Apcs cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Apcs
Entrez Gene ID	29339
Full Name	amyloid P component, serum
Synonyms	Sap
General protein information	Preferred Names amyloid P component, serum Names serum amyloid P-component
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q24
Summary	a component of amyloid P [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017170.2	NP_058866.2	serum amyloid P-component precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	APCS	XP_513916.2
Mus musculus (house mouse)	Apcs	NP_035448.2
Rattus norvegicus (Norway rat)	Apcs	NP_058866.2
Homo sapiens (human)	APCS	NP_001630.1
	LOC719421	XP_001117234.1
Bos taurus (cattle)	APCS	NP_001029638.1

Gene Ontology
Bibliography

Related articles in PubMed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M
Circulation134(11)817-32(2016 Sep)

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes.
Hall Z, Hern?ndez H, Marsh JA, Teichmann SA, Robinson CV
Structure (London, England : 1993)21(8)1325-37(2013 Aug)

Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses.
Job ER, Bottazzi B, Gilbertson B, Edenborough KM, Brown LE, Mantovani A, Brooks AG, Reading PC
PloS one8(3)e59623(2013)

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Bastos-Amador P, Royo F, Gonzalez E, Conde-Vancells J, Palomo-Diez L, Borras FE, Falcon-Perez JM
Journal of proteomics75(12)3574-84(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Glycosaminoglycans interfere with the binding site on beta-amyloid for serum amyloid P component and C1q, and might have therapeutical potential on neurodegeneration
Title: Glycosaminoglycans inhibit neurodegenerative effects of serum amyloid P component in vitro.

Serum Amyloid P-Component plays an important role in the pathomechanism of neurodegenerative diseases, including Alzheimer's disease by inducing neuronal apoptosis.
Title: Serum amyloid P component induces neuronal apoptosis and beta-amyloid immunoreactivity.

The following Apcs gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apcs cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03103	NM_017170.2 Latest version!	Rattus norvegicus amyloid P component, serum (Apcs), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Apcs ( NM_017170.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058866.2 Rattus norvegicus amyloid P component, serum (Apcs), mRNA.

Price & Availability↑

CloneID	ORa03103
Clone ID Related Accession (Same CDS sequence)	NM_017170.2
Accession Version	NM_017170.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Rattus norvegicus(Norway rat)
Product	serum amyloid P-component precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M83177.1. On Jun 10, 2007 this sequence version replaced NM_017170.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M83177.1, FQ218451.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906355, SAMN01906356 [ECO:0000348] ##Evidence-Data-END##

ATGGACAAGC TGCTGCTTTG GATGTCTGTC TTCACCAGCC TTCTTTCAGA AGCCTTTGCT 
CAGACAGACC TCAATCAGAA GGTATTTGTG TTCCCCAGAG AATCTGAAAC TGATTATGTG 
AAGCTGATCC CATGGCTAGA AAAACCGCTG CAGAATTTTA CACTGTGTTT CCGAGCCTAC 
AGTGACCTTT CCCGCTCTCA GAGTCTTTTC TCCTACAGTG TCAACAGCAG AGACAATGAG 
CTACTAATTT ATAAAGACAA AGTTGGACAA TATAGCCTAT ACATTGGAAA TTCAAAAGTC 
ACAGTCCGTG GTTTAGAAGA ATTCCCTTCT CCAATACATT TCTGTACCAG CTGGGAGTCC 
TCCTCTGGTA TTGCTGAATT TTGGGTCAAT GGAAAGCCTT GGGTAAAAAA GGGTTTGCAG 
AAGGGATACA CTGTGAAATC CTCACCCAGT ATTGTCCTGG GACAGGAGCA GGATACGTAT 
GGAGGAGGGT TTGATAAGAC ACAGTCCTTT GTGGGAGAGA TTGCAGATTT GTACATGTGG 
GACAGTGTGC TGACCCCAGA GAACATTCAT TCTGTGGACA GAGGTTTCCC ACCCAATCCT 
AATATTTTGG ATTGGCGGGC CCTGAATTAT GAAATAAATG GTTATGTAGT CATCAAGCCC 
CGTATGTGGG ACAACAAAAG CTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058866.2
CDS	1..687
Translation	MDKLLLWMSVFTSLLSEAFAQTDLNQKVFVFPRESETDYVKLIPWLEKPLQNFTLCFRAYSDLSRSQSLFSYSVNSRDNELLIYKDKVGQYSLYIGNSKVTVRGLEEFPSPIHFCTSWESSSGIAEFWVNGKPWVKKGLQKGYTVKSSPSIVLGQEQDTYGGGFDKTQSFVGEIADLYMWDSVLTPENIHSVDRGFPPNPNILDWRALNYEINGYVVIKPRMWDNKSS

Target ORF information:

RefSeq Version	NM_017170.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus amyloid P component, serum (Apcs), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017170.2

ORF Insert Sequence:

ATGGACAAGC TGCTGCTTTG GATGTCTGTC TTCACCAGCC TTCTTTCAGA AGCCTTTGCT 
CAGACAGACC TCAATCAGAA GGTATTTGTG TTCCCCAGAG AATCTGAAAC TGATTATGTG 
AAGCTGATCC CATGGCTAGA AAAACCGCTG CAGAATTTTA CACTGTGTTT CCGAGCCTAC 
AGTGACCTTT CCCGCTCTCA GAGTCTTTTC TCCTACAGTG TCAACAGCAG AGACAATGAG 
CTACTAATTT ATAAAGACAA AGTTGGACAA TATAGCCTAT ACATTGGAAA TTCAAAAGTC 
ACAGTCCGTG GTTTAGAAGA ATTCCCTTCT CCAATACATT TCTGTACCAG CTGGGAGTCC 
TCCTCTGGTA TTGCTGAATT TTGGGTCAAT GGAAAGCCTT GGGTAAAAAA GGGTTTGCAG 
AAGGGATACA CTGTGAAATC CTCACCCAGT ATTGTCCTGG GACAGGAGCA GGATACGTAT 
GGAGGAGGGT TTGATAAGAC ACAGTCCTTT GTGGGAGAGA TTGCAGATTT GTACATGTGG 
GACAGTGTGC TGACCCCAGA GAACATTCAT TCTGTGGACA GAGGTTTCCC ACCCAATCCT 
AATATTTTGG ATTGGCGGGC CCTGAATTAT GAAATAAATG GTTATGTAGT CATCAAGCCC 
CGTATGTGGG ACAACAAAAG CTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Circulation134(11)817-32(2016 Sep)
Barallobre-Barreiro J,Gupta SK,Zoccarato A,Kitazume-Taneike R,Fava M,Yin X,Werner T,Hirt MN,Zampetaki A,Viviano A,Chong M,Bern M,Kourliouros A,Domenech N,Willeit P,Shah AM,Jahangiri M,Schaefer L,Fischer JW,Iozzo RV,Viner R,Thum T,Heineke J,Kichler A,Otsu K,Mayr M

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes.
Structure (London, England : 1993)21(8)1325-37(2013 Aug)
Hall Z,Hern?ndez H,Marsh JA,Teichmann SA,Robinson CV

Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses.
PloS one8(3)e59623(2013)
Job ER,Bottazzi B,Gilbertson B,Edenborough KM,Brown LE,Mantovani A,Brooks AG,Reading PC

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Journal of proteomics75(12)3574-84(2012 Jun)
Bastos-Amador P,Royo F,Gonzalez E,Conde-Vancells J,Palomo-Diez L,Borras FE,Falcon-Perez JM