Map3k3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Map3k3
Entrez Gene ID	303604
Full Name	mitogen activated protein kinase kinase kinase 3
General protein information	Preferred Names mitogen activated protein kinase kinase kinase 3 Names mitogen-activated protein kinase kinase kinase 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107058.2	NP_001100528.1	mitogen-activated protein kinase kinase kinase 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MAP3K3	XP_537600.2
Rattus norvegicus (Norway rat)	Map3k3	NP_001100528.1
Homo sapiens (human)	MAP3K3	NP_976226.1
Mus musculus (house mouse)	Map3k3	NP_036077.1
Pan troglodytes (chimpanzee)	MAP3K3	XP_003315723.1
Bos taurus (cattle)	MAP3K3	XP_005221038.1
Gallus gallus (chicken)	MAP3K3	XP_418076.3
Xenopus tropicalis (tropical clawed frog)	map3k3	XP_002935600.2
	MAP3K3	XP_001116209.1
Danio rerio (zebrafish)	map3k3	XP_688694.2

Gene Ontology
Bibliography

Related articles in PubMed

miR-188 promotes senescence of lineage-negative bone marrow cells by targeting MAP3K3 expression.
Zheng Y, Liu H, Kong Y
FEBS letters591(15)2290-2298(2017 Aug)

Mechanisms and functions of p38 MAPK signalling.
Cuadrado A, Nebreda AR
The Biochemical journal429(3)403-17(2010 Aug)

The c-jun kinase/stress-activated pathway: regulation, function and role in human disease.
Johnson GL, Nakamura K
Biochimica et biophysica acta1773(8)1341-8(2007 Aug)

p38 MAP-kinases pathway regulation, function and role in human diseases.
Cuenda A, Rousseau S
Biochimica et biophysica acta1773(8)1358-75(2007 Aug)

Regulation of cellular functions by the ERK5 signalling pathway.
Wang X, Tournier C
Cellular signalling18(6)753-60(2006 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Map3k3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map3k3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02799	NM_001107058.2 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase kinase 3 (Map3k3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Map3k3 ( NM_001107058.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100528.1 Rattus norvegicus mitogen activated protein kinase kinase kinase 3 (Map3k3), mRNA.

Price & Availability↑

CloneID	ORa02799
Clone ID Related Accession (Same CDS sequence)	NM_001107058.2
Accession Version	NM_001107058.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-30
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase kinase kinase 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC168979.1. On Jun 9, 2011 this sequence version replaced NM_001107058.1. ##Evidence-Data-START## Transcript exon combination :: BC168979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGATGAAC AAGAGGCATT AGACTCAATC ATGAAGGACC TGGTGGCCCT CCAGATGAGC 
CGACGTCCCC GGGTGTCTGG ATATGAGACC ATGAAGAACA AGGACACAGG TCACCCAAAC 
AGGCAGAGTG ACGTCAGAAT CAAGTTTGAA CACAATGGGG AGAGACGAAT TATAGCATTC 
AGCCGGCCTG TGAGATATGA AGATGTGGAA CACAAGGTGA CAACGGTCTT TGGGCAGCCT 
CTTGATTTGC ATTATATGAA TAATGAGCTC TCCATCCTGT TGAAAAACCA AGATGATCTC 
GATAAAGCAA TTGACATTTT GGATAGAAGC GCGAGTATGA AAAGCCTTAG GATACTACTG 
TTATCCCAAG ACAGAAACCA TACTAGTTCC TCTCCCCACT CTGGAGTGTC CAGGCAGGTT 
CGGGTCAAGC CTTCCCAGTC TGCAGGGGAT ATAAATACCA TCTACCAAGC TCCTGAGCCC 
AGAAGCAGGC ACCTCTCTGT CAGCTCCCAG AACCCTGGCC GAAGCTCTCC TCCCCCTGGT 
TATGTACCTG AGCGACAACA GCACATTGCC CGGCAGGGAT CATATACGAG CATCAATAGT 
GAAGGTGAAT TCATCCCAGA GACCAGCGAG CAGTGCATGC TAGATCCCCT GAGCAGTGCC 
GAAAATTCCT TGTCAGGAAG CTGCCAATCC TTGGACAGGT CAGCAGACAG CCCATCTTTC 
AGGAAATCAC AAATGTCCCG AGCCCGGAGC TTCCCAGACA ACAGAAAGGA ATGCTCGGAT 
CGGGAGACCC AGCTCTATGA TAAAGGAGTT AAAGGCGGAA CCTATCCCAG GCGTTACCAT 
GTATCTGTGC ATCATAAAGA CTACAATGAT GGCAGAAGAA CGTTTCCCCG AATACGACGG 
CACCAGGGCA ACCTATTCAC TCTGGTGCCC TCAAGTCGCT CCTTGAGCAC AAATGGCGAG 
AACATGGGTG CCGCTGTGCA GTACTTGGAC CCCCGCGGGC GCCTACGGAG TGCAGACAGT 
GAAAATGCCC TCACTGTGCA GGAAAGAAGT GTGCCAACCA AGTCTCCTAG TGCTCCCATC 
AATTGGCGTC GGGGGAAGCT CCTGGGTCAA GGTGCCTTCG GCAGGGTCTA CTTATGCTAT 
GATGTGGACA CAGGACGTGA ACTTGCTTCT AAGCAGGTTC AGTTTGACCC AGATAGTCCT 
GAGACTAGCA AGGAGGTGAG TGCTCTGGAG TGCGAGATCC AGTTGCTGAA GAACTTGCAG 
CATGAGCGCA TCGTGCAGTA CTATGGCTGC CTGCGGGACC GTGCTGAGAA GATCCTCACC 
ATCTTTATGG AGTATATGCC AGGGGGCTCT GTAAAAGACC AGTTGAAGGC CTACGGAGCT 
CTGACGGAGA GTGTGACCCG CAAGTATACA CGGCAGATCC TGGAGGGCAT GTCCTACCTG 
CACAGCAACA TGATCGTGCA TCGTGACATC AAGGGAGCCA ATATCCTCCG AGACTCGGCT 
GGGAATGTGA AGCTTGGGGA TTTTGGGGCC AGCAAACGCC TGCAAACCAT CTGCATGTCA 
GGGACAGGCA TGCGCTCTGT CACTGGCACA CCCTACTGGA TGAGTCCTGA AGTCATCAGT 
GGCGAGGGCT ATGGAAGAAA GGCAGATGTG TGGAGCCTGG GCTGTACCGT GGTGGAGATG 
CTGACAGAGA AACCACCTTG GGCAGAGTAT GAAGCTATGG CTGCCATTTT CAAGATTGCC 
ACCCAGCCTA CCAATCCTCA GCTGCCCTCT CACATCTCAG AACACGGCAG GGACTTCCTG 
AGGCGCATAT TTGTGGAAGC TCGTCAGAGA CCCTCGGCTG AGGAGCTGCT CACACACCAC 
TTTGCACAGC TAGTGTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100528.1
CDS	290..2170
Translation	MDEQEALDSIMKDLVALQMSRRPRVSGYETMKNKDTGHPNRQSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSASMKSLRILLLSQDRNHTSSSPHSGVSRQVRVKPSQSAGDINTIYQAPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSQMSRARSFPDNRKECSDRETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGAAVQYLDPRGRLRSADSENALTVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY

Target ORF information:

RefSeq Version	NM_001107058.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase kinase 3 (Map3k3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107058.2

ORF Insert Sequence:

ATGGATGAAC AAGAGGCATT AGACTCAATC ATGAAGGACC TGGTGGCCCT CCAGATGAGC 
CGACGTCCCC GGGTGTCTGG ATATGAGACC ATGAAGAACA AGGACACAGG TCACCCAAAC 
AGGCAGAGTG ACGTCAGAAT CAAGTTTGAA CACAATGGGG AGAGACGAAT TATAGCATTC 
AGCCGGCCTG TGAGATATGA AGATGTGGAA CACAAGGTGA CAACGGTCTT TGGGCAGCCT 
CTTGATTTGC ATTATATGAA TAATGAGCTC TCCATCCTGT TGAAAAACCA AGATGATCTC 
GATAAAGCAA TTGACATTTT GGATAGAAGC GCGAGTATGA AAAGCCTTAG GATACTACTG 
TTATCCCAAG ACAGAAACCA TACTAGTTCC TCTCCCCACT CTGGAGTGTC CAGGCAGGTT 
CGGGTCAAGC CTTCCCAGTC TGCAGGGGAT ATAAATACCA TCTACCAAGC TCCTGAGCCC 
AGAAGCAGGC ACCTCTCTGT CAGCTCCCAG AACCCTGGCC GAAGCTCTCC TCCCCCTGGT 
TATGTACCTG AGCGACAACA GCACATTGCC CGGCAGGGAT CATATACGAG CATCAATAGT 
GAAGGTGAAT TCATCCCAGA GACCAGCGAG CAGTGCATGC TAGATCCCCT GAGCAGTGCC 
GAAAATTCCT TGTCAGGAAG CTGCCAATCC TTGGACAGGT CAGCAGACAG CCCATCTTTC 
AGGAAATCAC AAATGTCCCG AGCCCGGAGC TTCCCAGACA ACAGAAAGGA ATGCTCGGAT 
CGGGAGACCC AGCTCTATGA TAAAGGAGTT AAAGGCGGAA CCTATCCCAG GCGTTACCAT 
GTATCTGTGC ATCATAAAGA CTACAATGAT GGCAGAAGAA CGTTTCCCCG AATACGACGG 
CACCAGGGCA ACCTATTCAC TCTGGTGCCC TCAAGTCGCT CCTTGAGCAC AAATGGCGAG 
AACATGGGTG CCGCTGTGCA GTACTTGGAC CCCCGCGGGC GCCTACGGAG TGCAGACAGT 
GAAAATGCCC TCACTGTGCA GGAAAGAAGT GTGCCAACCA AGTCTCCTAG TGCTCCCATC 
AATTGGCGTC GGGGGAAGCT CCTGGGTCAA GGTGCCTTCG GCAGGGTCTA CTTATGCTAT 
GATGTGGACA CAGGACGTGA ACTTGCTTCT AAGCAGGTTC AGTTTGACCC AGATAGTCCT 
GAGACTAGCA AGGAGGTGAG TGCTCTGGAG TGCGAGATCC AGTTGCTGAA GAACTTGCAG 
CATGAGCGCA TCGTGCAGTA CTATGGCTGC CTGCGGGACC GTGCTGAGAA GATCCTCACC 
ATCTTTATGG AGTATATGCC AGGGGGCTCT GTAAAAGACC AGTTGAAGGC CTACGGAGCT 
CTGACGGAGA GTGTGACCCG CAAGTATACA CGGCAGATCC TGGAGGGCAT GTCCTACCTG 
CACAGCAACA TGATCGTGCA TCGTGACATC AAGGGAGCCA ATATCCTCCG AGACTCGGCT 
GGGAATGTGA AGCTTGGGGA TTTTGGGGCC AGCAAACGCC TGCAAACCAT CTGCATGTCA 
GGGACAGGCA TGCGCTCTGT CACTGGCACA CCCTACTGGA TGAGTCCTGA AGTCATCAGT 
GGCGAGGGCT ATGGAAGAAA GGCAGATGTG TGGAGCCTGG GCTGTACCGT GGTGGAGATG 
CTGACAGAGA AACCACCTTG GGCAGAGTAT GAAGCTATGG CTGCCATTTT CAAGATTGCC 
ACCCAGCCTA CCAATCCTCA GCTGCCCTCT CACATCTCAG AACACGGCAG GGACTTCCTG 
AGGCGCATAT TTGTGGAAGC TCGTCAGAGA CCCTCGGCTG AGGAGCTGCT CACACACCAC 
TTTGCACAGC TAGTGTACTG A