Lpar4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lpar4
Entrez Gene ID	78134
Full Name	lysophosphatidic acid receptor 4
Synonyms	5730485F04Rik,Gpr23,LPA4,p2y9
General protein information	Preferred Names lysophosphatidic acid receptor 4 Names lysophosphatidic acid receptor 4 G protein-coupled receptor 23 LPA receptor 4 LPA-4 P2Y purinoceptor 9 purinergic receptor 9
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X D

mRNA and Protein(s)

mRNA	Protein	Name
NM_175271.4	NP_780480.2	lysophosphatidic acid receptor 4

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Lpar4	NP_001100410.1
Pan troglodytes (chimpanzee)	LPAR4	XP_521150.2
Bos taurus (cattle)	LPAR4	NP_001091574.1
Mus musculus (house mouse)	Lpar4	NP_780480.2
Gallus gallus (chicken)	LPAR4	NP_001264978.1
	LPAR4	XP_001101441.1
Homo sapiens (human)	LPAR4	NP_001264929.1
Canis lupus familiaris (dog)	LPAR4	XP_549098.2
Danio rerio (zebrafish)	LOC794698	XP_001334713.1
Xenopus tropicalis (tropical clawed frog)	lpar4	NP_001072847.1

Gene Ontology
Bibliography

Related articles in PubMed

Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact.
Takara K, Eino D, Ando K, Yasuda D, Naito H, Tsukada Y, Iba T, Wakabayashi T, Muramatsu F, Kidoya H, Fukuhara S, Mochizuki N, Ishii S, Kishima H, Takakura N
Cell reports20(9)2072-2086(2017 Aug)

Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.
Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M
International immunology28(6)283-92(2016 Jun)

The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells.
Igarashi H, Akahoshi N, Ohto-Nakanishi T, Yasuda D, Ishii S
Scientific reports511410(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells
Title: The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells.

These results suggest that LPA(4) regulates establishment of the structure and function of blood and lymphatic vessels during mouse embryogenesis
Title: LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.

These results provide genetic and biochemical evidence that LPA(4) is a suppressor of LPA-dependent cell migration and invasion in contrast to the motility-stimulating Edg LPA receptors.
Title: Role of LPA4/p2y9/GPR23 in negative regulation of cell motility.

a direct role for LPA receptor signaling in cell transformation and tumorigenesis in conjunction with c-Myc
Title: In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.

Affymetrix expression profiling shows that the C terminus of Runx2 regulates genes involved in G protein-coupled receptor signaling Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13.
Title: Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors.

The following Lpar4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lpar4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05101	NM_175271.4 Latest version!	Mus musculus lysophosphatidic acid receptor 4 (Lpar4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lpar4 ( NM_175271.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_780480.2 Mus musculus lysophosphatidic acid receptor 4 (Lpar4), mRNA.

Price & Availability↑

CloneID	OMu05101
Clone ID Related Accession (Same CDS sequence)	NM_175271.4
Accession Version	NM_175271.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-12
Organism	Mus musculus(house mouse)
Product	lysophosphatidic acid receptor 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB619126.1, BC138893.1 and AL670943.14. On May 30, 2009 this sequence version replaced NM_175271.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052178.1, AK045289.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTGACA GAAGATTTAT TGACTTCCAA TTCCAAGATT TAAATTCAAG TCTCAGACCC 
AGGTTGGGAA ATGCAACTGC CAATAATACT TGCATTGTTG ATGATTCCTT CAAGTATAAT 
TTGAATGGTG CTGTCTATAG TGTTGTATTC ATCCTGGGTC TAATAACCAA CAGTGCCTCC 
CTGTTTGTCT TCTGCTTCCG CATGAAAATG AGAAGTGAGA CGGCTATTTT CATCACCAAC 
CTGGCCCTCT CTGATTTGCT TTTTGTTTGT ACCCTACCTT TCAAAATATT TTACAACTTT 
AATCGCCACT GGCCTTTTGG TGACACCCTC TGTAAGATCT CAGGGACTGC GTTCCTCACC 
AACATCTATG GGAGCATGCT CTTCCTCACC TGCATCAGTG TGGATCGTTT CCTAGCCATT 
GTCTATCCCT TCCGATCGCG TACCATCAGG ACCAGGAGGA ATTCCGCCAT TGTGTGCGCT 
GGAGTCTGGA TCCTAGTCCT CAGTGGTGGT ATTTCAGCTT CTTTGTTCTC CACCACTAAT 
GTCAACAATG CGACCACCAC TTGCTTTGAA GGCTTCTCCA AACGTGTCTG GAAGACATAC 
CTGTCCAAGA TCACTATATT CATTGAAGTT GTTGGATTCA TCATTCCTCT GATATTGAAT 
GTTTCTTGTT CTTCTGTGGT GCTTAGAACC CTCCGCAAGC CTGCAACATT GTCTCAGATT 
GGGACCAATA AAAAAAAAGT GTTGAAGATG ATCACAGTGC ATATGGCAGT GTTTGTGGTA 
TGCTTTGTAC CATACAACTC CGTTCTCTTT TTATATGCCT TGGTACGCTC CCAAGCCATT 
ACTAATTGCT TATTGGAAAG GTTTGCAAAG ATCATGTACC CAATTACCTT GTGCCTTGCA 
ACTCTGAATT GTTGCTTTGA TCCTTTTATC TATTACTTCA CTCTTGAATC CTTTCAGAAG 
TCCTTTTATA TCAATACACA TATAAGGATG GAGTCGCTGT TTAAGACTGA GACACCTCTG 
ACCCCCAAAC CTTCCCTTCC AGCTATCCAA GAGGAAGTTA GTGATCAAAC AACAAATAAT 
GGTGGTGAAT TAATGCTGGA ATCCACCTTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_780480.2
CDS	550..1662
Translation	MGDRRFIDFQFQDLNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSASLFVFCFRMKMRSETAIFITNLALSDLLFVCTLPFKIFYNFNRHWPFGDTLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVNNATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKPATLSQIGTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRSQAITNCLLERFAKIMYPITLCLATLNCCFDPFIYYFTLESFQKSFYINTHIRMESLFKTETPLTPKPSLPAIQEEVSDQTTNNGGELMLESTF

Target ORF information:

RefSeq Version	NM_175271.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus lysophosphatidic acid receptor 4 (Lpar4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175271.4

ORF Insert Sequence:

ATGGGTGACA GAAGATTTAT TGACTTCCAA TTCCAAGATT TAAATTCAAG TCTCAGACCC 
AGGTTGGGAA ATGCAACTGC CAATAATACT TGCATTGTTG ATGATTCCTT CAAGTATAAT 
TTGAATGGTG CTGTCTATAG TGTTGTATTC ATCCTGGGTC TAATAACCAA CAGTGCCTCC 
CTGTTTGTCT TCTGCTTCCG CATGAAAATG AGAAGTGAGA CGGCTATTTT CATCACCAAC 
CTGGCCCTCT CTGATTTGCT TTTTGTTTGT ACCCTACCTT TCAAAATATT TTACAACTTT 
AATCGCCACT GGCCTTTTGG TGACACCCTC TGTAAGATCT CAGGGACTGC GTTCCTCACC 
AACATCTATG GGAGCATGCT CTTCCTCACC TGCATCAGTG TGGATCGTTT CCTAGCCATT 
GTCTATCCCT TCCGATCGCG TACCATCAGG ACCAGGAGGA ATTCCGCCAT TGTGTGCGCT 
GGAGTCTGGA TCCTAGTCCT CAGTGGTGGT ATTTCAGCTT CTTTGTTCTC CACCACTAAT 
GTCAACAATG CGACCACCAC TTGCTTTGAA GGCTTCTCCA AACGTGTCTG GAAGACATAC 
CTGTCCAAGA TCACTATATT CATTGAAGTT GTTGGATTCA TCATTCCTCT GATATTGAAT 
GTTTCTTGTT CTTCTGTGGT GCTTAGAACC CTCCGCAAGC CTGCAACATT GTCTCAGATT 
GGGACCAATA AAAAAAAAGT GTTGAAGATG ATCACAGTGC ATATGGCAGT GTTTGTGGTA 
TGCTTTGTAC CATACAACTC CGTTCTCTTT TTATATGCCT TGGTACGCTC CCAAGCCATT 
ACTAATTGCT TATTGGAAAG GTTTGCAAAG ATCATGTACC CAATTACCTT GTGCCTTGCA 
ACTCTGAATT GTTGCTTTGA TCCTTTTATC TATTACTTCA CTCTTGAATC CTTTCAGAAG 
TCCTTTTATA TCAATACACA TATAAGGATG GAGTCGCTGT TTAAGACTGA GACACCTCTG 
ACCCCCAAAC CTTCCCTTCC AGCTATCCAA GAGGAAGTTA GTGATCAAAC AACAAATAAT 
GGTGGTGAAT TAATGCTGGA ATCCACCTTC TAG