Cmtm2a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cmtm2a
Entrez Gene ID	307616
Full Name	CKLF-like MARVEL transmembrane domain containing 2A
Synonyms	Cklfsf1
General protein information	Preferred Names CKLF-like MARVEL transmembrane domain containing 2A Names CKLF-like MARVEL transmembrane domain-containing protein 2A chemokine-like factor super family 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19p14

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013142.1	NP_001013160.1	CKLF-like MARVEL transmembrane domain-containing protein 2A

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cmtm2a	NP_081298.1
Rattus norvegicus (Norway rat)	Cmtm2a	NP_001013160.1

Gene Ontology
Bibliography

Related articles in PubMed

Intratesticular alpha1-adrenergic receptors mediate stress-disturbed transcription of steroidogenic stimulator NUR77 as well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of adult rats.
Stojkov-Mimic NJ, Bjelic MM, Radovic SM, Mihajlovic AI, Sokanovic SJ, Baburski AZ, Janjic MM, Kostic TS, Andric SA
Molecular and cellular endocrinology412309-19(2015 Sep)

Bacterial lipopolysaccharide differently modulates steroidogenic enzymes gene expressions in the brain and testis in rats.
Sadasivam M, Ramatchandirin B, Ayyanar A, Prahalathan C
Neuroscience research8381-8(2014 Jun)

[Effect of testosterone on the expression of CMTM family of the male spermatogenesis suppression rats].
Li G, Li GY, Ji HJ, Zhao WJ, Chu SF, Chen NH
Yao xue xue bao = Acta pharmaceutica Sinica45(8)995-1000(2010 Aug)

ARR19 (androgen receptor corepressor of 19 kDa), an antisteroidogenic factor, is regulated by GATA-1 in testicular Leydig cells.
Qamar I, Park E, Gong EY, Lee HJ, Lee K
The Journal of biological chemistry284(27)18021-32(2009 Jul)

Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase.
Jeong BC, Hong CY, Chattopadhyay S, Park JH, Gong EY, Kim HJ, Chun SY, Lee K
Molecular endocrinology (Baltimore, Md.)18(1)13-25(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In vivo blockade of testicular alpha1-adrenergic receptors changed the stress-induced decrease of Nur77 and increase of Arr19 and Dax1 in Leydig cells.
Title: Intratesticular alpha1-adrenergic receptors mediate stress-disturbed transcription of steroidogenic stimulator NUR77 as well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of adult rats.

These findings show ARR19 might play a crucial role in regulation of neuronal and testicular steroidogenesis in inflammatory diseases
Title: Bacterial lipopolysaccharide differently modulates steroidogenic enzymes gene expressions in the brain and testis in rats.

Testosterone was associated with the expression of CMTM family during spermatogenesis, and CMTM2 and CMTM4 may take part in the spermatogenesis process.
Title: [Effect of testosterone on the expression of CMTM family of the male spermatogenesis suppression rats].

The following Cmtm2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cmtm2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03516	NM_001013142.1 Latest version!	Rattus norvegicus CKLF-like MARVEL transmembrane domain containing 2A (Cmtm2a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cmtm2a ( NM_001013142.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013160.1 Rattus norvegicus CKLF-like MARVEL transmembrane domain containing 2A (Cmtm2a), mRNA.

Price & Availability↑

CloneID	ORa03516
Clone ID Related Accession (Same CDS sequence)	NM_001013142.1
Accession Version	NM_001013142.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	CKLF-like MARVEL transmembrane domain-containing protein 2A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078975.1. On Apr 20, 2005 this sequence version replaced XM_226209.3. ##Evidence-Data-START## Transcript exon combination :: BC078975.1, CK652927.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689604, SAMN02642627 [ECO:0000348] ##Evidence-Data-END##

ATGGCATCAG GAATAAGGTA TGCATTTCGG CCCAAAGGAG CTCAGCGCAA GGAGGACACG 
ACCCCCAAAA AAGGGATTCG ACGCTATCTG TTTGAACTGA AAGAGGGCAA TAAACAGTTC 
TGGCTGTCGG GACACGCCGT TACAAAGCTT ATAACTTTGG GCTGCATAAT CACTGCACTA 
GACTACTTTG AATCAATGCT CCCACATCCT GTTCTGGTCC TGGTCCTCAG TATGGAAGTG 
GCAATCTACA TATTCTTCAT CTTCCTTAAT ACCTTTGCCA TCAACCGGTA CATTACCTTC 
ATCTTCTGGC CTATGACAGA TCTATTGAAC AGCCTGTTCT CCTGTGTGTT CCTCGCAGGC 
TCTGTATTCT TTGCTTTCAA GGCTAGACGA ACATTGCCAA AGCCCTACTT AACTGCTATG 
ATCTTCATGG GAGTTGCTGC AATCTCTTGT TTCCTCGATA TTTTTCTTCA ACTCCCACAC 
TTCAGAGGCC TTCAGATGAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013160.1
CDS	106..609
Translation	MASGIRYAFRPKGAQRKEDTTPKKGIRRYLFELKEGNKQFWLSGHAVTKLITLGCIITALDYFESMLPHPVLVLVLSMEVAIYIFFIFLNTFAINRYITFIFWPMTDLLNSLFSCVFLAGSVFFAFKARRTLPKPYLTAMIFMGVAAISCFLDIFLQLPHFRGLQMR

Target ORF information:

RefSeq Version	NM_001013142.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CKLF-like MARVEL transmembrane domain containing 2A (Cmtm2a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013142.1

ORF Insert Sequence:

ATGGCATCAG GAATAAGGTA TGCATTTCGG CCCAAAGGAG CTCAGCGCAA GGAGGACACG 
ACCCCCAAAA AAGGGATTCG ACGCTATCTG TTTGAACTGA AAGAGGGCAA TAAACAGTTC 
TGGCTGTCGG GACACGCCGT TACAAAGCTT ATAACTTTGG GCTGCATAAT CACTGCACTA 
GACTACTTTG AATCAATGCT CCCACATCCT GTTCTGGTCC TGGTCCTCAG TATGGAAGTG 
GCAATCTACA TATTCTTCAT CTTCCTTAAT ACCTTTGCCA TCAACCGGTA CATTACCTTC 
ATCTTCTGGC CTATGACAGA TCTATTGAAC AGCCTGTTCT CCTGTGTGTT CCTCGCAGGC 
TCTGTATTCT TTGCTTTCAA GGCTAGACGA ACATTGCCAA AGCCCTACTT AACTGCTATG 
ATCTTCATGG GAGTTGCTGC AATCTCTTGT TTCCTCGATA TTTTTCTTCA ACTCCCACAC 
TTCAGAGGCC TTCAGATGAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intratesticular alpha1-adrenergic receptors mediate stress-disturbed transcription of steroidogenic stimulator NUR77 as well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of adult rats.
Molecular and cellular endocrinology412309-19(2015 Sep)
Stojkov-Mimic NJ,Bjelic MM,Radovic SM,Mihajlovic AI,Sokanovic SJ,Baburski AZ,Janjic MM,Kostic TS,Andric SA

Bacterial lipopolysaccharide differently modulates steroidogenic enzymes gene expressions in the brain and testis in rats.
Neuroscience research8381-8(2014 Jun)
Sadasivam M,Ramatchandirin B,Ayyanar A,Prahalathan C

[Effect of testosterone on the expression of CMTM family of the male spermatogenesis suppression rats].
Yao xue xue bao = Acta pharmaceutica Sinica45(8)995-1000(2010 Aug)
Li G,Li GY,Ji HJ,Zhao WJ,Chu SF,Chen NH

ARR19 (androgen receptor corepressor of 19 kDa), an antisteroidogenic factor, is regulated by GATA-1 in testicular Leydig cells.
The Journal of biological chemistry284(27)18021-32(2009 Jul)
Qamar I,Park E,Gong EY,Lee HJ,Lee K

Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase.
Molecular endocrinology (Baltimore, Md.)18(1)13-25(2004 Jan)
Jeong BC,Hong CY,Chattopadhyay S,Park JH,Gong EY,Kim HJ,Chun SY,Lee K