Ppy cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppy
Entrez Gene ID	24677
Full Name	pancreatic polypeptide
General protein information	Preferred Names pancreatic polypeptide Names pancreatic prohormone PP
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1
Summary	peptide hormone; functions as regulator of pancreatic and astrointestinal functions [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597005.1	XP_017452494.1	pancreatic prohormone isoform X1
NM_012626.2	NP_036758.1	pancreatic prohormone precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PPY	XP_003315459.1
Bos taurus (cattle)	PPY	NP_776377.2
Mus musculus (house mouse)	Ppy	NP_032944.1
Rattus norvegicus (Norway rat)	Ppy	NP_036758.1
Homo sapiens (human)	PPY	NP_002713.1
Canis lupus familiaris (dog)	PPY	XP_548067.2
	PPY	XP_001113906.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.
Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G
Mechanisms of development124(11-12)898-910(2007 Nov-Dec)

Effects of pancreatic polypeptide on pancreas-projecting rat dorsal motor nucleus of the vagus neurons.
Browning KN, Coleman FH, Travagli RA
American journal of physiology. Gastrointestinal and liver physiology289(2)G209-19(2005 Aug)

Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18.
Kov?cs P, Voigt B, Kl?ting I
Biochemical and biophysical research communications235(2)343-8(1997 Jun)

Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family.
Gregor P, Millham ML, Feng Y, DeCarr LB, McCaleb ML, Cornfield LJ
FEBS letters381(1-2)58-62(1996 Feb)

Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.
Bard JA, Walker MW, Branchek TA, Weinshank RL
The Journal of biological chemistry270(45)26762-5(1995 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

pancreas-projecting rat dorsal motor nucleus of the vagus neurons are heterogeneous with respect to their response to PP, which may underlie functional differences in the vagal modulation of pancreatic functions
Title: Effects of pancreatic polypeptide on pancreas-projecting rat dorsal motor nucleus of the vagus neurons.

The following Ppy gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppy cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00490	NM_012626.2 Latest version!	Rattus norvegicus pancreatic polypeptide (Ppy), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa57175	XM_017597005.1 Latest version!	Rattus norvegicus pancreatic polypeptide (Ppy), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppy ( NM_012626.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036758.1 Rattus norvegicus pancreatic polypeptide (Ppy), mRNA.

Price & Availability↑

CloneID	ORa00490
Clone ID Related Accession (Same CDS sequence)	NM_012626.2
Accession Version	NM_012626.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-23
Organism	Rattus norvegicus(Norway rat)
Product	pancreatic prohormone precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M13588.1 and BP484139.1. On Oct 3, 2006 this sequence version replaced NM_012626.1. ##Evidence-Data-START## Transcript exon combination :: M13588.1, BP484139.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689599, SAMN01906349 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGTCG CATACTACTG CCTCTCCCTG TTTCTCCTAT CCACTTGGGT GGCTCTGCTG 
CTACAGCCCC TGCAGGGTGC CTGGGGAGCC CCACTGGAGC CAATGTACCC GGGGGACTAT 
GCTACGCATG AACAGAGGGC TCAATACGAA ACTCAGCTCC GAAGATACAT CAACACACTG 
ACCAGGCCTA GGTATGGGAA GAGAGATGAG GACACAGCTG GGCTTCCTGG AAGGCAGCTC 
CCACCATGCA CCAGCCTTCT GGTGGGTTTG ATGCCCTGCG CTGCTGCCCG GAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036758.1
CDS	55..351
Translation	MAVAYYCLSLFLLSTWVALLLQPLQGAWGAPLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRYGKRDEDTAGLPGRQLPPCTSLLVGLMPCAAARS

Target ORF information:

RefSeq Version	NM_012626.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus pancreatic polypeptide (Ppy), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012626.2

ORF Insert Sequence:

ATGGCCGTCG CATACTACTG CCTCTCCCTG TTTCTCCTAT CCACTTGGGT GGCTCTGCTG 
CTACAGCCCC TGCAGGGTGC CTGGGGAGCC CCACTGGAGC CAATGTACCC GGGGGACTAT 
GCTACGCATG AACAGAGGGC TCAATACGAA ACTCAGCTCC GAAGATACAT CAACACACTG 
ACCAGGCCTA GGTATGGGAA GAGAGATGAG GACACAGCTG GGCTTCCTGG AAGGCAGCTC 
CCACCATGCA CCAGCCTTCT GGTGGGTTTG ATGCCCTGCG CTGCTGCCCG GAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ppy ( XM_017597005.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452494.1 Rattus norvegicus pancreatic polypeptide (Ppy), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57175
Clone ID Related Accession (Same CDS sequence)	XM_017597005.1
Accession Version	XM_017597005.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	pancreatic prohormone isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTAGGGA TGGCCGTCGC ATACTACTGC CTCTCCCTGT TTCTCCTATC CACTTGGGTG 
GCTCTGCTGC TACAGCCCCT GCAGGGTGCC TGGGGAGCCC CACTGGAGCC AATGTACCCG 
GGGGACTATG CTACGCATGA ACAGAGGGCT CAATACGAAA CTCAGCTCCG AAGATACATC 
AACACACTGA CCAGGCCTAG GTATGGGAAG AGAGATGAGG ACACAGCTGG GCTTCCTGGA 
AGGCAGCTCC CACCATGCAC CAGCCTTCTG GTGGGTTTGA TGCCCTGCGC TGCTGCCCGG 
AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452494.1
CDS	30..335
Translation	MLGMAVAYYCLSLFLLSTWVALLLQPLQGAWGAPLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRYGKRDEDTAGLPGRQLPPCTSLLVGLMPCAAARS

Target ORF information:

RefSeq Version	XM_017597005.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus pancreatic polypeptide (Ppy), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597005.1

ORF Insert Sequence:

ATGCTAGGGA TGGCCGTCGC ATACTACTGC CTCTCCCTGT TTCTCCTATC CACTTGGGTG 
GCTCTGCTGC TACAGCCCCT GCAGGGTGCC TGGGGAGCCC CACTGGAGCC AATGTACCCG 
GGGGACTATG CTACGCATGA ACAGAGGGCT CAATACGAAA CTCAGCTCCG AAGATACATC 
AACACACTGA CCAGGCCTAG GTATGGGAAG AGAGATGAGG ACACAGCTGG GCTTCCTGGA 
AGGCAGCTCC CACCATGCAC CAGCCTTCTG GTGGGTTTGA TGCCCTGCGC TGCTGCCCGG 
AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.
Mechanisms of development124(11-12)898-910(2007 Nov-Dec)
Wang S,Zhang J,Zhao A,Hipkens S,Magnuson MA,Gu G

Effects of pancreatic polypeptide on pancreas-projecting rat dorsal motor nucleus of the vagus neurons.
American journal of physiology. Gastrointestinal and liver physiology289(2)G209-19(2005 Aug)
Browning KN,Coleman FH,Travagli RA

Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18.
Biochemical and biophysical research communications235(2)343-8(1997 Jun)
Kov?cs P,Voigt B,Kl?ting I

Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family.
FEBS letters381(1-2)58-62(1996 Feb)
Gregor P,Millham ML,Feng Y,DeCarr LB,McCaleb ML,Cornfield LJ

Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.
The Journal of biological chemistry270(45)26762-5(1995 Nov)
Bard JA,Walker MW,Branchek TA,Weinshank RL