Foxa3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Foxa3
Entrez Gene ID	25100
Full Name	forkhead box A3
Synonyms	Hnf3g
General protein information	Preferred Names forkhead box A3 Names hepatocyte nuclear factor 3-gamma HNF-3-gamma HNF-3G forkhead box protein A3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	member of the Forkhead box a (Foxa) transcription factor family; binds rat proglucagon gene G2 promoter element [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017077.2	NP_058773.1	hepatocyte nuclear factor 3-gamma

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FOXA3	XP_541549.3
Mus musculus (house mouse)	Foxa3	NP_032286.1
Pan troglodytes (chimpanzee)	FOXA3	XP_512763.2
Rattus norvegicus (Norway rat)	Foxa3	NP_058773.1
Homo sapiens (human)	FOXA3	NP_004488.2
	FOXA3	XP_001111513.1
Bos taurus (cattle)	FOXA3	NP_001028291.1
Danio rerio (zebrafish)	foxa3	NP_571374.1

Gene Ontology
Bibliography

Related articles in PubMed

Forkhead box A3 attenuated the progression of fibrosis in a rat model of biliary atresia.
Dong R, Yang Y, Shen Z, Zheng C, Jin Z, Huang Y, Zhang Z, Zheng S, Chen G
Cell death & disease8(3)e2719(2017 Mar)

Induction of Functional Hepatocyte-Like Cells by Overexpression of FOXA3 and HNF4? in Rat Bone Marrow Mesenchymal Stem Cells.
Dai K, Chen R, Ding Y, Niu Z, Fan J, Xu C
Cells, tissues, organs200(2)132-40(2014)

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.
Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA
The Journal of clinical investigation119(10)2914-24(2009 Oct)

Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain.
Zhou B, Zhong Q, Minoo P, Li C, Ann DK, Frenkel B, Morrisey EE, Crandall ED, Borok Z
American journal of respiratory cell and molecular biology38(6)750-8(2008 Jun)

Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3.
Behr R, Sackett SD, Bochkis IM, Le PP, Kaestner KH
Developmental biology306(2)636-45(2007 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggested a protection role for Foxa3 during the progression of liver fibrosis in biliary atresia, and thereby supported increasing Foxa3 as a targeted treatment strategy.
Title: Forkhead box A3 attenuated the progression of fibrosis in a rat model of biliary atresia.

FOXA3 and HNF4alpha are powerful transcription factors for inducing rat bone marrow mesenchymal stem cells to differentiate into functional hepatocyte-like cells.
Title: Induction of Functional Hepatocyte-Like Cells by Overexpression of FOXA3 and HNF4? in Rat Bone Marrow Mesenchymal Stem Cells.

The following Foxa3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Foxa3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02741	NM_017077.2 Latest version!	Rattus norvegicus forkhead box A3 (Foxa3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Foxa3 ( NM_017077.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058773.1 Rattus norvegicus forkhead box A3 (Foxa3), mRNA.

Price & Availability↑

CloneID	ORa02741
Clone ID Related Accession (Same CDS sequence)	NM_017077.2
Accession Version	NM_017077.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	hepatocyte nuclear factor 3-gamma
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L09648.1. On Aug 30, 2012 this sequence version replaced NM_017077.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L09648.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689595, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END##

ATGCTGGGCT CAGTGAAGAT GGAGGCCCAT GACCTGGCCG AGTGGAGCTA CTACCCGGAG 
GCGGGCGAGG TGTATTCTCC AGTGAATCCT GTGCCCACCA TGGCCCCTCT CAACTCCTAC 
ATGTCCTTGA ACCCTCTTAG CTCTCCCTAC CCTCCCGGAG GGCTTCAGGC CTCCCCTCTG 
CCTACAGGAC CCCTGGCACC CCCAGCCCCC ACCGCTCCCC TGGGGCCCAC CTTCCCAGGC 
CTGGGCGCAG GCAGCGGCAC CGGAGGCAGT GCTTCCGGGT ATGGCGCCCC AGGGCCCGGG 
CTTGTACACG GAAAGGAAAT GGCCAAGGGG TACCGGCGGC CACTGACTCA TGCCAAACCA 
CCTTATTCCT ACATCTCTCT CATCACCATG GCTATCCAGC AGGCACCAGG CAAGATGCTG 
ACCCTGAGTG AAATCTACCA ATGGATCATG GACCTCTTCC CGTACTACCG GGAGAACCAG 
CAACGTTGGC AGAACTCCAT CCGGCACTCG CTGTCCTTCA ATGACTGCTT CGTCAAGGTG 
GCACGCTCCC CAGACAAACC GGGCAAAGGC TCCTACTGGG CCTTGCATCC CAGCTCTGGG 
AACATGTTTG AGAACGGCTG CTATCTCCGC CGTCAGAAGC GCTTCAAGCT GGAGGAGAAG 
GCAAAGAAAG GAAACAGTGC CACATCCGCC ACCAGGAATG GAACAGTGGG GTCAGCCACC 
TCTGCCACCA CTACAGCTGC CACTGCAGTC ACTTCCCCGG CTCAGCCCCA GCCTACGCCG 
CCGTCTGAGC CCGAGGCCCA GAGTGGGGAA GATGTGGGGG GTCTGGACTG CGCCTCGCCT 
CCTTCATCCG CACCCTATTT CACTGGCCTG GAGCTCCCAG GGGAACTGAA GTTGGATGCG 
CCCTACAACT TCAACCACCC TTTCTCTATC AACAACCTGA TGTCAGAACA GACATCAACA 
CCTTCCAAAC TAGATGTGGG GTTTGGGGGC TACGGTGCTG AGAGTGGGGA ACCTGGGGTC 
TACTACCAGA GCCTCTATTC CCGCTCTCTG CTCAATGCAT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058773.1
CDS	77..1141
Translation	MLGSVKMEAHDLAEWSYYPEAGEVYSPVNPVPTMAPLNSYMSLNPLSSPYPPGGLQASPLPTGPLAPPAPTAPLGPTFPGLGAGSGTGGSASGYGAPGPGLVHGKEMAKGYRRPLTHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKAKKGNSATSATRNGTVGSATSATTTAATAVTSPAQPQPTPPSEPEAQSGEDVGGLDCASPPSSAPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQTSTPSKLDVGFGGYGAESGEPGVYYQSLYSRSLLNAS

Target ORF information:

RefSeq Version	NM_017077.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus forkhead box A3 (Foxa3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017077.2

ORF Insert Sequence:

ATGCTGGGCT CAGTGAAGAT GGAGGCCCAT GACCTGGCCG AGTGGAGCTA CTACCCGGAG 
GCGGGCGAGG TGTATTCTCC AGTGAATCCT GTGCCCACCA TGGCCCCTCT CAACTCCTAC 
ATGTCCTTGA ACCCTCTTAG CTCTCCCTAC CCTCCCGGAG GGCTTCAGGC CTCCCCTCTG 
CCTACAGGAC CCCTGGCACC CCCAGCCCCC ACCGCTCCCC TGGGGCCCAC CTTCCCAGGC 
CTGGGCGCAG GCAGCGGCAC CGGAGGCAGT GCTTCCGGGT ATGGCGCCCC AGGGCCCGGG 
CTTGTACACG GAAAGGAAAT GGCCAAGGGG TACCGGCGGC CACTGACTCA TGCCAAACCA 
CCTTATTCCT ACATCTCTCT CATCACCATG GCTATCCAGC AGGCACCAGG CAAGATGCTG 
ACCCTGAGTG AAATCTACCA ATGGATCATG GACCTCTTCC CGTACTACCG GGAGAACCAG 
CAACGTTGGC AGAACTCCAT CCGGCACTCG CTGTCCTTCA ATGACTGCTT CGTCAAGGTG 
GCACGCTCCC CAGACAAACC GGGCAAAGGC TCCTACTGGG CCTTGCATCC CAGCTCTGGG 
AACATGTTTG AGAACGGCTG CTATCTCCGC CGTCAGAAGC GCTTCAAGCT GGAGGAGAAG 
GCAAAGAAAG GAAACAGTGC CACATCCGCC ACCAGGAATG GAACAGTGGG GTCAGCCACC 
TCTGCCACCA CTACAGCTGC CACTGCAGTC ACTTCCCCGG CTCAGCCCCA GCCTACGCCG 
CCGTCTGAGC CCGAGGCCCA GAGTGGGGAA GATGTGGGGG GTCTGGACTG CGCCTCGCCT 
CCTTCATCCG CACCCTATTT CACTGGCCTG GAGCTCCCAG GGGAACTGAA GTTGGATGCG 
CCCTACAACT TCAACCACCC TTTCTCTATC AACAACCTGA TGTCAGAACA GACATCAACA 
CCTTCCAAAC TAGATGTGGG GTTTGGGGGC TACGGTGCTG AGAGTGGGGA ACCTGGGGTC 
TACTACCAGA GCCTCTATTC CCGCTCTCTG CTCAATGCAT CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Forkhead box A3 attenuated the progression of fibrosis in a rat model of biliary atresia.
Cell death & disease8(3)e2719(2017 Mar)
Dong R,Yang Y,Shen Z,Zheng C,Jin Z,Huang Y,Zhang Z,Zheng S,Chen G

Induction of Functional Hepatocyte-Like Cells by Overexpression of FOXA3 and HNF4? in Rat Bone Marrow Mesenchymal Stem Cells.
Cells, tissues, organs200(2)132-40(2014)
Dai K,Chen R,Ding Y,Niu Z,Fan J,Xu C

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.
The Journal of clinical investigation119(10)2914-24(2009 Oct)
Chen G,Korfhagen TR,Xu Y,Kitzmiller J,Wert SE,Maeda Y,Gregorieff A,Clevers H,Whitsett JA

Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain.
American journal of respiratory cell and molecular biology38(6)750-8(2008 Jun)
Zhou B,Zhong Q,Minoo P,Li C,Ann DK,Frenkel B,Morrisey EE,Crandall ED,Borok Z

Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3.
Developmental biology306(2)636-45(2007 Jun)
Behr R,Sackett SD,Bochkis IM,Le PP,Kaestner KH