Rgcc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rgcc
Entrez Gene ID	117183
Full Name	regulator of cell cycle
Synonyms	Rgc32
General protein information	Preferred Names regulator of cell cycle Names regulator of cell cycle RGCC RGC-32 response gene to complement 32 protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15q12
Summary	increased expression is detected in oligodendrocytes in response to complement activation; may play a role in cell cycle activation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_054008.1	NP_446460.1	regulator of cell cycle RGCC

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RGCC	NP_001095746.1
Xenopus tropicalis (tropical clawed frog)	rgcc	NP_001096268.1
Gallus gallus (chicken)	C1H13ORF15	XP_417029.1
Danio rerio (zebrafish)	rgcc	NP_001002190.1
Mus musculus (house mouse)	Rgcc	NP_079703.2
Homo sapiens (human)	RGCC	NP_054778.2
Pan troglodytes (chimpanzee)	RGCC	XP_001170481.2
	C13orf15	XP_001091614.1
Rattus norvegicus (Norway rat)	LOC683573	XP_003750007.1
Rattus norvegicus (Norway rat)	Rgcc	NP_446460.1

Gene Ontology
Bibliography

Related articles in PubMed

Response gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair.
Shen YL, Liu HJ, Sun L, Niu XL, Kuang XY, Wang P, Hao S, Huang WY
Cellular & molecular biology letters2119(2016)

Response gene to complement 32 is essential for fibroblast activation in renal fibrosis.
Li Z, Xie WB, Escano CS, Asico LD, Xie Q, Jose PA, Chen SY
The Journal of biological chemistry286(48)41323-30(2011 Dec)

Response gene to complement 32 promotes vascular lesion formation through stimulation of smooth muscle cell proliferation and migration.
Wang JN, Shi N, Xie WB, Guo X, Chen SY
Arteriosclerosis, thrombosis, and vascular biology31(8)e19-26(2011 Aug)

Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells.
Guo X, Jose PA, Chen SY
American journal of physiology. Cell physiology300(6)C1415-21(2011 Jun)

Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor.
An X, Jin Y, Guo H, Foo SY, Cully BL, Wu J, Zeng H, Rosenzweig A, Li J
Circulation120(7)617-27(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RGC-32 probably has an important impact on the repair process of renal tubular epithelial cells in vitro by regulating the G2/M phase checkpoint, cell fibrosis and cell adhesion.
Title: Response gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair.

Using a carotid artery balloon-injury model, we documented for the first time that neointima formation was closely associated with a significantly increased expression of RGC-32 protein.
Title: Response gene to complement 32 promotes vascular lesion formation through stimulation of smooth muscle cell proliferation and migration.

Spacial/temporal-specific expression of Rgc32 in the ovary and expression in granulosa cells.
Title: Response gene to complement 32 expression is induced by the luteinizing hormone (LH) surge and regulated by LH-induced mediators in the rodent ovary.

The following Rgcc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rgcc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11321	NM_054008.1 Latest version!	Rattus norvegicus regulator of cell cycle (Rgcc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rgcc ( NM_054008.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446460.1 Rattus norvegicus regulator of cell cycle (Rgcc), mRNA.

Price & Availability↑

CloneID	ORa11321
Clone ID Related Accession (Same CDS sequence)	NM_054008.1
Accession Version	NM_054008.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	regulator of cell cycle RGCC
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF036548.1. On Oct 23, 2008 this sequence version replaced XM_001072931.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF036548.1, FN800497.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAAGCCGC CCTCCACGCA GAGCAGCCCC GCGGCCGTGG CGGCCGCAGC CCCGGCCATG 
GACTCCGCGG CCGCTGCAGA CCTGACGGAC GTGCTGTGCG AGTTCGACGC GGTGCTGGCC 
GACTTCGCGT CGCCCTTCCA CGAGCGCCAC TTCCACTATG AGGAGCACCT GGAGCGCATG 
AAGCGGCGCA GCAGCGCCAG CGTCAGTGAC AGCAGCGGCT TCAGCGACTC CGAGAGTGCA 
GACTCGTTGT ACAGGGACAG CTTCACCTTC AGTGATGAGA AGCTGAATTC TCCGACGGAC 
TCCACTCCAG CCCTCTTGTC CTCCGCTGTC ACTCCTCGGA AAGCCAAATT AGGTGACACT 
AAAGAGCTCG AAGACTTCAT CGCTGATCTG GACAGAACCT TAGCAAGTAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446460.1
CDS	93..506
Translation	MKPPSTQSSPAAVAAAAPAMDSAAAADLTDVLCEFDAVLADFASPFHERHFHYEEHLERMKRRSSASVSDSSGFSDSESADSLYRDSFTFSDEKLNSPTDSTPALLSSAVTPRKAKLGDTKELEDFIADLDRTLASM

Target ORF information:

RefSeq Version	NM_054008.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus regulator of cell cycle (Rgcc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_054008.1

ORF Insert Sequence:

ATGAAGCCGC CCTCCACGCA GAGCAGCCCC GCGGCCGTGG CGGCCGCAGC CCCGGCCATG 
GACTCCGCGG CCGCTGCAGA CCTGACGGAC GTGCTGTGCG AGTTCGACGC GGTGCTGGCC 
GACTTCGCGT CGCCCTTCCA CGAGCGCCAC TTCCACTATG AGGAGCACCT GGAGCGCATG 
AAGCGGCGCA GCAGCGCCAG CGTCAGTGAC AGCAGCGGCT TCAGCGACTC CGAGAGTGCA 
GACTCGTTGT ACAGGGACAG CTTCACCTTC AGTGATGAGA AGCTGAATTC TCCGACGGAC 
TCCACTCCAG CCCTCTTGTC CTCCGCTGTC ACTCCTCGGA AAGCCAAATT AGGTGACACT 
AAAGAGCTCG AAGACTTCAT CGCTGATCTG GACAGAACCT TAGCAAGTAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Response gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair.
Cellular & molecular biology letters2119(2016)
Shen YL,Liu HJ,Sun L,Niu XL,Kuang XY,Wang P,Hao S,Huang WY

Response gene to complement 32 is essential for fibroblast activation in renal fibrosis.
The Journal of biological chemistry286(48)41323-30(2011 Dec)
Li Z,Xie WB,Escano CS,Asico LD,Xie Q,Jose PA,Chen SY

Response gene to complement 32 promotes vascular lesion formation through stimulation of smooth muscle cell proliferation and migration.
Arteriosclerosis, thrombosis, and vascular biology31(8)e19-26(2011 Aug)
Wang JN,Shi N,Xie WB,Guo X,Chen SY

Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells.
American journal of physiology. Cell physiology300(6)C1415-21(2011 Jun)
Guo X,Jose PA,Chen SY

Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor.
Circulation120(7)617-27(2009 Aug)
An X,Jin Y,Guo H,Foo SY,Cully BL,Wu J,Zeng H,Rosenzweig A,Li J