Blvrb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Blvrb
Entrez Gene ID	292737
Full Name	biliverdin reductase B
General protein information	Preferred Names biliverdin reductase B Names flavin reductase (NADPH) NADPH-dependent diaphorase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001106236.1	NP_001099706.1	flavin reductase (NADPH)
XM_008759117.1	XP_008757339.1	flavin reductase (NADPH) isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	BLVRB	NP_000704.1
Pan troglodytes (chimpanzee)	BLVRB	XP_512666.3
Danio rerio (zebrafish)	blvrb	NP_001002686.1
Bos taurus (cattle)	BLVRB	NP_776676.1
Rattus norvegicus (Norway rat)	Blvrb	NP_001099706.1
Drosophila melanogaster (fruit fly)	CG9471	NP_649943.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001321	XP_321824.3
Mus musculus (house mouse)	Blvrb	NP_659172.1
Xenopus tropicalis (tropical clawed frog)	blvrb	NP_001096269.1
	BLVRB	XP_001091330.1
Canis lupus familiaris (dog)	BLVRB	XP_533666.2

Gene Ontology
Bibliography

Related articles in PubMed

The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters ?-adrenergic receptor ligand-mediated cardiac dysfunction.
Ding B, Gibbs PE, Brookes PS, Maines MD
FASEB journal : official publication of the Federation of American Societies for Experimental Biology25(1)301-13(2011 Jan)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme.
Pereira PJ, Macedo-Ribeiro S, P?rraga A, P?rez-Luque R, Cunningham O, Darcy K, Mantle TJ, Coll M
Nature structural biology8(3)215-20(2001 Mar)

Nitric oxide synthase localized in a subpopulation of vestibular efferents with NADPH diaphorase histochemistry and nitric oxide synthase immunohistochemistry.
Lysakowski A, Singer M
The Journal of comparative neurology427(4)508-21(2000 Nov)

Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization.
Yamaguchi T, Komoda Y, Nakajima H
The Journal of biological chemistry269(39)24343-8(1994 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that siRNA blockage of BVR protein expression in cardiomyocytes inhibits HO-2 protein induction but not vice versa.
Title: The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters ?-adrenergic receptor ligand-mediated cardiac dysfunction.

The following Blvrb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Blvrb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00502	NM_001106236.1 Latest version!	Rattus norvegicus biliverdin reductase B (Blvrb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa45057	XM_008759117.1 Latest version!	Rattus norvegicus biliverdin reductase B (Blvrb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Blvrb ( NM_001106236.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099706.1 Rattus norvegicus biliverdin reductase B (Blvrb), mRNA.

Price & Availability↑

CloneID	ORa00502
Clone ID Related Accession (Same CDS sequence)	NM_001106236.1
Accession Version	NM_001106236.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	flavin reductase (NADPH)
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473979.2. On or before Oct 4, 2007 this sequence version replaced XM_001072142.1, XM_214823.4. ##Evidence-Data-START## Transcript exon combination :: FQ230737.1, FQ232598.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGTCA AGAAGATCGC GATCTTCGGT GCCACCGGAA GGACCGGGCT CACCACACTG 
GCGCAGGCGG TGCAAGCAGG TTACGAGGTG ACGGTGCTGG TTCGAGATTC CAGCAGGTTA 
CCGTCAGAGG GGCCCCAGCC AGCCCACGTG GTGGTGGGAG ATGTTCTGCA GGCGGGCGAT 
GTGGACAAGA CTGTGGCTGG ACAGGATGCC GTCATCGTGC TACTGGGCAC TGGCAACGAC 
CTCAGTCCTA CTACAGTAAT GTCCGAGGGC ACCCGGAACA TTGTGGCAGC CATGAAGGCA 
CATGGAGTGG ACAAGGTCGT GGCCTGCACC TCGGCCTTCC TACTCTGGGA CCCGAGCAAG 
GTGCCCCCTC GCCTACAGGA CGTGACCGAT GACCACATCC GGATGCATAA GATTCTGGAG 
GAGTCAGGAC TGAAGTACGT GGCTGTAATG CCCCCACACA TTGGGGACCA ACCACTAACC 
GGGGCCTACA CAGTGACCCT GGATGGACGA GGGCCCTCGA GGGTCATATC CAAGCATGAT 
CTGGGTCACT TCATGCTACG GTGCCTCACC ACCCATGAGT ATGACGGACA GAAGACCTAC 
CCTTCCCACC AGTATGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099706.1
CDS	144..764
Translation	MAVKKIAIFGATGRTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPQPAHVVVGDVLQAGDVDKTVAGQDAVIVLLGTGNDLSPTTVMSEGTRNIVAAMKAHGVDKVVACTSAFLLWDPSKVPPRLQDVTDDHIRMHKILEESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTHEYDGQKTYPSHQYD

Target ORF information:

RefSeq Version	NM_001106236.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus biliverdin reductase B (Blvrb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106236.1

ORF Insert Sequence:

ATGGCTGTCA AGAAGATCGC GATCTTCGGT GCCACCGGAA GGACCGGGCT CACCACACTG 
GCGCAGGCGG TGCAAGCAGG TTACGAGGTG ACGGTGCTGG TTCGAGATTC CAGCAGGTTA 
CCGTCAGAGG GGCCCCAGCC AGCCCACGTG GTGGTGGGAG ATGTTCTGCA GGCGGGCGAT 
GTGGACAAGA CTGTGGCTGG ACAGGATGCC GTCATCGTGC TACTGGGCAC TGGCAACGAC 
CTCAGTCCTA CTACAGTAAT GTCCGAGGGC ACCCGGAACA TTGTGGCAGC CATGAAGGCA 
CATGGAGTGG ACAAGGTCGT GGCCTGCACC TCGGCCTTCC TACTCTGGGA CCCGAGCAAG 
GTGCCCCCTC GCCTACAGGA CGTGACCGAT GACCACATCC GGATGCATAA GATTCTGGAG 
GAGTCAGGAC TGAAGTACGT GGCTGTAATG CCCCCACACA TTGGGGACCA ACCACTAACC 
GGGGCCTACA CAGTGACCCT GGATGGACGA GGGCCCTCGA GGGTCATATC CAAGCATGAT 
CTGGGTCACT TCATGCTACG GTGCCTCACC ACCCATGAGT ATGACGGACA GAAGACCTAC 
CCTTCCCACC AGTATGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Blvrb ( XM_008759117.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757339.1 Rattus norvegicus biliverdin reductase B (Blvrb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa45057
Clone ID Related Accession (Same CDS sequence)	XM_008759117.1
Accession Version	XM_008759117.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	flavin reductase (NADPH) isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCGAGG GCACCCGGAA CATTGTGGCA GCCATGAAGG CACATGGAGT GGACAAGGTC 
GTGGCCTGCA CCTCGGCCTT CCTACTCTGG GACCCGAGCA AGGTGCCCCC TCGCCTACAG 
GACGTGACCG ATGACCACAT CCGGATGCAT AAGATTCTGG AGGAGTCAGG ACTGAAGTAC 
GTGGCTGTAA TGCCCCCACA CATTGGGGAC CAACCACTAA CCGGGGCCTA CACAGTGACC 
CTGGATGGAC GAGGGCCCTC GAGGGTCATA TCCAAGCATG ATCTGGGTCA CTTCATGCTA 
CGGTGCCTCA CCACCCATGA GTATGACGGA CAGAAGACCT ACCCTTCCCA CCAGTATGAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757339.1
CDS	323..685
Translation	MSEGTRNIVAAMKAHGVDKVVACTSAFLLWDPSKVPPRLQDVTDDHIRMHKILEESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTHEYDGQKTYPSHQYD

Target ORF information:

RefSeq Version	XM_008759117.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus biliverdin reductase B (Blvrb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008759117.1

ORF Insert Sequence:

ATGTCCGAGG GCACCCGGAA CATTGTGGCA GCCATGAAGG CACATGGAGT GGACAAGGTC 
GTGGCCTGCA CCTCGGCCTT CCTACTCTGG GACCCGAGCA AGGTGCCCCC TCGCCTACAG 
GACGTGACCG ATGACCACAT CCGGATGCAT AAGATTCTGG AGGAGTCAGG ACTGAAGTAC 
GTGGCTGTAA TGCCCCCACA CATTGGGGAC CAACCACTAA CCGGGGCCTA CACAGTGACC 
CTGGATGGAC GAGGGCCCTC GAGGGTCATA TCCAAGCATG ATCTGGGTCA CTTCATGCTA 
CGGTGCCTCA CCACCCATGA GTATGACGGA CAGAAGACCT ACCCTTCCCA CCAGTATGAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters ?-adrenergic receptor ligand-mediated cardiac dysfunction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology25(1)301-13(2011 Jan)
Ding B,Gibbs PE,Brookes PS,Maines MD

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme.
Nature structural biology8(3)215-20(2001 Mar)
Pereira PJ,Macedo-Ribeiro S,P?rraga A,P?rez-Luque R,Cunningham O,Darcy K,Mantle TJ,Coll M

Nitric oxide synthase localized in a subpopulation of vestibular efferents with NADPH diaphorase histochemistry and nitric oxide synthase immunohistochemistry.
The Journal of comparative neurology427(4)508-21(2000 Nov)
Lysakowski A,Singer M

Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization.
The Journal of biological chemistry269(39)24343-8(1994 Sep)
Yamaguchi T,Komoda Y,Nakajima H