Hs6st1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hs6st1
Entrez Gene ID	316325
Full Name	heparan sulfate 6-O-sulfotransferase 1
General protein information	Preferred Names heparan sulfate 6-O-sulfotransferase 1 Names heparan-sulfate 6-O-sulfotransferase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108210.1	NP_001101680.1	heparan-sulfate 6-O-sulfotransferase 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	HS6ST1	NP_004798.3
	LOC715479	XP_001105734.2
Xenopus tropicalis (tropical clawed frog)	hs6st1	NP_001017317.1
Gallus gallus (chicken)	HS6ST1	NP_989813.1
Danio rerio (zebrafish)	hs6st1b	NP_001073672.1
Drosophila melanogaster (fruit fly)	Hs6st	NP_001262750.1
Bos taurus (cattle)	HS6ST1	NP_001179420.1
Mus musculus (house mouse)	Hs6st1	NP_056633.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001444	XP_321686.5
Rattus norvegicus (Norway rat)	Hs6st1	NP_001101680.1
Danio rerio (zebrafish)	hs6st1a	NP_001018344.2
Pan troglodytes (chimpanzee)	HS6ST1	XP_001141733.1

Gene Ontology
Bibliography

Related articles in PubMed

Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism.
Tornberg J, Sykiotis GP, Keefe K, Plummer L, Hoang X, Hall JE, Quinton R, Seminara SB, Hughes V, Van Vliet G, Van Uum S, Crowley WF, Habuchi H, Kimata K, Pitteloud N, B?low HE
Proceedings of the National Academy of Sciences of the United States of America108(28)11524-9(2011 Jul)

Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality.
Habuchi H, Nagai N, Sugaya N, Atsumi F, Stevens RL, Kimata K
The Journal of biological chemistry282(21)15578-88(2007 May)

The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.
Habuchi H, Tanaka M, Habuchi O, Yoshida K, Suzuki H, Ban K, Kimata K
The Journal of biological chemistry275(4)2859-68(2000 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Hs6st1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hs6st1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06902	NM_001108210.1 Latest version!	Rattus norvegicus heparan sulfate 6-O-sulfotransferase 1 (Hs6st1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hs6st1 ( NM_001108210.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101680.1 Rattus norvegicus heparan sulfate 6-O-sulfotransferase 1 (Hs6st1), mRNA.

Price & Availability↑

CloneID	ORa06902
Clone ID Related Accession (Same CDS sequence)	NM_001108210.1
Accession Version	NM_001108210.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	heparan-sulfate 6-O-sulfotransferase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473965.2. On or before Oct 4, 2007 this sequence version replaced XM_237060.4, XM_001056379.1. ##Evidence-Data-START## Transcript exon combination :: CB707126.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGGCG ACGACGTGAT AGTCTTCCTG CATATCCAGA AGACCGGCGG CACCACCTTC 
GGCCGCCACC TAGTGCAGAA CGTGCGCCTC GAGGTGCCCT GCGACTGTCG CCCGGGCCAG 
AAGAAGTGCA CCTGCTATCG GCCCAATCGC CGCGAGACCT GGCTCTTCTC TCGCTTCTCC 
ACCGGCTGGA GCTGCGGGCT GCACGCTGAC TGGACCGAAC TCACCAACTG TGTTCCCGGT 
GTGCTAGACC GCCGCGACCC AGCAGGTCTG CGTTCGCCCA GAAAGTTCTA CTACATCACC 
CTGCTGCGAG ACCCTGTATC CCGCTACCTG AGTGAATGGC GACATGTACA GCGTGGGGCC 
ACGTGGAAGA CCTCCTTGCA CATGTGTGAC GGGCGCACAC CGACCCCAGA GGAGCTGCCA 
CCCTGCTACG AGGGCACAGA CTGGTCGGGC TGCACATTGC AGGAGTTCAT GGATTGCCCC 
TACAACCTGG CCAACAACCG GCAGGTGCGC ATGCTGGCTG ACCTCAGCCT GGTGGGCTGC 
TACAACCTGT CTTTCATCCC CGAGAGCAAG CGGGCCCAGC TGCTGCTGGA GAGCGCCAAG 
AAGAACCTGC GCGGCATGGC CTTCTTCGGC CTCACGGAGT TCCAGCGCAA GACGCAGTAC 
CTATTTGAGC GGACGTTCAA CCTCAAGTTC ATCCGGCCCT TCATGCAGTA CAACAGCACG 
CGGGCGGGCG GTGTGGAGGT GGATGAGGAC ACTATCCGGC ACATCGAGGA GCTCAACGAC 
CTGGACATGC AGCTTTATGA CTATGCCAAG GACCTCTTCC AGCAGCGTTA CCAGTACAAG 
AGACAGCTGG AGCGCAGGGA GCAGCGCCTG CGCAATCGCG AAGAGCGCCT CCTGCATCGC 
TCCAAGGAAG CGCTGCCACG GGAGGACACG GAAGAGCCAG GCCGAGTACC CACCGAGGAC 
TACATGAGCC ATATCATTGA GAAGTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101680.1
CDS	63..1052
Translation	MKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRPGQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDPAGLRSPRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMDCPYNLANNRQVRMLADLSLVGCYNLSFIPESKRAQLLLESAKKNLRGMAFFGLTEFQRKTQYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRHIEELNDLDMQLYDYAKDLFQQRYQYKRQLERREQRLRNREERLLHRSKEALPREDTEEPGRVPTEDYMSHIIEKW

Target ORF information:

RefSeq Version	NM_001108210.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus heparan sulfate 6-O-sulfotransferase 1 (Hs6st1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108210.1

ORF Insert Sequence:

ATGAAGGGCG ACGACGTGAT AGTCTTCCTG CATATCCAGA AGACCGGCGG CACCACCTTC 
GGCCGCCACC TAGTGCAGAA CGTGCGCCTC GAGGTGCCCT GCGACTGTCG CCCGGGCCAG 
AAGAAGTGCA CCTGCTATCG GCCCAATCGC CGCGAGACCT GGCTCTTCTC TCGCTTCTCC 
ACCGGCTGGA GCTGCGGGCT GCACGCTGAC TGGACCGAAC TCACCAACTG TGTTCCCGGT 
GTGCTAGACC GCCGCGACCC AGCAGGTCTG CGTTCGCCCA GAAAGTTCTA CTACATCACC 
CTGCTGCGAG ACCCTGTATC CCGCTACCTG AGTGAATGGC GACATGTACA GCGTGGGGCC 
ACGTGGAAGA CCTCCTTGCA CATGTGTGAC GGGCGCACAC CGACCCCAGA GGAGCTGCCA 
CCCTGCTACG AGGGCACAGA CTGGTCGGGC TGCACATTGC AGGAGTTCAT GGATTGCCCC 
TACAACCTGG CCAACAACCG GCAGGTGCGC ATGCTGGCTG ACCTCAGCCT GGTGGGCTGC 
TACAACCTGT CTTTCATCCC CGAGAGCAAG CGGGCCCAGC TGCTGCTGGA GAGCGCCAAG 
AAGAACCTGC GCGGCATGGC CTTCTTCGGC CTCACGGAGT TCCAGCGCAA GACGCAGTAC 
CTATTTGAGC GGACGTTCAA CCTCAAGTTC ATCCGGCCCT TCATGCAGTA CAACAGCACG 
CGGGCGGGCG GTGTGGAGGT GGATGAGGAC ACTATCCGGC ACATCGAGGA GCTCAACGAC 
CTGGACATGC AGCTTTATGA CTATGCCAAG GACCTCTTCC AGCAGCGTTA CCAGTACAAG 
AGACAGCTGG AGCGCAGGGA GCAGCGCCTG CGCAATCGCG AAGAGCGCCT CCTGCATCGC 
TCCAAGGAAG CGCTGCCACG GGAGGACACG GAAGAGCCAG GCCGAGTACC CACCGAGGAC 
TACATGAGCC ATATCATTGA GAAGTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism.
Proceedings of the National Academy of Sciences of the United States of America108(28)11524-9(2011 Jul)
Tornberg J,Sykiotis GP,Keefe K,Plummer L,Hoang X,Hall JE,Quinton R,Seminara SB,Hughes V,Van Vliet G,Van Uum S,Crowley WF,Habuchi H,Kimata K,Pitteloud N,B?low HE

Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality.
The Journal of biological chemistry282(21)15578-88(2007 May)
Habuchi H,Nagai N,Sugaya N,Atsumi F,Stevens RL,Kimata K

The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.
The Journal of biological chemistry275(4)2859-68(2000 Jan)
Habuchi H,Tanaka M,Habuchi O,Yoshida K,Suzuki H,Ban K,Kimata K