Mrgprx2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mrgprx2
Entrez Gene ID	404640
Full Name	MAS related GPR family member X2
Synonyms	Mgrg6,MrgB1,Mrgprb1
General protein information	Preferred Names MAS related GPR family member X2 Names mas-related G-protein coupled receptor member X2 MAS-related G protein-coupled receptor, member B1 MAS-related GPR, member X2 MAS-related gene B1 Mas-related G protein-coupled receptor g6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22
Summary	seven transmembrane domain G-protein coupled receptor; most often found in sensory neurons [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017589513.1	XP_017445002.1	mas-related G-protein coupled receptor member X2 isoform X1
NM_001002280.1	NP_001002280.1	mas-related G-protein coupled receptor member X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MRGPRX2	XP_521864.3
Homo sapiens (human)	MRGPRX2	NP_473371.1
	MRGPRX2	NP_001035512.1
Bos taurus (cattle)	MRGPRX2	NP_001179379.1
Mus musculus (house mouse)	Mrgprb1	NP_991379.3
Canis lupus familiaris (dog)	MRGPRX2	XP_005633869.1
Rattus norvegicus (Norway rat)	Mrgprx2	NP_001002280.1
Mus musculus (house mouse)	Mrgprx2	NP_001030040.2

Gene Ontology
Bibliography

Related articles in PubMed

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions.
McNeil BD, Pundir P, Meeker S, Han L, Undem BJ, Kulka M, Dong X
Nature519(7542)237-41(2015 Mar)

Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.
Premzl M
Gene540(1)16-9(2014 Apr)

G protein-coupled receptors participate in cytokinesis.
Zhang X, Bedigian AV, Wang W, Eggert US
Cytoskeleton (Hoboken, N.J.)69(10)810-8(2012 Oct)

Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization.
Subramanian H, Gupta K, Guo Q, Price R, Ali H
The Journal of biological chemistry286(52)44739-49(2011 Dec)

MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.
Robas N, Mead E, Fidock M
The Journal of biological chemistry278(45)44400-4(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mrgprx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mrgprx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12584	NM_001002280.1 Latest version!	Rattus norvegicus MAS related GPR family member X2 (Mrgprx2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa56765	XM_017589513.1 Latest version!	Rattus norvegicus MAS-related GPR, member X2 (Mrgprx2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mrgprx2 ( NM_001002280.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001002280.1 Rattus norvegicus MAS related GPR family member X2 (Mrgprx2), mRNA.

Price & Availability↑

CloneID	ORa12584
Clone ID Related Accession (Same CDS sequence)	NM_001002280.1
Accession Version	NM_001002280.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	mas-related G-protein coupled receptor member X2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF518239.1. On Apr 19, 2005 this sequence version replaced XM_218596.3.

ATGTCATTTT GTGAAGTTGT ATCTTGTGCC ATAATTTTGC TTTCTCTCAT CATTGCCCTA 
GTTGGGCTTG TTGGAAATGG AACAGTGTTT TGGCTCCTGG GCTTCCAGAT GCGCAGAAAT 
GCCTTTTCAG TCTACATCCT CAACCTGGCT GGTGCTGATT TTCTCTTCAT GTGCTTCCAA 
ATTGTTTATT GTTCTCATAT CATGTTGGAC ATGTACTACA TCCCTATCAA ATTTCCCCTG 
TTTTCAATTG TTGTGTTAAA CATTGGTTAT CTTTGTGGCA TGAGCATCCT CAGTGCCATT 
AGCATTGAAC GCTGCCTATC TGTCATGTGG CCCATCTGGT ATCGCTGCCA ACGCCCAAGG 
CACACATCAG CTGTCATATG TACCTTGCTT TGGGTCTTGG CCCTAGTGTG GAGCCTCATA 
GAAGGAAAGG AATGTGGCTT TCTATTTGAT ACCAATGGCC CTGGTTGGTG TGAGACATTT 
GATTTAATTG CTACTGCATG GCTAATTGTT TTAATTGTGG TTCTCCTGGG GTCCAGTCTA 
GCCTTAGTGA TTAATATCTT CTGTGGCTTA TACAGGATTC CTGTGACCAG GCTGTATGTG 
ACCATTGTGT TCACAGTGCT GGTCTTCCTG CTCTGTGGTC TGCCCTATGG GATCTACTGG 
TTCCTCTTAG AATGGACCGA GAAATTTAAT TATAACTTAC CTTGTGGTTT TCATCCCGTG 
ACAGTACTTC TATCCTGTGT TAACAGCTGT GCCAACCCTA TCATTTACTT CCTTGTTGGC 
TCTATTAGGC ACCACAGGTT CCAACGCAAG ACTCTCAAGC TACTTTTGCA GAAAGCCATG 
CAAGACACTC CTGAAGAAGA AGAATGTGGA GAGATGGGCT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002280.1
CDS	1..885
Translation	MSFCEVVSCAIILLSLIIALVGLVGNGTVFWLLGFQMRRNAFSVYILNLAGADFLFMCFQIVYCSHIMLDMYYIPIKFPLFSIVVLNIGYLCGMSILSAISIERCLSVMWPIWYRCQRPRHTSAVICTLLWVLALVWSLIEGKECGFLFDTNGPGWCETFDLIATAWLIVLIVVLLGSSLALVINIFCGLYRIPVTRLYVTIVFTVLVFLLCGLPYGIYWFLLEWTEKFNYNLPCGFHPVTVLLSCVNSCANPIIYFLVGSIRHHRFQRKTLKLLLQKAMQDTPEEEECGEMGS

Target ORF information:

RefSeq Version	NM_001002280.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAS related GPR family member X2 (Mrgprx2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002280.1

ORF Insert Sequence:

ATGTCATTTT GTGAAGTTGT ATCTTGTGCC ATAATTTTGC TTTCTCTCAT CATTGCCCTA 
GTTGGGCTTG TTGGAAATGG AACAGTGTTT TGGCTCCTGG GCTTCCAGAT GCGCAGAAAT 
GCCTTTTCAG TCTACATCCT CAACCTGGCT GGTGCTGATT TTCTCTTCAT GTGCTTCCAA 
ATTGTTTATT GTTCTCATAT CATGTTGGAC ATGTACTACA TCCCTATCAA ATTTCCCCTG 
TTTTCAATTG TTGTGTTAAA CATTGGTTAT CTTTGTGGCA TGAGCATCCT CAGTGCCATT 
AGCATTGAAC GCTGCCTATC TGTCATGTGG CCCATCTGGT ATCGCTGCCA ACGCCCAAGG 
CACACATCAG CTGTCATATG TACCTTGCTT TGGGTCTTGG CCCTAGTGTG GAGCCTCATA 
GAAGGAAAGG AATGTGGCTT TCTATTTGAT ACCAATGGCC CTGGTTGGTG TGAGACATTT 
GATTTAATTG CTACTGCATG GCTAATTGTT TTAATTGTGG TTCTCCTGGG GTCCAGTCTA 
GCCTTAGTGA TTAATATCTT CTGTGGCTTA TACAGGATTC CTGTGACCAG GCTGTATGTG 
ACCATTGTGT TCACAGTGCT GGTCTTCCTG CTCTGTGGTC TGCCCTATGG GATCTACTGG 
TTCCTCTTAG AATGGACCGA GAAATTTAAT TATAACTTAC CTTGTGGTTT TCATCCCGTG 
ACAGTACTTC TATCCTGTGT TAACAGCTGT GCCAACCCTA TCATTTACTT CCTTGTTGGC 
TCTATTAGGC ACCACAGGTT CCAACGCAAG ACTCTCAAGC TACTTTTGCA GAAAGCCATG 
CAAGACACTC CTGAAGAAGA AGAATGTGGA GAGATGGGCT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mrgprx2 ( XM_017589513.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017445002.1 Rattus norvegicus MAS-related GPR, member X2 (Mrgprx2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56765
Clone ID Related Accession (Same CDS sequence)	XM_017589513.1
Accession Version	XM_017589513.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mas-related G-protein coupled receptor member X2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGTTTCA TATTGACAGC TGATTTGGGA CAGACCAACT TAACATCTTC CATAAGAAAA 
ATGGAGGAAA GAAACATCAG CAGAAGGCTT CTAAGAGTGG ATTCAAACAA TCCAAATTGG 
GGAACTAACA TCACAGCTCT GAATGATAGT AACGACCCTG AAATGTCATT TTGTGAAGTT 
GTATCTTGTG CCATAATTTT GCTTTCTCTC ATCATTGCCC TAGTTGGGCT TGTTGGAAAT 
GGAACAGTGT TTTGGCTCCT GGGCTTCCAG ATGCGCAGAA ATGCCTTTTC AGTCTACATC 
CTCAACCTGG CTGGTGCTGA TTTTCTCTTC ATGTGCTTCC AAATTGTTTA TTGTTCTCAT 
ATCATGTTGG ACATGTACTA CATCCCTATC AAATTTCCCC TGTTTTCAAT TGTTGTGTTA 
AACATTGGTT ATCTTTGTGG CATGAGCATC CTCAGTGCCA TTAGCATTGA ACGCTGCCTA 
TCTGTCATGT GGCCCATCTG GTATCGCTGC CAACGCCCAA GGCACACATC AGCTGTCATA 
TGTACCTTGC TTTGGGTCTT GGCCCTAGTG TGGAGCCTCA TAGAAGGAAA GGAATGTGGC 
TTTCTATTTG ATACCAATGG CCCTGGTTGG TGTGAGACAT TTGATTTAAT TGCTACTGCA 
TGGCTAATTG TTTTAATTGT GGTTCTCCTG GGGTCCAGTC TAGCCTTAGT GATTAATATC 
TTCTGTGGCT TATACAGGAT TCCTGTGACC AGGCTGTATG TGACCATTGT GTTCACAGTG 
CTGGTCTTCC TGCTCTGTGG TCTGCCCTAT GGGATCTACT GGTTCCTCTT AGAATGGACC 
GAGAAATTTA ATTATAACTT ACCTTGTGGT TTTCATCCCG TGACAGTACT TCTATCCTGT 
GTTAACAGCT GTGCCAACCC TATCATTTAC TTCCTTGTTG GCTCTATTAG GCACCACAGG 
TTCCAACGCA AGACTCTCAA GCTACTTTTG CAGAAAGCCA TGCAAGACAC TCCTGAAGAA 
GAAGAATGTG GAGAGATGGG CTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017445002.1
CDS	149..1195
Translation	MCFILTADLGQTNLTSSIRKMEERNISRRLLRVDSNNPNWGTNITALNDSNDPEMSFCEVVSCAIILLSLIIALVGLVGNGTVFWLLGFQMRRNAFSVYILNLAGADFLFMCFQIVYCSHIMLDMYYIPIKFPLFSIVVLNIGYLCGMSILSAISIERCLSVMWPIWYRCQRPRHTSAVICTLLWVLALVWSLIEGKECGFLFDTNGPGWCETFDLIATAWLIVLIVVLLGSSLALVINIFCGLYRIPVTRLYVTIVFTVLVFLLCGLPYGIYWFLLEWTEKFNYNLPCGFHPVTVLLSCVNSCANPIIYFLVGSIRHHRFQRKTLKLLLQKAMQDTPEEEECGEMGS

Target ORF information:

RefSeq Version	XM_017589513.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAS-related GPR, member X2 (Mrgprx2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589513.1

ORF Insert Sequence:

ATGTGTTTCA TATTGACAGC TGATTTGGGA CAGACCAACT TAACATCTTC CATAAGAAAA 
ATGGAGGAAA GAAACATCAG CAGAAGGCTT CTAAGAGTGG ATTCAAACAA TCCAAATTGG 
GGAACTAACA TCACAGCTCT GAATGATAGT AACGACCCTG AAATGTCATT TTGTGAAGTT 
GTATCTTGTG CCATAATTTT GCTTTCTCTC ATCATTGCCC TAGTTGGGCT TGTTGGAAAT 
GGAACAGTGT TTTGGCTCCT GGGCTTCCAG ATGCGCAGAA ATGCCTTTTC AGTCTACATC 
CTCAACCTGG CTGGTGCTGA TTTTCTCTTC ATGTGCTTCC AAATTGTTTA TTGTTCTCAT 
ATCATGTTGG ACATGTACTA CATCCCTATC AAATTTCCCC TGTTTTCAAT TGTTGTGTTA 
AACATTGGTT ATCTTTGTGG CATGAGCATC CTCAGTGCCA TTAGCATTGA ACGCTGCCTA 
TCTGTCATGT GGCCCATCTG GTATCGCTGC CAACGCCCAA GGCACACATC AGCTGTCATA 
TGTACCTTGC TTTGGGTCTT GGCCCTAGTG TGGAGCCTCA TAGAAGGAAA GGAATGTGGC 
TTTCTATTTG ATACCAATGG CCCTGGTTGG TGTGAGACAT TTGATTTAAT TGCTACTGCA 
TGGCTAATTG TTTTAATTGT GGTTCTCCTG GGGTCCAGTC TAGCCTTAGT GATTAATATC 
TTCTGTGGCT TATACAGGAT TCCTGTGACC AGGCTGTATG TGACCATTGT GTTCACAGTG 
CTGGTCTTCC TGCTCTGTGG TCTGCCCTAT GGGATCTACT GGTTCCTCTT AGAATGGACC 
GAGAAATTTA ATTATAACTT ACCTTGTGGT TTTCATCCCG TGACAGTACT TCTATCCTGT 
GTTAACAGCT GTGCCAACCC TATCATTTAC TTCCTTGTTG GCTCTATTAG GCACCACAGG 
TTCCAACGCA AGACTCTCAA GCTACTTTTG CAGAAAGCCA TGCAAGACAC TCCTGAAGAA 
GAAGAATGTG GAGAGATGGG CTCCTGA