Fosl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fosl2
Entrez Gene ID	25446
Full Name	FOS like 2, AP-1 transcription factor subunit
Synonyms	Fra2
General protein information	Preferred Names FOS like 2, AP-1 transcription factor subunit Names fos-related antigen 2 FOS like 2, AP-1 trancription factor subunit FRA-2 fos-like antigen 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q14
Summary	member of the Fos family of transcription factors with circadian regulation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012954.1	NP_037086.1	fos-related antigen 2 isoform 1
NM_001013146.1	NP_001013164.1	fos-related antigen 2 isoform 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	fosl2	NP_001076467.1
Homo sapiens (human)	FOSL2	NP_005244.1
Mus musculus (house mouse)	Fosl2	NP_032063.2
Gallus gallus (chicken)	FOSL2	NP_001039301.1
Rattus norvegicus (Norway rat)	Fosl2	NP_037086.1
Pan troglodytes (chimpanzee)	FOSL2	XP_001160962.1
Canis lupus familiaris (dog)	FOSL2	XP_850717.1
Bos taurus (cattle)	FOSL2	NP_001179879.1
Xenopus tropicalis (tropical clawed frog)	fosl2	XP_002938465.1
	FOSL2	XP_001101118.1

Gene Ontology
Bibliography

Related articles in PubMed

Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2.
Wurm S, Zhang J, Guinea-Viniegra J, Garc?a F, Mu?oz J, Bakiri L, Ezhkova E, Wagner EF
Genes & development29(2)144-56(2015 Jan)

AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling.
Watanabe M, Nakajima S, Ohnuki K, Ogawa S, Yamashita M, Nakayama T, Murakami Y, Tanabe K, Abe R
European journal of immunology42(7)1850-62(2012 Jul)

In cardiac myoblasts, cellular redox regulates FosB and Fra-1 through multiple cis-regulatory modules.
Jindal E, Goswami SK
Free radical biology & medicine51(8)1512-21(2011 Oct)

Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson's disease.
Ebihara K, Ishida Y, Takeda R, Abe H, Matsuo H, Kawai K, Magata Y, Nishimori T
Neuroscience letters496(2)90-4(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified novel, functional FRA-2 targets across the genome through expression profile analysis
Title: Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism.

The following Fosl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fosl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01445	NM_012954.1 Latest version!	Rattus norvegicus FOS like 2, AP-1 transcription factor subunit (Fosl2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa03542	NM_001013146.1 Latest version!	Rattus norvegicus FOS like 2, AP-1 transcription factor subunit (Fosl2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fosl2 ( NM_012954.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037086.1 Rattus norvegicus FOS like 2, AP-1 transcription factor subunit (Fosl2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa01445
Clone ID Related Accession (Same CDS sequence)	NM_012954.1
Accession Version	NM_012954.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	fos-related antigen 2 isoform 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U18913.1. On Jun 25, 2006 this sequence version replaced XM_001052980.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U18913.1, AY622611.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906354, SAMN01906356 [ECO:0000348] ##Evidence-Data-END##

ATGTACCAGG ATTATCCCGG GAACTTTGAC ACCTCGTCCC GGGGCAGCAG TGGCTCTCCT 
GCGCACGCCG AGTCCTACTC CAGCGGTGGC GGCGGCCAGC AGAAGTTCCG GGTAGATATG 
CCTGGCTCAG GCAGTGCCTT CATCCCCACA ATCAACGCCA TCACCACCAC CAGCCAGGAC 
CTGCAGTGGA TGGTACAGCC CACAGTGATT ACCTCCATGT CCAACCCCTA TCCGCGCTCG 
CACCCCTACA GCCCCCTGCC AGGCTTGCGA TCAGTCCCTG GGCACATGGC TCTCCCCAGA 
CCAGGAGTGA TCAAGACCAT TGGTACCACC GTGGGCCGCA GAAGGAGAGA TGAGCAGCTG 
TCTCCCGAAG AGGAGGAGAA GCGTCGAATC CGGCGAGAGA GAAACAAGCT GGCCGCTGCC 
AAGTGTCGGA ACCGTCGACG TGAGCTGACG GAGAAGCTGC AGACGGAGAC AGAGGAGCTG 
GAGGAGGAGA AGTCCGGTCT GCAGAAAGAA ATCGCTGAGC TGCAGAAGGA GAAGGAGAAG 
CTGGAGTTCA TGCTGGTGGC TCACGGCCCT GTGTGCAAAA TCAGTCCTGA GGAACGCCGA 
TCTTCCCCCA CCTCCGGGGT ACAGTCCTTA CGCGGTACGG GCAGTGCTGT CGGCCCTGTG 
GTGGTGAAAC AGGAGCCTCC TGAAGAGGAC AGCCCCTCTT CCTCAGCAGG GATGGACAAG 
ACCCAGCGCT CTGTCATCAA GCCCATTAGC ATTGCTGGGG GTGGTTTCTA CGGGGAAGAG 
CCTCTGCACA CCCCCATCGT GGTGACCTCC ACACCTGCCA TCACTCCGGG CACTTCAAAC 
CTTGTCTTCA CCTACCCCAG TGTCCTGGAG CAGGAGTCGC CTGCGTCGCC CTCCGAGTCC 
TGTTCCAAGG CTCACCGCAG AAGCAGTAGC AGTGGGGACC AGTCATCAGA CTCCTTGAAC 
TCCCCCACTC TGCTGGCTCT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037086.1
CDS	1..984
Translation	MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFRVDMPGSGSAFIPTINAITTTSQDLQWMVQPTVITSMSNPYPRSHPYSPLPGLRSVPGHMALPRPGVIKTIGTTVGRRRRDEQLSPEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQTETEELEEEKSGLQKEIAELQKEKEKLEFMLVAHGPVCKISPEERRSSPTSGVQSLRGTGSAVGPVVVKQEPPEEDSPSSSAGMDKTQRSVIKPISIAGGGFYGEEPLHTPIVVTSTPAITPGTSNLVFTYPSVLEQESPASPSESCSKAHRRSSSSGDQSSDSLNSPTLLAL

Target ORF information:

RefSeq Version	NM_012954.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FOS like 2, AP-1 transcription factor subunit (Fosl2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012954.1

ORF Insert Sequence:

ATGTACCAGG ATTATCCCGG GAACTTTGAC ACCTCGTCCC GGGGCAGCAG TGGCTCTCCT 
GCGCACGCCG AGTCCTACTC CAGCGGTGGC GGCGGCCAGC AGAAGTTCCG GGTAGATATG 
CCTGGCTCAG GCAGTGCCTT CATCCCCACA ATCAACGCCA TCACCACCAC CAGCCAGGAC 
CTGCAGTGGA TGGTACAGCC CACAGTGATT ACCTCCATGT CCAACCCCTA TCCGCGCTCG 
CACCCCTACA GCCCCCTGCC AGGCTTGCGA TCAGTCCCTG GGCACATGGC TCTCCCCAGA 
CCAGGAGTGA TCAAGACCAT TGGTACCACC GTGGGCCGCA GAAGGAGAGA TGAGCAGCTG 
TCTCCCGAAG AGGAGGAGAA GCGTCGAATC CGGCGAGAGA GAAACAAGCT GGCCGCTGCC 
AAGTGTCGGA ACCGTCGACG TGAGCTGACG GAGAAGCTGC AGACGGAGAC AGAGGAGCTG 
GAGGAGGAGA AGTCCGGTCT GCAGAAAGAA ATCGCTGAGC TGCAGAAGGA GAAGGAGAAG 
CTGGAGTTCA TGCTGGTGGC TCACGGCCCT GTGTGCAAAA TCAGTCCTGA GGAACGCCGA 
TCTTCCCCCA CCTCCGGGGT ACAGTCCTTA CGCGGTACGG GCAGTGCTGT CGGCCCTGTG 
GTGGTGAAAC AGGAGCCTCC TGAAGAGGAC AGCCCCTCTT CCTCAGCAGG GATGGACAAG 
ACCCAGCGCT CTGTCATCAA GCCCATTAGC ATTGCTGGGG GTGGTTTCTA CGGGGAAGAG 
CCTCTGCACA CCCCCATCGT GGTGACCTCC ACACCTGCCA TCACTCCGGG CACTTCAAAC 
CTTGTCTTCA CCTACCCCAG TGTCCTGGAG CAGGAGTCGC CTGCGTCGCC CTCCGAGTCC 
TGTTCCAAGG CTCACCGCAG AAGCAGTAGC AGTGGGGACC AGTCATCAGA CTCCTTGAAC 
TCCCCCACTC TGCTGGCTCT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fosl2 ( NM_001013146.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013164.1 Rattus norvegicus FOS like 2, AP-1 transcription factor subunit (Fosl2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa03542
Clone ID Related Accession (Same CDS sequence)	NM_001013146.1
Accession Version	NM_001013146.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	fos-related antigen 2 isoform 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U18982.1. On Apr 20, 2005 this sequence version replaced XM_218419.2. Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U18982.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTACCAGG ATTATCCCGG GAACTTTGAC ACCTCGTCCC GGGGCAGCAG TGGCTCTCCT 
GCGCACGCCG AGTCCTACTC CAGCGGTGGC GGCGGCCAGC AGCTGTCTCC CGAAGAGGAG 
GAGAAGCGTC GAATCCGGAG GGAGAGAAAC AAGCTGGCCG CTGCCAAGTG TCGGAACCGT 
CGACGTGAGC TGACGGAGAA GCTGCAGGCG GAGACAGAGG AGCTGGAGGA GGAGAAGTCC 
GGTCTGCAGA AAGAAATCGC TGAGCTGCAG AAGGAGAAGG AGAAGCTGGA GTTCATGCTG 
GTGGCTCACG GCCCTGTGTG CAAAATCAGT CCTGAGGAAC GCCGATCTCC CCCCACCTCC 
GGGCTACAGT CCTTACGCGG TACGGGCAGT GCTGTCGGCC CTGTGGTGGT GAAACAGGAG 
CCTCCTGAAG AGGACAGCCC CTCTTCCTCA GCAGGGATGG ACAAGACCCA GCGCTCTGTC 
ATCAAGCCCA TTAGCATTGC TGGGGGTGGT TTCTACGGGG AAGAGCCTCT GCACACCCCC 
ATCGTGGTGA CCTCCACACC TGCCATCACT CCGGGCACTT CAAACCTTGT CTTCACCTAC 
CCCAGTGTCC TGGAGCAGGA GTCGCCTGCG TCGCCCTCCG AGTCCTGTTC CAAGGCTCAC 
CGCAGAAGCA GTAGCAGTGG GGACCAGTCA TCAGACTCCT TGAACTCCCC CACACTGCTG 
GCTCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013164.1
CDS	1..729
Translation	MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQLSPEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELEEEKSGLQKEIAELQKEKEKLEFMLVAHGPVCKISPEERRSPPTSGLQSLRGTGSAVGPVVVKQEPPEEDSPSSSAGMDKTQRSVIKPISIAGGGFYGEEPLHTPIVVTSTPAITPGTSNLVFTYPSVLEQESPASPSESCSKAHRRSSSSGDQSSDSLNSPTLLAL

Target ORF information:

RefSeq Version	NM_001013146.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FOS like 2, AP-1 transcription factor subunit (Fosl2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013146.1

ORF Insert Sequence:

ATGTACCAGG ATTATCCCGG GAACTTTGAC ACCTCGTCCC GGGGCAGCAG TGGCTCTCCT 
GCGCACGCCG AGTCCTACTC CAGCGGTGGC GGCGGCCAGC AGCTGTCTCC CGAAGAGGAG 
GAGAAGCGTC GAATCCGGAG GGAGAGAAAC AAGCTGGCCG CTGCCAAGTG TCGGAACCGT 
CGACGTGAGC TGACGGAGAA GCTGCAGGCG GAGACAGAGG AGCTGGAGGA GGAGAAGTCC 
GGTCTGCAGA AAGAAATCGC TGAGCTGCAG AAGGAGAAGG AGAAGCTGGA GTTCATGCTG 
GTGGCTCACG GCCCTGTGTG CAAAATCAGT CCTGAGGAAC GCCGATCTCC CCCCACCTCC 
GGGCTACAGT CCTTACGCGG TACGGGCAGT GCTGTCGGCC CTGTGGTGGT GAAACAGGAG 
CCTCCTGAAG AGGACAGCCC CTCTTCCTCA GCAGGGATGG ACAAGACCCA GCGCTCTGTC 
ATCAAGCCCA TTAGCATTGC TGGGGGTGGT TTCTACGGGG AAGAGCCTCT GCACACCCCC 
ATCGTGGTGA CCTCCACACC TGCCATCACT CCGGGCACTT CAAACCTTGT CTTCACCTAC 
CCCAGTGTCC TGGAGCAGGA GTCGCCTGCG TCGCCCTCCG AGTCCTGTTC CAAGGCTCAC 
CGCAGAAGCA GTAGCAGTGG GGACCAGTCA TCAGACTCCT TGAACTCCCC CACACTGCTG 
GCTCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2.
Genes & development29(2)144-56(2015 Jan)
Wurm S,Zhang J,Guinea-Viniegra J,Garc?a F,Mu?oz J,Bakiri L,Ezhkova E,Wagner EF

AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling.
European journal of immunology42(7)1850-62(2012 Jul)
Watanabe M,Nakajima S,Ohnuki K,Ogawa S,Yamashita M,Nakayama T,Murakami Y,Tanabe K,Abe R

In cardiac myoblasts, cellular redox regulates FosB and Fra-1 through multiple cis-regulatory modules.
Free radical biology & medicine51(8)1512-21(2011 Oct)
Jindal E,Goswami SK

Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson's disease.
Neuroscience letters496(2)90-4(2011 Jun)
Ebihara K,Ishida Y,Takeda R,Abe H,Matsuo H,Kawai K,Magata Y,Nishimori T