Hnf1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hnf1a
Entrez Gene ID	24817
Full Name	HNF1 homeobox A
Synonyms	HNF1,LF-B1,Lfb1,Tcf1
General protein information	Preferred Names HNF1 homeobox A Names hepatocyte nuclear factor 1-alpha HNF-1-alpha HNF-1A LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1 TCF-1 Transcription factor 1, hepatic albumin proximal factor hepatic nuclear factor 1 hepatic nuclear factor-1-alpha liver-specific transcription factor LF-B1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q16
Summary	acts as a transcriptional activator; plays a role in the regulation of liver-specific genes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012669.1	NP_036801.1	hepatocyte nuclear factor 1-alpha

Pathways from BioSystems

Homologies

Homo sapiens (human)	HNF1A	NP_000536.5
Rattus norvegicus (Norway rat)	Hnf1a	NP_036801.1
Canis lupus familiaris (dog)	HNF1A	XP_543429.2
	LOC701243	XP_001089567.1
Pan troglodytes (chimpanzee)	HNF1A	XP_001148554.2
Danio rerio (zebrafish)	hnf1a	NP_739570.1
Bos taurus (cattle)	HNF1A	NP_001179453.1
Mus musculus (house mouse)	Hnf1a	NP_033353.2
Gallus gallus (chicken)	HNF1A	NP_001025839.2
Xenopus tropicalis (tropical clawed frog)	hnf1a	NP_001116920.1

Gene Ontology
Bibliography

Related articles in PubMed

Hepatocyte nuclear factors as possible C-reactive protein transcriptional inducer in the liver and white adipose tissue of rats with experimental chronic renal failure.
Sucajtys-Szulc E, Debska-Slizien A, Rutkowski B, Milczarek R, Pelikant-Malecka I, Sledzinski T, Swierczynski J, Szolkiewicz M
Molecular and cellular biochemistry(2018 Jan)

Hepatocyte nuclear factor 1? suppresses steatosis-associated liver cancer by inhibiting PPAR? transcription.
Patitucci C, Couchy G, Bagattin A, Ca?eque T, de Reyni?s A, Scoazec JY, Rodriguez R, Pontoglio M, Zucman-Rossi J, Pende M, Panasyuk G
The Journal of clinical investigation127(5)1873-1888(2017 May)

Up-regulation of Hnf1? gene expression in the liver of rats with experimentally induced chronic renal failure - A possible link between circulating PCSK9 and triacylglycerol concentrations.
Sucajtys-Szulc E, Szolkiewicz M, Swierczynski J, Rutkowski B
Atherosclerosis24817-26(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hnf1alpha gene expression is upregulated in the liver of rats with experimentally induced chronic renal failure, showing an association between circulating PCSK9 and TAGs
Title: Up-regulation of Hnf1? gene expression in the liver of rats with experimentally induced chronic renal failure - A possible link between circulating PCSK9 and triacylglycerol concentrations.

HNF-1alpha, HNF-4alpha and FOXA2 transcriptional factors are involved in diabetes-induced overexpression of Slc2a2 gene in the liver and kidney.
Title: Hepatocyte nuclear factors 1?/4? and forkhead box A2 regulate the solute carrier 2A2 (Slc2a2) gene expression in the liver and kidney of diabetic rats.

De novo synthesis of HNF-1alpha was seen in rat brain, and an increased interaction of HNF-1alpha with p300 and albumin promoter seems to be responsible for overexpression of albumin in ischemic condition.
Title: Hepatocyte nuclear factor-1alpha mediated upregulation of albumin expression in focal ischemic rat brain.

Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.
Title: Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.

a critical link between HNF1A-MODY-induced alterations in Bmp-3 expression and insulin gene levels
Title: Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.

The following Hnf1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hnf1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00573	NM_012669.1 Latest version!	Rattus norvegicus HNF1 homeobox A (Hnf1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hnf1a ( NM_012669.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036801.1 Rattus norvegicus HNF1 homeobox A (Hnf1a), mRNA.

Price & Availability↑

CloneID	ORa00573
Clone ID Related Accession (Same CDS sequence)	NM_012669.1
Accession Version	NM_012669.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1887bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	hepatocyte nuclear factor 1-alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J03170.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J03170.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END##

ATGGTTTCTA AGTTGAGCCA GCTGCAGACG GAGCTCCTGG CTGCTCTGCT CGAGTCGGGC 
CTGAGCAAAG AGGCTCTGAT CCAGGCTCTG GGGGAGCCCG GGCCCTACCT GATGGTTGGA 
GATGGTCCCC TGGACAAGGG GGAGTCCTGC GGTGGGACTC GAGGGGACCT GACCGAGCTG 
CCCAATGGCC TGGGGGAGAC GCGTGGCTCG GAAGATGACA CGGATGACGA TGGGGAAGAC 
TTCGCGCCAC CCATTCTGAA AGAGCTGGAG AACCTCAGCC CAGAGGAGGC AGCCCACCAG 
AAAGCCGTGG TGGAGTCACT TCTTCAGGAG GACCCATGGC GCGTGGCAAA GATGGTCAAG 
TCGTACCTGC AGCAACACAA CATCCCCCAG CGGGAGGTGG TGGACACTAC GGGTCTCAAC 
CAGTCCCACC TGTCCCAGCA CCTCAACAAG GGCACCCCCA TGAAGACGCA GAAGCGGGCC 
GCGCTGTACA CCTGGTACGT CCGCAAGCAG CGAGAGGTGG CTCAGCAATT CACCCACGCG 
GGGCAGGGCG GACTGATTGA AGAGCCCACA GGTGATGAGC TGCCAACCAA AAAGGGGCGG 
AGGAACCGGT TCAAGTGGGG CCCCGCATCC CAGCAGATCC TGTTCCAGGC TTACGAGAGG 
CAGAAGAACC CCAGCAAGGA AGAGCGAGAG ACCTTGGTGG AGGAGTGCAA TAGGGCGGAG 
TGCATCCAGA GAGGGGTGTC ACCATCGCAG GCCCAGGGGC TAGGCTCCAA CCTTGTCACC 
GAGGTGCGTG TCTACAACTG GTTTGCCAAC CGGCGCAAGG AAGAAGCCTT TCGGCATAAG 
CTGGCCATGG ACACGTATAA CGGGCCTCCA CCCGGGCCAG GCCCCGGCCC TGCGCTACCT 
GCCCACAGTT CCCCGGGCCT GCCCACAACC ACCCTCTCTC CCAGTAAGGT CCACGGTGTG 
CGGTATGGAC AGTCTGCAAC CAGCGAGGCA GCTGAGGTGC CCTCCAGCAG CGGAGGTCCC 
TTAGTCACAG TGTCTGCGGC CTTACACCAA GTGTCCCCCA CAGGCTTGGA GCCCAGCAGC 
CTGCTGAGCA CCGAGGCCAA GCTGGTCTCA GCCACGGGGG GTCCCCTGCC TCCCGTCAGC 
ACCCTGACAG CACTGCACAG CTTGGAGCAG ACGTCTCCAG GTCTCAACCA GCAGCCGCAG 
AACCTTATCA TGGCCTCGCT GCCTGGGGTC ATGACCATCG GCCCAGGGGA GCCCGCCTCC 
CTGGGTCCCA CGTTCACTAA CACGGGTGCC TCTACCCTGG TCATTGGTCT GGCCTCCACA 
CAGGCACAGA GCGTGCCAGT CATCAACAGC ATGGGGAGCA GCCTGACCAC CCTGCAGCCG 
GTCCAGTTTT CCCAGCCACT GCACCCTTCC TATCAGCAGC CTCTCATGCC CCCTGTACAG 
AGCCACGTGG CCCAGAGTCC CTTCATGGCA ACCATGGCCC AGCTGCAGAG CCCCCACGCC 
CTGTACAGCC ACAAGCCTGA GGTGGCCCAG TACACGCATA CAAGCCTGCT TCCGCAGACC 
ATGCTGATCA CAGACACCAA CCTCAGCACC CTTGCCAGCC TCACGCCCAC CAAGCAGGTC 
TTCACCTCAG ACACAGAGGC CTCCAGTGAG CCTGGGCTTC ATGAGCCGTC GTCTCCAGCC 
ACAACCATTC ACATCCCCAG CCAGGACCCG TCAAACATCC AGCACCTGCA GCCTGCTCAC 
CGGCTCAGCA CCAGTCCCAC AGTGTCCTCC AGCAGCCTGG TGTTGTACCA GAGTTCTGAC 
TCCAACGGGC ACAGCCACCT GCTGCCATCC AACCACGGTG TCATCGAGAC TTTTATCTCC 
ACCCAGATGG CCTCCTCCTC CCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036801.1
CDS	151..2037
Translation	MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGDGPLDKGESCGGTRGDLTELPNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKAVVESLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALPAHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSSLLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNLSTLASLTPTKQVFTSDTEASSEPGLHEPSSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSDSNGHSHLLPSNHGVIETFISTQMASSSQ

Target ORF information:

RefSeq Version	NM_012669.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus HNF1 homeobox A (Hnf1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012669.1

ORF Insert Sequence:

ATGGTTTCTA AGTTGAGCCA GCTGCAGACG GAGCTCCTGG CTGCTCTGCT CGAGTCGGGC 
CTGAGCAAAG AGGCTCTGAT CCAGGCTCTG GGGGAGCCCG GGCCCTACCT GATGGTTGGA 
GATGGTCCCC TGGACAAGGG GGAGTCCTGC GGTGGGACTC GAGGGGACCT GACCGAGCTG 
CCCAATGGCC TGGGGGAGAC GCGTGGCTCG GAAGATGACA CGGATGACGA TGGGGAAGAC 
TTCGCGCCAC CCATTCTGAA AGAGCTGGAG AACCTCAGCC CAGAGGAGGC AGCCCACCAG 
AAAGCCGTGG TGGAGTCACT TCTTCAGGAG GACCCATGGC GCGTGGCAAA GATGGTCAAG 
TCGTACCTGC AGCAACACAA CATCCCCCAG CGGGAGGTGG TGGACACTAC GGGTCTCAAC 
CAGTCCCACC TGTCCCAGCA CCTCAACAAG GGCACCCCCA TGAAGACGCA GAAGCGGGCC 
GCGCTGTACA CCTGGTACGT CCGCAAGCAG CGAGAGGTGG CTCAGCAATT CACCCACGCG 
GGGCAGGGCG GACTGATTGA AGAGCCCACA GGTGATGAGC TGCCAACCAA AAAGGGGCGG 
AGGAACCGGT TCAAGTGGGG CCCCGCATCC CAGCAGATCC TGTTCCAGGC TTACGAGAGG 
CAGAAGAACC CCAGCAAGGA AGAGCGAGAG ACCTTGGTGG AGGAGTGCAA TAGGGCGGAG 
TGCATCCAGA GAGGGGTGTC ACCATCGCAG GCCCAGGGGC TAGGCTCCAA CCTTGTCACC 
GAGGTGCGTG TCTACAACTG GTTTGCCAAC CGGCGCAAGG AAGAAGCCTT TCGGCATAAG 
CTGGCCATGG ACACGTATAA CGGGCCTCCA CCCGGGCCAG GCCCCGGCCC TGCGCTACCT 
GCCCACAGTT CCCCGGGCCT GCCCACAACC ACCCTCTCTC CCAGTAAGGT CCACGGTGTG 
CGGTATGGAC AGTCTGCAAC CAGCGAGGCA GCTGAGGTGC CCTCCAGCAG CGGAGGTCCC 
TTAGTCACAG TGTCTGCGGC CTTACACCAA GTGTCCCCCA CAGGCTTGGA GCCCAGCAGC 
CTGCTGAGCA CCGAGGCCAA GCTGGTCTCA GCCACGGGGG GTCCCCTGCC TCCCGTCAGC 
ACCCTGACAG CACTGCACAG CTTGGAGCAG ACGTCTCCAG GTCTCAACCA GCAGCCGCAG 
AACCTTATCA TGGCCTCGCT GCCTGGGGTC ATGACCATCG GCCCAGGGGA GCCCGCCTCC 
CTGGGTCCCA CGTTCACTAA CACGGGTGCC TCTACCCTGG TCATTGGTCT GGCCTCCACA 
CAGGCACAGA GCGTGCCAGT CATCAACAGC ATGGGGAGCA GCCTGACCAC CCTGCAGCCG 
GTCCAGTTTT CCCAGCCACT GCACCCTTCC TATCAGCAGC CTCTCATGCC CCCTGTACAG 
AGCCACGTGG CCCAGAGTCC CTTCATGGCA ACCATGGCCC AGCTGCAGAG CCCCCACGCC 
CTGTACAGCC ACAAGCCTGA GGTGGCCCAG TACACGCATA CAAGCCTGCT TCCGCAGACC 
ATGCTGATCA CAGACACCAA CCTCAGCACC CTTGCCAGCC TCACGCCCAC CAAGCAGGTC 
TTCACCTCAG ACACAGAGGC CTCCAGTGAG CCTGGGCTTC ATGAGCCGTC GTCTCCAGCC 
ACAACCATTC ACATCCCCAG CCAGGACCCG TCAAACATCC AGCACCTGCA GCCTGCTCAC 
CGGCTCAGCA CCAGTCCCAC AGTGTCCTCC AGCAGCCTGG TGTTGTACCA GAGTTCTGAC 
TCCAACGGGC ACAGCCACCT GCTGCCATCC AACCACGGTG TCATCGAGAC TTTTATCTCC 
ACCCAGATGG CCTCCTCCTC CCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepatocyte nuclear factors as possible C-reactive protein transcriptional inducer in the liver and white adipose tissue of rats with experimental chronic renal failure.
Molecular and cellular biochemistry(2018 Jan)
Sucajtys-Szulc E,Debska-Slizien A,Rutkowski B,Milczarek R,Pelikant-Malecka I,Sledzinski T,Swierczynski J,Szolkiewicz M

Hepatocyte nuclear factor 1? suppresses steatosis-associated liver cancer by inhibiting PPAR? transcription.
The Journal of clinical investigation127(5)1873-1888(2017 May)
Patitucci C,Couchy G,Bagattin A,Ca?eque T,de Reyni?s A,Scoazec JY,Rodriguez R,Pontoglio M,Zucman-Rossi J,Pende M,Panasyuk G

Up-regulation of Hnf1? gene expression in the liver of rats with experimentally induced chronic renal failure - A possible link between circulating PCSK9 and triacylglycerol concentrations.
Atherosclerosis24817-26(2016 May)
Sucajtys-Szulc E,Szolkiewicz M,Swierczynski J,Rutkowski B