Ubd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ubd
Entrez Gene ID	29168
Full Name	ubiquitin D
General protein information	Preferred Names ubiquitin D Names ubiquitin D diubiquitin ubiquitin-like protein FAT10
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	human homolog is a diubiquitin protein that may function in antigen processing and presentation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053299.2	NP_445751.2	ubiquitin D

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC504548	XP_002697423.1
Mus musculus (house mouse)	Ubd	NP_075626.1
Rattus norvegicus (Norway rat)	Ubd	NP_445751.2
Pan troglodytes (chimpanzee)	UBD	XP_527322.2
	UBD	XP_001102785.1
Bos taurus (cattle)	UBD	NP_001193402.1
Canis lupus familiaris (dog)	LOC100687262	XP_003434230.1
Homo sapiens (human)	UBD	NP_006389.2

Gene Ontology
Bibliography

Related articles in PubMed

Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats.
Cort L, Habib M, Eberwine RA, Hessner MJ, Mordes JP, Blankenhorn EP
Genes and immunity15(3)168-75(2014 Apr-May)

FAT10 protects cardiac myocytes against apoptosis.
Peng X, Shao J, Shen Y, Zhou Y, Cao Q, Hu J, He W, Yu X, Liu X, Marian AJ, Hong K
Journal of molecular and cellular cardiology591-10(2013 Jun)

Transcriptional microarray analysis reveals suppression of histamine signaling by Kujin alleviates allergic symptoms through down-regulation of FAT10 expression.
Dev S, Mizuguchi H, Das AK, Baba Y, Fukui H
International immunopharmacology11(10)1504-9(2011 Oct)

The ubiquitin-like protein FAT10 mediates NF-kappaB activation.
Gong P, Canaan A, Wang B, Leventhal J, Snyder A, Nair V, Cohen CD, Kretzler M, D'Agati V, Weissman S, Ross MJ
Journal of the American Society of Nephrology : JASN21(2)316-26(2010 Feb)

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.
Kalveram B, Schmidtke G, Groettrup M
Journal of cell science121(Pt 24)4079-88(2008 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data prove that Ubd is a diabetes susceptibility gene, providing insight into the interplay of multiple genes and environmental factors in T1D susceptibility.
Title: Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats.

FAT10 protects cardiac myocytes against apoptosis.
Title: FAT10 protects cardiac myocytes against apoptosis.

down-regulation of expression alleviates allergic symptoms
Title: Transcriptional microarray analysis reveals suppression of histamine signaling by Kujin alleviates allergic symptoms through down-regulation of FAT10 expression.

The following Ubd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ubd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09211	NM_053299.2 Latest version!	Rattus norvegicus ubiquitin D (Ubd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ubd ( NM_053299.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445751.2 Rattus norvegicus ubiquitin D (Ubd), mRNA.

Price & Availability↑

CloneID	ORa09211
Clone ID Related Accession (Same CDS sequence)	NM_053299.2
Accession Version	NM_053299.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Rattus norvegicus(Norway rat)
Product	ubiquitin D
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX883052.1. On Dec 3, 2009 this sequence version replaced NM_053299.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ312394.1, FM052813.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689596 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCCT GCGTCTGTGT TGTCCATTCG GAGCAATGGC CATTAATGAC CTTTGACACC 
ACCATGAGTG ACAAAGTGAA GAAAATCAAT GAGCATATTA GGTCCCAAAC CAAGGTCTCT 
GTGCAGGACC AGATCCTTCT GCTAGACTCC AAGATCCTCA AGCCCCATAG AGCGTTGTCA 
TCTTATGGGA TCGACAAGGA AAACACTATC CACCTCACCC TAAAGGTGGT GAAGCCCAGT 
GATGAAGAGC TGCCCTTGTC TCTGGTGGAG TCGGGCGACG AGGGGCAAAG GCACCTCCTT 
CGAGTTCGAA GATCCAGCTC CGTGGCCCAG GTGAAGGAAA TGATCGAGAA TGTGACTGCT 
GTGCCTCCCA AGAAGCAGTT CGTGAATTGC AATGGAAAGA GGCTGGAAGA TGGAAAGATC 
ATGGCCGACT ACAACATCAA GAGTGGTAGT TTGCTCTTTC TCACAGCGCA CTGCATTGGG 
GGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445751.2
CDS	61..546
Translation	MASCVCVVHSEQWPLMTFDTTMSDKVKKINEHIRSQTKVSVQDQILLLDSKILKPHRALSSYGIDKENTIHLTLKVVKPSDEELPLSLVESGDEGQRHLLRVRRSSSVAQVKEMIENVTAVPPKKQFVNCNGKRLEDGKIMADYNIKSGSLLFLTAHCIGG

Target ORF information:

RefSeq Version	NM_053299.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ubiquitin D (Ubd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053299.2

ORF Insert Sequence:

ATGGCTTCCT GCGTCTGTGT TGTCCATTCG GAGCAATGGC CATTAATGAC CTTTGACACC 
ACCATGAGTG ACAAAGTGAA GAAAATCAAT GAGCATATTA GGTCCCAAAC CAAGGTCTCT 
GTGCAGGACC AGATCCTTCT GCTAGACTCC AAGATCCTCA AGCCCCATAG AGCGTTGTCA 
TCTTATGGGA TCGACAAGGA AAACACTATC CACCTCACCC TAAAGGTGGT GAAGCCCAGT 
GATGAAGAGC TGCCCTTGTC TCTGGTGGAG TCGGGCGACG AGGGGCAAAG GCACCTCCTT 
CGAGTTCGAA GATCCAGCTC CGTGGCCCAG GTGAAGGAAA TGATCGAGAA TGTGACTGCT 
GTGCCTCCCA AGAAGCAGTT CGTGAATTGC AATGGAAAGA GGCTGGAAGA TGGAAAGATC 
ATGGCCGACT ACAACATCAA GAGTGGTAGT TTGCTCTTTC TCACAGCGCA CTGCATTGGG 
GGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats.
Genes and immunity15(3)168-75(2014 Apr-May)
Cort L,Habib M,Eberwine RA,Hessner MJ,Mordes JP,Blankenhorn EP

FAT10 protects cardiac myocytes against apoptosis.
Journal of molecular and cellular cardiology591-10(2013 Jun)
Peng X,Shao J,Shen Y,Zhou Y,Cao Q,Hu J,He W,Yu X,Liu X,Marian AJ,Hong K

Transcriptional microarray analysis reveals suppression of histamine signaling by Kujin alleviates allergic symptoms through down-regulation of FAT10 expression.
International immunopharmacology11(10)1504-9(2011 Oct)
Dev S,Mizuguchi H,Das AK,Baba Y,Fukui H

The ubiquitin-like protein FAT10 mediates NF-kappaB activation.
Journal of the American Society of Nephrology : JASN21(2)316-26(2010 Feb)
Gong P,Canaan A,Wang B,Leventhal J,Snyder A,Nair V,Cohen CD,Kretzler M,D'Agati V,Weissman S,Ross MJ

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.
Journal of cell science121(Pt 24)4079-88(2008 Dec)
Kalveram B,Schmidtke G,Groettrup M