| Gene Symbol | PRNP |
| Entrez Gene ID | 493887 |
| Full Name | prion protein |
| Synonyms | PRPC,Prp,SIP |
| Gene Type | protein-coding |
| Organism | Ovis aries(sheep) |
ORF » Species Summary » Ovis aries » PRNP cDNA ORF clone
| Gene Symbol | PRNP |
| Entrez Gene ID | 493887 |
| Full Name | prion protein |
| Synonyms | PRPC,Prp,SIP |
| Gene Type | protein-coding |
| Organism | Ovis aries(sheep) |
| mRNA | Protein | Name |
|---|---|---|
| NM_001009481.1 | NP_001009481.1 | major prion protein precursor |
| XM_012188090.2 | XP_012043480.1 | major prion protein isoform X1 |
Determining the Relative Susceptibility of Four Prion Protein Genotypes to Atypical Scrapie.
Silva CJ, Erickson-Beltran ML, Mart?n-Burriel I, Badiola JJ, Requena JR, Bolea R
Analytical chemistry90(2)1255-1262(2018 Jan)
The mechanism of monomer transfer between two structurally distinct PrP oligomers.
Armiento A, Moireau P, Martin D, Lepejova N, Doumic M, Rezaei H
PloS one12(7)e0180538(2017)
Ovine leukocyte profiles do not associate with variation in the prion gene, but are breed dependent.
Mousel MR, White SN, Herndon DR, Reynolds JO, Gonzalez MV, Johnson WC, Ueti MW, Taylor JB, Knowles DP
Animal genetics47(1)136-7(2016 Feb)
Sheep prions with molecular properties intermediate between classical scrapie, BSE and CH1641-scrapie.
Langeveld JP, Jacobs JG, Erkens JH, Baron T, Andr?oletti O, Yokoyama T, van Keulen LJ, van Zijderveld FG, Davidse A, Hope J, Tang Y, Bossers A
Prion8(4)296-305(2014)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data suggest that prion protein (PrP) oligomers constitute a highly dynamic population.
Title: The mechanism of monomer transfer between two structurally distinct PrP oligomers.
There were no associations of any PRNP genotype with any leukocyte count
Title: Ovine leukocyte profiles do not associate with variation in the prion gene, but are breed dependent.
The predominant Q allele occurred at codon 171 of prion with a 88.68 %frequency.
Title: Allelic variants of PRNP in 16 Chinese local sheep breeds.
This study examined 7 deviant ovine field cases of scrapie for some typical molecular aspects of PrP(res) found in CH1641scrapie, classical scrapie and bovine spongiform encephalopathy.
Title: Sheep prions with molecular properties intermediate between classical scrapie, BSE and CH1641-scrapie.
our observations show amino acid residues 141 and 154 influence secondary structure and conformational change in ovine PrP that may correlate with different forms of scrapie
Title: Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP.
The following PRNP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRNP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSm00172 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001009481.1 | |
| Accession Version | NM_001009481.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-24 | |
| Organism | Ovis aries(sheep) | |
| Product | major prion protein precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U67922.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DY512663.1, DY513952.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA104494974, SAMEA104494976 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGTGAAAA GCCACATAGG CAGTTGGATC CTGGTTCTCT TTGTGGCCAT GTGGAGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001009481.1 |
| CDS | 161..931 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001009481.1 |
1 | ATGGTGAAAA GCCACATAGG CAGTTGGATC CTGGTTCTCT TTGTGGCCAT GTGGAGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21936 | |
| Clone ID Related Accession (Same CDS sequence) | XM_012188090.2 | |
| Accession Version | XM_012188090.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-12-16 | |
| Organism | Ovis aries(sheep) | |
| Product | major prion protein isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639022.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 17, 2015 this sequence version replaced XM_012188090.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGTGAAAA GCCACATAGG CAGTTGGATC CTGGTTCTCT TTGTGGCCAT GTGGAGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_012043480.1 |
| CDS | 114..884 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_012188090.2 |
1 | ATGGTGAAAA GCCACATAGG CAGTTGGATC CTGGTTCTCT TTGTGGCCAT GTGGAGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Determining the Relative Susceptibility of Four Prion Protein Genotypes to Atypical Scrapie. |
The mechanism of monomer transfer between two structurally distinct PrP oligomers. |
Ovine leukocyte profiles do not associate with variation in the prion gene, but are breed dependent. |
Sheep prions with molecular properties intermediate between classical scrapie, BSE and CH1641-scrapie. |