Hoxb8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hoxb8
Entrez Gene ID	24457
Full Name	homeo box B8
Synonyms	Hox2r1a
General protein information	Preferred Names homeo box B8 Names homeobox protein Hox-B8 Hox2.4 homeobox homolog homeobox gene B8 homeobox protein R1a
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q26
Summary	mouse homolog is a homeobox transcription factor; involved in control of developmental pathways [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006247175.3	XP_006247237.1	homeobox protein Hox-B8 isoform X1
NM_001191649.1	NP_001178578.1	homeobox protein Hox-B8

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC100337349	XP_002695987.2
Rattus norvegicus (Norway rat)	Hoxb8	NP_001178578.1
Gallus gallus (chicken)	HOXB8	NP_990242.1
Danio rerio (zebrafish)	hoxb8a	NP_571195.1
Mus musculus (house mouse)	Hoxb8	NP_034591.1
Homo sapiens (human)	HOXB8	NP_076921.1
Canis lupus familiaris (dog)	HOXB8	XP_548179.1
Xenopus tropicalis (tropical clawed frog)	hoxb8	XP_004918718.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice.
Holstege JC, de Graaff W, Hossaini M, Cardona Cano S, Jaarsma D, van den Akker E, Deschamps J
Proceedings of the National Academy of Sciences of the United States of America105(17)6338-43(2008 Apr)

Regulation of smooth muscle-specific gene expression by homeodomain proteins, Hoxa10 and Hoxb8.
El-Mounayri O, Triplett JW, Yates CW, Herring BP
The Journal of biological chemistry280(27)25854-63(2005 Jul)

In vivo mutagenesis of the Hoxb8 hexapeptide domain leads to dominant homeotic transformations that mimic the loss-of-function mutations in genes of the Hoxb cluster.
Medina-Mart?nez O, Ram?rez-Solis R
Developmental biology264(1)77-90(2003 Dec)

Hoxb8 is required for normal grooming behavior in mice.
Greer JM, Capecchi MR
Neuron33(1)23-34(2002 Jan)

HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.
Knoepfler PS, Sykes DB, Pasillas M, Kamps MP
Oncogene20(39)5440-8(2001 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Hoxb8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hoxb8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07334	NM_001191649.1 Latest version!	Rattus norvegicus homeo box B8 (Hoxb8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa33609	XM_006247175.3 Latest version!	Rattus norvegicus homeo box B8 (Hoxb8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hoxb8 ( NM_001191649.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001178578.1 Rattus norvegicus homeo box B8 (Hoxb8), mRNA.

Price & Availability↑

CloneID	ORa07334
Clone ID Related Accession (Same CDS sequence)	NM_001191649.1
Accession Version	NM_001191649.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	homeobox protein Hox-B8
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07030395.1. On Jul 17, 2010 this sequence version replaced XM_220888.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689597, SAMN02642595 [ECO:0000348] ##Evidence-Data-END##

ATGAGCTCTT ATTTCGTCAA CTCACTGTTC TCCAAATACA AAACCGGGGA GTCCCTGCGC 
CCCAATTATT ATGACTGCGG CTTCGCCCAG GACCTGGGCG GCCGACCCAC CGTGGTGTAC 
GGTCCCAGCA GCGGCGGCAG CTTCCAGCAC CCTTCGCAAA TCCAGGAGTT CTACCACGGG 
CCATCGTCGC TGTCCACGGC TCCCTACCAG CAGAACCCGT GCGCCGTGGC GTGCCACGGG 
GACCCGGGCA ACTTCTACGG CTACGACCCT CTGCAGCGCC AGAGCCTGTT CGGTGCGCAG 
GATCCAGACC TGGTGCAGTA CGCAGACTGC AAGCTCGCGG CAGCCAGCGG CCTGGGCGAG 
GAGGCCGAGG GGTCTGAGCA GAGCCCGTCG CCCACACAGC TCTTCCCCTG GATGCGCCCT 
CAAGCAGCCG CCGGACGCAG GCGAGGCCGC CAGACCTACA GCCGCTACCA GACCCTGGAG 
CTGGAGAAGG AGTTCCTATT TAATCCCTAT CTGACTCGCA AGCGGAGGAT CGAGGTATCG 
CACGCGCTGG GACTGACAGA AAGACAGGTC AAAATCTGGT TCCAGAATCG GAGAATGAAG 
TGGAAAAAGG AGAACAACAA AGACAAGTTC CCCAGCAGTA AATGCGAGCA GGAGGAGCTG 
GAGAAAGAGA AGCTGGAGCG GGCGCCAGAG ACCGCCGAGC AGGGCGATGC GCAGAAGGGT 
GACAAAAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001178578.1
CDS	1..732
Translation	MSSYFVNSLFSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSSGGSFQHPSQIQEFYHGPSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDPDLVQYADCKLAAASGLGEEAEGSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKEKLERAPETAEQGDAQKGDKK

Target ORF information:

RefSeq Version	NM_001191649.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus homeo box B8 (Hoxb8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191649.1

ORF Insert Sequence:

ATGAGCTCTT ATTTCGTCAA CTCACTGTTC TCCAAATACA AAACCGGGGA GTCCCTGCGC 
CCCAATTATT ATGACTGCGG CTTCGCCCAG GACCTGGGCG GCCGACCCAC CGTGGTGTAC 
GGTCCCAGCA GCGGCGGCAG CTTCCAGCAC CCTTCGCAAA TCCAGGAGTT CTACCACGGG 
CCATCGTCGC TGTCCACGGC TCCCTACCAG CAGAACCCGT GCGCCGTGGC GTGCCACGGG 
GACCCGGGCA ACTTCTACGG CTACGACCCT CTGCAGCGCC AGAGCCTGTT CGGTGCGCAG 
GATCCAGACC TGGTGCAGTA CGCAGACTGC AAGCTCGCGG CAGCCAGCGG CCTGGGCGAG 
GAGGCCGAGG GGTCTGAGCA GAGCCCGTCG CCCACACAGC TCTTCCCCTG GATGCGCCCT 
CAAGCAGCCG CCGGACGCAG GCGAGGCCGC CAGACCTACA GCCGCTACCA GACCCTGGAG 
CTGGAGAAGG AGTTCCTATT TAATCCCTAT CTGACTCGCA AGCGGAGGAT CGAGGTATCG 
CACGCGCTGG GACTGACAGA AAGACAGGTC AAAATCTGGT TCCAGAATCG GAGAATGAAG 
TGGAAAAAGG AGAACAACAA AGACAAGTTC CCCAGCAGTA AATGCGAGCA GGAGGAGCTG 
GAGAAAGAGA AGCTGGAGCG GGCGCCAGAG ACCGCCGAGC AGGGCGATGC GCAGAAGGGT 
GACAAAAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hoxb8 ( XM_006247175.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006247237.1 Rattus norvegicus homeo box B8 (Hoxb8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa33609
Clone ID Related Accession (Same CDS sequence)	XM_006247175.3
Accession Version	XM_006247175.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	homeobox protein Hox-B8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006247175.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCTCTT ATTTCGTCAA CTCACTGTTC TCCAAATACA AAACCGGGGA GTCCCTGCGC 
CCCAATTATT ATGACTGCGG CTTCGCCCAG GACCTGGGCG GCCGACCCAC CGTGGTGTAC 
GGTCCCAGCA GCGGCGGCAG CTTCCAGCAC CCTTCGCAAA TCCAGGAGTT CTACCACGGG 
CCATCGTCGC TGTCCACGGC TCCCTACCAG CAGAACCCGT GCGCCGTGGC GTGCCACGGG 
GACCCGGGCA ACTTCTACGG CTACGACCCT CTGCAGCGCC AGAGCCTGTT CGGTGCGCAG 
GATCCAGACC TGGTGCAGTA CGCAGACTGC AAGCTCGCGG CAGCCAGCGG CCTGGGCGAG 
GAGGCCGAGG GGTCTGAGCA GAGCCCGTCG CCCACACAGC TCTTCCCCTG GATGCGCCCT 
CAAGCCGCCG GACGCAGGCG AGGCCGCCAG ACCTACAGCC GCTACCAGAC CCTGGAGCTG 
GAGAAGGAGT TCCTATTTAA TCCCTATCTG ACTCGCAAGC GGAGGATCGA GGTATCGCAC 
GCGCTGGGAC TGACAGAAAG ACAGGTCAAA ATCTGGTTCC AGAATCGGAG AATGAAGTGG 
AAAAAGGAGA ACAACAAAGA CAAGTTCCCC AGCAGTAAAT GCGAGCAGGA GGAGCTGGAG 
AAAGAGAAGC TGGAGCGGGC GCCAGAGACC GCCGAGCAGG GCGATGCGCA GAAGGGTGAC 
AAAAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006247237.1
CDS	12..740
Translation	MSSYFVNSLFSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSSGGSFQHPSQIQEFYHGPSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDPDLVQYADCKLAAASGLGEEAEGSEQSPSPTQLFPWMRPQAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKEKLERAPETAEQGDAQKGDKK

Target ORF information:

RefSeq Version	XM_006247175.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus homeo box B8 (Hoxb8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006247175.3

ORF Insert Sequence:

ATGAGCTCTT ATTTCGTCAA CTCACTGTTC TCCAAATACA AAACCGGGGA GTCCCTGCGC 
CCCAATTATT ATGACTGCGG CTTCGCCCAG GACCTGGGCG GCCGACCCAC CGTGGTGTAC 
GGTCCCAGCA GCGGCGGCAG CTTCCAGCAC CCTTCGCAAA TCCAGGAGTT CTACCACGGG 
CCATCGTCGC TGTCCACGGC TCCCTACCAG CAGAACCCGT GCGCCGTGGC GTGCCACGGG 
GACCCGGGCA ACTTCTACGG CTACGACCCT CTGCAGCGCC AGAGCCTGTT CGGTGCGCAG 
GATCCAGACC TGGTGCAGTA CGCAGACTGC AAGCTCGCGG CAGCCAGCGG CCTGGGCGAG 
GAGGCCGAGG GGTCTGAGCA GAGCCCGTCG CCCACACAGC TCTTCCCCTG GATGCGCCCT 
CAAGCCGCCG GACGCAGGCG AGGCCGCCAG ACCTACAGCC GCTACCAGAC CCTGGAGCTG 
GAGAAGGAGT TCCTATTTAA TCCCTATCTG ACTCGCAAGC GGAGGATCGA GGTATCGCAC 
GCGCTGGGAC TGACAGAAAG ACAGGTCAAA ATCTGGTTCC AGAATCGGAG AATGAAGTGG 
AAAAAGGAGA ACAACAAAGA CAAGTTCCCC AGCAGTAAAT GCGAGCAGGA GGAGCTGGAG 
AAAGAGAAGC TGGAGCGGGC GCCAGAGACC GCCGAGCAGG GCGATGCGCA GAAGGGTGAC 
AAAAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice.
Proceedings of the National Academy of Sciences of the United States of America105(17)6338-43(2008 Apr)
Holstege JC,de Graaff W,Hossaini M,Cardona Cano S,Jaarsma D,van den Akker E,Deschamps J

Regulation of smooth muscle-specific gene expression by homeodomain proteins, Hoxa10 and Hoxb8.
The Journal of biological chemistry280(27)25854-63(2005 Jul)
El-Mounayri O,Triplett JW,Yates CW,Herring BP

In vivo mutagenesis of the Hoxb8 hexapeptide domain leads to dominant homeotic transformations that mimic the loss-of-function mutations in genes of the Hoxb cluster.
Developmental biology264(1)77-90(2003 Dec)
Medina-Mart?nez O,Ram?rez-Solis R

Hoxb8 is required for normal grooming behavior in mice.
Neuron33(1)23-34(2002 Jan)
Greer JM,Capecchi MR

HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.
Oncogene20(39)5440-8(2001 Sep)
Knoepfler PS,Sykes DB,Pasillas M,Kamps MP