Cxcl13 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcl13
Entrez Gene ID	498335
Full Name	C-X-C motif chemokine ligand 13
General protein information	Preferred Names C-X-C motif chemokine ligand 13 Names C-X-C motif chemokine 13 chemokine (C-X-C motif) ligand 13
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001017496.1	NP_001017496.1	C-X-C motif chemokine 13 precursor
XM_006250710.3	XP_006250772.1	C-X-C motif chemokine 13 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cxcl13	NP_061354.1
Rattus norvegicus (Norway rat)	Cxcl13	NP_001017496.1
Homo sapiens (human)	CXCL13	NP_006410.1
Canis lupus familiaris (dog)	CXCL13	XP_850182.1
Bos taurus (cattle)	CXCL13	NP_001015576.1
	CXCL13	NP_001028052.1
Pan troglodytes (chimpanzee)	CXCL13	XP_001147148.1

Gene Ontology
Bibliography

Related articles in PubMed

CXCL13 regulates the trafficking of GluN2B-containing NMDA receptor via IL-17 in the development of remifentanil-induced hyperalgesia in rats.
Zhu M, Yuan ST, Yu WL, Jia LL, Sun Y
Neuroscience letters64826-33(2017 May)

Upregulation of (C-X-C motif) Ligand 13 (CXCL13) Attenuates Morphine Analgesia in Rats with Cancer-Induced Bone Pain.
Wang SF, Dong CG, Yang X, Yin JJ
Medical science monitor : international medical journal of experimental and clinical research224612-4622(2016 Nov)

An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation.
Poddar D, Basu A, Baldwin WM 3rd, Kondratov RV, Barik S, Mazumder B
Journal of immunology (Baltimore, Md. : 1950)190(7)3600-12(2013 Apr)

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
van de Pavert SA, Olivier BJ, Goverse G, Vondenhoff MF, Greuter M, Beke P, Kusser K, H?pken UE, Lipp M, Niederreither K, Blomhoff R, Sitnik K, Agace WW, Randall TD, de Jonge WJ, Mebius RE
Nature immunology10(11)1193-9(2009 Nov)

Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia.
B?rkle A, Niedermeier M, Schmitt-Gr?ff A, Wierda WG, Keating MJ, Burger JA
Blood110(9)3316-25(2007 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study highlighted the contribution of IL-17 pathway in the trafficking of CXCL13-induced GluN2B-containing N-methyl-d-aspartate receptor in the pathogenesis of remifentanil-induced hyperalgesia.
Title: CXCL13 regulates the trafficking of GluN2B-containing NMDA receptor via IL-17 in the development of remifentanil-induced hyperalgesia in rats.

Up-regulated CXCL13 has a negative role in morphine analgesia in relief of CIBP, which may provide a new target for the management of CIBP.
Title: Upregulation of (C-X-C motif) Ligand 13 (CXCL13) Attenuates Morphine Analgesia in Rats with Cancer-Induced Bone Pain.

The following Cxcl13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcl13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05988	NM_001017496.1 Latest version!	Rattus norvegicus C-X-C motif chemokine ligand 13 (Cxcl13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa35885	XM_006250710.3 Latest version!	Rattus norvegicus C-X-C motif chemokine ligand 13 (Cxcl13), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcl13 ( NM_001017496.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001017496.1 Rattus norvegicus C-X-C motif chemokine ligand 13 (Cxcl13), mRNA.

Price & Availability↑

CloneID	ORa05988
Clone ID Related Accession (Same CDS sequence)	NM_001017496.1
Accession Version	NM_001017496.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	C-X-C motif chemokine 13 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088260.1. On Apr 29, 2005 this sequence version replaced XM_573561.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC088260.1, CO572827.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCTCT GCACCGCAGC CCTGCTTCTT CTACTGGCCA TCTGCCTCCC TCCAGGCCAC 
GGTATTCTGG AGACCCATTA CACAAACTTG AAATGTAGGT GTTCCAAGGT GAGCTCGACC 
TTTATCAATC TAATTCTCGT AGATTGGATT CAAGTTATAC GCCCTGGGAA TGGCTGCCCC 
AAAACTGAAA TCATTTTCTG GACCAAGGCC AAGAAAGCTA TATGTGTGAA TCCTACTGCC 
AGATGGTTAC CAAAAGTATT AAAATTTGTC CGAAGAAGTA TTACTTCAAC TCCCCAAGCT 
CCAGTGAGTA AGAAAAGAGC TGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017496.1
CDS	23..349
Translation	MRLCTAALLLLLAICLPPGHGILETHYTNLKCRCSKVSSTFINLILVDWIQVIRPGNGCPKTEIIFWTKAKKAICVNPTARWLPKVLKFVRRSITSTPQAPVSKKRAA

Target ORF information:

RefSeq Version	NM_001017496.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine ligand 13 (Cxcl13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017496.1

ORF Insert Sequence:

ATGAGGCTCT GCACCGCAGC CCTGCTTCTT CTACTGGCCA TCTGCCTCCC TCCAGGCCAC 
GGTATTCTGG AGACCCATTA CACAAACTTG AAATGTAGGT GTTCCAAGGT GAGCTCGACC 
TTTATCAATC TAATTCTCGT AGATTGGATT CAAGTTATAC GCCCTGGGAA TGGCTGCCCC 
AAAACTGAAA TCATTTTCTG GACCAAGGCC AAGAAAGCTA TATGTGTGAA TCCTACTGCC 
AGATGGTTAC CAAAAGTATT AAAATTTGTC CGAAGAAGTA TTACTTCAAC TCCCCAAGCT 
CCAGTGAGTA AGAAAAGAGC TGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cxcl13 ( XM_006250710.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006250772.1 Rattus norvegicus C-X-C motif chemokine ligand 13 (Cxcl13), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa35885
Clone ID Related Accession (Same CDS sequence)	XM_006250710.3
Accession Version	XM_006250710.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	C-X-C motif chemokine 13 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006250710.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGCTCT GCACCGCAGC CCTGCTTCTT CTACTGGCCA TCTGCCTCCC TCCAGGCCAC 
GGTATTCTGG AGACCCATTA CACAAACTTG AAATGTAGGT GTTCCAAGGT GAGCTCGACC 
TTTATCAATC TAATTCTCGT AGATTGGATT CAAGTTATAC GCCCTGGGAA TGGCTGCCCC 
AAAACTGAAA TCATTTTCTG GACCAAGGCC AAGAAAGCTA TATGTGTGAA TCCTACTGCC 
AGATGGTTAC CAAAAGTATT AAAATTTGTC CGAAGCAGAA GTATTACTTC AACTCCCCAA 
GCTCCAGTGA GTAAGAAAAG AGCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006250772.1
CDS	59..388
Translation	MRLCTAALLLLLAICLPPGHGILETHYTNLKCRCSKVSSTFINLILVDWIQVIRPGNGCPKTEIIFWTKAKKAICVNPTARWLPKVLKFVRSRSITSTPQAPVSKKRAA

Target ORF information:

RefSeq Version	XM_006250710.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine ligand 13 (Cxcl13), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006250710.3

ORF Insert Sequence:

ATGAGGCTCT GCACCGCAGC CCTGCTTCTT CTACTGGCCA TCTGCCTCCC TCCAGGCCAC 
GGTATTCTGG AGACCCATTA CACAAACTTG AAATGTAGGT GTTCCAAGGT GAGCTCGACC 
TTTATCAATC TAATTCTCGT AGATTGGATT CAAGTTATAC GCCCTGGGAA TGGCTGCCCC 
AAAACTGAAA TCATTTTCTG GACCAAGGCC AAGAAAGCTA TATGTGTGAA TCCTACTGCC 
AGATGGTTAC CAAAAGTATT AAAATTTGTC CGAAGCAGAA GTATTACTTC AACTCCCCAA 
GCTCCAGTGA GTAAGAAAAG AGCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CXCL13 regulates the trafficking of GluN2B-containing NMDA receptor via IL-17 in the development of remifentanil-induced hyperalgesia in rats.
Neuroscience letters64826-33(2017 May)
Zhu M,Yuan ST,Yu WL,Jia LL,Sun Y

Upregulation of (C-X-C motif) Ligand 13 (CXCL13) Attenuates Morphine Analgesia in Rats with Cancer-Induced Bone Pain.
Medical science monitor : international medical journal of experimental and clinical research224612-4622(2016 Nov)
Wang SF,Dong CG,Yang X,Yin JJ

An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation.
Journal of immunology (Baltimore, Md. : 1950)190(7)3600-12(2013 Apr)
Poddar D,Basu A,Baldwin WM 3rd,Kondratov RV,Barik S,Mazumder B

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
Nature immunology10(11)1193-9(2009 Nov)
van de Pavert SA,Olivier BJ,Goverse G,Vondenhoff MF,Greuter M,Beke P,Kusser K,H?pken UE,Lipp M,Niederreither K,Blomhoff R,Sitnik K,Agace WW,Randall TD,de Jonge WJ,Mebius RE

Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia.
Blood110(9)3316-25(2007 Nov)
B?rkle A,Niedermeier M,Schmitt-Gr?ff A,Wierda WG,Keating MJ,Burger JA