Cdk5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdk5
Entrez Gene ID	140908
Full Name	cyclin-dependent kinase 5
General protein information	Preferred Names cyclin-dependent kinase 5 Names cyclin-dependent-like kinase 5 TPKII catalytic subunit cell division protein kinase 5 serine/threonine-protein kinase PSSALRE tau protein kinase II catalytic subunit
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q11
Summary	serine/threonine kinase involved in synaptic regulation and neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_080885.1	NP_543161.1	cyclin-dependent-like kinase 5

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cdk5	NP_543161.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005772	XP_315787.4
Saccharomyces cerevisiae (baker's yeast)	PHO85	NP_015294.1
Neurospora crassa	NCU07580	XP_958274.1
Xenopus tropicalis (tropical clawed frog)	cdk5	NP_001072776.1
Homo sapiens (human)	CDK5	NP_004926.1
	CDK5	XP_001102523.1
Canis lupus familiaris (dog)	CDK5	XP_005629809.1
Bos taurus (cattle)	CDK5	NP_776442.1
Gallus gallus (chicken)	CDK5	NP_001129258.1
Eremothecium gossypii	AGOS_AGL242C	NP_986425.2
Pan troglodytes (chimpanzee)	CDK5	XP_519523.2
Mus musculus (house mouse)	Cdk5	NP_031694.1
Danio rerio (zebrafish)	cdk5	NP_571794.1
Drosophila melanogaster (fruit fly)	Cdk5	NP_477080.1
Caenorhabditis elegans (roundworm)	cdk-5	NP_499783.1
Kluyveromyces lactis	KLLA0D11990g	XP_453596.1
Schizosaccharomyces pombe (fission yeast)	pef1	NP_587921.1
Magnaporthe oryzae (rice blast fungus)	MGG_04660	XP_003713655.1

Gene Ontology
Bibliography

Related articles in PubMed

CDK5-dependent activation of dynein in the axon initial segment regulates polarized cargo transport in neurons.
Klinman E, Tokito M, Holzbaur ELF
Traffic (Copenhagen, Denmark)18(12)808-824(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hippocampal calpain-2/p35-p25/Cdk5 pathway was involved in BDE-153-induced neuronal apoptosis.
Title: Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153.

Data indicate that transforming growth factor beta1 (TGF-beta1) decreased Tunel-positive cells while cyclin-dependent kinase 5 (Cdk5) inhibitor treatment blunted the effects of TGF-beta1.
Title: Cdk5 is required for the neuroprotective effect of transforming growth factor-?1 against cerebral ischemia-reperfusion.

These experiments suggest that an age-dependent loss in synaptic function and Cdk5/p39 activity in the nucleus accumbens may be partially responsible for age-related declines in voluntary running behaviour
Title: Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age-related declines in voluntary physical activity.

Data show that cyclin-dependent kinase 5 (CDK5) siRNA inhibits epithelial-to-mesenchymal transition (EMT) via extracellular signal-regulated kinase 1/2 (ERK1/2)/peroxisome proliferator-activated receptor gamma (PPRAgamma) pathway in high glucose cultured renal tubular cell line NRK-52E cells.
Title: CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via ERK1/2/PPAR? pathway.

The behavioral and molecular data indicated that TRPV1 is strongly modulated by Cdk5-mediated phosphorylation at position threonine-407(mouse)/threonine406(rat).
Title: TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception.

The following Cdk5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdk5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13525	NM_080885.1 Latest version!	Rattus norvegicus cyclin-dependent kinase 5 (Cdk5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdk5 ( NM_080885.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_543161.1 Rattus norvegicus cyclin-dependent kinase 5 (Cdk5), mRNA.

Price & Availability↑

CloneID	ORa13525
Clone ID Related Accession (Same CDS sequence)	NM_080885.1
Accession Version	NM_080885.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-dependent-like kinase 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L02121.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L02121.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCAGAAAT ACGAGAAACT GGAGAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAAACCCA TGAGATTGTG GCTCTGAAGC GAGTCAGGCT GGACGATGAC 
GATGAGGGTG TGCCAAGTTC AGCCCTCCGG GAGATCTGTC TACTCAAAGA ACTGAAGCAC 
AAAAACATTG TCAGGCTTCA TGATGTCCTG CATAGTGACA AGAAGCTCAC ATTGGTGTTT 
GAGTTCTGTG ATCAGGACCT GAAGAAATAT TTTGACAGCT GCAATGGTGA CCTGGACCCT 
GAGATTGTGA AGTCACTCCT CTTCCAGCTG CTGAAAGGCC TGGGATTCTG TCACAGCCGT 
AACGTGCTGC ACAGGGACCT GAAGCCCCAG AATCTGCTCA TTAACAGGAA TGGGGAACTG 
AAATTGGCTG ATTTTGGCCT GGCCCGAGCC TTTGGTATCC CAGTCCGCTG CTACTCTGCT 
GAGGTGGTCA CGCTGTGGTA CCGCCCACCG GATGTCCTCT TTGGGGCCAA GCTGTACTCC 
ACGTCCATCG ACATGTGGTC AGCCGGCTGC ATCTTTGCAG AGCTGGCCAA TGCAGGGCGA 
CCTCTCTTCC CCGGCAATGA TGTGGATGAC CAGCTGAAGA GGATCTTTCG ACTGCTAGGG 
ACACCGACTG AGGAACAGTG GCCTGCCATG ACCAAACTGC CAGACTATAA GCCCTACCCA 
ATGTACCCAG CTACAACATC CTTGGTGAAT GTCGTGCCCA AACTCAATGC CACGGGGAGA 
GACCTGTTGC AGAACCTGTT GAAGTGTAAC CCAGTGCAGC GCATCTCGGC AGAGGAGGCC 
TTGCAGCACC CCTATTTCTC TGACTTCTGT CCCCCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_543161.1
CDS	94..972
Translation	MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSLLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP

Target ORF information:

RefSeq Version	NM_080885.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin-dependent kinase 5 (Cdk5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080885.1

ORF Insert Sequence:

ATGCAGAAAT ACGAGAAACT GGAGAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAAACCCA TGAGATTGTG GCTCTGAAGC GAGTCAGGCT GGACGATGAC 
GATGAGGGTG TGCCAAGTTC AGCCCTCCGG GAGATCTGTC TACTCAAAGA ACTGAAGCAC 
AAAAACATTG TCAGGCTTCA TGATGTCCTG CATAGTGACA AGAAGCTCAC ATTGGTGTTT 
GAGTTCTGTG ATCAGGACCT GAAGAAATAT TTTGACAGCT GCAATGGTGA CCTGGACCCT 
GAGATTGTGA AGTCACTCCT CTTCCAGCTG CTGAAAGGCC TGGGATTCTG TCACAGCCGT 
AACGTGCTGC ACAGGGACCT GAAGCCCCAG AATCTGCTCA TTAACAGGAA TGGGGAACTG 
AAATTGGCTG ATTTTGGCCT GGCCCGAGCC TTTGGTATCC CAGTCCGCTG CTACTCTGCT 
GAGGTGGTCA CGCTGTGGTA CCGCCCACCG GATGTCCTCT TTGGGGCCAA GCTGTACTCC 
ACGTCCATCG ACATGTGGTC AGCCGGCTGC ATCTTTGCAG AGCTGGCCAA TGCAGGGCGA 
CCTCTCTTCC CCGGCAATGA TGTGGATGAC CAGCTGAAGA GGATCTTTCG ACTGCTAGGG 
ACACCGACTG AGGAACAGTG GCCTGCCATG ACCAAACTGC CAGACTATAA GCCCTACCCA 
ATGTACCCAG CTACAACATC CTTGGTGAAT GTCGTGCCCA AACTCAATGC CACGGGGAGA 
GACCTGTTGC AGAACCTGTT GAAGTGTAAC CCAGTGCAGC GCATCTCGGC AGAGGAGGCC 
TTGCAGCACC CCTATTTCTC TGACTTCTGT CCCCCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CDK5-dependent activation of dynein in the axon initial segment regulates polarized cargo transport in neurons.
Traffic (Copenhagen, Denmark)18(12)808-824(2017 Dec)
Klinman E,Tokito M,Holzbaur ELF