Cox7b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cox7b
Entrez Gene ID	303393
Full Name	cytochrome c oxidase subunit 7B
General protein information	Preferred Names cytochrome c oxidase subunit 7B Names cytochrome c oxidase subunit 7B, mitochondrial cytochrome c oxidase polypeptide VIIb cytochrome c oxidase subunit VIIb
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq22
Summary	human homolog is a nuclear encoded, probably regulatory, subunit for cytochrome c oxidase, which transfers electrons from cytochrome c to oxygen as the terminal component of the mitochondrial respiratory chain [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_182819.2	NP_877971.2	cytochrome c oxidase subunit 7B, mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	COX7B	NP_001857.1
Pan troglodytes (chimpanzee)	COX7B	XP_003954072.1
Bos taurus (cattle)	COX7B	NP_786989.3
Mus musculus (house mouse)	Cox7b	NP_079655.1
Xenopus tropicalis (tropical clawed frog)	cox7b	NP_001165069.1
	COX7B	XP_001100150.1
Rattus norvegicus (Norway rat)	Cox7b	NP_877971.2

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease.
Indrieri A, van Rahden VA, Tiranti V, Morleo M, Iaconis D, Tammaro R, D'Amato I, Conte I, Maystadt I, Demuth S, Zvulunov A, Kutsche K, Zeviani M, Franco B
American journal of human genetics91(5)942-9(2012 Nov)

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)

Cytochrome-c oxidase in developing rat heart. Enzymic properties and amino-terminal sequences suggest identity of the fetal heart and the adult liver isoform.
Sch?gger H, Noack H, Halangk W, Brandt U, von Jagow G
European journal of biochemistry230(1)235-41(1995 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cox7b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cox7b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12461	NM_182819.2 Latest version!	Rattus norvegicus cytochrome c oxidase subunit 7B (Cox7b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cox7b ( NM_182819.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_877971.2 Rattus norvegicus cytochrome c oxidase subunit 7B (Cox7b), mRNA.

Price & Availability↑

CloneID	ORa12461
Clone ID Related Accession (Same CDS sequence)	NM_182819.2
Accession Version	NM_182819.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	cytochrome c oxidase subunit 7B, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079123.1. On May 15, 2005 this sequence version replaced NM_182819.1. ##Evidence-Data-START## Transcript exon combination :: BC079123.1, FQ217570.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGTTGCCCT TGGCCAAAAA CGCACTAAGT CGTCTCCAAG TTCGAAGCAT TCAGCAAGTG 
GTGGCAAGGC AGAGCCATCA GAAGAAGACA CCTACTTTCC ATGACAAATA TGGAAATGCT 
GTATTAGCAG GTGGAAGCAT CTTCTGTATT TCTGCATGGA CATATACAGC CACACAAATT 
GGAATAGAAT GGAACCTGTC CCCTGTTGGC AGAGTCACCC CAAAGGAATG GAGAGATCAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_877971.2
CDS	63..305
Translation	MLPLAKNALSRLQVRSIQQVVARQSHQKKTPTFHDKYGNAVLAGGSIFCISAWTYTATQIGIEWNLSPVGRVTPKEWRDQ

Target ORF information:

RefSeq Version	NM_182819.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytochrome c oxidase subunit 7B (Cox7b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182819.2

ORF Insert Sequence:

ATGTTGCCCT TGGCCAAAAA CGCACTAAGT CGTCTCCAAG TTCGAAGCAT TCAGCAAGTG 
GTGGCAAGGC AGAGCCATCA GAAGAAGACA CCTACTTTCC ATGACAAATA TGGAAATGCT 
GTATTAGCAG GTGGAAGCAT CTTCTGTATT TCTGCATGGA CATATACAGC CACACAAATT 
GGAATAGAAT GGAACCTGTC CCCTGTTGGC AGAGTCACCC CAAAGGAATG GAGAGATCAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease.
American journal of human genetics91(5)942-9(2012 Nov)
Indrieri A,van Rahden VA,Tiranti V,Morleo M,Iaconis D,Tammaro R,D'Amato I,Conte I,Maystadt I,Demuth S,Zvulunov A,Kutsche K,Zeviani M,Franco B

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Cell115(5)629-40(2003 Nov)
Mootha VK,Bunkenborg J,Olsen JV,Hjerrild M,Wisniewski JR,Stahl E,Bolouri MS,Ray HN,Sihag S,Kamal M,Patterson N,Lander ES,Mann M

Cytochrome-c oxidase in developing rat heart. Enzymic properties and amino-terminal sequences suggest identity of the fetal heart and the adult liver isoform.
European journal of biochemistry230(1)235-41(1995 May)
Sch?gger H,Noack H,Halangk W,Brandt U,von Jagow G