Kpna6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kpna6
Entrez Gene ID	362607
Full Name	karyopherin subunit alpha 6
General protein information	Preferred Names karyopherin subunit alpha 6 Names importin subunit alpha-7 karyopherin (importin) alpha 6 karyopherin (importin) alpha 6-like karyopherin alpha 6 (importin alpha 7)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36

mRNA and Protein(s)

mRNA	Protein	Name
NM_001015029.2	NP_001015029.2	importin subunit alpha-7

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KPNA6	XP_003307992.1
Canis lupus familiaris (dog)	KPNA6	XP_005617710.1
Gallus gallus (chicken)	KPNA6	NP_001012859.2
Arabidopsis thaliana (thale cress)	IMPA-2	NP_567485.4
Danio rerio (zebrafish)	LOC100149852	XP_001923921.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005401	XP_315411.4
Oryza sativa (rice)	Os05g0155500	NP_001054692.1
Bos taurus (cattle)	KPNA6	NP_001069422.1
Mus musculus (house mouse)	Kpna6	NP_032494.3
Drosophila melanogaster (fruit fly)	Kap-alpha1	NP_524167.1
Schizosaccharomyces pombe (fission yeast)	imp1	NP_596632.1
Homo sapiens (human)	KPNA6	NP_036448.1
	KPNA6	XP_001102290.1
Rattus norvegicus (Norway rat)	Kpna6	NP_001015029.2
Arabidopsis thaliana (thale cress)	IMPA-1	NP_187328.1
Oryza sativa (rice)	Os01g0253300	NP_001042611.1
Xenopus tropicalis (tropical clawed frog)	kpna6	NP_001008018.1

Gene Ontology
Bibliography

Related articles in PubMed

H7N9 Influenza A Virus Exhibits Importin-?7-Mediated Replication in the Mammalian Respiratory Tract.
Bertram S, Thiele S, Dreier C, Resa-Infante P, Preu? A, van Riel D, Mok CKP, Schwalm F, Peiris JSM, Klenk HD, Gabriel G
The American journal of pathology187(4)831-840(2017 Apr)

Importin ?7 is essential for zygotic genome activation and early mouse development.
Rother F, Shmidt T, Popova E, Krivokharchenko A, H?gel S, Vilianovich L, Ridders M, Tenner K, Alenina N, K?hler M, Hartmann E, Bader M
PloS one6(3)e18310(2011 Mar)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth.
Plant KE, Everett DM, Gordon Gibson G, Lyon J, Plant NJ
Pharmacogenetics and genomics16(9)647-58(2006 Sep)

Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal.
Sakakida Y, Miyamoto Y, Nagoshi E, Akashi M, Nakamura TJ, Mamine T, Kasahara M, Minami Y, Yoneda Y, Takumi T
The Journal of biological chemistry280(14)13272-8(2005 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kpna6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kpna6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05755	NM_001015029.2 Latest version!	Rattus norvegicus karyopherin subunit alpha 6 (Kpna6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$321.30 $459.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kpna6 ( NM_001015029.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001015029.2 Rattus norvegicus karyopherin subunit alpha 6 (Kpna6), mRNA.

Price & Availability↑

CloneID	ORa05755
Clone ID Related Accession (Same CDS sequence)	NM_001015029.2
Accession Version	NM_001015029.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1626bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	importin subunit alpha-7
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC105813.1. On Oct 19, 2005 this sequence version replaced NM_001015029.1. ##Evidence-Data-START## Transcript exon combination :: BC105813.1, AY779030.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAAAAACT ATGTGTCAGA GACCATGGCA AGCCCAGGGA AAGACAATTA TCGAATGAAG 
AGCTATAAGA ACAATGCCTT AAACCCTGAG GAAATGAGAC GAAGAAGGGA GGAAGAGGGC 
ATTCAGCTTC GGAAACAGAA GCGGGAGCAG CAACTTTTTA AACGGAGAAA TGTGGAGCTG 
ATTAATGAAG AAGCTGCCAT GTTTGACAGT CTGCTGATGG ATTCCTACGT GAGCTCCACA 
ACTGGGGAGA GTGTGATCAC AAGGGAAATG GTGGAGATGC TCTTTTCTGA CGATTCTGAC 
TTACAGTTAG CAACCACACA GAAATTCCGG AAACTCCTTT CCAAAGAGCC AAGTCCTCCA 
ATAGATGAAG TTATTAACAC TCCAGGAGTA GTTGATCGGT TTGTGGAGTT TCTGAAGAGG 
AGTGAGAATT GTACATTACA GTTTGAAGCT GCCTGGGCTC TAACAAACAT TGCCTCTGGA 
ACCTCTCAGC AGACCAAAAT TGTCATTGAA GCAGGAGCTG TCCCCATTTT TATAGAGCTG 
CTTAACTCAG ACTTTGAAGA TGTACAAGAA CAGGCAGTCT GGGCTCTTGG AAACATAGCT 
GGAGACAGTT CAGTCTGCAG AGACTATGTC TTGAATTGTT CCATCCTTAA TCCTCTGTTA 
ACACTCCTTA CTAAGTCCAC ACGACTGACG ATGACACGGA ATGCAGTCTG GGCCCTGTCA 
AACCTCTGCC GAGGGAAGAA CCCTCCTCCA GAGTTCGCAA AGGTCTCTCC TTGTTTGCCT 
GTATTGTCTC GCCTACTCTT CAGCAGCGAC TCAGACTTGC TGGCAGATGC TTGCTGGGCC 
CTCTCTTACC TGTCTGATGG CCCCAATGAG AAGATCCAGG CAGTCATAGA CTCTGGAGTC 
TGCCGGAGAT TGGTAGAGCT TCTGATGCAC AACGATTACA AAGTGGCGTC TCCTGCCTTG 
AGAGCTGTGG GTAATATTGT CACCGGGGAT GATATCCAGA CCCAGGTCAT TCTTAACTGT 
TCAGCCCTCC CTTGCCTCCT CCACCTGCTG AGCAGCTCTA AGGAATCAAT CCGGAAGGAA 
GCTTGCTGGA CCATTTCAAA CATCACTGCT GGCAACAGGG CTCAAATACA GGCTGTCATA 
GATGCAAATA TCTTCCCTGT ATTGATCGAA ATCCTTCAGA AAGCAGAGTT CCGTACGAGG 
AAAGAAGCAG CCTGGGCCAT CACCAATGCA ACCTCAGGAG GAACCCCTGA GCAAATCAGG 
TACTTGGTAT CACTGGGCTG CATTAAGCCC CTGTGTGACT TGCTGACTGT AATGGATTCA 
AAAATTGTAC AAGTGGCCCT CAATGGACTA GAGAACATTC TGCGGCTCGG AGAGCAAGAG 
GGCAAGCGCA GTGGCTCAGG GGTCAATCCC TACTGTGGCC TCATCGAGGA AGCCTATGGC 
TTGGATAAGA TTGAGTTTCT CCAGAGCCAT GAGAACCAGG AGATCTACCA GAAGGCCTTT 
GACCTCATCG AGCACTACTT TGGTGTAGAG GATGACGACA GCAGCCTGGC CCCTCAGGTG 
GACGAGACTC AGCAGCAGTT CATCTTCCAG CAGCCCGAGG CCCCCATGGA GGGCTTCCAG 
CTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001015029.2
CDS	29..1654
Translation	MKNYVSETMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPGVVDRFVEFLKRSENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAPQVDETQQQFIFQQPEAPMEGFQL

Target ORF information:

RefSeq Version	NM_001015029.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus karyopherin subunit alpha 6 (Kpna6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001015029.2

ORF Insert Sequence:

ATGAAAAACT ATGTGTCAGA GACCATGGCA AGCCCAGGGA AAGACAATTA TCGAATGAAG 
AGCTATAAGA ACAATGCCTT AAACCCTGAG GAAATGAGAC GAAGAAGGGA GGAAGAGGGC 
ATTCAGCTTC GGAAACAGAA GCGGGAGCAG CAACTTTTTA AACGGAGAAA TGTGGAGCTG 
ATTAATGAAG AAGCTGCCAT GTTTGACAGT CTGCTGATGG ATTCCTACGT GAGCTCCACA 
ACTGGGGAGA GTGTGATCAC AAGGGAAATG GTGGAGATGC TCTTTTCTGA CGATTCTGAC 
TTACAGTTAG CAACCACACA GAAATTCCGG AAACTCCTTT CCAAAGAGCC AAGTCCTCCA 
ATAGATGAAG TTATTAACAC TCCAGGAGTA GTTGATCGGT TTGTGGAGTT TCTGAAGAGG 
AGTGAGAATT GTACATTACA GTTTGAAGCT GCCTGGGCTC TAACAAACAT TGCCTCTGGA 
ACCTCTCAGC AGACCAAAAT TGTCATTGAA GCAGGAGCTG TCCCCATTTT TATAGAGCTG 
CTTAACTCAG ACTTTGAAGA TGTACAAGAA CAGGCAGTCT GGGCTCTTGG AAACATAGCT 
GGAGACAGTT CAGTCTGCAG AGACTATGTC TTGAATTGTT CCATCCTTAA TCCTCTGTTA 
ACACTCCTTA CTAAGTCCAC ACGACTGACG ATGACACGGA ATGCAGTCTG GGCCCTGTCA 
AACCTCTGCC GAGGGAAGAA CCCTCCTCCA GAGTTCGCAA AGGTCTCTCC TTGTTTGCCT 
GTATTGTCTC GCCTACTCTT CAGCAGCGAC TCAGACTTGC TGGCAGATGC TTGCTGGGCC 
CTCTCTTACC TGTCTGATGG CCCCAATGAG AAGATCCAGG CAGTCATAGA CTCTGGAGTC 
TGCCGGAGAT TGGTAGAGCT TCTGATGCAC AACGATTACA AAGTGGCGTC TCCTGCCTTG 
AGAGCTGTGG GTAATATTGT CACCGGGGAT GATATCCAGA CCCAGGTCAT TCTTAACTGT 
TCAGCCCTCC CTTGCCTCCT CCACCTGCTG AGCAGCTCTA AGGAATCAAT CCGGAAGGAA 
GCTTGCTGGA CCATTTCAAA CATCACTGCT GGCAACAGGG CTCAAATACA GGCTGTCATA 
GATGCAAATA TCTTCCCTGT ATTGATCGAA ATCCTTCAGA AAGCAGAGTT CCGTACGAGG 
AAAGAAGCAG CCTGGGCCAT CACCAATGCA ACCTCAGGAG GAACCCCTGA GCAAATCAGG 
TACTTGGTAT CACTGGGCTG CATTAAGCCC CTGTGTGACT TGCTGACTGT AATGGATTCA 
AAAATTGTAC AAGTGGCCCT CAATGGACTA GAGAACATTC TGCGGCTCGG AGAGCAAGAG 
GGCAAGCGCA GTGGCTCAGG GGTCAATCCC TACTGTGGCC TCATCGAGGA AGCCTATGGC 
TTGGATAAGA TTGAGTTTCT CCAGAGCCAT GAGAACCAGG AGATCTACCA GAAGGCCTTT 
GACCTCATCG AGCACTACTT TGGTGTAGAG GATGACGACA GCAGCCTGGC CCCTCAGGTG 
GACGAGACTC AGCAGCAGTT CATCTTCCAG CAGCCCGAGG CCCCCATGGA GGGCTTCCAG 
CTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

H7N9 Influenza A Virus Exhibits Importin-?7-Mediated Replication in the Mammalian Respiratory Tract.
The American journal of pathology187(4)831-840(2017 Apr)
Bertram S,Thiele S,Dreier C,Resa-Infante P,Preu? A,van Riel D,Mok CKP,Schwalm F,Peiris JSM,Klenk HD,Gabriel G

Importin ?7 is essential for zygotic genome activation and early mouse development.
PloS one6(3)e18310(2011 Mar)
Rother F,Shmidt T,Popova E,Krivokharchenko A,H?gel S,Vilianovich L,Ridders M,Tenner K,Alenina N,K?hler M,Hartmann E,Bader M

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth.
Pharmacogenetics and genomics16(9)647-58(2006 Sep)
Plant KE,Everett DM,Gordon Gibson G,Lyon J,Plant NJ

Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal.
The Journal of biological chemistry280(14)13272-8(2005 Apr)
Sakakida Y,Miyamoto Y,Nagoshi E,Akashi M,Nakamura TJ,Mamine T,Kasahara M,Minami Y,Yoneda Y,Takumi T