| Gene Symbol | KDR |
| Entrez Gene ID | 443087 |
| Full Name | kinase insert domain receptor |
| Synonyms | VEGFR-2,flk-1 |
| Gene Type | protein-coding |
| Organism | Ovis aries(sheep) |
ORF » Species Summary » Ovis aries » KDR cDNA ORF clone
| Gene Symbol | KDR |
| Entrez Gene ID | 443087 |
| Full Name | kinase insert domain receptor |
| Synonyms | VEGFR-2,flk-1 |
| Gene Type | protein-coding |
| Organism | Ovis aries(sheep) |
| mRNA | Protein | Name |
|---|---|---|
| XM_012179355.2 | XP_012034745.1 | vascular endothelial growth factor receptor 2 isoform X1 |
| XM_012179355.3 | XP_012034745.1 | vascular endothelial growth factor receptor 2 isoform X1 |
| NM_001278565.1 | NP_001265494.1 | vascular endothelial growth factor receptor 2 precursor |
VEGF increases the permeability of sheep pleura ex vivo through VEGFR2 stimulation.
Peppa VI, Arsenopoulou ZV, Zarogiannis SG, Deligiorgi T, Jagirdar R, Makantasis I, Stefanidis I, Liakopoulos V, Molyvdas PA, Gourgoulianis KI, Hatzoglou C
Cytokine69(2)284-8(2014 Oct)
VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries.
Adeoye OO, Bouthors V, Hubbell MC, Williams JM, Pearce WJ
Journal of applied physiology (Bethesda, Md. : 1985)117(7)777-87(2014 Oct)
Pattern of expression of vascular endothelial growth factor and its receptors in the ovine choroid plexus during long and short photoperiods.
Szczepkowska A, W?sowska B, Gilun PD, Lagaraine C, Robert V, Dufourny L, Thi?ry JC, Skipor J
Cell and tissue research350(1)157-66(2012 Oct)
A genome resource to address mechanisms of developmental programming: determination of the fetal sheep heart transcriptome.
Cox LA, Glenn JP, Spradling KD, Nijland MJ, Garcia R, Nathanielsz PW, Ford SP
The Journal of physiology590(12)2873-84(2012 Jun)
Vascular endothelial growth factor acts through novel, pregnancy-enhanced receptor signalling pathways to stimulate endothelial nitric oxide synthase activity in uterine artery endothelial cells.
Grummer MA, Sullivan JA, Magness RR, Bird IM
The Biochemical journal417(2)501-11(2009 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
VEGF has a direct effect on the pleural mesothelium rendering it more permeable and this effect is mediated through the stimulation of VEGF receptor 2.
Title: VEGF increases the permeability of sheep pleura ex vivo through VEGFR2 stimulation.
VEGF receptor levels were significantly increased by 107% (VEGF-R1) and 156% (VEGF-R2) in hypoxic compared with normoxic arteries.
Title: VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries.
The objective of the study was to determine the expression of vascular endothelial growth factor (VEGF-A), tyrosine kinase receptors Flt-1 and KDR and KDR co-receptor neuropilin 1 (NRP-1) in ovine choroid plexus during different photoperiods.
Title: Pattern of expression of vascular endothelial growth factor and its receptors in the ovine choroid plexus during long and short photoperiods.
VEGF(165) activation of eNOS is completely inhibited by wortmannin
Title: Vascular endothelial growth factor acts through novel, pregnancy-enhanced receptor signalling pathways to stimulate endothelial nitric oxide synthase activity in uterine artery endothelial cells.
The following KDR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KDR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSm81585 | |
| Clone ID Related Accession (Same CDS sequence) | XM_012179355.3 | |
| Accession Version | XM_012179355.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3849bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-05 | |
| Organism | Ovis aries(sheep) | |
| Product | vascular endothelial growth factor receptor 2 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040257.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 6, 2019 this sequence version replaced XM_012179355.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGAGAGCA AGGCGCTGCT GGCTCTTGCT CTGTGGCTCT GCGTGGAGAC CCGGGCTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_012034745.1 |
| CDS | 258..4106 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_012179355.3 |
1 | ATGGAGAGCA AGGCGCTGCT GGCTCTTGCT CTGTGGCTCT GCGTGGAGAC CCGGGCTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21626 | |
| Clone ID Related Accession (Same CDS sequence) | XM_012179355.2 | |
| Accession Version | XM_012179355.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3849bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-12-16 | |
| Organism | Ovis aries(sheep) | |
| Product | vascular endothelial growth factor receptor 2 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639015.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 17, 2015 this sequence version replaced XM_012179355.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGAGAGCA AGGCGCTGCT GGCTCTTGCT CTGTGGCTCT GCGTGGAGAC CCGGGCTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_012034745.1 |
| CDS | 254..4102 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_012179355.2 |
1 | ATGGAGAGCA AGGCGCTGCT GGCTCTTGCT CTGTGGCTCT GCGTGGAGAC CCGGGCTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21460 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001278565.1 | |
| Accession Version | NM_001278565.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4071bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-09 | |
| Organism | Ovis aries(sheep) | |
| Product | vascular endothelial growth factor receptor 2 precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AMGL02018339.1. On Jun 22, 2013 this sequence version replaced XM_004009831.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## CDS exon combination :: GAAI01005611.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA104494974, SAMEA104494976 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGGAGAGCA AGGCGCTGCT GGCTCTTGCT CTGTGGCTCT GCGTGGAGAC CCGGGCTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001265494.1 |
| CDS | 34..4104 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001278565.1 |
1 | ATGGAGAGCA AGGCGCTGCT GGCTCTTGCT CTGTGGCTCT GCGTGGAGAC CCGGGCTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
VEGF increases the permeability of sheep pleura ex vivo through VEGFR2 stimulation. |
VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries. |
Pattern of expression of vascular endothelial growth factor and its receptors in the ovine choroid plexus during long and short photoperiods. |
A genome resource to address mechanisms of developmental programming: determination of the fetal sheep heart transcriptome. |
Vascular endothelial growth factor acts through novel, pregnancy-enhanced receptor signalling pathways to stimulate endothelial nitric oxide synthase activity in uterine artery endothelial cells. |