Srgn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Srgn
Entrez Gene ID	56782
Full Name	serglycin
Synonyms	Pgsg
General protein information	Preferred Names serglycin Names serglycin PG19 core protein chondroitin sulfate proteoglycan core protein cytolytic granule proteoglycan core protein proteoglycan 10K core protein proteoglycan peptide core protein secretory granule proteoglycan core protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20q11
Summary	precursor for the core protein of the yolk sac carcinoma proteoglycan, PG19, component of extracellular matrices, cell membranes, and some intracellular organelles [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006256483.3	XP_006256545.1	serglycin isoform X1
XM_006256484.3	XP_006256546.1	serglycin isoform X1
NM_020074.2	NP_064459.1	serglycin precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Srgn	NP_035287.1
Rattus norvegicus (Norway rat)	Srgn	NP_064459.1

Gene Ontology
Bibliography

Related articles in PubMed

PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/?1-Integrin Signaling.
Liu X, Huai J, Endle H, Schl?ter L, Fan W, Li Y, Richers S, Yurugi H, Rajalingam K, Ji H, Cheng H, Rister B, Horta G, Baumgart J, Berger H, Laube G, Schmitt U, Schmeisser MJ, Boeckers TM, Tenzer S, Vlachos A, Deller T, Nitsch R, Vogt J
Developmental cell38(3)275-90(2016 08)

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Br?uer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R
Cell138(6)1222-35(2009 Sep)

Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro.
Theocharis AD, Seidel C, Borset M, Dobra K, Baykov V, Labropoulou V, Kanakis I, Dalas E, Karamanos NK, Sundan A, Hjerpe A
The Journal of biological chemistry281(46)35116-28(2006 Nov)

A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components.
Henningsson F, Hergeth S, Cortelius R, Abrink M, Pejler G
The FEBS journal273(21)4901-12(2006 Nov)

Mast cell-dependent activation of pro matrix metalloprotease 2: A role for serglycin proteoglycan-dependent mast cell proteases.
Lundequist A, Abrink M, Pejler G
Biological chemistry387(10-11)1513-9(2006 Oct-Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Srgn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Srgn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa04699	NM_020074.2 Latest version!	Rattus norvegicus serglycin (Srgn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
ORa04699	XM_006256484.3 Latest version!	Rattus norvegicus serglycin (Srgn), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
ORa04699	XM_006256483.3 Latest version!	Rattus norvegicus serglycin (Srgn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Srgn ( NM_020074.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_064459.1 Rattus norvegicus serglycin (Srgn), mRNA.

Price & Availability↑

CloneID	ORa04699
Clone ID Related Accession (Same CDS sequence)	XM_006256483.3 , XM_006256484.3 , NM_020074.2
Accession Version	NM_020074.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	serglycin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088144.1. On Jan 12, 2005 this sequence version replaced NM_020074.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC088144.1, K02934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCGGCAGG TTCCTGTGGG CACCAGGCTT GTCCTGGCTC TCGCCTTCGT CCTGGTTTGG 
GGATCTTCAG TTCAAGGTTA TCCTGCTCGG AGAGCCAGGT ACCAATGGGT CCGCTGTAAA 
CCAGATGGCA TTTTTGCAAA CTGCATTGAG GAGAAAGGAC CACGGTTCGA CCTAATAGCA 
GAGGAATCCA ACGTTGGCCC CCCGATGACC GATCCTGTTT TGATGAGAGG ATTCCCGAAT 
GATTTCTTCC CCATTTCTGA TGACTATTCT GGCTCCGGCT CCGGCTCTGG CTCTGGCTCT 
GGCTCCGGCT CTGGCTCTGG CTCTGGCTCC GGCTCAGGTT CCGGCTCCGG TTCCGGTTCT 
GGCTCTGGCT CGGGTTCTGG CTCCGGCTCG GGCTCTGGCT CAGGAAGCGG CTCCCTAGCT 
GACATGGAAT GGGAATACCA GCCAACAGAT GAAAACAATA TTGTCTATTT CAACTATGGG 
CCTTTTGATA GGATGCTCAC CGAGCAAAAC CAAGAACAAC CAGGAGATTT TATTATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064459.1
CDS	25..564
Translation	MRQVPVGTRLVLALAFVLVWGSSVQGYPARRARYQWVRCKPDGIFANCIEEKGPRFDLIAEESNVGPPMTDPVLMRGFPNDFFPISDDYSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSLADMEWEYQPTDENNIVYFNYGPFDRMLTEQNQEQPGDFII

Target ORF information:

RefSeq Version	NM_020074.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serglycin (Srgn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020074.2

ORF Insert Sequence:

ATGCGGCAGG TTCCTGTGGG CACCAGGCTT GTCCTGGCTC TCGCCTTCGT CCTGGTTTGG 
GGATCTTCAG TTCAAGGTTA TCCTGCTCGG AGAGCCAGGT ACCAATGGGT CCGCTGTAAA 
CCAGATGGCA TTTTTGCAAA CTGCATTGAG GAGAAAGGAC CACGGTTCGA CCTAATAGCA 
GAGGAATCCA ACGTTGGCCC CCCGATGACC GATCCTGTTT TGATGAGAGG ATTCCCGAAT 
GATTTCTTCC CCATTTCTGA TGACTATTCT GGCTCCGGCT CCGGCTCTGG CTCTGGCTCT 
GGCTCCGGCT CTGGCTCTGG CTCTGGCTCC GGCTCAGGTT CCGGCTCCGG TTCCGGTTCT 
GGCTCTGGCT CGGGTTCTGG CTCCGGCTCG GGCTCTGGCT CAGGAAGCGG CTCCCTAGCT 
GACATGGAAT GGGAATACCA GCCAACAGAT GAAAACAATA TTGTCTATTT CAACTATGGG 
CCTTTTGATA GGATGCTCAC CGAGCAAAAC CAAGAACAAC CAGGAGATTT TATTATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Srgn ( XM_006256483.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006256545.1 Rattus norvegicus serglycin (Srgn), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa04699
Clone ID Related Accession (Same CDS sequence)	XM_006256483.3 , XM_006256484.3 , NM_020074.2
Accession Version	XM_006256483.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serglycin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005119.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006256483.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGCAGG TTCCTGTGGG CACCAGGCTT GTCCTGGCTC TCGCCTTCGT CCTGGTTTGG 
GGATCTTCAG TTCAAGGTTA TCCTGCTCGG AGAGCCAGGT ACCAATGGGT CCGCTGTAAA 
CCAGATGGCA TTTTTGCAAA CTGCATTGAG GAGAAAGGAC CACGGTTCGA CCTAATAGCA 
GAGGAATCCA ACGTTGGCCC CCCGATGACC GATCCTGTTT TGATGAGAGG ATTCCCGAAT 
GATTTCTTCC CCATTTCTGA TGACTATTCT GGCTCCGGCT CCGGCTCTGG CTCTGGCTCT 
GGCTCCGGCT CTGGCTCTGG CTCTGGCTCC GGCTCAGGTT CCGGCTCCGG TTCCGGTTCT 
GGCTCTGGCT CGGGTTCTGG CTCCGGCTCG GGCTCTGGCT CAGGAAGCGG CTCCCTAGCT 
GACATGGAAT GGGAATACCA GCCAACAGAT GAAAACAATA TTGTCTATTT CAACTATGGG 
CCTTTTGATA GGATGCTCAC CGAGCAAAAC CAAGAACAAC CAGGAGATTT TATTATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006256545.1
CDS	462..1001
Translation	MRQVPVGTRLVLALAFVLVWGSSVQGYPARRARYQWVRCKPDGIFANCIEEKGPRFDLIAEESNVGPPMTDPVLMRGFPNDFFPISDDYSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSLADMEWEYQPTDENNIVYFNYGPFDRMLTEQNQEQPGDFII

Target ORF information:

RefSeq Version	XM_006256483.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serglycin (Srgn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006256483.3

ORF Insert Sequence:

ATGCGGCAGG TTCCTGTGGG CACCAGGCTT GTCCTGGCTC TCGCCTTCGT CCTGGTTTGG 
GGATCTTCAG TTCAAGGTTA TCCTGCTCGG AGAGCCAGGT ACCAATGGGT CCGCTGTAAA 
CCAGATGGCA TTTTTGCAAA CTGCATTGAG GAGAAAGGAC CACGGTTCGA CCTAATAGCA 
GAGGAATCCA ACGTTGGCCC CCCGATGACC GATCCTGTTT TGATGAGAGG ATTCCCGAAT 
GATTTCTTCC CCATTTCTGA TGACTATTCT GGCTCCGGCT CCGGCTCTGG CTCTGGCTCT 
GGCTCCGGCT CTGGCTCTGG CTCTGGCTCC GGCTCAGGTT CCGGCTCCGG TTCCGGTTCT 
GGCTCTGGCT CGGGTTCTGG CTCCGGCTCG GGCTCTGGCT CAGGAAGCGG CTCCCTAGCT 
GACATGGAAT GGGAATACCA GCCAACAGAT GAAAACAATA TTGTCTATTT CAACTATGGG 
CCTTTTGATA GGATGCTCAC CGAGCAAAAC CAAGAACAAC CAGGAGATTT TATTATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Srgn ( XM_006256484.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006256546.1 Rattus norvegicus serglycin (Srgn), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa04699
Clone ID Related Accession (Same CDS sequence)	XM_006256483.3 , XM_006256484.3 , NM_020074.2
Accession Version	XM_006256484.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serglycin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005119.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006256484.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGCAGG TTCCTGTGGG CACCAGGCTT GTCCTGGCTC TCGCCTTCGT CCTGGTTTGG 
GGATCTTCAG TTCAAGGTTA TCCTGCTCGG AGAGCCAGGT ACCAATGGGT CCGCTGTAAA 
CCAGATGGCA TTTTTGCAAA CTGCATTGAG GAGAAAGGAC CACGGTTCGA CCTAATAGCA 
GAGGAATCCA ACGTTGGCCC CCCGATGACC GATCCTGTTT TGATGAGAGG ATTCCCGAAT 
GATTTCTTCC CCATTTCTGA TGACTATTCT GGCTCCGGCT CCGGCTCTGG CTCTGGCTCT 
GGCTCCGGCT CTGGCTCTGG CTCTGGCTCC GGCTCAGGTT CCGGCTCCGG TTCCGGTTCT 
GGCTCTGGCT CGGGTTCTGG CTCCGGCTCG GGCTCTGGCT CAGGAAGCGG CTCCCTAGCT 
GACATGGAAT GGGAATACCA GCCAACAGAT GAAAACAATA TTGTCTATTT CAACTATGGG 
CCTTTTGATA GGATGCTCAC CGAGCAAAAC CAAGAACAAC CAGGAGATTT TATTATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006256546.1
CDS	220..759
Translation	MRQVPVGTRLVLALAFVLVWGSSVQGYPARRARYQWVRCKPDGIFANCIEEKGPRFDLIAEESNVGPPMTDPVLMRGFPNDFFPISDDYSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSLADMEWEYQPTDENNIVYFNYGPFDRMLTEQNQEQPGDFII

Target ORF information:

RefSeq Version	XM_006256484.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serglycin (Srgn), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006256484.3

ORF Insert Sequence:

ATGCGGCAGG TTCCTGTGGG CACCAGGCTT GTCCTGGCTC TCGCCTTCGT CCTGGTTTGG 
GGATCTTCAG TTCAAGGTTA TCCTGCTCGG AGAGCCAGGT ACCAATGGGT CCGCTGTAAA 
CCAGATGGCA TTTTTGCAAA CTGCATTGAG GAGAAAGGAC CACGGTTCGA CCTAATAGCA 
GAGGAATCCA ACGTTGGCCC CCCGATGACC GATCCTGTTT TGATGAGAGG ATTCCCGAAT 
GATTTCTTCC CCATTTCTGA TGACTATTCT GGCTCCGGCT CCGGCTCTGG CTCTGGCTCT 
GGCTCCGGCT CTGGCTCTGG CTCTGGCTCC GGCTCAGGTT CCGGCTCCGG TTCCGGTTCT 
GGCTCTGGCT CGGGTTCTGG CTCCGGCTCG GGCTCTGGCT CAGGAAGCGG CTCCCTAGCT 
GACATGGAAT GGGAATACCA GCCAACAGAT GAAAACAATA TTGTCTATTT CAACTATGGG 
CCTTTTGATA GGATGCTCAC CGAGCAAAAC CAAGAACAAC CAGGAGATTT TATTATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/?1-Integrin Signaling.
Developmental cell38(3)275-90(2016 08)
Liu X,Huai J,Endle H,Schl?ter L,Fan W,Li Y,Richers S,Yurugi H,Rajalingam K,Ji H,Cheng H,Rister B,Horta G,Baumgart J,Berger H,Laube G,Schmitt U,Schmeisser MJ,Boeckers TM,Tenzer S,Vlachos A,Deller T,Nitsch R,Vogt J

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Cell138(6)1222-35(2009 Sep)
Trimbuch T,Beed P,Vogt J,Schuchmann S,Maier N,Kintscher M,Breustedt J,Schuelke M,Streu N,Kieselmann O,Brunk I,Laube G,Strauss U,Battefeld A,Wende H,Birchmeier C,Wiese S,Sendtner M,Kawabe H,Kishimoto-Suga M,Brose N,Baumgart J,Geist B,Aoki J,Savaskan NE,Br?uer AU,Chun J,Ninnemann O,Schmitz D,Nitsch R

Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro.
The Journal of biological chemistry281(46)35116-28(2006 Nov)
Theocharis AD,Seidel C,Borset M,Dobra K,Baykov V,Labropoulou V,Kanakis I,Dalas E,Karamanos NK,Sundan A,Hjerpe A

A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components.
The FEBS journal273(21)4901-12(2006 Nov)
Henningsson F,Hergeth S,Cortelius R,Abrink M,Pejler G

Mast cell-dependent activation of pro matrix metalloprotease 2: A role for serglycin proteoglycan-dependent mast cell proteases.
Biological chemistry387(10-11)1513-9(2006 Oct-Nov)
Lundequist A,Abrink M,Pejler G