CXCL8 cDNA ORF clone, Oryctolagus cuniculus(rabbit)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCL8
Entrez Gene ID	100009129
Full Name	C-X-C motif chemokine ligand 8
Synonyms	IL8
Gene Type	protein-coding
Organism	Oryctolagus cuniculus(rabbit)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001082293.1	NP_001075762.1	interleukin-8 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Genetic characterization of interleukins (IL-1?, IL-1?, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs.
Neves F, Abrantes J, Almeida T, de Matos AL, Costa PP, Esteves PJ
Innate immunity21(8)787-801(2015 Nov)

Allogeneic Articular Chondrocyte Transplantation Downregulates Interleukin 8 Gene Expression in the Degenerating Rabbit Intervertebral Disk In Vivo.
Zhang Y, Chee A, Shi P, Wang R, Moss I, Chen EY, He TC, An HS
American journal of physical medicine & rehabilitation94(7)530-8(2015 Jul)

[Dachengqi decoction reduces the serum levels of mast cell tryptase and inflammatory cytokines in rabbits with post-cardiac arrest syndrome].
Yang J, Xiao M, Wang X, Li X, Liang P, Chai L, Luo M
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology30(10)1026-9(2014 Oct)

Role of the JNK pathway on the expression of inflammatory factors in alveolar macrophages under mechanical ventilation.
Tong J, Zhou XD, Kolosov VP, Perelman JM
International immunopharmacology17(3)821-7(2013 Nov)

Correlation of neutrophil and monocyte derived interleukin-1 receptor antagonist and interleukin-8 with colitis severity in the rabbit.
Kaneda K, Saitoh F, Shibusawa H, Maegawa H, Saniabadi AR, Kashiwagi N, Matsukawa A
Cytokine56(2)508-14(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

At the 2-wk time point, interleukin 8 gene expression was comparable in intervertebral discs injected with chondrocytes in controls, whereas its expression in IVDs injected with saline increased 50-fold
Title: Allogeneic Articular Chondrocyte Transplantation Downregulates Interleukin 8 Gene Expression in the Degenerating Rabbit Intervertebral Disk In Vivo.

Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.
Title: [Dachengqi decoction reduces the serum levels of mast cell tryptase and inflammatory cytokines in rabbits with post-cardiac arrest syndrome].

The JNK pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 expression may be regulated by other signaling pathways.
Title: Role of the JNK pathway on the expression of inflammatory factors in alveolar macrophages under mechanical ventilation.

IL-8 and IL-1ra showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis
Title: Correlation of neutrophil and monocyte derived interleukin-1 receptor antagonist and interleukin-8 with colitis severity in the rabbit.

The following CXCL8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OOb30084	NM_001082293.1 Latest version!	Oryctolagus cuniculus C-X-C motif chemokine ligand 8 (CXCL8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCL8 ( NM_001082293.1 ) cDNA ORF clone, Oryctolagus cuniculus(rabbit) -> NP_001075762.1 Oryctolagus cuniculus C-X-C motif chemokine ligand 8 (CXCL8), mRNA.

Price & Availability↑

CloneID	OOb30084
Clone ID Related Accession (Same CDS sequence)	NM_001082293.1
Accession Version	NM_001082293.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Oryctolagus cuniculus(rabbit)
Product	interleukin-8 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M57439.1. ##Evidence-Data-START## Transcript exon combination :: M57439.1, EC620163.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3321799, SAMEA3321801 [ECO:0000348] ##Evidence-Data-END##

ATGAACTCCA AGCTGGCTGT GGCTCTCTTG GCAACCTTCC TGCTGTCTCT GACTCTTTGT 
GAAGCTGCAG TTCTGACACG GATTGGTACA GAGCTTCGAT GCCAGTGCAT AAAGACACAC 
TCCACACCTT TCCATCCCAA ATTTATCAAA GAATTGAGAG TGATTGAGAG TGGACCTCAC 
TGTGCAAATT CAGAAATCAT TGTAAAACTT GTTGATGGAA GAGAACTCTG CCTGGACCCC 
AAGGAAAAGT GGGTGCAGAA GGTTGTGCAA ATATTCTTGA AGAGGGCTGA GCAGCAAGAG 
TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001075762.1
CDS	30..335
Translation	MNSKLAVALLATFLLSLTLCEAAVLTRIGTELRCQCIKTHSTPFHPKFIKELRVIESGPHCANSEIIVKLVDGRELCLDPKEKWVQKVVQIFLKRAEQQES

Target ORF information:

RefSeq Version	NM_001082293.1
Organism	Oryctolagus cuniculus(rabbit)
Definition	Oryctolagus cuniculus C-X-C motif chemokine ligand 8 (CXCL8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001082293.1

ORF Insert Sequence:

ATGAACTCCA AGCTGGCTGT GGCTCTCTTG GCAACCTTCC TGCTGTCTCT GACTCTTTGT 
GAAGCTGCAG TTCTGACACG GATTGGTACA GAGCTTCGAT GCCAGTGCAT AAAGACACAC 
TCCACACCTT TCCATCCCAA ATTTATCAAA GAATTGAGAG TGATTGAGAG TGGACCTCAC 
TGTGCAAATT CAGAAATCAT TGTAAAACTT GTTGATGGAA GAGAACTCTG CCTGGACCCC 
AAGGAAAAGT GGGTGCAGAA GGTTGTGCAA ATATTCTTGA AGAGGGCTGA GCAGCAAGAG 
TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic characterization of interleukins (IL-1?, IL-1?, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs.
Innate immunity21(8)787-801(2015 Nov)
Neves F,Abrantes J,Almeida T,de Matos AL,Costa PP,Esteves PJ

Allogeneic Articular Chondrocyte Transplantation Downregulates Interleukin 8 Gene Expression in the Degenerating Rabbit Intervertebral Disk In Vivo.
American journal of physical medicine & rehabilitation94(7)530-8(2015 Jul)
Zhang Y,Chee A,Shi P,Wang R,Moss I,Chen EY,He TC,An HS

[Dachengqi decoction reduces the serum levels of mast cell tryptase and inflammatory cytokines in rabbits with post-cardiac arrest syndrome].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology30(10)1026-9(2014 Oct)
Yang J,Xiao M,Wang X,Li X,Liang P,Chai L,Luo M

Role of the JNK pathway on the expression of inflammatory factors in alveolar macrophages under mechanical ventilation.
International immunopharmacology17(3)821-7(2013 Nov)
Tong J,Zhou XD,Kolosov VP,Perelman JM

Correlation of neutrophil and monocyte derived interleukin-1 receptor antagonist and interleukin-8 with colitis severity in the rabbit.
Cytokine56(2)508-14(2011 Nov)
Kaneda K,Saitoh F,Shibusawa H,Maegawa H,Saniabadi AR,Kashiwagi N,Matsukawa A