AGTR1 cDNA ORF clone, Ovis aries(sheep)

Gene
Clones
gRNAs

Summary

Gene Symbol	AGTR1
Entrez Gene ID	443107
Full Name	angiotensin II receptor type 1
Synonyms	AT1-R
Gene Type	protein-coding
Organism	Ovis aries(sheep)

mRNA and Protein(s)

mRNA	Protein	Name
XM_012148215.2	XP_012003605.1	type-1 angiotensin II receptor isoform X1
NM_001009744.1	NP_001009744.1	type-1 angiotensin II receptor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Do angiotensin type 2 receptors modulate haemodynamic effects of type 1 receptors in conscious newborn lambs?
Vinturache AE, Smith FG
Journal of the renin-angiotensin-aldosterone system : JRAAS15(4)450-7(2014 Dec)

Dietary restriction in the periconceptional period in normal-weight or obese ewes results in increased abundance of angiotensin-converting enzyme (ACE) and angiotensin type 1 receptor (AT1R) in the absence of changes in ACE or AT1R methylation in the adrenal of the offspring.
Zhang S, Morrison JL, Gill A, Rattanatray L, MacLaughlin SM, Kleemann D, Walker SK, McMillen IC
Reproduction (Cambridge, England)146(5)443-54(2013)

Renal growth retardation following angiotensin II type 1 (AT?) receptor antagonism is associated with increased AT? receptor protein in fetal sheep.
Forhead AJ, Jellyman JK, Gillham K, Ward JW, Blache D, Fowden AL
The Journal of endocrinology208(2)137-45(2011 Feb)

Mild chronic hypoxemia modifies expression of brain stem angiotensin peptide receptors and reflex responses in fetal sheep.
Pulgar VM, Hong JK, Jessup JA, Massmann AG, Diz DI, Figueroa JP
American journal of physiology. Regulatory, integrative and comparative physiology297(2)R446-52(2009 Aug)

Thyroid hormone replacement normalizes renal renin and angiotensin receptor expression in thyroidectomized fetal sheep.
Chen K, Carey LC, Valego NK, Rose JC
American journal of physiology. Regulatory, integrative and comparative physiology293(2)R701-6(2007 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AT2Rs do not counterbalance the pressor and renal vasoconstrictor effects elicited by activation of AT1Rs in the immediate newborn period.
Title: Do angiotensin type 2 receptors modulate haemodynamic effects of type 1 receptors in conscious newborn lambs?

Data from an embryo transfer model suggest that weight loss around time of conception in both normal-weight and obese ewes results in changes within intra-adrenal renin-angiotensin system in offspring consistent with increased AT1R activation.
Title: Dietary restriction in the periconceptional period in normal-weight or obese ewes results in increased abundance of angiotensin-converting enzyme (ACE) and angiotensin type 1 receptor (AT1R) in the absence of changes in ACE or AT1R methylation in the adrenal of the offspring.

In the ovine fetus, AT receptor antagonism causes increased renal protein expression of the AT receptor subtype, which, combined with inhibition of AT receptor activity, may be partly responsible for growth retardation of the developing kidney.
Title: Renal growth retardation following angiotensin II type 1 (AT?) receptor antagonism is associated with increased AT? receptor protein in fetal sheep.

Chronic mild hypoxemia increased binding of angiotensin receptors in brain stem nuclei, decreased spontaneous baroreflex gain, and increased chemoreflex responses to asphyxia in the fetus.
Title: Mild chronic hypoxemia modifies expression of brain stem angiotensin peptide receptors and reflex responses in fetal sheep.

replacement of thyroid hormone in hypothyroid sheep fetuses can restore renal ANG II receptor and renin expression and secretion to normal
Title: Thyroid hormone replacement normalizes renal renin and angiotensin receptor expression in thyroidectomized fetal sheep.

The following AGTR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AGTR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSm00201	NM_001009744.1 Latest version!	Ovis aries angiotensin II receptor type 1 (AGTR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OSm21641	XM_012148215.2 Latest version!	Ovis aries angiotensin II receptor, type 1 (AGTR1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AGTR1 ( NM_001009744.1 ) cDNA ORF clone, Ovis aries(sheep) -> NP_001009744.1 Ovis aries angiotensin II receptor type 1 (AGTR1), mRNA.

Price & Availability↑

CloneID	OSm00201
Clone ID Related Accession (Same CDS sequence)	NM_001009744.1
Accession Version	NM_001009744.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-23
Organism	Ovis aries(sheep)
Product	type-1 angiotensin II receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF254119.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF254119.1, AF056308.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA104494977, SAMEA104494983 [ECO:0000348] ##Evidence-Data-END##

ATGATCCTCA ACTCTTCCAC CGAAGATGGT ATTAAAAGAA TCCAAGATGA CTGTCCCAAA 
GCTGGAAGGC ACAATTACAT ATTTATCATG ATCCCTACTT TATACAGTAT TATCTTTGTG 
GTGGGGCTAT TTGGAAACAG CTTGGTGGTG ATTGTGATTT ACTTTTACAT GAAACTGAAG 
ACTGTGGCCA GTGTTTTTCT TTTGAATTTA GCTCTGGCTG ACTTATGCTT TTTACTGACT 
TTGCCGCTGT GGGCTGTCTA CACTGCTATG GAATACCGCT GGCCCTTCGG CAATTACCTA 
TGTAAGATCG CTTCCGGCAG TGTCAGTTTC AACCTCTACG CCAGTGTGTT TCTACTCACA 
TGTCTAAGCA TTGACCGCTA CCTGGCTATT GTTCACCCAA TGAAGTCCCG CCTCCGGCGC 
ACAATGCTTG TGGCCAAAGT CACCTGCATC ATTATTTGGC TGCTGGCAGG TTTGGCCAGT 
TTGCCAACTA TAATCCACCG CAATGTATTT TTCATCGAGA ATACCAATAT CACAGTTTGC 
GCTTTCCATT ACGAATCCCA AAATTCTACC CTCCCGGTAG GGCTGGGCCT CACCAAGAAT 
ATACTGGGAT TCTTGTTTCC TTTTCTGATC ATTCTTACAA GCTACACTCT TATTTGGAAG 
ACCCTCAAGA AGGCTTATGA AATTCAGAAG AACAAACCAA GGAAAGATGA TATTTTCAAG 
ATAATTTTGG CAATCGTGCT TTTCTTTTTC TTCTCCTGGG TTCCCCACCA GATATTCACT 
TTTATGGATG TGTTAATTCA GTTGGGCCTC ATTCGTGACT GTAAAATTGA AGATATTGTT 
GACACTGCCA TGCCCATCAC TATTTGCTTG GCTTATTTTA ACAATTGCCT GAATCCTCTC 
TTTTATGGCT TTCTAGGGAA AAAATTTAAA AAATATTTTC TGCAGCTTCT GAAATACATT 
CCCCCGAAGG CCAAATCCCA CTCAAACCTG TCAACAAAAA TGAGCACACT CTCCTACCGC 
CCCTCAGAAA ATGGAAACTC CTCTACCAAG AAGCCTGCCC CATGCACTGA GGTTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009744.1
CDS	322..1401
Translation	MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGLFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASGSVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCTEVE

Target ORF information:

RefSeq Version	NM_001009744.1
Organism	Ovis aries(sheep)
Definition	Ovis aries angiotensin II receptor type 1 (AGTR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001009744.1

ORF Insert Sequence:

ATGATCCTCA ACTCTTCCAC CGAAGATGGT ATTAAAAGAA TCCAAGATGA CTGTCCCAAA 
GCTGGAAGGC ACAATTACAT ATTTATCATG ATCCCTACTT TATACAGTAT TATCTTTGTG 
GTGGGGCTAT TTGGAAACAG CTTGGTGGTG ATTGTGATTT ACTTTTACAT GAAACTGAAG 
ACTGTGGCCA GTGTTTTTCT TTTGAATTTA GCTCTGGCTG ACTTATGCTT TTTACTGACT 
TTGCCGCTGT GGGCTGTCTA CACTGCTATG GAATACCGCT GGCCCTTCGG CAATTACCTA 
TGTAAGATCG CTTCCGGCAG TGTCAGTTTC AACCTCTACG CCAGTGTGTT TCTACTCACA 
TGTCTAAGCA TTGACCGCTA CCTGGCTATT GTTCACCCAA TGAAGTCCCG CCTCCGGCGC 
ACAATGCTTG TGGCCAAAGT CACCTGCATC ATTATTTGGC TGCTGGCAGG TTTGGCCAGT 
TTGCCAACTA TAATCCACCG CAATGTATTT TTCATCGAGA ATACCAATAT CACAGTTTGC 
GCTTTCCATT ACGAATCCCA AAATTCTACC CTCCCGGTAG GGCTGGGCCT CACCAAGAAT 
ATACTGGGAT TCTTGTTTCC TTTTCTGATC ATTCTTACAA GCTACACTCT TATTTGGAAG 
ACCCTCAAGA AGGCTTATGA AATTCAGAAG AACAAACCAA GGAAAGATGA TATTTTCAAG 
ATAATTTTGG CAATCGTGCT TTTCTTTTTC TTCTCCTGGG TTCCCCACCA GATATTCACT 
TTTATGGATG TGTTAATTCA GTTGGGCCTC ATTCGTGACT GTAAAATTGA AGATATTGTT 
GACACTGCCA TGCCCATCAC TATTTGCTTG GCTTATTTTA ACAATTGCCT GAATCCTCTC 
TTTTATGGCT TTCTAGGGAA AAAATTTAAA AAATATTTTC TGCAGCTTCT GAAATACATT 
CCCCCGAAGG CCAAATCCCA CTCAAACCTG TCAACAAAAA TGAGCACACT CTCCTACCGC 
CCCTCAGAAA ATGGAAACTC CTCTACCAAG AAGCCTGCCC CATGCACTGA GGTTGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AGTR1 ( XM_012148215.2 ) cDNA ORF clone, Ovis aries(sheep) -> XP_012003605.1 Ovis aries angiotensin II receptor, type 1 (AGTR1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OSm21641
Clone ID Related Accession (Same CDS sequence)	XM_012148215.2
Accession Version	XM_012148215.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-12-16
Organism	Ovis aries(sheep)
Product	type-1 angiotensin II receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639010.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Dec 17, 2015 this sequence version replaced XM_012148215.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGTGG CATCATCCCT CTTCCGTCAG CATCTGGAGA GGAAAGGGGG TTGGGCCGAG 
AGGGTCTCCC GGGCGGGGCG GAGGAGGAGA GAGTGCAAAA CACAGCCTCG CCCCTGGAAC 
CCTCGAAGCA GCAACGCCCC TCGCTATAAA TTTGGAGCTG CCTCAGAGAG GACGATTCCA 
GCGCCAGTCA GCCAAGGGCC TGAGGCGACT GAGCGCCCGG GCAGACGCGC AATTAGCAGC 
TCTGCCTACC TACCCGAGAC GGCGATCCAT GAGGAGGAAC CCAAGCGAGC CCCGGGAGTG 
AGGGCGCACC CTGAACCGTT GCCGCCAGCT CGGCCCAACG CCGGCGCAGC GTCCCGAGTG 
AGCGCGGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_012003605.1
CDS	352..723
Translation	MAVASSLFRQHLERKGGWAERVSRAGRRRRECKTQPRPWNPRSSNAPRYKFGAASERTIPAPVSQGPEATERPGRRAISSSAYLPETAIHEEEPKRAPGVRAHPEPLPPARPNAGAASRVSAD

Target ORF information:

RefSeq Version	XM_012148215.2
Organism	Ovis aries(sheep)
Definition	Ovis aries angiotensin II receptor, type 1 (AGTR1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_012148215.2

ORF Insert Sequence:

ATGGCTGTGG CATCATCCCT CTTCCGTCAG CATCTGGAGA GGAAAGGGGG TTGGGCCGAG 
AGGGTCTCCC GGGCGGGGCG GAGGAGGAGA GAGTGCAAAA CACAGCCTCG CCCCTGGAAC 
CCTCGAAGCA GCAACGCCCC TCGCTATAAA TTTGGAGCTG CCTCAGAGAG GACGATTCCA 
GCGCCAGTCA GCCAAGGGCC TGAGGCGACT GAGCGCCCGG GCAGACGCGC AATTAGCAGC 
TCTGCCTACC TACCCGAGAC GGCGATCCAT GAGGAGGAAC CCAAGCGAGC CCCGGGAGTG 
AGGGCGCACC CTGAACCGTT GCCGCCAGCT CGGCCCAACG CCGGCGCAGC GTCCCGAGTG 
AGCGCGGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Do angiotensin type 2 receptors modulate haemodynamic effects of type 1 receptors in conscious newborn lambs?
Journal of the renin-angiotensin-aldosterone system : JRAAS15(4)450-7(2014 Dec)
Vinturache AE,Smith FG

Dietary restriction in the periconceptional period in normal-weight or obese ewes results in increased abundance of angiotensin-converting enzyme (ACE) and angiotensin type 1 receptor (AT1R) in the absence of changes in ACE or AT1R methylation in the adrenal of the offspring.
Reproduction (Cambridge, England)146(5)443-54(2013)
Zhang S,Morrison JL,Gill A,Rattanatray L,MacLaughlin SM,Kleemann D,Walker SK,McMillen IC

Renal growth retardation following angiotensin II type 1 (AT?) receptor antagonism is associated with increased AT? receptor protein in fetal sheep.
The Journal of endocrinology208(2)137-45(2011 Feb)
Forhead AJ,Jellyman JK,Gillham K,Ward JW,Blache D,Fowden AL

Mild chronic hypoxemia modifies expression of brain stem angiotensin peptide receptors and reflex responses in fetal sheep.
American journal of physiology. Regulatory, integrative and comparative physiology297(2)R446-52(2009 Aug)
Pulgar VM,Hong JK,Jessup JA,Massmann AG,Diz DI,Figueroa JP

Thyroid hormone replacement normalizes renal renin and angiotensin receptor expression in thyroidectomized fetal sheep.
American journal of physiology. Regulatory, integrative and comparative physiology293(2)R701-6(2007 Aug)
Chen K,Carey LC,Valego NK,Rose JC