Trip10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trip10
Entrez Gene ID	116717
Full Name	thyroid hormone receptor interactor 10
Synonyms	Cip4,STP
General protein information	Preferred Names thyroid hormone receptor interactor 10 Names cdc42-interacting protein 4 TR-interacting protein 10 TRIP-10 salt tolerant protein thyroid receptor-interacting protein 10
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q12
Summary	may mediate salt tolerance by modulating the cation transport system [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053920.1	NP_446372.1	cdc42-interacting protein 4

Pathways from BioSystems

Homologies

Homo sapiens (human)	TRIP10	NP_001275891.1
Canis lupus familiaris (dog)	TRIP10	XP_005633025.1
Bos taurus (cattle)	TRIP10	NP_001074999.1
Mus musculus (house mouse)	Trip10	NP_001229319.1
Danio rerio (zebrafish)	zgc:101777	NP_001007404.1
Rattus norvegicus (Norway rat)	Trip10	NP_446372.1

Gene Ontology
Bibliography

Related articles in PubMed

Suppression of CIP4/Par6 attenuates TGF-?1-induced epithelial-mesenchymal transition in NRK-52E cells.
Zhu YC, Wang YK, Bai SJ, Zha FF, Feng G, Gao CP, Liu J
International journal of molecular medicine40(4)1165-1171(2017 Oct)

ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function.
Ba W, Selten MM, van der Raadt J, van Veen H, Li LL, Benevento M, Oudakker AR, Lasabuda RSE, Letteboer SJ, Roepman R, van Wezel RJA, Courtney MJ, van Bokhoven H, Nadif Kasri N
Cell reports14(6)1355-1368(2016 Feb)

Cdc42-Interacting Protein 4 Represses E-Cadherin Expression by Promoting ?-Catenin Translocation to the Nucleus in Murine Renal Tubular Epithelial Cells.
Xu C, Zhou Q, Liu L, Liu P, Pei G, Zeng R, Han M, Xu G
International journal of molecular sciences16(8)19170-83(2015 Aug)

Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-?1 and CIP4 in diabetic nephropathy rat.
Yu R, Mao J, Yang Y, Zhang Y, Tian Y, Zhu J
International journal of clinical and experimental pathology8(4)3503-12(2015)

CIP4 is required for the hypertrophic growth of neonatal cardiac myocytes.
Rusconi F, Thakur H, Li J, Kapiloff MS
Journal of biomedical science2056(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ARHGAP12 negatively controls dendritic spine size via its RhoGAP activity and promotes, by interacting with CIP4, postsynaptic AMPA receptor endocytosis.
Title: ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function.

CIP4 overexpression represses E-cadherin expression by promoting beta-catenin translocation to the nucleus.
Title: Cdc42-Interacting Protein 4 Represses E-Cadherin Expression by Promoting ?-Catenin Translocation to the Nucleus in Murine Renal Tubular Epithelial Cells.

Calcitriol may protect diabetic nephropathy from fibrosis via inhibition of TGF-beta1 and CIP4.
Title: Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-?1 and CIP4 in diabetic nephropathy rat.

CIP4 is capable of inducing ECM deposition and exacerbating progressive fibrosis in chronic renal failure.
Title: Cdc42-interacting protein-4 promotes TGF-?1-induced epithelial-mesenchymal transition and extracellular matrix deposition in renal proximal tubular epithelial cells.

a new role for Trip10, showing that the level of Trip10 expression is associated with the maintenance and differentiation of MSCs, was established.
Title: DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination.

The following Trip10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trip10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11061	NM_053920.1 Latest version!	Rattus norvegicus thyroid hormone receptor interactor 10 (Trip10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trip10 ( NM_053920.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446372.1 Rattus norvegicus thyroid hormone receptor interactor 10 (Trip10), mRNA.

Price & Availability↑

CloneID	ORa11061
Clone ID Related Accession (Same CDS sequence)	NM_053920.1
Accession Version	NM_053920.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1644bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	cdc42-interacting protein 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB006914.1. On Dec 17, 2003 this sequence version replaced XM_346862.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB006914.1, BC061840.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGATTGGG GTACCGAGTT GTGGGATCAG TTTGAGGTGC TGGAACGCCA CACACAGTGG 
GGGCTGGATC TGTTGGACAA ATACGTGAAG TTCGTGAAAG AACGCGTCGA GGTGGAGCAG 
TCTTATGCGA AGCAACTCAG GAGTCTGGTG AAAAAGTATC TTCCCAAGAG ACCTGCCAAA 
GATGACCCCG AAATCAAGTT TAGCCAGCAA CAGTCATTTG TCCAGCTTCT CCAGGAGGTC 
AATGATTTTG CAGGCCAACG AGAGCTGGTG GCCGAGAGCC TTGGCATCCG AGTGTGTCTG 
GAGCTGGCTA AGTATTCACA GGAGATGAAG CAAGAGAGGA AGATGCACTT CCAAGAAGGC 
CGTCGGGCCC AGCAGCAGCT GGAAAATGGC TTCAAACAGC TGGAGAATAG TAAGCGAAAG 
TTTGAACGAG ACTGTCGCGA GGCTGAGAAA GCGGCTCACA CCGCAGAGCG GCTGGACCAG 
GACATTAATG CCACCAAGGC GGATGTGGAG AAGGCCAAGC AGCAAGCCCA CCTTCGGAAC 
CACATGGCAG AAGAGAGCAA GAACGAATAC GCGGCCCAGC TGCAGCGCTT CAACCGGGAC 
CAGGCTCACT TCTACTTCTC ACAGATGCCG CAGATATTCG ACAAGCTGCA GGACATGGAT 
GAACGCCGGG CCACCCGCCT TGGGGCCGGG TATGGGCTCT TATCTGAAGC TGAACTGCAG 
GTGGTTCCCA TTATTGGCAA ATGCTTGGAG GGCATGAAGG TGGCCGCAGA GTCCGTGGAT 
GCTAAGAACG ACTCGAAGGT CCTCATCGAA TTACACAAGT CAGGGTTTGC CCGCCCGGGT 
GACTTGGAAT TTGAAGACTT CAGCCAAGTT ATGAACCGAG TGCCGTCGGA CAGCAGCCTG 
GGCACCCCAG ATGGCAGGCC TGAGCTCCGA GCAGCTTCCA GCCGTAGTCG TGCCAAGCGT 
TGGCCTTTTG GGAAAAAGAA CAAGACCGTG GTCACCGAAG ATTTCAGTCA CCTGCCCCCG 
GAGCAGCAGA GAAAGCGACT CCAGCAACAG TTGGAAGAGC GGAACCGAGA GTTGCAGAAG 
GAGGAGGACC AGAGGGAGGC CCTGAAGAAG ATGAAAGATG TATATGAGAA AACACCACAA 
ATGGGGGACC CCGCCAGCTT AGAGCCCCGC ATTGCAGAGA CCCTGGGCAA CATTGAAAGG 
CTGAACGTGG AAGTGCAGAA GTATGAGGCT TGGTTGGCAG AAGCTGAAAC GCGGGTCCTC 
AGTAACCGAG GGGACAGCCT AAGCCGTCAC ACTAGGCCTC CTGATCCCCC AACTACTGCC 
CCACCTGATA GTAGCAGTAG CAGCAACAAC AGTGGATCCC AGGATAATAT GGAGAGCTCA 
GAAGAGCCCC CTTCAGAAGA AGGCCAGGAC ACCCCCATCT ACACTGAGTT CGATGAGGAC 
TTTGAAGAAC CTGCATCCCC CATCGGCCAG TGTGTGGCTA TCTACCATTT TGAAGGATCC 
AGTGAGGGGA CCGTCTCCAT GTCCGAGGGG GAAGACCTCA GTCTGATGGA GGAAGACAAG 
GGTGATGGAT GGACACGGGT GAGGAGGAAA CAGGGAGGCG AGGGCTATGT GCCCACCTCT 
TACCTCCGAG TCACACTCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446372.1
CDS	49..1692
Translation	MDWGTELWDQFEVLERHTQWGLDLLDKYVKFVKERVEVEQSYAKQLRSLVKKYLPKRPAKDDPEIKFSQQQSFVQLLQEVNDFAGQRELVAESLGIRVCLELAKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAHTAERLDQDINATKADVEKAKQQAHLRNHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELQVVPIIGKCLEGMKVAAESVDAKNDSKVLIELHKSGFARPGDLEFEDFSQVMNRVPSDSSLGTPDGRPELRAASSRSRAKRWPFGKKNKTVVTEDFSHLPPEQQRKRLQQQLEERNRELQKEEDQREALKKMKDVYEKTPQMGDPASLEPRIAETLGNIERLNVEVQKYEAWLAEAETRVLSNRGDSLSRHTRPPDPPTTAPPDSSSSSNNSGSQDNMESSEEPPSEEGQDTPIYTEFDEDFEEPASPIGQCVAIYHFEGSSEGTVSMSEGEDLSLMEEDKGDGWTRVRRKQGGEGYVPTSYLRVTLN

Target ORF information:

RefSeq Version	NM_053920.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus thyroid hormone receptor interactor 10 (Trip10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053920.1

ORF Insert Sequence:

ATGGATTGGG GTACCGAGTT GTGGGATCAG TTTGAGGTGC TGGAACGCCA CACACAGTGG 
GGGCTGGATC TGTTGGACAA ATACGTGAAG TTCGTGAAAG AACGCGTCGA GGTGGAGCAG 
TCTTATGCGA AGCAACTCAG GAGTCTGGTG AAAAAGTATC TTCCCAAGAG ACCTGCCAAA 
GATGACCCCG AAATCAAGTT TAGCCAGCAA CAGTCATTTG TCCAGCTTCT CCAGGAGGTC 
AATGATTTTG CAGGCCAACG AGAGCTGGTG GCCGAGAGCC TTGGCATCCG AGTGTGTCTG 
GAGCTGGCTA AGTATTCACA GGAGATGAAG CAAGAGAGGA AGATGCACTT CCAAGAAGGC 
CGTCGGGCCC AGCAGCAGCT GGAAAATGGC TTCAAACAGC TGGAGAATAG TAAGCGAAAG 
TTTGAACGAG ACTGTCGCGA GGCTGAGAAA GCGGCTCACA CCGCAGAGCG GCTGGACCAG 
GACATTAATG CCACCAAGGC GGATGTGGAG AAGGCCAAGC AGCAAGCCCA CCTTCGGAAC 
CACATGGCAG AAGAGAGCAA GAACGAATAC GCGGCCCAGC TGCAGCGCTT CAACCGGGAC 
CAGGCTCACT TCTACTTCTC ACAGATGCCG CAGATATTCG ACAAGCTGCA GGACATGGAT 
GAACGCCGGG CCACCCGCCT TGGGGCCGGG TATGGGCTCT TATCTGAAGC TGAACTGCAG 
GTGGTTCCCA TTATTGGCAA ATGCTTGGAG GGCATGAAGG TGGCCGCAGA GTCCGTGGAT 
GCTAAGAACG ACTCGAAGGT CCTCATCGAA TTACACAAGT CAGGGTTTGC CCGCCCGGGT 
GACTTGGAAT TTGAAGACTT CAGCCAAGTT ATGAACCGAG TGCCGTCGGA CAGCAGCCTG 
GGCACCCCAG ATGGCAGGCC TGAGCTCCGA GCAGCTTCCA GCCGTAGTCG TGCCAAGCGT 
TGGCCTTTTG GGAAAAAGAA CAAGACCGTG GTCACCGAAG ATTTCAGTCA CCTGCCCCCG 
GAGCAGCAGA GAAAGCGACT CCAGCAACAG TTGGAAGAGC GGAACCGAGA GTTGCAGAAG 
GAGGAGGACC AGAGGGAGGC CCTGAAGAAG ATGAAAGATG TATATGAGAA AACACCACAA 
ATGGGGGACC CCGCCAGCTT AGAGCCCCGC ATTGCAGAGA CCCTGGGCAA CATTGAAAGG 
CTGAACGTGG AAGTGCAGAA GTATGAGGCT TGGTTGGCAG AAGCTGAAAC GCGGGTCCTC 
AGTAACCGAG GGGACAGCCT AAGCCGTCAC ACTAGGCCTC CTGATCCCCC AACTACTGCC 
CCACCTGATA GTAGCAGTAG CAGCAACAAC AGTGGATCCC AGGATAATAT GGAGAGCTCA 
GAAGAGCCCC CTTCAGAAGA AGGCCAGGAC ACCCCCATCT ACACTGAGTT CGATGAGGAC 
TTTGAAGAAC CTGCATCCCC CATCGGCCAG TGTGTGGCTA TCTACCATTT TGAAGGATCC 
AGTGAGGGGA CCGTCTCCAT GTCCGAGGGG GAAGACCTCA GTCTGATGGA GGAAGACAAG 
GGTGATGGAT GGACACGGGT GAGGAGGAAA CAGGGAGGCG AGGGCTATGT GCCCACCTCT 
TACCTCCGAG TCACACTCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppression of CIP4/Par6 attenuates TGF-?1-induced epithelial-mesenchymal transition in NRK-52E cells.
International journal of molecular medicine40(4)1165-1171(2017 Oct)
Zhu YC,Wang YK,Bai SJ,Zha FF,Feng G,Gao CP,Liu J

ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function.
Cell reports14(6)1355-1368(2016 Feb)
Ba W,Selten MM,van der Raadt J,van Veen H,Li LL,Benevento M,Oudakker AR,Lasabuda RSE,Letteboer SJ,Roepman R,van Wezel RJA,Courtney MJ,van Bokhoven H,Nadif Kasri N

Cdc42-Interacting Protein 4 Represses E-Cadherin Expression by Promoting ?-Catenin Translocation to the Nucleus in Murine Renal Tubular Epithelial Cells.
International journal of molecular sciences16(8)19170-83(2015 Aug)
Xu C,Zhou Q,Liu L,Liu P,Pei G,Zeng R,Han M,Xu G

Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-?1 and CIP4 in diabetic nephropathy rat.
International journal of clinical and experimental pathology8(4)3503-12(2015)
Yu R,Mao J,Yang Y,Zhang Y,Tian Y,Zhu J

CIP4 is required for the hypertrophic growth of neonatal cardiac myocytes.
Journal of biomedical science2056(2013 Aug)
Rusconi F,Thakur H,Li J,Kapiloff MS