Tnfrsf4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tnfrsf4
Entrez Gene ID	25572
Full Name	TNF receptor superfamily member 4
Synonyms	Ox40,Txgp1
General protein information	Preferred Names TNF receptor superfamily member 4 Names tumor necrosis factor receptor superfamily member 4 MRC OX40 OX40 antigen OX40L receptor Tax-transcriptionally activated glycoprotein 1 tumor necrosis factor (ligand) superfamily member 4 tumor necrosis factor receptor superfamily, member 4 tumor necrosis factor superfamily, member 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	membrane-bound receptor, binds adaptor proteins Traf2 and Traf5; member of the tumor necrosis factor (TNF)-receptor superfamily [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013049.1	NP_037181.1	tumor necrosis factor receptor superfamily member 4 precursor

Pathways from BioSystems

Homologies

	TNFRSF4	XP_001090870.1
Gallus gallus (chicken)	TNFRSF4	XP_004947480.1
Xenopus tropicalis (tropical clawed frog)	tnfrsf4	XP_004916593.1
Canis lupus familiaris (dog)	TNFRSF4	XP_546720.3
Mus musculus (house mouse)	Tnfrsf4	NP_035789.1
Bos taurus (cattle)	TNFRSF4	NP_001092513.1
Rattus norvegicus (Norway rat)	Tnfrsf4	NP_037181.1
Homo sapiens (human)	TNFRSF4	NP_003318.1
Pan troglodytes (chimpanzee)	TNFRSF4	XP_513705.3

Gene Ontology
Bibliography

Related articles in PubMed

[Dynamic change OX40/OX40L mRNA in experimental allergic neuritis].
Zhang N, Li G, Xiao B, Liu Y, Cai Y, Sun X, Liang J
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences35(9)964-8(2010 Sep)

Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus.
Abe J, Ueha S, Suzuki J, Tokano Y, Matsushima K, Ishikawa S
The American journal of pathology173(6)1682-92(2008 Dec)

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes.
Chen Z, Herman AE, Matos M, Mathis D, Benoist C
The Journal of experimental medicine202(10)1387-97(2005 Nov)

The costimulation-regulated duration of PKB activation controls T cell longevity.
Song J, Salek-Ardakani S, Rogers PR, Cheng M, Van Parijs L, Croft M
Nature immunology5(2)150-8(2004 Feb)

OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice.
Obermeier F, Schwarz H, Dunger N, Strauch UG, Grunwald N, Sch?lmerich J, Falk W
European journal of immunology33(12)3265-74(2003 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

OX40 and OX40L may play a role in the pathogenesis of experimental allegic neuritis.
Title: [Dynamic change OX40/OX40L mRNA in experimental allergic neuritis].

Ox40-Ox40 ligand is a critical pathway in alloimmune responses, especially recall/primed responses, and is synergistic with CD28-B7 in mediating T cell effector responses during allograft rejection.
Title: The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo.

The following Tnfrsf4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tnfrsf4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01776	NM_013049.1 Latest version!	Rattus norvegicus TNF receptor superfamily member 4 (Tnfrsf4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tnfrsf4 ( NM_013049.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037181.1 Rattus norvegicus TNF receptor superfamily member 4 (Tnfrsf4), mRNA.

Price & Availability↑

CloneID	ORa01776
Clone ID Related Accession (Same CDS sequence)	NM_013049.1
Accession Version	NM_013049.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	tumor necrosis factor receptor superfamily member 4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X17037.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X17037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689599, SAMEA2689603 [ECO:0000348] ##Evidence-Data-END##

ATGTATGTGT GGGTTCAGCA GCCCACAGCA TTTCTGCTCC TGGGACTCTC ACTTGGAGTT 
ACAGTGAAGC TCAACTGTGT TAAAGATACC TACCCCAGTG GTCACAAGTG CTGTCGTGAG 
TGCCAGCCAG GCCATGGTAT GGTGAGCCGC TGTGATCACA CCAGGGACAC TGTATGTCAT 
CCATGTGAGC CTGGCTTCTA CAATGAGGCT GTCAATTACG ACACCTGCAA GCAGTGTACA 
CAGTGCAACC ACCGAAGTGG AAGTGAACTC AAGCAGAACT GCACACCTAC TGAGGATACT 
GTCTGCCAGT GTAGACCAGG CACCCAACCC CGGCAAGACA GCAGCCACAA GCTTGGAGTT 
GACTGTGTTC CCTGCCCCCC TGGCCACTTT TCTCCAGGCA GCAACCAAGC CTGCAAGCCC 
TGGACCAATT GTACCTTATC TGGAAAGCAG ATCCGCCACC CAGCCAGTAA CAGCTTGGAC 
ACAGTCTGTG AAGACAGAAG CCTCCTGGCC ACACTGCTCT GGGAGACCCA GCGCACTACA 
TTCAGGCCAA CCACTGTCCC GTCCACCACA GTCTGGCCCA GGACTTCTCA GTTGCCCTCT 
ACACCCACCT TGGTGGCTCC TGAGGGCCCT GCATTTGCTG TTATCCTAGG CCTAGGCCTG 
GGCTTGCTGG CTCCCTTGAC TGTCCTGCTA GCCTTGTACC TGCTCCGAAA GGCTTGGAGA 
TCGCCCAACA CTCCCAAACC TTGTTGGGGA AACAGCTTCA GGACCCCTAT CCAGGAGGAG 
CAGACCGACA CACACTTTAC TCTAGCCAAG ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037181.1
CDS	15..830
Translation	MYVWVQQPTAFLLLGLSLGVTVKLNCVKDTYPSGHKCCRECQPGHGMVSRCDHTRDTVCHPCEPGFYNEAVNYDTCKQCTQCNHRSGSELKQNCTPTEDTVCQCRPGTQPRQDSSHKLGVDCVPCPPGHFSPGSNQACKPWTNCTLSGKQIRHPASNSLDTVCEDRSLLATLLWETQRTTFRPTTVPSTTVWPRTSQLPSTPTLVAPEGPAFAVILGLGLGLLAPLTVLLALYLLRKAWRSPNTPKPCWGNSFRTPIQEEQTDTHFTLAKI

Target ORF information:

RefSeq Version	NM_013049.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TNF receptor superfamily member 4 (Tnfrsf4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013049.1

ORF Insert Sequence:

ATGTATGTGT GGGTTCAGCA GCCCACAGCA TTTCTGCTCC TGGGACTCTC ACTTGGAGTT 
ACAGTGAAGC TCAACTGTGT TAAAGATACC TACCCCAGTG GTCACAAGTG CTGTCGTGAG 
TGCCAGCCAG GCCATGGTAT GGTGAGCCGC TGTGATCACA CCAGGGACAC TGTATGTCAT 
CCATGTGAGC CTGGCTTCTA CAATGAGGCT GTCAATTACG ACACCTGCAA GCAGTGTACA 
CAGTGCAACC ACCGAAGTGG AAGTGAACTC AAGCAGAACT GCACACCTAC TGAGGATACT 
GTCTGCCAGT GTAGACCAGG CACCCAACCC CGGCAAGACA GCAGCCACAA GCTTGGAGTT 
GACTGTGTTC CCTGCCCCCC TGGCCACTTT TCTCCAGGCA GCAACCAAGC CTGCAAGCCC 
TGGACCAATT GTACCTTATC TGGAAAGCAG ATCCGCCACC CAGCCAGTAA CAGCTTGGAC 
ACAGTCTGTG AAGACAGAAG CCTCCTGGCC ACACTGCTCT GGGAGACCCA GCGCACTACA 
TTCAGGCCAA CCACTGTCCC GTCCACCACA GTCTGGCCCA GGACTTCTCA GTTGCCCTCT 
ACACCCACCT TGGTGGCTCC TGAGGGCCCT GCATTTGCTG TTATCCTAGG CCTAGGCCTG 
GGCTTGCTGG CTCCCTTGAC TGTCCTGCTA GCCTTGTACC TGCTCCGAAA GGCTTGGAGA 
TCGCCCAACA CTCCCAAACC TTGTTGGGGA AACAGCTTCA GGACCCCTAT CCAGGAGGAG 
CAGACCGACA CACACTTTAC TCTAGCCAAG ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[Dynamic change OX40/OX40L mRNA in experimental allergic neuritis].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences35(9)964-8(2010 Sep)
Zhang N,Li G,Xiao B,Liu Y,Cai Y,Sun X,Liang J

Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus.
The American journal of pathology173(6)1682-92(2008 Dec)
Abe J,Ueha S,Suzuki J,Tokano Y,Matsushima K,Ishikawa S

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes.
The Journal of experimental medicine202(10)1387-97(2005 Nov)
Chen Z,Herman AE,Matos M,Mathis D,Benoist C

The costimulation-regulated duration of PKB activation controls T cell longevity.
Nature immunology5(2)150-8(2004 Feb)
Song J,Salek-Ardakani S,Rogers PR,Cheng M,Van Parijs L,Croft M

OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice.
European journal of immunology33(12)3265-74(2003 Dec)
Obermeier F,Schwarz H,Dunger N,Strauch UG,Grunwald N,Sch?lmerich J,Falk W