Adck3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adck3
Entrez Gene ID	360887
Full Name	coenzyme Q8A
Synonyms	Adck3,Cabc1
General protein information	Preferred Names coenzyme Q8A Names atypical kinase COQ8A, mitochondrial atypical kinase ADCK3, mitochondrial aarF domain containing kinase 3 aarF domain-containing protein kinase 3 chaperone activity of bc1 complex-like, mitochondrial chaperone, ABC1 activity of bc1 complex like coenzyme Q protein 8A
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q26

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013185.1	NP_001013203.1	atypical kinase COQ8A, mitochondrial
XM_006250387.1	XP_006250449.1	atypical kinase ADCK3, mitochondrial isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ADCK3	NP_064632.2
Magnaporthe oryzae (rice blast fungus)	MGG_06939	XP_003709679.1
Bos taurus (cattle)	ADCK3	NP_001039884.1
Gallus gallus (chicken)	ADCK3	NP_001186342.1
Danio rerio (zebrafish)	adck3	NP_001002728.2
Caenorhabditis elegans (roundworm)	coq-8	NP_498014.2
Pan troglodytes (chimpanzee)	ADCK3	XP_514248.3
	ADCK3	XP_001089596.1
Neurospora crassa	NCU03823	XP_961212.1
Rattus norvegicus (Norway rat)	Adck3	NP_001013203.1
Saccharomyces cerevisiae (baker's yeast)	COQ8	NP_011396.1
Eremothecium gossypii	AGOS_AAR181W	NP_982724.1
Canis lupus familiaris (dog)	ADCK3	XP_005623029.1
Mus musculus (house mouse)	Adck3	NP_075830.2
Kluyveromyces lactis	KLLA0B00539g	XP_451554.1
Schizosaccharomyces pombe (fission yeast)	abc1	NP_596237.1
Xenopus tropicalis (tropical clawed frog)	adck3	XP_002938888.1

Gene Ontology
Bibliography

Related articles in PubMed

Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.
Stefely JA, Licitra F, Laredj L, Reidenbach AG, Kemmerer ZA, Grangeray A, Jaeg-Ehret T, Minogue CE, Ulbrich A, Hutchins PD, Wilkerson EM, Ruan Z, Aydin D, Hebert AS, Guo X, Freiberger EC, Reutenauer L, Jochem A, Chergova M, Johnson IE, Lohman DC, Rush MJP, Kwiecien NW, Singh PK, Schlagowski AI, Floyd BJ, Forsman U, Sindelar PJ, Westphall MS, Pierrel F, Zoll J, Dal Peraro M, Kannan N, Bingman CA, Coon JJ, Isope P, Puccio H, Pagliarini DJ
Molecular cell63(4)608-620(2016 Aug)

Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis.
Stefely JA, Reidenbach AG, Ulbrich A, Oruganty K, Floyd BJ, Jochem A, Saunders JM, Johnson IE, Minogue CE, Wrobel RL, Barber GE, Lee D, Li S, Kannan N, Coon JJ, Bingman CA, Pagliarini DJ
Molecular cell57(1)83-94(2015 Jan)

Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy.
Gerards M, van den Bosch B, Calis C, Schoonderwoerd K, van Engelen K, Tijssen M, de Coo R, van der Kooi A, Smeets H
Mitochondrion10(5)510-5(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that CABC1 is an important candidate for mutation analysis in progressive cerebellar ataxia and atrophy on MRI to identify those patients who may benefit from CoQ10 treatment.
Title: Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy.

The following Adck3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adck3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12407	NM_001013185.1 Latest version!	Rattus norvegicus coenzyme Q8A (Coq8a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
ORa12407	XM_006250387.1 Latest version!	Rattus norvegicus aarF domain containing kinase 3 (Adck3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adck3 ( NM_001013185.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013203.1 Rattus norvegicus coenzyme Q8A (Coq8a), mRNA.

Price & Availability↑

CloneID	ORa12407
Clone ID Related Accession (Same CDS sequence)	NM_001013185.1 , XM_006250387.1
Accession Version	NM_001013185.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1950bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-15
Organism	Rattus norvegicus(Norway rat)
Product	atypical kinase COQ8A, mitochondrial
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091388.1. On Apr 20, 2005 this sequence version replaced XM_341162.2. ##Evidence-Data-START## Transcript exon combination :: BC091388.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCTGCTA TGTTGGGGGA TGCCATCATG GTGGCCAAAG GCCTTGCCAA GCTGACCCAG 
GCAGCTGTGG AAACTCACCT GCAGAACCTG GGCCTTGGTG GGGAGCTCAT CCTGGCAGCC 
AGGGCCCTGC AGTCTACAGC TGTGGAGCAG ATCAGCATGG TCTTTGGAAA GGTGCAGGGT 
CAGGATAAGC ATGAAGATTC ATATGCCACT GAGAACTTCG AAGATCTGGA AGCCGAAGTT 
CAGTTCTCAA CACCACAGGC AGCTGGAAGC TCCCCAGATT TCTCCACAGC CTCCTCCCTG 
GACCAGCCAC TGTCTTCATC CCTGGGTCAT GCCCACAGGG AGGGCCCAGC TCCTGCCTAT 
GTTTCCAGTG GACCTTTCAG GGAAGCAGGG CTCTCTGGCC AGGCTACCTC TCCTCTGGGC 
AGAGTCAATG GAAGGCTCTT TGTAGATTGT AGAGACTTGT TCTTGGCCAA CAGCATCCAG 
CGAAGATTCT TCCACCAGGA CCAGGCCCCT GTGGGAGGCC TCACCGCTGA AGACATTGAA 
AAGGCCCGTC AGGCCAAGGC TCGCCCAGAG AGCAAGCCAC ACAAGCAGAT GCTCAGTGAG 
CGGGCTCGGG AGCGGAAGGT GCCAGTTACC CGGATTGGGC GGTTGGCCAA CTTTGGAGGG 
CTGGCTGTAG GTCTGGGCTT TGGGGCTTTG GCTGAGGTTG CCAAGAAGAG TCTGCGTTCT 
GAGAACTCCA CAGGGAAGAA AGCTGTGCTG GATTCTAGCC CCTTCCTGTC AGAGGCGAAT 
GCAGAGCGCA TTGTGAGTAC ATTGTGCAAG GTGCGTGGGG CCGCACTGAA GCTGGGCCAG 
ATGCTGAGCA TCCAGGATGA TGCCTTCATC AACCCTCACC TGGCCAAGAT CTTTGAGCGG 
GTGAGGCAGA GCGCTGACTT CATGCCACTG AAACAGATGA CGAAAACTCT CAACAATGAC 
CTGGGCCCCC ATTGGAGGGA CAAGCTGGAG TACTTTGAAG AGCGGCCCTT TGCGGCTGCC 
TCCATAGGGC AGGTGCACCT GGCCCGTTTG AAGGGTGGCC GTGAGGTGGC CATGAAGATT 
CAGTACCCTG GTGTGGCCCA GAGCATTAAC AGTGACGTCA ACAACCTCAT GGCTGTGCTG 
AACATGAGTA ACATGCTTCC AGAAGGCCTG TTCCCAGAGC ACCTGATTGA TGTGCTGAGG 
CGGGAGCTTA CCCTTGAGTG TGACTACCAG CGGGAGGCTG CCTATGCCAA GAAGTTCAGG 
GAGCTGCTGA AGGACCACCC CTTCTTCTAT GTGCCTGAGA TTGTGGACGA GCTGTGCAGC 
CCCCATGTGC TGACCACAGA GCTGATAACA GGCTTCCCCC TGGACCAGGC AGAAGGGCTG 
AGCCAGGAAG TGCGGAATGA GATCTGCTAC AACATTTTGG TGCTGTGCCT GAGGGAGCTG 
TTTGAGTTCC ATGTCATGCA GACTGACCCC AACTGGTCCA ATTTCTTTTA TGACCCTCAG 
CAGCACAAGG TGGCTCTCCT GGACTTTGGG GCAACTCGAG AATATGACCG ATCCTTTACT 
GACCTCTACA TTCAGGTCAT CCGGGCTGCT GCTGACCAGG ACAGGGAGGC AGTGCTGAAG 
AAGTCCATAG AGATGAAGTT CCTCACTGGT TATGAGGTCA AGGCCATGGA GGATGCCCAC 
CTGGATGCCA TTCTCATCCT GGGGGAGGCC TTTGCTTCGG AAGAGCCCTT TGACTTCGGC 
ACGCAGAGCA CCACTGAGAA GATCCATAAC CTGATCCCCA TCATGCTGAA GCACCGCCTC 
ATCCCGCCTC CTGAGGAGAC CTACTCTCTG CACCGCAAGA TGGGGGGCTC TTTCCTCATC 
TGTTCCAAGC TGAAGGCCTG CTTCCCCTGC AAGGCCATGT TTGAGGAAGC GTACAGTAAC 
TACTGCAGGA TGAAGTCTGG GCTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013203.1
CDS	37..1986
Translation	MAAMLGDAIMVAKGLAKLTQAAVETHLQNLGLGGELILAARALQSTAVEQISMVFGKVQGQDKHEDSYATENFEDLEAEVQFSTPQAAGSSPDFSTASSLDQPLSSSLGHAHREGPAPAYVSSGPFREAGLSGQATSPLGRVNGRLFVDCRDLFLANSIQRRFFHQDQAPVGGLTAEDIEKARQAKARPESKPHKQMLSERARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSENSTGKKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMTKTLNNDLGPHWRDKLEYFEERPFAAASIGQVHLARLKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELTLECDYQREAAYAKKFRELLKDHPFFYVPEIVDELCSPHVLTTELITGFPLDQAEGLSQEVRNEICYNILVLCLRELFEFHVMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQVIRAAADQDREAVLKKSIEMKFLTGYEVKAMEDAHLDAILILGEAFASEEPFDFGTQSTTEKIHNLIPIMLKHRLIPPPEETYSLHRKMGGSFLICSKLKACFPCKAMFEEAYSNYCRMKSGLQ

Target ORF information:

RefSeq Version	NM_001013185.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus coenzyme Q8A (Coq8a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013185.1

ORF Insert Sequence:

ATGGCTGCTA TGTTGGGGGA TGCCATCATG GTGGCCAAAG GCCTTGCCAA GCTGACCCAG 
GCAGCTGTGG AAACTCACCT GCAGAACCTG GGCCTTGGTG GGGAGCTCAT CCTGGCAGCC 
AGGGCCCTGC AGTCTACAGC TGTGGAGCAG ATCAGCATGG TCTTTGGAAA GGTGCAGGGT 
CAGGATAAGC ATGAAGATTC ATATGCCACT GAGAACTTCG AAGATCTGGA AGCCGAAGTT 
CAGTTCTCAA CACCACAGGC AGCTGGAAGC TCCCCAGATT TCTCCACAGC CTCCTCCCTG 
GACCAGCCAC TGTCTTCATC CCTGGGTCAT GCCCACAGGG AGGGCCCAGC TCCTGCCTAT 
GTTTCCAGTG GACCTTTCAG GGAAGCAGGG CTCTCTGGCC AGGCTACCTC TCCTCTGGGC 
AGAGTCAATG GAAGGCTCTT TGTAGATTGT AGAGACTTGT TCTTGGCCAA CAGCATCCAG 
CGAAGATTCT TCCACCAGGA CCAGGCCCCT GTGGGAGGCC TCACCGCTGA AGACATTGAA 
AAGGCCCGTC AGGCCAAGGC TCGCCCAGAG AGCAAGCCAC ACAAGCAGAT GCTCAGTGAG 
CGGGCTCGGG AGCGGAAGGT GCCAGTTACC CGGATTGGGC GGTTGGCCAA CTTTGGAGGG 
CTGGCTGTAG GTCTGGGCTT TGGGGCTTTG GCTGAGGTTG CCAAGAAGAG TCTGCGTTCT 
GAGAACTCCA CAGGGAAGAA AGCTGTGCTG GATTCTAGCC CCTTCCTGTC AGAGGCGAAT 
GCAGAGCGCA TTGTGAGTAC ATTGTGCAAG GTGCGTGGGG CCGCACTGAA GCTGGGCCAG 
ATGCTGAGCA TCCAGGATGA TGCCTTCATC AACCCTCACC TGGCCAAGAT CTTTGAGCGG 
GTGAGGCAGA GCGCTGACTT CATGCCACTG AAACAGATGA CGAAAACTCT CAACAATGAC 
CTGGGCCCCC ATTGGAGGGA CAAGCTGGAG TACTTTGAAG AGCGGCCCTT TGCGGCTGCC 
TCCATAGGGC AGGTGCACCT GGCCCGTTTG AAGGGTGGCC GTGAGGTGGC CATGAAGATT 
CAGTACCCTG GTGTGGCCCA GAGCATTAAC AGTGACGTCA ACAACCTCAT GGCTGTGCTG 
AACATGAGTA ACATGCTTCC AGAAGGCCTG TTCCCAGAGC ACCTGATTGA TGTGCTGAGG 
CGGGAGCTTA CCCTTGAGTG TGACTACCAG CGGGAGGCTG CCTATGCCAA GAAGTTCAGG 
GAGCTGCTGA AGGACCACCC CTTCTTCTAT GTGCCTGAGA TTGTGGACGA GCTGTGCAGC 
CCCCATGTGC TGACCACAGA GCTGATAACA GGCTTCCCCC TGGACCAGGC AGAAGGGCTG 
AGCCAGGAAG TGCGGAATGA GATCTGCTAC AACATTTTGG TGCTGTGCCT GAGGGAGCTG 
TTTGAGTTCC ATGTCATGCA GACTGACCCC AACTGGTCCA ATTTCTTTTA TGACCCTCAG 
CAGCACAAGG TGGCTCTCCT GGACTTTGGG GCAACTCGAG AATATGACCG ATCCTTTACT 
GACCTCTACA TTCAGGTCAT CCGGGCTGCT GCTGACCAGG ACAGGGAGGC AGTGCTGAAG 
AAGTCCATAG AGATGAAGTT CCTCACTGGT TATGAGGTCA AGGCCATGGA GGATGCCCAC 
CTGGATGCCA TTCTCATCCT GGGGGAGGCC TTTGCTTCGG AAGAGCCCTT TGACTTCGGC 
ACGCAGAGCA CCACTGAGAA GATCCATAAC CTGATCCCCA TCATGCTGAA GCACCGCCTC 
ATCCCGCCTC CTGAGGAGAC CTACTCTCTG CACCGCAAGA TGGGGGGCTC TTTCCTCATC 
TGTTCCAAGC TGAAGGCCTG CTTCCCCTGC AAGGCCATGT TTGAGGAAGC GTACAGTAAC 
TACTGCAGGA TGAAGTCTGG GCTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Adck3 ( XM_006250387.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006250449.1 Rattus norvegicus aarF domain containing kinase 3 (Adck3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa12407
Clone ID Related Accession (Same CDS sequence)	NM_001013185.1 , XM_006250387.1
Accession Version	XM_006250387.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1950bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	atypical kinase ADCK3, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCTA TGTTGGGGGA TGCCATCATG GTGGCCAAAG GCCTTGCCAA GCTGACCCAG 
GCAGCTGTGG AAACTCACCT GCAGAACCTG GGCCTTGGTG GGGAGCTCAT CCTGGCAGCC 
AGGGCCCTGC AGTCTACAGC TGTGGAGCAG ATCAGCATGG TCTTTGGAAA GGTGCAGGGT 
CAGGATAAGC ATGAAGATTC ATATGCCACT GAGAACTTCG AAGATCTGGA AGCCGAAGTT 
CAGTTCTCAA CACCACAGGC AGCTGGAAGC TCCCCAGATT TCTCCACAGC CTCCTCCCTG 
GACCAGCCAC TGTCTTCATC CCTGGGTCAT GCCCACAGGG AGGGCCCAGC TCCTGCCTAT 
GTTTCCAGTG GACCTTTCAG GGAAGCAGGG CTCTCTGGCC AGGCTACCTC TCCTCTGGGC 
AGAGTCAATG GAAGGCTCTT TGTAGATTGT AGAGACTTGT TCTTGGCCAA CAGCATCCAG 
CGAAGATTCT TCCACCAGGA CCAGGCCCCT GTGGGAGGCC TCACCGCTGA AGACATTGAA 
AAGGCCCGTC AGGCCAAGGC TCGCCCAGAG AGCAAGCCAC ACAAGCAGAT GCTCAGTGAG 
CGGGCTCGGG AGCGGAAGGT GCCAGTTACC CGGATTGGGC GGTTGGCCAA CTTTGGAGGG 
CTGGCTGTAG GTCTGGGCTT TGGGGCTTTG GCTGAGGTTG CCAAGAAGAG TCTGCGTTCT 
GAGAACTCCA CAGGGAAGAA AGCTGTGCTG GATTCTAGCC CCTTCCTGTC AGAGGCGAAT 
GCAGAGCGCA TTGTGAGTAC ATTGTGCAAG GTGCGTGGGG CCGCACTGAA GCTGGGCCAG 
ATGCTGAGCA TCCAGGATGA TGCCTTCATC AACCCTCACC TGGCCAAGAT CTTTGAGCGG 
GTGAGGCAGA GCGCTGACTT CATGCCACTG AAACAGATGA CGAAAACTCT CAACAATGAC 
CTGGGCCCCC ATTGGAGGGA CAAGCTGGAG TACTTTGAAG AGCGGCCCTT TGCGGCTGCC 
TCCATAGGGC AGGTGCACCT GGCCCGTTTG AAGGGTGGCC GTGAGGTGGC CATGAAGATT 
CAGTACCCTG GTGTGGCCCA GAGCATTAAC AGTGACGTCA ACAACCTCAT GGCTGTGCTG 
AACATGAGTA ACATGCTTCC AGAAGGCCTG TTCCCAGAGC ACCTGATTGA TGTGCTGAGG 
CGGGAGCTTA CCCTTGAGTG TGACTACCAG CGGGAGGCTG CCTATGCCAA GAAGTTCAGG 
GAGCTGCTGA AGGACCACCC CTTCTTCTAT GTGCCTGAGA TTGTGGACGA GCTGTGCAGC 
CCCCATGTGC TGACCACAGA GCTGATAACA GGCTTCCCCC TGGACCAGGC AGAAGGGCTG 
AGCCAGGAAG TGCGGAATGA GATCTGCTAC AACATTTTGG TGCTGTGCCT GAGGGAGCTG 
TTTGAGTTCC ATGTCATGCA GACTGACCCC AACTGGTCCA ATTTCTTTTA TGACCCTCAG 
CAGCACAAGG TGGCTCTCCT GGACTTTGGG GCAACTCGAG AATATGACCG ATCCTTTACT 
GACCTCTACA TTCAGGTCAT CCGGGCTGCT GCTGACCAGG ACAGGGAGGC AGTGCTGAAG 
AAGTCCATAG AGATGAAGTT CCTCACTGGT TATGAGGTCA AGGCCATGGA GGATGCCCAC 
CTGGATGCCA TTCTCATCCT GGGGGAGGCC TTTGCTTCGG AAGAGCCCTT TGACTTCGGC 
ACGCAGAGCA CCACTGAGAA GATCCATAAC CTGATCCCCA TCATGCTGAA GCACCGCCTC 
ATCCCGCCTC CTGAGGAGAC CTACTCTCTG CACCGCAAGA TGGGGGGCTC TTTCCTCATC 
TGTTCCAAGC TGAAGGCCTG CTTCCCCTGC AAGGCCATGT TTGAGGAAGC GTACAGTAAC 
TACTGCAGGA TGAAGTCTGG GCTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006250449.1
CDS	120..2069
Translation	MAAMLGDAIMVAKGLAKLTQAAVETHLQNLGLGGELILAARALQSTAVEQISMVFGKVQGQDKHEDSYATENFEDLEAEVQFSTPQAAGSSPDFSTASSLDQPLSSSLGHAHREGPAPAYVSSGPFREAGLSGQATSPLGRVNGRLFVDCRDLFLANSIQRRFFHQDQAPVGGLTAEDIEKARQAKARPESKPHKQMLSERARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSENSTGKKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMTKTLNNDLGPHWRDKLEYFEERPFAAASIGQVHLARLKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELTLECDYQREAAYAKKFRELLKDHPFFYVPEIVDELCSPHVLTTELITGFPLDQAEGLSQEVRNEICYNILVLCLRELFEFHVMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQVIRAAADQDREAVLKKSIEMKFLTGYEVKAMEDAHLDAILILGEAFASEEPFDFGTQSTTEKIHNLIPIMLKHRLIPPPEETYSLHRKMGGSFLICSKLKACFPCKAMFEEAYSNYCRMKSGLQ

Target ORF information:

RefSeq Version	XM_006250387.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aarF domain containing kinase 3 (Adck3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006250387.1

ORF Insert Sequence:

ATGGCTGCTA TGTTGGGGGA TGCCATCATG GTGGCCAAAG GCCTTGCCAA GCTGACCCAG 
GCAGCTGTGG AAACTCACCT GCAGAACCTG GGCCTTGGTG GGGAGCTCAT CCTGGCAGCC 
AGGGCCCTGC AGTCTACAGC TGTGGAGCAG ATCAGCATGG TCTTTGGAAA GGTGCAGGGT 
CAGGATAAGC ATGAAGATTC ATATGCCACT GAGAACTTCG AAGATCTGGA AGCCGAAGTT 
CAGTTCTCAA CACCACAGGC AGCTGGAAGC TCCCCAGATT TCTCCACAGC CTCCTCCCTG 
GACCAGCCAC TGTCTTCATC CCTGGGTCAT GCCCACAGGG AGGGCCCAGC TCCTGCCTAT 
GTTTCCAGTG GACCTTTCAG GGAAGCAGGG CTCTCTGGCC AGGCTACCTC TCCTCTGGGC 
AGAGTCAATG GAAGGCTCTT TGTAGATTGT AGAGACTTGT TCTTGGCCAA CAGCATCCAG 
CGAAGATTCT TCCACCAGGA CCAGGCCCCT GTGGGAGGCC TCACCGCTGA AGACATTGAA 
AAGGCCCGTC AGGCCAAGGC TCGCCCAGAG AGCAAGCCAC ACAAGCAGAT GCTCAGTGAG 
CGGGCTCGGG AGCGGAAGGT GCCAGTTACC CGGATTGGGC GGTTGGCCAA CTTTGGAGGG 
CTGGCTGTAG GTCTGGGCTT TGGGGCTTTG GCTGAGGTTG CCAAGAAGAG TCTGCGTTCT 
GAGAACTCCA CAGGGAAGAA AGCTGTGCTG GATTCTAGCC CCTTCCTGTC AGAGGCGAAT 
GCAGAGCGCA TTGTGAGTAC ATTGTGCAAG GTGCGTGGGG CCGCACTGAA GCTGGGCCAG 
ATGCTGAGCA TCCAGGATGA TGCCTTCATC AACCCTCACC TGGCCAAGAT CTTTGAGCGG 
GTGAGGCAGA GCGCTGACTT CATGCCACTG AAACAGATGA CGAAAACTCT CAACAATGAC 
CTGGGCCCCC ATTGGAGGGA CAAGCTGGAG TACTTTGAAG AGCGGCCCTT TGCGGCTGCC 
TCCATAGGGC AGGTGCACCT GGCCCGTTTG AAGGGTGGCC GTGAGGTGGC CATGAAGATT 
CAGTACCCTG GTGTGGCCCA GAGCATTAAC AGTGACGTCA ACAACCTCAT GGCTGTGCTG 
AACATGAGTA ACATGCTTCC AGAAGGCCTG TTCCCAGAGC ACCTGATTGA TGTGCTGAGG 
CGGGAGCTTA CCCTTGAGTG TGACTACCAG CGGGAGGCTG CCTATGCCAA GAAGTTCAGG 
GAGCTGCTGA AGGACCACCC CTTCTTCTAT GTGCCTGAGA TTGTGGACGA GCTGTGCAGC 
CCCCATGTGC TGACCACAGA GCTGATAACA GGCTTCCCCC TGGACCAGGC AGAAGGGCTG 
AGCCAGGAAG TGCGGAATGA GATCTGCTAC AACATTTTGG TGCTGTGCCT GAGGGAGCTG 
TTTGAGTTCC ATGTCATGCA GACTGACCCC AACTGGTCCA ATTTCTTTTA TGACCCTCAG 
CAGCACAAGG TGGCTCTCCT GGACTTTGGG GCAACTCGAG AATATGACCG ATCCTTTACT 
GACCTCTACA TTCAGGTCAT CCGGGCTGCT GCTGACCAGG ACAGGGAGGC AGTGCTGAAG 
AAGTCCATAG AGATGAAGTT CCTCACTGGT TATGAGGTCA AGGCCATGGA GGATGCCCAC 
CTGGATGCCA TTCTCATCCT GGGGGAGGCC TTTGCTTCGG AAGAGCCCTT TGACTTCGGC 
ACGCAGAGCA CCACTGAGAA GATCCATAAC CTGATCCCCA TCATGCTGAA GCACCGCCTC 
ATCCCGCCTC CTGAGGAGAC CTACTCTCTG CACCGCAAGA TGGGGGGCTC TTTCCTCATC 
TGTTCCAAGC TGAAGGCCTG CTTCCCCTGC AAGGCCATGT TTGAGGAAGC GTACAGTAAC 
TACTGCAGGA TGAAGTCTGG GCTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.
Molecular cell63(4)608-620(2016 Aug)
Stefely JA,Licitra F,Laredj L,Reidenbach AG,Kemmerer ZA,Grangeray A,Jaeg-Ehret T,Minogue CE,Ulbrich A,Hutchins PD,Wilkerson EM,Ruan Z,Aydin D,Hebert AS,Guo X,Freiberger EC,Reutenauer L,Jochem A,Chergova M,Johnson IE,Lohman DC,Rush MJP,Kwiecien NW,Singh PK,Schlagowski AI,Floyd BJ,Forsman U,Sindelar PJ,Westphall MS,Pierrel F,Zoll J,Dal Peraro M,Kannan N,Bingman CA,Coon JJ,Isope P,Puccio H,Pagliarini DJ

Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis.
Molecular cell57(1)83-94(2015 Jan)
Stefely JA,Reidenbach AG,Ulbrich A,Oruganty K,Floyd BJ,Jochem A,Saunders JM,Johnson IE,Minogue CE,Wrobel RL,Barber GE,Lee D,Li S,Kannan N,Coon JJ,Bingman CA,Pagliarini DJ

Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy.
Mitochondrion10(5)510-5(2010 Aug)
Gerards M,van den Bosch B,Calis C,Schoonderwoerd K,van Engelen K,Tijssen M,de Coo R,van der Kooi A,Smeets H

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Adck3 cDNA ORF clone, Rattus norvegicus(Norway rat)

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