| Gene Symbol | BMP4 |
| Entrez Gene ID | 443502 |
| Full Name | bone morphogenetic protein 4 |
| Gene Type | protein-coding |
| Organism | Ovis aries(sheep) |
ORF » Species Summary » Ovis aries » BMP4 cDNA ORF clone
| Gene Symbol | BMP4 |
| Entrez Gene ID | 443502 |
| Full Name | bone morphogenetic protein 4 |
| Gene Type | protein-coding |
| Organism | Ovis aries(sheep) |
| mRNA | Protein | Name |
|---|---|---|
| XM_012180610.2 | XP_012036000.1 | bone morphogenetic protein 4 isoform X1 |
| XM_015096688.1 | XP_014952174.1 | bone morphogenetic protein 4 isoform X2 |
| XM_012180607.2 | XP_012035997.1 | bone morphogenetic protein 4 isoform X1 |
| XM_012180609.2 | XP_012035999.1 | bone morphogenetic protein 4 isoform X1 |
| XM_027971440.1 | XP_027827241.1 | bone morphogenetic protein 4 isoform X2 |
| XM_012180607.3 | XP_012035997.1 | bone morphogenetic protein 4 isoform X1 |
| XM_015096687.1 | XP_014952173.1 | bone morphogenetic protein 4 isoform X1 |
| NM_001110277.1 | NP_001103747.1 | bone morphogenetic protein 4 precursor |
Anti-M?llerian hormone regulation by the bone morphogenetic proteins in the sheep ovary: deciphering a direct regulatory pathway.
Estienne A, Pierre A, di Clemente N, Picard JY, Jarrier P, Mansanet C, Monniaux D, Fabre S
Endocrinology156(1)301-13(2015 Jan)
Dynamic regulation of pituitary mRNAs for bone morphogenetic protein (BMP) 4, BMP receptors, and activin/inhibin subunits in the ewe during the estrous cycle and in cultured pituitary cells.
Sallon C, Faure MO, Fontaine J, Taragnat C
The Journal of endocrinology207(1)55-65(2010 Oct)
Gene expression profiles of BMP4, FGF10 and cognate inhibitors, in the skin of foetal Merino sheep, at the time of secondary follicle branching.
Menzies M, Stockwell S, Brownlee A, Cam G, Ingham A
Experimental dermatology18(10)877-9(2009 Oct)
Sequence diversity and rates of molecular evolution between sheep and cattle genes.
Kijas JW, Menzies M, Ingham A
Animal genetics37(2)171-4(2006 Apr)
The role of bone morphogenetic proteins 2, 4, 6 and 7 during ovarian follicular development in sheep: contrast to rat.
Juengel JL, Reader KL, Bibby AH, Lun S, Ross I, Haydon LJ, McNatty KP
Reproduction (Cambridge, England)131(3)501-13(2006 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This study concluded that AMH could mediate the actions of BMPs in regulating follicular development and contributing to the determination of ovulation numbers.
Title: Anti-M?llerian hormone regulation by the bone morphogenetic proteins in the sheep ovary: deciphering a direct regulatory pathway.
pituitary BMP4 would not play a crucial role in the regulation of FSH production during the estrous cycle, whereas local activin B would be a major stimulus of FSH synthesis necessary for the secondary FSH surge
Title: Dynamic regulation of pituitary mRNAs for bone morphogenetic protein (BMP) 4, BMP receptors, and activin/inhibin subunits in the ewe during the estrous cycle and in cultured pituitary cells.
At the time of secondary follicle branching in the skin of fetal Merino sheep, BMP4 transcript levels rapidly increased from day 105 to maximal levels that were maintained until 131 days, before declining.
Title: Gene expression profiles of BMP4, FGF10 and cognate inhibitors, in the skin of foetal Merino sheep, at the time of secondary follicle branching.
The following BMP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BMP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSm21178 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001110277.1 | |
| Accession Version | NM_001110277.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-03 | |
| Organism | Ovis aries(sheep) | |
| Product | bone morphogenetic protein 4 precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU183348.1. ##Evidence-Data-START## Transcript exon combination :: EU183348.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA104494974, SAMEA104494977 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001103747.1 |
| CDS | 69..1298 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001110277.1 |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21884 | |
| Clone ID Related Accession (Same CDS sequence) | XM_012180610.2 , XM_012180607.2 , XM_012180609.2 , XM_012180607.3 , XM_015096687.1 | |
| Accession Version | XM_012180610.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-12-16 | |
| Organism | Ovis aries(sheep) | |
| Product | bone morphogenetic protein 4 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639016.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 17, 2015 this sequence version replaced XM_012180610.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_012036000.1 |
| CDS | 184..1413 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_012180610.2 |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21884 | |
| Clone ID Related Accession (Same CDS sequence) | XM_012180610.2 , XM_012180607.2 , XM_012180609.2 , XM_012180607.3 , XM_015096687.1 | |
| Accession Version | XM_012180607.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-12-16 | |
| Organism | Ovis aries(sheep) | |
| Product | bone morphogenetic protein 4 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639016.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 17, 2015 this sequence version replaced XM_012180607.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_012035997.1 |
| CDS | 443..1672 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_012180607.2 |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21884 | |
| Clone ID Related Accession (Same CDS sequence) | XM_012180610.2 , XM_012180607.2 , XM_012180609.2 , XM_012180607.3 , XM_015096687.1 | |
| Accession Version | XM_012180609.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-12-16 | |
| Organism | Ovis aries(sheep) | |
| Product | bone morphogenetic protein 4 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639016.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 17, 2015 this sequence version replaced XM_012180609.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_012035999.1 |
| CDS | 341..1570 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_012180609.2 |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21884 | |
| Clone ID Related Accession (Same CDS sequence) | XM_012180610.2 , XM_012180607.2 , XM_012180609.2 , XM_012180607.3 , XM_015096687.1 | |
| Accession Version | XM_012180607.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-05 | |
| Organism | Ovis aries(sheep) | |
| Product | bone morphogenetic protein 4 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040258.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 6, 2019 this sequence version replaced XM_012180607.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_012035997.1 |
| CDS | 435..1664 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_012180607.3 |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21884 | |
| Clone ID Related Accession (Same CDS sequence) | XM_012180610.2 , XM_012180607.2 , XM_012180609.2 , XM_012180607.3 , XM_015096687.1 | |
| Accession Version | XM_015096687.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-12-16 | |
| Organism | Ovis aries(sheep) | |
| Product | bone morphogenetic protein 4 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639016.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_014952173.1 |
| CDS | 979..2208 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_015096687.1 |
1 | ATGATTCCTG GTAACCGAAT GCTGATGGTC GTTTTATTAT GCCAAGTCCT GCTAGGAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21885 | |
| Clone ID Related Accession (Same CDS sequence) | XM_015096688.1 , XM_027971440.1 | |
| Accession Version | XM_015096688.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-12-16 | |
| Organism | Ovis aries(sheep) | |
| Product | bone morphogenetic protein 4 isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639016.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGTTCGGGC TGCGCCGCCG CCCGCAGCCT AGCAAGAGCG CAGTCATCCC GGATTACATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_014952174.1 |
| CDS | 1116..2156 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_015096688.1 |
1 | ATGTTCGGGC TGCGCCGCCG CCCGCAGCCT AGCAAGAGCG CAGTCATCCC GGATTACATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21885 | |
| Clone ID Related Accession (Same CDS sequence) | XM_015096688.1 , XM_027971440.1 | |
| Accession Version | XM_027971440.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-05 | |
| Organism | Ovis aries(sheep) | |
| Product | bone morphogenetic protein 4 isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040258.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGTTCGGGC TGCGCCGCCG CCCGCAGCCT AGCAAGAGCG CAGTCATCCC GGATTACATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_027827241.1 |
| CDS | 571..1611 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_027971440.1 |
1 | ATGTTCGGGC TGCGCCGCCG CCCGCAGCCT AGCAAGAGCG CAGTCATCCC GGATTACATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Anti-M?llerian hormone regulation by the bone morphogenetic proteins in the sheep ovary: deciphering a direct regulatory pathway. |
Dynamic regulation of pituitary mRNAs for bone morphogenetic protein (BMP) 4, BMP receptors, and activin/inhibin subunits in the ewe during the estrous cycle and in cultured pituitary cells. |
Gene expression profiles of BMP4, FGF10 and cognate inhibitors, in the skin of foetal Merino sheep, at the time of secondary follicle branching. |
Sequence diversity and rates of molecular evolution between sheep and cattle genes. |
The role of bone morphogenetic proteins 2, 4, 6 and 7 during ovarian follicular development in sheep: contrast to rat. |