Bloc1s5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bloc1s5
Entrez Gene ID	306868
Full Name	biogenesis of lysosomal organelles complex 1 subunit 5
Synonyms	Muted
General protein information	Preferred Names biogenesis of lysosomal organelles complex 1 subunit 5 Names biogenesis of lysosome-related organelles complex 1 subunit 5 BLOC-1 subunit 5 biogenesis of lysosomal organelles complex-1, subunit 5, muted protein Muted homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107347.1	NP_001100817.1	biogenesis of lysosome-related organelles complex 1 subunit 5
XM_006253807.3	XP_006253869.1	biogenesis of lysosome-related organelles complex 1 subunit 5 isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	BLOC1S5	NP_001006373.1
Xenopus tropicalis (tropical clawed frog)	bloc1s5	NP_001107140.1
Homo sapiens (human)	BLOC1S5	NP_958437.1
Pan troglodytes (chimpanzee)	MUTED	XP_001166060.1
	MUTED	XP_002803634.1
Canis lupus familiaris (dog)	BLOC1S5	XP_851825.3
Danio rerio (zebrafish)	bloc1s5	NP_001025237.1
Mus musculus (house mouse)	Bloc1s5	NP_620702.1
Rattus norvegicus (Norway rat)	Bloc1s5	NP_001100817.1

Gene Ontology
Bibliography

Related articles in PubMed

Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
Lee HH, Nemecek D, Schindler C, Smith WJ, Ghirlando R, Steven AC, Bonifacino JS, Hurley JH
The Journal of biological chemistry287(8)5882-90(2012 Feb)

The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.
Larimore J, Tornieri K, Ryder PV, Gokhale A, Zlatic SA, Craige B, Lee JD, Talbot K, Pare JF, Smith Y, Faundez V
Molecular biology of the cell22(24)4854-67(2011 Dec)

BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles.
Setty SR, Tenza D, Truschel ST, Chou E, Sviderskaya EV, Theos AC, Lamoreux ML, Di Pietro SM, Starcevic M, Bennett DC, Dell'Angelica EC, Raposo G, Marks MS
Molecular biology of the cell18(3)768-80(2007 Mar)

Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
Starcevic M, Dell'Angelica EC
The Journal of biological chemistry279(27)28393-401(2004 Jul)

Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1).
Ciciotte SL, Gwynn B, Moriyama K, Huizing M, Gahl WA, Bonifacino JS, Peters LL
Blood101(11)4402-7(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Bloc1s5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bloc1s5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03330	NM_001107347.1 Latest version!	Rattus norvegicus biogenesis of lysosomal organelles complex 1 subunit 5 (Bloc1s5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa37807	XM_006253807.3 Latest version!	Rattus norvegicus biogenesis of lysosomal organelles complex 1 subunit 5 (Bloc1s5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bloc1s5 ( NM_001107347.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100817.1 Rattus norvegicus biogenesis of lysosomal organelles complex 1 subunit 5 (Bloc1s5), mRNA.

Price & Availability↑

CloneID	ORa03330
Clone ID Related Accession (Same CDS sequence)	NM_001107347.1
Accession Version	NM_001107347.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	biogenesis of lysosome-related organelles complex 1 subunit 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473977.1. On or before Oct 4, 2007 this sequence version replaced XM_225255.4, XM_001063623.1. ##Evidence-Data-START## Transcript exon combination :: BC166529.1, CK602089.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGTGGCG GAGGGACAGA GACCCCGGTA GCATGCGAGG CCGCCCAGGG CGGCGGCGGC 
AAGAAGCGAG ACTCGCTGGG GACTGCGGGT GCGGCGCACC TCATTATCAA GGATCTTGGA 
GAAATTCATT CAAGACTGCT GGATCACAGA CCAGTTACCC AAGGTGAAAT CCGTTACTTT 
GTAAAAGAAT TTGAAGAAAA ACGTGGTCTT CGAGAATTGC GCGTTCTTGA GAACTTGAAG 
AATATGATCC AGGAAACAAA TGAGCGCATG CTTCCCAAGT GCAGAGAGAC CATGCAGGGT 
GGCCTGGAGG AGACCCTGCA GAGATTGCAA GCTGCTACTG ACTCCATCCA TAGACTCCAG 
CAGAGAGAAC AGGAGCGGAA AAAGGTGATT AATGACCACT TGACAGCTAG TGAGAAGCAG 
CGTATGCTCC AGTGGGAGGA GTTCCTGAGA GGACAGCCGC AGCGCAGAGC CGAAGTGGAT 
GCCGAGCACA GAAAAGCCAT GGAGAGGCTC AGAGAGCAAT ATGCAGCAAT GGAGAAGGAC 
CTAGCCAAGT TTTCCACCTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100817.1
CDS	77..640
Translation	MSGGGTETPVACEAAQGGGGKKRDSLGTAGAAHLIIKDLGEIHSRLLDHRPVTQGEIRYFVKEFEEKRGLRELRVLENLKNMIQETNERMLPKCRETMQGGLEETLQRLQAATDSIHRLQQREQERKKVINDHLTASEKQRMLQWEEFLRGQPQRRAEVDAEHRKAMERLREQYAAMEKDLAKFSTF

Target ORF information:

RefSeq Version	NM_001107347.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus biogenesis of lysosomal organelles complex 1 subunit 5 (Bloc1s5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107347.1

ORF Insert Sequence:

ATGAGTGGCG GAGGGACAGA GACCCCGGTA GCATGCGAGG CCGCCCAGGG CGGCGGCGGC 
AAGAAGCGAG ACTCGCTGGG GACTGCGGGT GCGGCGCACC TCATTATCAA GGATCTTGGA 
GAAATTCATT CAAGACTGCT GGATCACAGA CCAGTTACCC AAGGTGAAAT CCGTTACTTT 
GTAAAAGAAT TTGAAGAAAA ACGTGGTCTT CGAGAATTGC GCGTTCTTGA GAACTTGAAG 
AATATGATCC AGGAAACAAA TGAGCGCATG CTTCCCAAGT GCAGAGAGAC CATGCAGGGT 
GGCCTGGAGG AGACCCTGCA GAGATTGCAA GCTGCTACTG ACTCCATCCA TAGACTCCAG 
CAGAGAGAAC AGGAGCGGAA AAAGGTGATT AATGACCACT TGACAGCTAG TGAGAAGCAG 
CGTATGCTCC AGTGGGAGGA GTTCCTGAGA GGACAGCCGC AGCGCAGAGC CGAAGTGGAT 
GCCGAGCACA GAAAAGCCAT GGAGAGGCTC AGAGAGCAAT ATGCAGCAAT GGAGAAGGAC 
CTAGCCAAGT TTTCCACCTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bloc1s5 ( XM_006253807.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006253869.1 Rattus norvegicus biogenesis of lysosomal organelles complex 1 subunit 5 (Bloc1s5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa37807
Clone ID Related Accession (Same CDS sequence)	XM_006253807.3
Accession Version	XM_006253807.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	biogenesis of lysosome-related organelles complex 1 subunit 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006253807.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTGGCG GAGGGACAGA GACCCCGGTA GCATGCGAGG CCGCCCAGGG CGGCGGCGGC 
AAGAAGCGAG ACTCGCTGGG GACTGCGGGT GCGGCGCACC TCATTATCAA GGATCTTGGA 
GAAATTCATT CAAGACTGCT GGATCACAGA CCAGTTACCC AAGGTGAAAT CCGTTACTTT 
GTAAAAGAAT TTGAAGAAAA ACGTGGTCTT CGAGAATTGC GCGTTCTTGA GAACTTGAAG 
AATATGATCC AGGAAACAAA TGAGCGCATG CTTCCCAAGT GCAGAGAGAC CATGCAGGGT 
GGCCTGGAGG AGACCCTGCA GAGATTGCAA GCTGCTACTG ACTCCATCCA TAGACTCCAG 
CAGAGAGAAC AGGAGCGGAA AAAGACAGGG ACTCGTGACC CTGGGCTCGT GGATTTGGGT 
GCATTGCTGA GCAGTGAGCT GCTGCCGAGA TCCTCCTGTC TCTACACCCC CTCCCCAGCA 
CGTAGTTACA GCGGCCTGCT GCACCCCCAC GATCTGTATG TGATTAATGA CCACTTGACA 
GCTAGTGAGA AGCAGCGTAT GCTCCAGTGG GAGGAGTTCC TGAGAGGACA GCCGCAGCGC 
AGAGCCGAAG TGGATGCCGA GCACAGAAAA GCCATGGAGA GGCTCAGAGA GCAATATGCA 
GCAATGGAGA AGGACCTAGC CAAGTTTTCC ACCTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006253869.1
CDS	214..912
Translation	MSGGGTETPVACEAAQGGGGKKRDSLGTAGAAHLIIKDLGEIHSRLLDHRPVTQGEIRYFVKEFEEKRGLRELRVLENLKNMIQETNERMLPKCRETMQGGLEETLQRLQAATDSIHRLQQREQERKKTGTRDPGLVDLGALLSSELLPRSSCLYTPSPARSYSGLLHPHDLYVINDHLTASEKQRMLQWEEFLRGQPQRRAEVDAEHRKAMERLREQYAAMEKDLAKFSTF

Target ORF information:

RefSeq Version	XM_006253807.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus biogenesis of lysosomal organelles complex 1 subunit 5 (Bloc1s5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006253807.3

ORF Insert Sequence:

ATGAGTGGCG GAGGGACAGA GACCCCGGTA GCATGCGAGG CCGCCCAGGG CGGCGGCGGC 
AAGAAGCGAG ACTCGCTGGG GACTGCGGGT GCGGCGCACC TCATTATCAA GGATCTTGGA 
GAAATTCATT CAAGACTGCT GGATCACAGA CCAGTTACCC AAGGTGAAAT CCGTTACTTT 
GTAAAAGAAT TTGAAGAAAA ACGTGGTCTT CGAGAATTGC GCGTTCTTGA GAACTTGAAG 
AATATGATCC AGGAAACAAA TGAGCGCATG CTTCCCAAGT GCAGAGAGAC CATGCAGGGT 
GGCCTGGAGG AGACCCTGCA GAGATTGCAA GCTGCTACTG ACTCCATCCA TAGACTCCAG 
CAGAGAGAAC AGGAGCGGAA AAAGACAGGG ACTCGTGACC CTGGGCTCGT GGATTTGGGT 
GCATTGCTGA GCAGTGAGCT GCTGCCGAGA TCCTCCTGTC TCTACACCCC CTCCCCAGCA 
CGTAGTTACA GCGGCCTGCT GCACCCCCAC GATCTGTATG TGATTAATGA CCACTTGACA 
GCTAGTGAGA AGCAGCGTAT GCTCCAGTGG GAGGAGTTCC TGAGAGGACA GCCGCAGCGC 
AGAGCCGAAG TGGATGCCGA GCACAGAAAA GCCATGGAGA GGCTCAGAGA GCAATATGCA 
GCAATGGAGA AGGACCTAGC CAAGTTTTCC ACCTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
The Journal of biological chemistry287(8)5882-90(2012 Feb)
Lee HH,Nemecek D,Schindler C,Smith WJ,Ghirlando R,Steven AC,Bonifacino JS,Hurley JH

The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.
Molecular biology of the cell22(24)4854-67(2011 Dec)
Larimore J,Tornieri K,Ryder PV,Gokhale A,Zlatic SA,Craige B,Lee JD,Talbot K,Pare JF,Smith Y,Faundez V

BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles.
Molecular biology of the cell18(3)768-80(2007 Mar)
Setty SR,Tenza D,Truschel ST,Chou E,Sviderskaya EV,Theos AC,Lamoreux ML,Di Pietro SM,Starcevic M,Bennett DC,Dell'Angelica EC,Raposo G,Marks MS

Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
The Journal of biological chemistry279(27)28393-401(2004 Jul)
Starcevic M,Dell'Angelica EC

Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1).
Blood101(11)4402-7(2003 Jun)
Ciciotte SL,Gwynn B,Moriyama K,Huizing M,Gahl WA,Bonifacino JS,Peters LL