Acot11 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acot11
Entrez Gene ID	100363074
Full Name	acyl-CoA thioesterase 11
Synonyms	Thea
General protein information	Preferred Names acyl-CoA thioesterase 11 Names acyl-coenzyme A thioesterase 11 thioesterase, adipose associated
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001271383.1	NP_001258312.1	acyl-coenzyme A thioesterase 11

Pathways from BioSystems

Homologies

	ACOT11	XP_001113972.2
Gallus gallus (chicken)	ACOT11	XP_426664.3
Xenopus tropicalis (tropical clawed frog)	acot11	XP_002931507.2
Mus musculus (house mouse)	Acot11	NP_079866.2
Homo sapiens (human)	ACOT11	NP_671517.1
Rattus norvegicus (Norway rat)	Acot11	NP_001258312.1
Danio rerio (zebrafish)	acot11a	NP_001093445.1
Canis lupus familiaris (dog)	ACOT11	XP_005620315.1
Pan troglodytes (chimpanzee)	ACOT11	XP_001152786.1

Gene Ontology
Bibliography

Related articles in PubMed

Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue.
Okada K, LeClair KB, Zhang Y, Li Y, Ozdemir C, Krisko TI, Hagen SJ, Betensky RA, Banks AS, Cohen DE
Molecular metabolism5(5)340-51(2016 May)

Human brown fat inducible thioesterase variant 2 cellular localization and catalytic function.
Chen D, Latham J, Zhao H, Bisoffi M, Farelli J, Dunaway-Mariano D
Biochemistry51(35)6990-9(2012 Sep)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity.
Adams SH, Chui C, Schilbach SL, Yu XX, Goddard AD, Grimaldi JC, Lee J, Dowd P, Colman S, Lewin DA
The Biochemical journal360(Pt 1)135-42(2001 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Acot11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acot11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11145	NM_001271383.1 Latest version!	Rattus norvegicus acyl-CoA thioesterase 11 (Acot11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acot11 ( NM_001271383.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001258312.1 Rattus norvegicus acyl-CoA thioesterase 11 (Acot11), mRNA.

Price & Availability↑

CloneID	ORa11145
Clone ID Related Accession (Same CDS sequence)	NM_001271383.1
Accession Version	NM_001271383.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1785bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-18
Organism	Rattus norvegicus(Norway rat)
Product	acyl-coenzyme A thioesterase 11
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC122593.5. On or before Sep 21, 2012 this sequence version replaced XM_003749990.1, XM_002729507.2, XM_003754071.1, XM_003754072.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGATACAGA ATGTGGGCAA CCACTTACGA AGGGGCTTCG CCTCTATGTT CTCTAGTCGG 
ACATCCCGGA AGTCAGTCTC TCATCCGGAG TCCGGAGACG CTTCCGCCAT GGCAGAGGGT 
GAAGGCTACC GGAACCCCAC GGAGGTGCAG ATGAGCCAGC TGGTGCTGCC CTGCCACACT 
AACCACCGTG GGGAGCTGAG CATTGGGCAG TTGCTCAAAT GGATCGACAC CACAGCCTGC 
CTATCAGCGG AGAGGCATGC TGGCTGTCCC TGTGTCACAG CCTCCATGGA TGACATCTAC 
TTCGACCATA CCATTAGTGT CGGCCAAGTG GTGAATATCA AGGCCAAGGT GAACCGGGCC 
TTCAACTCCA GCATGGAGGT AGGAATCCAG GTGGTCTCTG AAGATCTGTG CTCTGAGAAA 
CAGTGGAGTG TCTGCAAGGC CTTGGCCACC TTCGTGGCCC ACCGGGAGCT CTCCAAGGTG 
AAGCTGAAGC AGGTTGTCCC ATTGACGGAG GAGGAGAAGA CCGAGCATGG GGTGGCGGCT 
GAGCGCCGGC GTATGCGACT GGTCTACACA GACACCATCA AGGATCTCCT AGCTCACTAT 
GCCATCCAGG ATGATCTGGA CAAGGACTGC AGCAATATGG TGCCAGCCGA GAAGACCCGG 
GTGGAGAGTG TGGAACTGGT GCTGCCTCCT CACGCCAATC ATCAGGGCAA TACCTTTGGG 
GGCCAGATCA TGGCCTGGAT GGAGAACGTG GCCACCATTG CAGCCAGCCG GCTCTGTCAT 
GCCCACCCTA CACTCAAGGC CATCGAGATG TTCCATTTCC GAGGCCCATC TCAGGTGGGG 
GACCGTCTGG TGCTCAAGGC CATCGTGAAT AATGCCTTCA AGCATAGCAT GGAGGTGGGT 
GTGTGTGTAG AGGCTTACCG CCAGGAGGCT GAGACCCAGC GCCGGCACAT CAACAGCGCC 
TTCATGACTT TCGTGGTCCT GGACAAAGAT GACCAGCCTC AGAAGCTGCC CTGGATTCGT 
CCCCAGCCTG GGGATGGTGA ACGGCGATAC CGAGAGGCCA GTGCCAGGAA GAAGATCCGC 
CTGGACAGGA AGTACCTTGT GTCCTGTAAG CAGGCGGAAA TGGCCCTGTC TGTTCCCTGG 
GATCCTAGCA ACCAGGTATA CCTGAGCTAT TACAACGTGT CCTCTCTGAA GACGCTTATG 
GCCAAGGATA ACTGGGTGCT GTCTGTGGAG ATCAGTGAGG TTCGCCTGTA CATCCTGGAA 
GAGGAGTTCC TGTCCTTTCA CTTGGAGATG GTGGTAAATG TGGATGCCGC CCAGGTCTTT 
CAGCTGCTCT CAGACCTGAG CAGAAGACCA GAGTGGGACA AGCATTGCCG GAGTGTGGAG 
CTAGTGCAGC AAGTGGATGA GGATGACGCC ATCTACCATG TCATCAGCCC TACCCTGAGT 
GGTAACACCA AGCCCCAAGA CTTTGTGATC CTGGCCTCTA GGAGGAAGCC TTGTGACAGT 
GGGGACCCCT ACGTCATTGC CCTGAGGTCT GTCACACTGC CCACGCACCG TGAGACACCG 
GAATATCAAC GTGGGGAGAC TCTCTGTTCA GGCTTCTGTT TGTGGCGTGA GGGGGACCAG 
TCGACTAAGG TTTCTTACTA TAACCAGGCT ACCCCTGGTT TTCTCAACTA TGTGACCACC 
AATGTGGCTG GCCTGTCCTC GGAGTTCTAC AACACTTTCA AGGCTTGTGA GAGTTTCCTG 
TTGGACAACC GGAATGACCT GGCCCCCAGC CTCCAGACCC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258312.1
CDS	112..1896
Translation	MIQNVGNHLRRGFASMFSSRTSRKSVSHPESGDASAMAEGEGYRNPTEVQMSQLVLPCHTNHRGELSIGQLLKWIDTTACLSAERHAGCPCVTASMDDIYFDHTISVGQVVNIKAKVNRAFNSSMEVGIQVVSEDLCSEKQWSVCKALATFVAHRELSKVKLKQVVPLTEEEKTEHGVAAERRRMRLVYTDTIKDLLAHYAIQDDLDKDCSNMVPAEKTRVESVELVLPPHANHQGNTFGGQIMAWMENVATIAASRLCHAHPTLKAIEMFHFRGPSQVGDRLVLKAIVNNAFKHSMEVGVCVEAYRQEAETQRRHINSAFMTFVVLDKDDQPQKLPWIRPQPGDGERRYREASARKKIRLDRKYLVSCKQAEMALSVPWDPSNQVYLSYYNVSSLKTLMAKDNWVLSVEISEVRLYILEEEFLSFHLEMVVNVDAAQVFQLLSDLSRRPEWDKHCRSVELVQQVDEDDAIYHVISPTLSGNTKPQDFVILASRRKPCDSGDPYVIALRSVTLPTHRETPEYQRGETLCSGFCLWREGDQSTKVSYYNQATPGFLNYVTTNVAGLSSEFYNTFKACESFLLDNRNDLAPSLQTL

Target ORF information:

RefSeq Version	NM_001271383.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus acyl-CoA thioesterase 11 (Acot11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271383.1

ORF Insert Sequence:

ATGATACAGA ATGTGGGCAA CCACTTACGA AGGGGCTTCG CCTCTATGTT CTCTAGTCGG 
ACATCCCGGA AGTCAGTCTC TCATCCGGAG TCCGGAGACG CTTCCGCCAT GGCAGAGGGT 
GAAGGCTACC GGAACCCCAC GGAGGTGCAG ATGAGCCAGC TGGTGCTGCC CTGCCACACT 
AACCACCGTG GGGAGCTGAG CATTGGGCAG TTGCTCAAAT GGATCGACAC CACAGCCTGC 
CTATCAGCGG AGAGGCATGC TGGCTGTCCC TGTGTCACAG CCTCCATGGA TGACATCTAC 
TTCGACCATA CCATTAGTGT CGGCCAAGTG GTGAATATCA AGGCCAAGGT GAACCGGGCC 
TTCAACTCCA GCATGGAGGT AGGAATCCAG GTGGTCTCTG AAGATCTGTG CTCTGAGAAA 
CAGTGGAGTG TCTGCAAGGC CTTGGCCACC TTCGTGGCCC ACCGGGAGCT CTCCAAGGTG 
AAGCTGAAGC AGGTTGTCCC ATTGACGGAG GAGGAGAAGA CCGAGCATGG GGTGGCGGCT 
GAGCGCCGGC GTATGCGACT GGTCTACACA GACACCATCA AGGATCTCCT AGCTCACTAT 
GCCATCCAGG ATGATCTGGA CAAGGACTGC AGCAATATGG TGCCAGCCGA GAAGACCCGG 
GTGGAGAGTG TGGAACTGGT GCTGCCTCCT CACGCCAATC ATCAGGGCAA TACCTTTGGG 
GGCCAGATCA TGGCCTGGAT GGAGAACGTG GCCACCATTG CAGCCAGCCG GCTCTGTCAT 
GCCCACCCTA CACTCAAGGC CATCGAGATG TTCCATTTCC GAGGCCCATC TCAGGTGGGG 
GACCGTCTGG TGCTCAAGGC CATCGTGAAT AATGCCTTCA AGCATAGCAT GGAGGTGGGT 
GTGTGTGTAG AGGCTTACCG CCAGGAGGCT GAGACCCAGC GCCGGCACAT CAACAGCGCC 
TTCATGACTT TCGTGGTCCT GGACAAAGAT GACCAGCCTC AGAAGCTGCC CTGGATTCGT 
CCCCAGCCTG GGGATGGTGA ACGGCGATAC CGAGAGGCCA GTGCCAGGAA GAAGATCCGC 
CTGGACAGGA AGTACCTTGT GTCCTGTAAG CAGGCGGAAA TGGCCCTGTC TGTTCCCTGG 
GATCCTAGCA ACCAGGTATA CCTGAGCTAT TACAACGTGT CCTCTCTGAA GACGCTTATG 
GCCAAGGATA ACTGGGTGCT GTCTGTGGAG ATCAGTGAGG TTCGCCTGTA CATCCTGGAA 
GAGGAGTTCC TGTCCTTTCA CTTGGAGATG GTGGTAAATG TGGATGCCGC CCAGGTCTTT 
CAGCTGCTCT CAGACCTGAG CAGAAGACCA GAGTGGGACA AGCATTGCCG GAGTGTGGAG 
CTAGTGCAGC AAGTGGATGA GGATGACGCC ATCTACCATG TCATCAGCCC TACCCTGAGT 
GGTAACACCA AGCCCCAAGA CTTTGTGATC CTGGCCTCTA GGAGGAAGCC TTGTGACAGT 
GGGGACCCCT ACGTCATTGC CCTGAGGTCT GTCACACTGC CCACGCACCG TGAGACACCG 
GAATATCAAC GTGGGGAGAC TCTCTGTTCA GGCTTCTGTT TGTGGCGTGA GGGGGACCAG 
TCGACTAAGG TTTCTTACTA TAACCAGGCT ACCCCTGGTT TTCTCAACTA TGTGACCACC 
AATGTGGCTG GCCTGTCCTC GGAGTTCTAC AACACTTTCA AGGCTTGTGA GAGTTTCCTG 
TTGGACAACC GGAATGACCT GGCCCCCAGC CTCCAGACCC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue.
Molecular metabolism5(5)340-51(2016 May)
Okada K,LeClair KB,Zhang Y,Li Y,Ozdemir C,Krisko TI,Hagen SJ,Betensky RA,Banks AS,Cohen DE

Human brown fat inducible thioesterase variant 2 cellular localization and catalytic function.
Biochemistry51(35)6990-9(2012 Sep)
Chen D,Latham J,Zhao H,Bisoffi M,Farelli J,Dunaway-Mariano D

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity.
The Biochemical journal360(Pt 1)135-42(2001 Nov)
Adams SH,Chui C,Schilbach SL,Yu XX,Goddard AD,Grimaldi JC,Lee J,Dowd P,Colman S,Lewin DA