC CGGCCCAACA 
GATCCCAGCT CCCTGAAAGA CCTTGTGGCC ACGGGTGTCA TCGGGGCAGT GCTCTCAGCC 
ATGGGTGTGG TGGGCATGGT GGGAAATGTA TACACTTTGG TGGTCATGTG CCGGTTTCTG 
CGTGCCTCGG CCTCCATGTA CGTCTATGTG GTCAACCTAG CGCTGGCTGA TCTGCTGTAC 
CTGCTGAGCA TTCCCTTCAT CATAGCCACC TACGTCACTA AGGACTGGCA CTTTGGAGAT 
GTGGGCTGCA GAGTCCTCTT TAGCCTGGAC TTCCTGACAA TGCACGCCAG CATCTTCACC 
CTGACCATAA TGAGCAGCGA ACGCTATGCA GCCGTACTGA GGCCTCTGGA CACAGTCCAG 
CGCTCCAAGG GTTACCGTAA GCTGCTGGTG CTGGGCACCT GGTTGCTGGC ACTGCTGCTG 
ACCCTACCCA TGATGCTTGC CATCCAGCTG GTCCGCAGGG GCTCTAAGAG CCTCTGCCTG 
CCAGCCTGGG GCCCTCGTGC CCACCGTACT TACCTAACGT TGCTCTTTGG GACCAGCATT 
GTGGGGCCTG GCTTGGTCAT TGGGCTGCTC TATGTCCGTC TGGCCAGGGC CTACTGGCTA 
TCTCAGCAAG CTTCTTTCAA GCAGACACGG CGGCTGCCCA ACCCCAGGGT GCTCTACCTC 
ATCCTTGGTA TCGTCCTTCT CTTCTGGGCC TGCTTTCTAC CCTTCTGGCT GTGGCAGCTG 
CTGGCCCAGT ACCACGAGGC CATGCCACTG ACTCCCGAGA CTGCACGCAT TGTCAACTAC 
CTGACCACCT GCCTCACTTA TGGCAACAGT TGCATCAATC CCTTCCTCTA CACTCTGCTC 
ACCAAGAACT ATCGAGAGTA CCTACGTGGC CGCCAGCGGT CACTGGGTAG TAGTTGCCAC 
AGCCCAGGGA GTCCTGGCAG CTTCCTGCCC AGCCGAGTCC ACCTCCAGCA GGACTCGGGC 
CGCTCGCTGT CCTCCAGCAG CCAACAGGCC ACAGAGACCC TCATGCTGTC TCCAGTCCCC 
CGTAACGGGG CCCTTCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats.
Peptides8235-43(2016 Aug)
Cadirci E,Halici Z,Yayla M,Toktay E,Bayir Y,Karakus E,Topcu A,Buyuk B,Albayrak A

The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-?B pathways in LPS-stimulated Kupffer cells.
PloS one10(3)e0121383(2015)
Liu LM,Liang DY,Ye CG,Tu WJ,Zhu T

Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor.
Biochemical pharmacology92(2)280-8(2014 Nov)
Sainsily X,Cabana J,Holleran BJ,Escher E,Lavigne P,Leduc R

Expression of Urotensin II During Focal Cerebral Ischemic in Diabetic Rats.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques41(4)498-503(2014 Jul)
Tian L,Li Y,Hua W,Jia Y,Zhou M,Gu Y,Qi J

Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity.
PloS one7(5)e36319(2012)
Desrues L,Lefebvre T,Lecointre C,Schouft MT,Leprince J,Comp?re V,Morin F,Proust F,Gandolfo P,Tonon MC,Castel H