Apopt1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Apopt1
Entrez Gene ID	299341
Full Name	apoptogenic 1, mitochondrial
Synonyms	APOP-1,Apop1,RGD1304719
General protein information	Preferred Names apoptogenic 1, mitochondrial Names apoptogenic protein 1, mitochondrial UPF0671 protein C14orf153 homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037769.2	NP_001032858.1	cytochrome c oxidase assembly factor 8
XM_017594513.1	XP_017450002.1	apoptogenic protein 1, mitochondrial isoform X1
XM_017603300.1	XP_017458789.1	apoptogenic protein 1, mitochondrial isoform X2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	APOPT1	XP_003435153.2
Homo sapiens (human)	APOPT1	NP_115750.2
Bos taurus (cattle)	APOPT1	NP_001069927.1
Mus musculus (house mouse)	Apopt1	NP_080787.1
Xenopus tropicalis (tropical clawed frog)	apopt1	XP_004917236.1
Danio rerio (zebrafish)	apopt1	NP_001139091.1
Rattus norvegicus (Norway rat)	Apopt1	NP_001032858.1
	C14orf153	XP_001084683.2
Gallus gallus (chicken)	APOPT1	XP_421388.2

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in APOPT1, encoding a mitochondrial protein, cause cavitating leukoencephalopathy with cytochrome c oxidase deficiency.
Melchionda L, Haack TB, Hardy S, Abbink TE, Fernandez-Vizarra E, Lamantea E, Marchet S, Morandi L, Moggio M, Carrozzo R, Torraco A, Diodato D, Strom TM, Meitinger T, Tekturk P, Yapici Z, Al-Murshedi F, Stevens R, Rodenburg RJ, Lamperti C, Ardissone A, Moroni I, Uziel G, Prokisch H, Taylor RW, Bertini E, van der Knaap MS, Ghezzi D, Zeviani M
American journal of human genetics95(3)315-25(2014 Sep)

Akt activation prevents Apop-1-induced death of cells.
Sun X, Yasuda O, Takemura Y, Kawamoto H, Higuchi M, Baba Y, Katsuya T, Fukuo K, Ogihara T, Rakugi H
Biochemical and biophysical research communications377(4)1097-101(2008 Dec)

Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis.
Yasuda O, Fukuo K, Sun X, Nishitani M, Yotsui T, Higuchi M, Suzuki T, Rakugi H, Smithies O, Maeda N, Ogihara T
The Journal of biological chemistry281(33)23899-907(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Apopt1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apopt1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa12217	NM_001037769.2 Latest version!	Rattus norvegicus cytochrome c oxidase assembly factor 8 (Coa8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa12217	XM_017594513.1 Latest version!	Rattus norvegicus apoptogenic 1, mitochondrial (Apopt1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa12217	XM_017603300.1 Latest version!	Rattus norvegicus apoptogenic 1, mitochondrial (Apopt1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Apopt1 ( NM_001037769.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001032858.1 Rattus norvegicus cytochrome c oxidase assembly factor 8 (Coa8), mRNA.

Price & Availability↑

CloneID	ORa12217
Clone ID Related Accession (Same CDS sequence)	NM_001037769.2 , XM_017594513.1 , XM_017603300.1
Accession Version	NM_001037769.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	cytochrome c oxidase assembly factor 8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07065593.1, BC107661.1 and AABR07065594.1. On or before Sep 4, 2014 this sequence version replaced XM_008764981.1, NM_001037769.1. ##Evidence-Data-START## Transcript exon combination :: BC107661.1, EV775771.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCTT TGCGGCCCGG AAGCAAAGCT CTTCGCCGGC TGCTCTGCCG GTCCTTCTCC 
GGCGGCGGCG TTCGGCTGGC CCGTGAGCGC GCTACGGAGC GCAGGGATGC TGCGTCCAGC 
CGGGTCTCAA GATTCTGCCC TCCGAGACAG TCTTGCCATG ATTGGATAGG CCCCCCAGAC 
AAATACTCCA ACCTTCGTCC TGTTCATTTT CATGTCCCTG AAAATGAGTC TCCTTTGGAG 
CAAAGGCTTA GGGAATTGAG GCAAGAAACG CAGGAATGGA ATCAGCAGTT CTGGGCCAAG 
CAGAATCTGT CCTTTAATAA GGAAAAGGAA GAGTTCATTT ACTCAAGGCT ACAAGCTAAA 
GGCTCAGGCC CGCGAACCGA GTCAGGCCAA AGAGCAACGC TGGATGCCGA GGAGATGGCT 
GACTTCTATA AGGACTTTCT GAGCAAGAAT TTCCAGAAGC ACATGTGCTA TAACCGAGAC 
TGGTACAAGC GCAATTTTGC CATCACTTTC TTCATGGGGA AGGTGGCCCT GGAGAGGATG 
TGGAGCAAGC TGAAGCAGAA GCCAAAGAAG ACAAGCGGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032858.1
CDS	14..595
Translation	MAALRPGSKALRRLLCRSFSGGGVRLARERATERRDAASSRVSRFCPPRQSCHDWIGPPDKYSNLRPVHFHVPENESPLEQRLRELRQETQEWNQQFWAKQNLSFNKEKEEFIYSRLQAKGSGPRTESGQRATLDAEEMADFYKDFLSKNFQKHMCYNRDWYKRNFAITFFMGKVALERMWSKLKQKPKKTSG

Target ORF information:

RefSeq Version	NM_001037769.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytochrome c oxidase assembly factor 8 (Coa8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037769.2

ORF Insert Sequence:

ATGGCGGCTT TGCGGCCCGG AAGCAAAGCT CTTCGCCGGC TGCTCTGCCG GTCCTTCTCC 
GGCGGCGGCG TTCGGCTGGC CCGTGAGCGC GCTACGGAGC GCAGGGATGC TGCGTCCAGC 
CGGGTCTCAA GATTCTGCCC TCCGAGACAG TCTTGCCATG ATTGGATAGG CCCCCCAGAC 
AAATACTCCA ACCTTCGTCC TGTTCATTTT CATGTCCCTG AAAATGAGTC TCCTTTGGAG 
CAAAGGCTTA GGGAATTGAG GCAAGAAACG CAGGAATGGA ATCAGCAGTT CTGGGCCAAG 
CAGAATCTGT CCTTTAATAA GGAAAAGGAA GAGTTCATTT ACTCAAGGCT ACAAGCTAAA 
GGCTCAGGCC CGCGAACCGA GTCAGGCCAA AGAGCAACGC TGGATGCCGA GGAGATGGCT 
GACTTCTATA AGGACTTTCT GAGCAAGAAT TTCCAGAAGC ACATGTGCTA TAACCGAGAC 
TGGTACAAGC GCAATTTTGC CATCACTTTC TTCATGGGGA AGGTGGCCCT GGAGAGGATG 
TGGAGCAAGC TGAAGCAGAA GCCAAAGAAG ACAAGCGGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Apopt1 ( XM_017594513.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017450002.1 Rattus norvegicus apoptogenic 1, mitochondrial (Apopt1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa12217
Clone ID Related Accession (Same CDS sequence)	NM_001037769.2 , XM_017594513.1 , XM_017603300.1
Accession Version	XM_017594513.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	apoptogenic protein 1, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCTT TGCGGCCCGG AAGCAAAGCT CTTCGCCGGC TGCTCTGCCG GTCCTTCTCC 
GGCGGCGGCG TTCGGCTGGC CCGTGAGCGC GCTACGGAGC GCAGGGATGC TGCGTCCAGC 
CGGGTCTCAA GATTCTGCCC TCCGAGACAG TCTTGCCATG ATTGGATAGG CCCCCCAGAC 
AAATACTCCA ACCTTCGTCC TGTTCATTTT CATGTCCCTG AAAATGAGTC TCCTTTGGAG 
CAAAGGCTTA GGGAATTGAG GCAAGAAACG CAGGAATGGA ATCAGCAGTT CTGGGCCAAG 
CAGAATCTGT CCTTTAATAA GGAAAAGGAA GAGTTCATTT ACTCAAGGCT ACAAGCTAAA 
GGCTCAGGCC CGCGAACCGA GTCAGGCCAA AGAGCAACGC TGGATGCCGA GGAGATGGCT 
GACTTCTATA AGGACTTTCT GAGCAAGAAT TTCCAGAAGC ACATGTGCTA TAACCGAGAC 
TGGTACAAGC GCAATTTTGC CATCACTTTC TTCATGGGGA AGGTGGCCCT GGAGAGGATG 
TGGAGCAAGC TGAAGCAGAA GCCAAAGAAG ACAAGCGGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017450002.1
CDS	21..602
Translation	MAALRPGSKALRRLLCRSFSGGGVRLARERATERRDAASSRVSRFCPPRQSCHDWIGPPDKYSNLRPVHFHVPENESPLEQRLRELRQETQEWNQQFWAKQNLSFNKEKEEFIYSRLQAKGSGPRTESGQRATLDAEEMADFYKDFLSKNFQKHMCYNRDWYKRNFAITFFMGKVALERMWSKLKQKPKKTSG

Target ORF information:

RefSeq Version	XM_017594513.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus apoptogenic 1, mitochondrial (Apopt1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017594513.1

ORF Insert Sequence:

ATGGCGGCTT TGCGGCCCGG AAGCAAAGCT CTTCGCCGGC TGCTCTGCCG GTCCTTCTCC 
GGCGGCGGCG TTCGGCTGGC CCGTGAGCGC GCTACGGAGC GCAGGGATGC TGCGTCCAGC 
CGGGTCTCAA GATTCTGCCC TCCGAGACAG TCTTGCCATG ATTGGATAGG CCCCCCAGAC 
AAATACTCCA ACCTTCGTCC TGTTCATTTT CATGTCCCTG AAAATGAGTC TCCTTTGGAG 
CAAAGGCTTA GGGAATTGAG GCAAGAAACG CAGGAATGGA ATCAGCAGTT CTGGGCCAAG 
CAGAATCTGT CCTTTAATAA GGAAAAGGAA GAGTTCATTT ACTCAAGGCT ACAAGCTAAA 
GGCTCAGGCC CGCGAACCGA GTCAGGCCAA AGAGCAACGC TGGATGCCGA GGAGATGGCT 
GACTTCTATA AGGACTTTCT GAGCAAGAAT TTCCAGAAGC ACATGTGCTA TAACCGAGAC 
TGGTACAAGC GCAATTTTGC CATCACTTTC TTCATGGGGA AGGTGGCCCT GGAGAGGATG 
TGGAGCAAGC TGAAGCAGAA GCCAAAGAAG ACAAGCGGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Apopt1 ( XM_017603300.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017458789.1 Rattus norvegicus apoptogenic 1, mitochondrial (Apopt1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa12217
Clone ID Related Accession (Same CDS sequence)	NM_001037769.2 , XM_017594513.1 , XM_017603300.1
Accession Version	XM_017603300.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	apoptogenic protein 1, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (AC_000074.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCTT TGCGGCCCGG AAGCAAAGCT CTTCGCCGGC TGCTCTGCCG GTCCTTCTCC 
GGCGGCGGCG TTCGGCTGGC CCGTGAGCGC GCTACGGAGC GCAGGGATGC TGCGTCCAGC 
CGGGTCTCAA GATTCTGCCC TCCGAGACAG TCTTGCCATG ATTGGATAGG CCCCCCAGAC 
AAATACTCCA ACCTTCGTCC TGTTCATTTT CATGTCCCTG AAAATGAGTC TCCTTTGGAG 
CAAAGGCTTA GGGAATTGAG GCAAGAAACG CAGGAATGGA ATCAGCAGTT CTGGGCCAAG 
CAGAATCTGT CCTTTAATAA GGAAAAGGAA GAGTTCATTT ACTCAAGGCT ACAAGCTAAA 
GGCTCAGGCC CGCGAACCGA GTCAGGCCAA AGAGCAACGC TGGATGCCGA GGAGATGGCT 
GACTTCTATA AGGACTTTCT GAGCAAGAAT TTCCAGAAGC ACATGTGCTA TAACCGAGAC 
TGGTACAAGC GCAATTTTGC CATCACTTTC TTCATGGGGA AGGTGGCCCT GGAGAGGATG 
TGGAGCAAGC TGAAGCAGAA GCCAAAGAAG ACAAGCGGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017458789.1
CDS	233..814
Translation	MAALRPGSKALRRLLCRSFSGGGVRLARERATERRDAASSRVSRFCPPRQSCHDWIGPPDKYSNLRPVHFHVPENESPLEQRLRELRQETQEWNQQFWAKQNLSFNKEKEEFIYSRLQAKGSGPRTESGQRATLDAEEMADFYKDFLSKNFQKHMCYNRDWYKRNFAITFFMGKVALERMWSKLKQKPKKTSG

Target ORF information:

RefSeq Version	XM_017603300.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus apoptogenic 1, mitochondrial (Apopt1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017603300.1

ORF Insert Sequence:

ATGGCGGCTT TGCGGCCCGG AAGCAAAGCT CTTCGCCGGC TGCTCTGCCG GTCCTTCTCC 
GGCGGCGGCG TTCGGCTGGC CCGTGAGCGC GCTACGGAGC GCAGGGATGC TGCGTCCAGC 
CGGGTCTCAA GATTCTGCCC TCCGAGACAG TCTTGCCATG ATTGGATAGG CCCCCCAGAC 
AAATACTCCA ACCTTCGTCC TGTTCATTTT CATGTCCCTG AAAATGAGTC TCCTTTGGAG 
CAAAGGCTTA GGGAATTGAG GCAAGAAACG CAGGAATGGA ATCAGCAGTT CTGGGCCAAG 
CAGAATCTGT CCTTTAATAA GGAAAAGGAA GAGTTCATTT ACTCAAGGCT ACAAGCTAAA 
GGCTCAGGCC CGCGAACCGA GTCAGGCCAA AGAGCAACGC TGGATGCCGA GGAGATGGCT 
GACTTCTATA AGGACTTTCT GAGCAAGAAT TTCCAGAAGC ACATGTGCTA TAACCGAGAC 
TGGTACAAGC GCAATTTTGC CATCACTTTC TTCATGGGGA AGGTGGCCCT GGAGAGGATG 
TGGAGCAAGC TGAAGCAGAA GCCAAAGAAG ACAAGCGGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in APOPT1, encoding a mitochondrial protein, cause cavitating leukoencephalopathy with cytochrome c oxidase deficiency.
American journal of human genetics95(3)315-25(2014 Sep)
Melchionda L,Haack TB,Hardy S,Abbink TE,Fernandez-Vizarra E,Lamantea E,Marchet S,Morandi L,Moggio M,Carrozzo R,Torraco A,Diodato D,Strom TM,Meitinger T,Tekturk P,Yapici Z,Al-Murshedi F,Stevens R,Rodenburg RJ,Lamperti C,Ardissone A,Moroni I,Uziel G,Prokisch H,Taylor RW,Bertini E,van der Knaap MS,Ghezzi D,Zeviani M

Akt activation prevents Apop-1-induced death of cells.
Biochemical and biophysical research communications377(4)1097-101(2008 Dec)
Sun X,Yasuda O,Takemura Y,Kawamoto H,Higuchi M,Baba Y,Katsuya T,Fukuo K,Ogihara T,Rakugi H

Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis.
The Journal of biological chemistry281(33)23899-907(2006 Aug)
Yasuda O,Fukuo K,Sun X,Nishitani M,Yotsui T,Higuchi M,Suzuki T,Rakugi H,Smithies O,Maeda N,Ogihara T

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Apopt1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

見積依頼

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電話

FAX

オンラインフォーム