Il24 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il24
Entrez Gene ID	170819
Full Name	interleukin 24
Synonyms	Mda-7,Mda7
General protein information	Preferred Names interleukin 24 Names interleukin-24 IL-24 cytokine-like protein Mob-5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q13
Summary	may function in proliferation of fibroblasts during wound healing; human homologue suppresses the growth and colony formation of tumor cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017598655.1	XP_017454144.1	interleukin-24 isoform X1
NM_133311.1	NP_579845.1	interleukin-24 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	IL24	XP_851520.2
Mus musculus (house mouse)	Il24	NP_444325.2
Pan troglodytes (chimpanzee)	IL24	XP_514151.2
Homo sapiens (human)	IL24	NP_001172085.1
Rattus norvegicus (Norway rat)	Il24	NP_579845.1

Gene Ontology
Bibliography

Related articles in PubMed

Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction: A Potential Role of IL-24 in the Regulation of Inflammation and Tissue Remodeling.
Pap D, Sziksz E, Kiss Z, Rokonay R, Veres-Sz?kely A, Lippai R, Tak?cs IM, Kis ?, Fekete A, Reusz G, Szab? AJ, Vannay A
Kidney & blood pressure research42(1)16-32(2017)

Hypalgesia effect of IL-24, a quite new mechanism for IL-24 application in cancer treatment.
Zhao Y, Tian L, Sheng W, Miao J, Yang J
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research33(10)606-11(2013 Oct)

Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease.
Li Y, Messina C, Bendaoud M, Fine DH, Schreiner H, Tsiagbe VK
Molecular oral microbiology25(4)275-92(2010 Aug)

Interleukin-24 induces expression of beta4 integrin but suppresses anchorage-independent growth of rat mammary tumor cells by a mechanism that is independent of beta4.
Xuan W, Li YJ, Liu G, Ben-David Y, Archer MC
Molecular cancer research : MCR7(3)433-42(2009 Mar)

New microbicidal functions of tracheal glands: defective anti-infectious response to Pseudomonas aeruginosa in cystic fibrosis.
Bastonero S, Le Priol Y, Armand M, Bernard CS, Reynaud-Gaubert M, Olive D, Parzy D, de Bentzmann S, Capo C, Mege JL
PloS one4(4)e5357(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IL-24 has a potential treatment effect on cancers not only by inhibiting tumor proliferation, but also by the promotion of beta-endorphin synthesis, inhibition of IL-6 secretion to relieve cancer pain.
Title: Hypalgesia effect of IL-24, a quite new mechanism for IL-24 application in cancer treatment.

The following Il24 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il24 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13358	NM_133311.1 Latest version!	Rattus norvegicus interleukin 24 (Il24), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa44237	XM_017598655.1 Latest version!	Rattus norvegicus interleukin 24 (Il24), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il24 ( NM_133311.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_579845.1 Rattus norvegicus interleukin 24 (Il24), mRNA.

Price & Availability↑

CloneID	ORa13358
Clone ID Related Accession (Same CDS sequence)	NM_133311.1
Accession Version	NM_133311.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-24 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF269251.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF269251.1, AF004774.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689599, SAMEA2689604 [ECO:0000348] ##Evidence-Data-END##

ATGCAGACAA GCTTGAGACA ACAGATTCTC CCCGGCCTGA GCCTAATCCT TCTCGTTTTG 
AACCAAGTAC CAGAGCTTCA GGGTCAAGAG TTCCGATTTG GGCCTTGCCA AGTGACCGGG 
GTGGTTCTCC CAGAACTGTG GGAGGCCTTC TGGACTGTGA AGAACACTGT GAAAACTCAG 
GACGAGCTCA CAAGTGTCCG GCTGTTGAAA CCACAGGTTC TGCAGAATGT CTCGGATGCC 
GAGAGCTGTT ACCTTGCCCA CAGCCTGCTG AAGTTCTACT TGAACACTGT TTTCAAAAAC 
TATCACAGCA AAATAGTCAA ATTCAAGGTC TTGAAGTCAT TCTCCACTCT GGCCAACAAC 
TTTTTAGTCA TCATGTCCAA ACTGCAGCCT AGTAAGGACA ATGCCATGCT TCCCATTAGT 
GACAGTGCAC GCCGGCGTTT TTTGCTGTAC CACAGAACAT TCAAACAGTT GGACATAGAA 
GTGGCTTTGG CGAAAGCCTT TGGGGAAGTG GACATTCTCC TGGCCTGGAT GCAGAATTTC 
TACCAGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_579845.1
CDS	232..783
Translation	MQTSLRQQILPGLSLILLVLNQVPELQGQEFRFGPCQVTGVVLPELWEAFWTVKNTVKTQDELTSVRLLKPQVLQNVSDAESCYLAHSLLKFYLNTVFKNYHSKIVKFKVLKSFSTLANNFLVIMSKLQPSKDNAMLPISDSARRRFLLYHRTFKQLDIEVALAKAFGEVDILLAWMQNFYQL

Target ORF information:

RefSeq Version	NM_133311.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 24 (Il24), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133311.1

ORF Insert Sequence:

ATGCAGACAA GCTTGAGACA ACAGATTCTC CCCGGCCTGA GCCTAATCCT TCTCGTTTTG 
AACCAAGTAC CAGAGCTTCA GGGTCAAGAG TTCCGATTTG GGCCTTGCCA AGTGACCGGG 
GTGGTTCTCC CAGAACTGTG GGAGGCCTTC TGGACTGTGA AGAACACTGT GAAAACTCAG 
GACGAGCTCA CAAGTGTCCG GCTGTTGAAA CCACAGGTTC TGCAGAATGT CTCGGATGCC 
GAGAGCTGTT ACCTTGCCCA CAGCCTGCTG AAGTTCTACT TGAACACTGT TTTCAAAAAC 
TATCACAGCA AAATAGTCAA ATTCAAGGTC TTGAAGTCAT TCTCCACTCT GGCCAACAAC 
TTTTTAGTCA TCATGTCCAA ACTGCAGCCT AGTAAGGACA ATGCCATGCT TCCCATTAGT 
GACAGTGCAC GCCGGCGTTT TTTGCTGTAC CACAGAACAT TCAAACAGTT GGACATAGAA 
GTGGCTTTGG CGAAAGCCTT TGGGGAAGTG GACATTCTCC TGGCCTGGAT GCAGAATTTC 
TACCAGCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il24 ( XM_017598655.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017454144.1 Rattus norvegicus interleukin 24 (Il24), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa44237
Clone ID Related Accession (Same CDS sequence)	XM_017598655.1
Accession Version	XM_017598655.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-24 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGACAA GCTTGAGACA ACAGATTCTC CCCGGCCTGA GCCTAATCCT TCTCGTTTTG 
AACCAAGTAC CAGAGCTTCA GGGTCAAGAG TTCCGATTTG GGCCTTGCCA AGTGACCGGG 
GTGGTTCTCC CAGAACTGTG GGAGGCCTTC TGGACTGTGA AGAACACTGT GAAAACTCAG 
GACGAGCTCA CAAGTGTCCG GCTGTTGAAA CCACAGGTTC TGCAGAATGT CTCGGATGCC 
GAGAGCTGTT ACCTTGCCCA CAGCCTGCTG AAGTTCTACT TGAACACTGT TTTCAAAAAC 
TATCACAGCA AAATAGTCAA ATTCAAGGTC TTGAAGTCAT TCTCCACTCT GGCCAACAAC 
TTTTTAGTCA TCATGTCCAA ACTGCAGCCT AGTAAGGACA ATGCCATGCT TCCCATTAGT 
GACAGTGCAC GCCGGCGTTT TTTGCTGTAC CACAGAACAT TCAAACAGGT AAGGCCAAGA 
GCTGGGAGTC TGCCTACCCA ACAGCAGCAG ACTAGCTTGA ACTGTCACAG AGAGTACCCT 
AGAGACCTAA TGAAGAACCG AATGTGCCTC CTTTGGGCTT GTCCCAGACC TGCCTGTCTT 
GGTAGGATAA TTAATAAGCA CCTGCTTTGC ATAAGTCAAT GTGGGCCTTT TCCCCGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017454144.1
CDS	49..708
Translation	MQTSLRQQILPGLSLILLVLNQVPELQGQEFRFGPCQVTGVVLPELWEAFWTVKNTVKTQDELTSVRLLKPQVLQNVSDAESCYLAHSLLKFYLNTVFKNYHSKIVKFKVLKSFSTLANNFLVIMSKLQPSKDNAMLPISDSARRRFLLYHRTFKQVRPRAGSLPTQQQQTSLNCHREYPRDLMKNRMCLLWACPRPACLGRIINKHLLCISQCGPFPR

Target ORF information:

RefSeq Version	XM_017598655.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 24 (Il24), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017598655.1

ORF Insert Sequence:

ATGCAGACAA GCTTGAGACA ACAGATTCTC CCCGGCCTGA GCCTAATCCT TCTCGTTTTG 
AACCAAGTAC CAGAGCTTCA GGGTCAAGAG TTCCGATTTG GGCCTTGCCA AGTGACCGGG 
GTGGTTCTCC CAGAACTGTG GGAGGCCTTC TGGACTGTGA AGAACACTGT GAAAACTCAG 
GACGAGCTCA CAAGTGTCCG GCTGTTGAAA CCACAGGTTC TGCAGAATGT CTCGGATGCC 
GAGAGCTGTT ACCTTGCCCA CAGCCTGCTG AAGTTCTACT TGAACACTGT TTTCAAAAAC 
TATCACAGCA AAATAGTCAA ATTCAAGGTC TTGAAGTCAT TCTCCACTCT GGCCAACAAC 
TTTTTAGTCA TCATGTCCAA ACTGCAGCCT AGTAAGGACA ATGCCATGCT TCCCATTAGT 
GACAGTGCAC GCCGGCGTTT TTTGCTGTAC CACAGAACAT TCAAACAGGT AAGGCCAAGA 
GCTGGGAGTC TGCCTACCCA ACAGCAGCAG ACTAGCTTGA ACTGTCACAG AGAGTACCCT 
AGAGACCTAA TGAAGAACCG AATGTGCCTC CTTTGGGCTT GTCCCAGACC TGCCTGTCTT 
GGTAGGATAA TTAATAAGCA CCTGCTTTGC ATAAGTCAAT GTGGGCCTTT TCCCCGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction: A Potential Role of IL-24 in the Regulation of Inflammation and Tissue Remodeling.
Kidney & blood pressure research42(1)16-32(2017)
Pap D,Sziksz E,Kiss Z,Rokonay R,Veres-Sz?kely A,Lippai R,Tak?cs IM,Kis ?,Fekete A,Reusz G,Szab? AJ,Vannay A

Hypalgesia effect of IL-24, a quite new mechanism for IL-24 application in cancer treatment.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research33(10)606-11(2013 Oct)
Zhao Y,Tian L,Sheng W,Miao J,Yang J

Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease.
Molecular oral microbiology25(4)275-92(2010 Aug)
Li Y,Messina C,Bendaoud M,Fine DH,Schreiner H,Tsiagbe VK

Interleukin-24 induces expression of beta4 integrin but suppresses anchorage-independent growth of rat mammary tumor cells by a mechanism that is independent of beta4.
Molecular cancer research : MCR7(3)433-42(2009 Mar)
Xuan W,Li YJ,Liu G,Ben-David Y,Archer MC

New microbicidal functions of tracheal glands: defective anti-infectious response to Pseudomonas aeruginosa in cystic fibrosis.
PloS one4(4)e5357(2009)
Bastonero S,Le Priol Y,Armand M,Bernard CS,Reynaud-Gaubert M,Olive D,Parzy D,de Bentzmann S,Capo C,Mege JL