Lgals1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lgals1
Entrez Gene ID	56646
Full Name	galectin 1
General protein information	Preferred Names galectin 1 Names galectin-1 14 kDa lectin RL 14.5 S-Lac lectin 1 beta-galactoside-binding lectin L-14-I gal-1 galaptin lactose-binding lectin 1 lectin, galactose binding, soluble 1 lectin, galactoside-binding, soluble, 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	lectin that binds beta-galactoside [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019904.1	NP_063969.1	galectin-1

Pathways from BioSystems

Homologies

	LGALS1	NP_001162098.1
Bos taurus (cattle)	LGALS1	NP_786976.1
Danio rerio (zebrafish)	lgals2a	NP_998059.1
Danio rerio (zebrafish)	lgals1l1	XP_005164019.1
Homo sapiens (human)	LGALS1	NP_002296.1
Gallus gallus (chicken)	LGALS1	NP_996788.1
Pan troglodytes (chimpanzee)	LGALS1	XP_003953931.1
Danio rerio (zebrafish)	lgals2b	NP_956808.1
Canis lupus familiaris (dog)	LGALS1	NP_001188417.1
Mus musculus (house mouse)	Lgals1	NP_032521.1
Rattus norvegicus (Norway rat)	Lgals1	NP_063969.1
Xenopus tropicalis (tropical clawed frog)	LOC100485378	XP_002934260.1

Gene Ontology
Bibliography

Related articles in PubMed

Stress-induced galectin-1 influences immune tolerance in the spleen and thymus by modulating CD45 immunoreactive lymphocytes.
Sasaguri K, Yamada K, Narimatsu Y, Oonuki M, Oishi A, Koda K, Kubo KY, Yamamoto T, Kadoya T
The journal of physiological sciences : JPS67(4)489-496(2017 Jul)

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M
Circulation134(11)817-32(2016 Sep)

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

Protective effects of the galectin-1 protein on in vivo and in vitro models of ocular inflammation.
Zanon Cde F, Sonehara NM, Girol AP, Gil CD, Oliani SM
Molecular vision211036-50(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GAL1 has an essential role in HFD-induced obesity development. From a clinical viewpoint, pharmaceutical targeting of GAL1 using TDG and other inhibitor compounds would be a novel therapeutic approach for the treatment of obesity
Title: Targeted inhibition of galectin 1 by thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.

Galectin-1 protein is protective on in vivo and in vitro models of ocular inflammation.
Title: Protective effects of the galectin-1 protein on in vivo and in vitro models of ocular inflammation.

Gal-1 regulates I(Ca,L) by decreasing the surface expression of Ca(V)1.2 channels in a splice variant selective manner. This may modulate vasoconstriction. Gal-1 binds the I-II loop only in the absence of alternatively spliced exon 9*.
Title: Splice variant specific modulation of CaV1.2 calcium channel by galectin-1 regulates arterial constriction.

These results demonstrate that myenteric denervation downregulates endogenous Gal-1 and -3 expression, which might inhibit tumor development in this experimental model.
Title: Myenteric denervation downregulates galectin-1 and -3 expression in gastric carcinogenesis.

Galectin-1-binding glycoforms of haptoglobin
Title: Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients.

The following Lgals1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lgals1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04642	NM_019904.1 Latest version!	Rattus norvegicus galectin 1 (Lgals1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lgals1 ( NM_019904.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_063969.1 Rattus norvegicus galectin 1 (Lgals1), mRNA.

Price & Availability↑

CloneID	ORa04642
Clone ID Related Accession (Same CDS sequence)	NM_019904.1
Accession Version	NM_019904.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	galectin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M19036.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M19036.1, FQ217640.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTGTG GTCTGGTCGC CAGCAACCTG AATCTCAAAC CTGGGGAATG TCTCAAAGTT 
CGGGGAGAGC TGGCCCCGGA CGCCAAGAGC TTTGTGTTGA ACCTGGGGAA AGACAGCAAC 
AACCTGTGCC TACACTTCAA CCCCCGCTTC AACGCCCACG GAGATGCCAA CACCATTGTG 
TGTAACAGCA AGGACGATGG GACCTGGGGA ACAGAACAAC GGGAGACTGC CTTCCCTTTC 
CAGCCTGGGA GCATCACGGA GGTGTGCATC ACCTTTGACC AGGCTGACCT GACCATCAAG 
CTGCCAGACG GGCATGAATT CAAATTCCCC AACCGCCTCA ACATGGAGGC CATCAACTAC 
ATGGCGGCGG ATGGTGACTT CAAGATTAAG TGTGTGGCCT TTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_063969.1
CDS	37..444
Translation	MACGLVASNLNLKPGECLKVRGELAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDDGTWGTEQRETAFPFQPGSITEVCITFDQADLTIKLPDGHEFKFPNRLNMEAINYMAADGDFKIKCVAFE

Target ORF information:

RefSeq Version	NM_019904.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus galectin 1 (Lgals1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019904.1

ORF Insert Sequence:

ATGGCCTGTG GTCTGGTCGC CAGCAACCTG AATCTCAAAC CTGGGGAATG TCTCAAAGTT 
CGGGGAGAGC TGGCCCCGGA CGCCAAGAGC TTTGTGTTGA ACCTGGGGAA AGACAGCAAC 
AACCTGTGCC TACACTTCAA CCCCCGCTTC AACGCCCACG GAGATGCCAA CACCATTGTG 
TGTAACAGCA AGGACGATGG GACCTGGGGA ACAGAACAAC GGGAGACTGC CTTCCCTTTC 
CAGCCTGGGA GCATCACGGA GGTGTGCATC ACCTTTGACC AGGCTGACCT GACCATCAAG 
CTGCCAGACG GGCATGAATT CAAATTCCCC AACCGCCTCA ACATGGAGGC CATCAACTAC 
ATGGCGGCGG ATGGTGACTT CAAGATTAAG TGTGTGGCCT TTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Stress-induced galectin-1 influences immune tolerance in the spleen and thymus by modulating CD45 immunoreactive lymphocytes.
The journal of physiological sciences : JPS67(4)489-496(2017 Jul)
Sasaguri K,Yamada K,Narimatsu Y,Oonuki M,Oishi A,Koda K,Kubo KY,Yamamoto T,Kadoya T

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Circulation134(11)817-32(2016 Sep)
Barallobre-Barreiro J,Gupta SK,Zoccarato A,Kitazume-Taneike R,Fava M,Yin X,Werner T,Hirt MN,Zampetaki A,Viviano A,Chong M,Bern M,Kourliouros A,Domenech N,Willeit P,Shah AM,Jahangiri M,Schaefer L,Fischer JW,Iozzo RV,Viner R,Thum T,Heineke J,Kichler A,Otsu K,Mayr M

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

Protective effects of the galectin-1 protein on in vivo and in vitro models of ocular inflammation.
Molecular vision211036-50(2015)
Zanon Cde F,Sonehara NM,Girol AP,Gil CD,Oliani SM